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Results for "

Pim

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Pim (61) Akt (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (18) Autophagy (5) c-Kit (1) Casein Kinase (5) Caspase (1) CDK (6) Checkpoint Kinase (Chk) (1) DAPK (2) DYRK (3) EGFR (1) ERK (1) FLT3 (1) GSK-3 (2) HDAC (1) MELK (2) mTOR (5) PI3K (2) PKC (1) PKD (2) RIP kinase (2) Small Interfering RNA (siRNA) (9) Trk Receptor (1)
By Research Areas:	Cancer (64) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (3)

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Targets Recommended: Pim

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111552

PIM1-IN-1	Pim	Cancer
PIM1-IN-1 is a potent and highly selective *PIM1/3* inhibitor, with IC₅₀s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC₅₀ of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity .

HY-108605

PIM1-IN-2	Pim	Cancer
PIM1-IN-2 is a potent and ATP competitive *Pim-1* inhibitor with a K_i of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds .

HY-19322B

PIM-447 dihydrochloride 3 Publications Verification LGH447 dihydrochloride	Pim Apoptosis	Cancer
PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with K_i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis .

HY-160006

PIM-IN-2	Pim	Cancer
PIM-IN-2 (Pim-2) is a *Pim* kinases inhibitor (IC₅₀ = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors .

HY-143897

PIM1-IN-3	Pim Apoptosis	Cancer
PIM1-IN-3 (Compound HL8) is a potent inhibitor of *PIM1. PIM1-IN-3 shows selective inhibition for the PIM-1 enzyme. PIM1-IN-3 induces apoptosis efficiently in Colo320 cells. PIM*1-IN-3 has the potential for the research of cancer diseases .

HY-19322

PIM447 3 Publications Verification LGH447
PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with K_i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis .

HY-143898

PIM1-IN-4	Pim	Cancer
PIM1-IN-4 (Compound 8) is a potent inhibitor of *PIM1. PIM1-IN-4 reveals strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1. PIM*1-IN-4 has the potential for the research of cancer diseases .

HY-147921

PIM1-IN-7	Pim	Cancer
PIM1-IN-7 (compound 6c) is a potent *PIM-1* inhibitor, with an IC₅₀ of 0.67 μM. PIM1-IN-7 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC₅₀ values of 42.9 and 7.68 μM, respectively .

HY-147920

PIM1-IN-6	Pim	Cancer
PIM1-IN-6 (compound 5h) is a potent *PIM-1* inhibitor, with an IC₅₀ of 0.60 μM. PIM1-IN-6 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC₅₀ values of 1.51 and 15.2 μM, respectively .

HY-147785

Pim-1 kinase inhibitor 2	Pim Apoptosis	Cancer
Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of Pim-1 kinase. Pim-1 kinase inhibitor 2 induces apoptosis. Pim-1 kinase inhibitor 2 has the potential for the research of cancer diseases .

HY-143295

Pim-1 kinase inhibitor 1	Pim Apoptosis	Cancer
Pim-1 kinase inhibitor 1 is a *Pim-1* kinase inhibitor with an IC₅₀ of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer .

HY-143233

PIM-1/HDAC-IN-1	Pim HDAC Apoptosis	Cancer
PIM-1/HDAC-IN-1 (compound 4d) is a *PIM-1* inhibitor, with an IC₅₀ of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC₅₀ values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase .

HY-142656

PIM-IN-1

Pim Cancer

PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC₅₀ = 61 nM; pS6, EC₅₀ = 71 nM).

PIM-IN-1	Pim	Cancer
PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC₅₀ = 61 nM; pS6, EC₅₀ = 71 nM).

HY-162059

Pim-1 kinase inhibitor 10	Pim Apoptosis Caspase	Cancer
Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation .

HY-163119

Pim-1 kinase inhibitor 9	Pim	Cancer
Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC₅₀ value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity .

HY-149976

Pim-1 kinase inhibitor 4	Pim	Cancer
Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC₅₀: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC₅₀ of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer .

HY-150731

Pim-1 kinase inhibitor 3

Pim Cancer

Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor with an IC₅₀ of 35.13 nM .

Pim-1 kinase inhibitor 3	Pim	Cancer
Pim-1 kinase inhibitor 3 (Compound H5) is a potent *Pim-1* kinase inhibitor with an IC₅₀ of 35.13 nM .

HY-W412264

Pim-1/2 kinase inhibitor 1	Pim	Cancer
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27 ^Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer .

HY-162006

Pim-1 kinase inhibitor 8	PKC Pim	Cancer
Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC₅₀ of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC₅₀s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer .

HY-149996

Pim-1 kinase inhibitor 6	Pim	Cancer
Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC₅₀ value of 0.46 μM, and has significant cytotoxic effect on cancer cells .

HY-149995

Pim-1 kinase inhibitor 5	Pim	Cancer
Pim-1 kinase inhibitor 5 (Compound 4c) is a Pim-1 kinase inhibitor (IC₅₀: 0.61 μM). Pim-1 kinase inhibitor 5 shows cytotoxicity against cancer cells, with IC₅₀s of 6.95-20.19 μM for HepG2, MCF-7, PC3, and HCT-116 cells .

HY-157404

Pim-1/2 kinase inhibitor 2	Pim	Cancer
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive *PIM-1* and PIM-2 kinase inhibitor with IC₅₀s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines .

HY-101947

SMI-16a 3 Publications Verification Pim1/2 Kinase Inhibitor VI	Pim	Cancer
SMI-16a is a selective *Pim* kinase inhibitor with IC₅₀ values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

HY-RS10547

PIM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIM1 Human Pre-designed siRNA Set A PIM1 Human Pre-designed siRNA Set A

HY-RS10548

Pim1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim1 Mouse Pre-designed siRNA Set A Pim1 Mouse Pre-designed siRNA Set A

HY-RS10549

Pim1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pim1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pim1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim1 Rat Pre-designed siRNA Set A Pim1 Rat Pre-designed siRNA Set A

HY-RS10550

PIM2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for PIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIM2 Human Pre-designed siRNA Set A PIM2 Human Pre-designed siRNA Set A

HY-RS10551

Pim2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pim2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pim2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim2 Mouse Pre-designed siRNA Set A Pim2 Mouse Pre-designed siRNA Set A

HY-RS10552

Pim2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Pim2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pim2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim2 Rat Pre-designed siRNA Set A Pim2 Rat Pre-designed siRNA Set A

HY-RS10553

PIM3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PIM3 Human Pre-designed siRNA Set A contains three designed siRNAs for PIM3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIM3 Human Pre-designed siRNA Set A PIM3 Human Pre-designed siRNA Set A

HY-RS10554

Pim3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Pim3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pim3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim3 Mouse Pre-designed siRNA Set A Pim3 Mouse Pre-designed siRNA Set A

HY-RS10555

Pim3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Pim3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pim3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim3 Rat Pre-designed siRNA Set A Pim3 Rat Pre-designed siRNA Set A

HY-10371

Pim1/AKK1-IN-1 4 Publications Verification LKB1/AAK1 dual inhibitor	Pim	Cancer
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with K_d values of 35 nM/53 nM/75 nM/380 nM for *Pim1/AKK1/MST2/LKB1* respectively, and also inhibits MPSK1 and TNIK.

HY-135816

*CK2/PIM1-IN-1*	Casein Kinase Pim	Inflammation/Immunology Cancer
CK2/PIM1-IN-1 is an inhibitor of CK2 and *PIM1, with IC₅₀s of 3.787 μM and 4.327 μM for CK2 and PIM1, respectively. CK2/PIM*1-IN-1 is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders .

HY-18095

CX-6258

Pim Cancer

CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively .

CX-6258	Pim	Cancer
CX-6258 is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively .

HY-18095A

CX-6258 hydrochloride hydrate	Pim	Cancer
CX-6258 hydrochloride hydrate is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively .

HY-18095B

CX-6258 hydrochloride	Pim	Cancer
CX-6258 hydrochloride is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively .

HY-18086

*TCS PIM-1 1* 3 Publications Verification SC 204330	Pim	Cancer
TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive *Pim-1* kianse inhibitor with an IC₅₀ of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC₅₀s >20000 nM) .

HY-132867

MNK/PIM-IN-1

Pim Cancer

MNK/PIM-IN-1 represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.
HY-13287A

SGI-1776

Pim Apoptosis Autophagy Inflammation/Immunology

SGI-1776 is an inhibitor of Pim kinases, with IC₅₀s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively .

*MNK/PIM-IN-1*	Pim	Cancer
MNK/PIM-IN-1 represents an innovative dual *MNK/PIM* inhibitor with a good pharmacokinetic profile.

SGI-1776	Pim Apoptosis Autophagy	Inflammation/Immunology
SGI-1776 is an inhibitor of Pim kinases, with IC₅₀s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively .

HY-142696

*CDK6/PIM1-IN-1*	CDK Pim Apoptosis	Cancer
CDK6/PIM1-IN-1 is a potent and balanced dual *CDK6/PIM1* inhibitor with IC₅₀ values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 inhibits CDK4 (IC₅₀=3.6 nM). CDK6/PIM1-IN-1 significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity .

HY-16576A

SMI-4a TCS-Pim-1-4a	Pim	Cancer
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive *Pim-1* inhibitor with an IC₅₀ of 24 μM and a K_i of 0.6 μM. SMI-4a also inhibits *Pim-2* (IC₅₀ of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity .

HY-19322C

*(1S,3R,5R)-PIM447 dihydrochloride* (1S,3R,5R)-LGH447 dihydrochloride	Pim	Cancer
(1S,3R,5R)-PIM447 (dihydrochloride) an *PIM* inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC₅₀ values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

HY-123141

K00135	Pim	Cancer
K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets .

HY-15901A

LGB321 monohydrochloride	Pim mTOR	Cancer
LGB321 monohydrochloride is a potent, selective, orally active and ATP competitive inhibitor of all three *PIM* kinases. LGB321 monohydrochloride inhibits proliferation, mTOR-C1 signaling and phosphorylation of BAD in a number of cell lines derived from diverse hematologic malignancies. LGB321 monohydrochloride can be used for the research of hematologic malignancies .

HY-157169

IBL-302 AMU302	Pim mTOR Akt PI3K	Cancer
IBL-302 (AMU302) is an orally available dual-signaling inhibitor of PIM and PI3K/AKT/mTOR with activity against breast cancer and neuroblastoma. IBL-302 demonstrated in vivo efficacy in a nude mouse xenograft model, inhibiting trastuzumab (HY-P9907) resistance challenges. IBL-302 also enhances the effects of common cytotoxic chemotherapy drugs cisplatin (HY-17394), doxorubicin (HY-15142A), and etoposide (HY-13629) .

HY-101126

TP-3654

3 Publications Verification

Pim Cancer

TP-3654 is a second-generation Pim kinase inhibitor with K_i values of 5 and 42 nM for Pim-1 and Pim-3, respectively.
HY-101783

GNE-955

Pim Cancer

GNE-955 is a potent and orally active pan Pim kinase inhibitor with K_is of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

HY-12830

M-110	Pim	Cancer
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for *PIM-3* (IC₅₀=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC₅₀s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC₅₀s of 0.6 to 0.9 μM .

HY-123983

HS56	Pim DAPK	Cardiovascular Disease
HS56 is an ATP-competitive dual *Pim/DAPK3* inhibitor with K_i values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension .

Species:	Human (4)
Tag:	His (1) Tag Free (2) GST (1)
Source:	Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701746

	PIM2 Protein, Human Pim2; Serine/threonine-protein kinase Pim-2; Pim-2h	Human	E. coli
	The PIM2 protein is a proto-oncogene with serine/threonine kinase activity that critically promotes cell survival and proliferation through multiple mechanisms. It enhances MYC stability and transcriptional activity, explaining the synergistic effect in tumorigenesis. PIM2 Protein, Human is the recombinant human-derived PIM2 protein, expressed by E. coli , with tag free. The total length of PIM2 Protein, Human is 311 a.a., .

HY-P701747

	PIM2 Protein, Human (His) Pim2; Serine/threonine-protein kinase Pim-2; Pim-2h	Human	E. coli
	The PIM2 protein is a proto-oncogene with serine/threonine kinase activity that critically promotes cell survival and proliferation through multiple mechanisms. It enhances MYC stability and transcriptional activity, explaining the synergistic effect in tumorigenesis. PIM2 Protein, Human (His) is the recombinant human-derived PIM2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PIM2 Protein, Human (His) is 311 a.a., .

HY-P701745

	PIM1 Protein, Human Pim1; Serine/threonine-protein kinase Pim-1	Human	E. coli
	The PIM1 protein is a proto-oncogene with serine/threonine kinase activity that significantly promotes cell survival and proliferation, providing a selective advantage for tumorigenesis. It regulates MYC transcription, cell cycle progression, and inhibits pro-apoptotic proteins such as BAD, MAP3K5, and FOXO3 through phosphorylation. PIM1 Protein, Human is the recombinant human-derived PIM1 protein, expressed by E. coli , with tag free. The total length of PIM1 Protein, Human is 300 a.a., .

HY-P701749

	PIM3 Protein, Human (Sf9, GST) Pim3; Serine/threonine-protein kinase Pim-3	Human	Sf9 insect cells
	The PIM3 protein is a serine/threonine kinase proto-oncogene that is crucial in preventing apoptosis, promoting cell survival, and protein translation in underlying tumorigenesis. It phosphorylates BAD, releases anti-apoptotic Bcl-X(L) and affects cell cycle, protein synthesis and MYC transcriptional activity, showing multifaceted effects on tumorigenesis. PIM3 Protein, Human (Sf9, GST) is the recombinant human-derived PIM3 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PIM3 Protein, Human (Sf9, GST) is 325 a.a., .

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