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Scutellaria

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Bacterial (2) Enterovirus (2) HIV (1) Phosphodiesterase (PDE) (1) Polo-like Kinase (PLK) (1) Prolyl Endopeptidase (PREP) (1) STAT (1)
By Research Areas:	Cancer (6) Infection (4) Inflammation/Immunology (5) Neurological Disease (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2562

Norwogonin 5,7,8-Trihydroxyflavone	Enterovirus	Infection
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC₅₀ of 31.83 μg/ml

HY-N1264

Scutebarbatine Y

Others Others

Scutebarbatine Y is a neo-clerodane diterpenoid that can be isolated from Scutellaria barbata .

Scutebarbatine Y	Others	Others
Scutebarbatine Y is a neo-clerodane diterpenoid that can be isolated from Scutellaria barbata .

HY-N1664

2',4'-Dihydroxy-2,3',6'-trimethoxychalcone	Others	Others
2',4'-Dihydroxy-2,3',6'-trimethoxychalcone, a flavonoid, is a natural product that can be isolated from the roots of Scutellaria Luzonicatropical .

HY-N10799

Oroxylin A 7-O-β-D-glucuronide methyl ester	Others	Others
Oroxylin A 7-O-β-D-glucuronide methyl ester is a nature product that could be isolated form the roots of Scutellaria baicalensis Georgi .

HY-N12394

Norwogonin-8-O-glucuronide	Others	Inflammation/Immunology
Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity .

HY-N2658

5,7-Diacetoxy-8-methoxyflavone	Phosphodiesterase (PDE)	Others
5,7-Diacetoxy-8-methoxyflavone is a natural product that could come from scutellaria genus plants. 5,7-Diacetoxy-8-methoxyflavone has inhibitory activity for cAMP phosphodiesterase .

HY-N8462

6-O-Nicotinoylscutebarbatine G Scutebatin C	Others	Cancer
6-O-Nicotinoylscutebarbatine G is an alkaloid that can be isolated from Scutellaria barbata.6-O-Nicotinoylscutebarbatine has cytotoxic activities against HONE-1, KB and HT29 cells with IC₅₀s of 3.1, 2.1 and 5.7 μM, respectively .

HY-122941

Viscidulin II	Others	Inflammation/Immunology
Viscidulin II (FL6) is a flavone. Viscidulin II can be isolated from the root of Scutellaria baicalensis. Viscidulin II significantly suppresses P. acnes-induced IL-8 and IL-1β production in THP-1 cells .

HY-N1085

Viscidulin I

Others Others

Viscidulin I is found in Scutellaria baicalensis Georgi .
HY-N11508

Dihydrobaicalin

Others Others

Dihydrobaicalin is a flavonoid glycoside, which can be isolated from American skullcap (Scutellaria lateriflora L.) .
HY-N1267

Scutebata C

Others Others

Scutebata C is a neoclerodane diterpenoid isolated from Scutellaria barbata with weak cytotoxic activity .
HY-N1268

Scutebata E

Others Others

Scutebata E is a new neoclerodane diterpenoid isolated from Scutellaria barbata with weak cytotoxic activity .
HY-N2376

Chrysin-7-O-glucuronide

1 Publications Verification

Others Others

Chrysin-7-O-glucuronide is a flavonoid extracted from Scutellaria baicalensis, with antioxidant activity .

Viscidulin I	Others	Others
Viscidulin I is found in Scutellaria baicalensis Georgi .

Dihydrobaicalin	Others	Others
Dihydrobaicalin is a flavonoid glycoside, which can be isolated from American skullcap (Scutellaria lateriflora L.) .

Scutebata C	Others	Others
Scutebata C is a neoclerodane diterpenoid isolated from Scutellaria barbata with weak cytotoxic activity .

Scutebata E	Others	Others
Scutebata E is a new neoclerodane diterpenoid isolated from Scutellaria barbata with weak cytotoxic activity .

Chrysin-7-O-glucuronide 1 Publications Verification	Others	Others
Chrysin-7-O-glucuronide is a flavonoid extracted from Scutellaria baicalensis, with antioxidant activity .

HY-N1676

2′,3,5,6′,7-Pentahydroxyflavanone 3,5,7,2',6'-Pentahydroxyflavanone	Others	Others
2′,3,5,6′,7-Pentahydroxyflavanone (compound 4) is a flavonoid compound isolated from Scutellaria baicalensis roots .

HY-N1263

Scutebarbatine X	Others	Inflammation/Immunology
Scutebarbatine X (Compound 2) is a neo-clerodane diterpenoids isolated from Scutellaria barbatae (Labiatae) and has anti-inflammatory properties .

HY-N8737

Desrhamnosylmartynoside	Others	Others
Desrhamnosylmartynosideis extracted from the root of Scutellaria prostrata. Desrhamnosylmartynoside has absorption bands assignable to hydroxyl,α,β-unsanturate carbonyl groups .

HY-N12367

Oroxylin 7-O-glucoside

Others Others

Oroxylin 7-O-glucoside is a flavone. Oroxylin 7-O-glucoside can be isolated from? hot methanol extracts of? Scutellaria ouata .

Oroxylin 7-O-glucoside	Others	Others
Oroxylin 7-O-glucoside is a flavone. Oroxylin 7-O-glucoside can be isolated from? hot methanol extracts of? Scutellaria ouata .

HY-N1265

Scutebata A	Others	Cancer
Scutebata A is a diterpenoid isolated from Scutellaria barbata that exhibits antitumor activity. Scutebata A is weakly cytotoxic against SK-BR-3 with an IC₅₀ value of 15.2 μM .

HY-N11488

5,7,8-Trihydroxy-6-methoxy flavone-7-O-glucuronideb	Others	Others
5,7,8-Trihydroxy-6-methoxy flavone-7-O-glucuronideb is a natural product that can be isolated from Scutellaria baicalensis Georgi .

HY-N8692

Dihydrobaicalein	Polo-like Kinase (PLK)	Cancer
Dihydrobaicalein is a PLK1 Inhibitor with an IC₅₀ of 6.3 μM. Dihydrobaicalein also inhibits VRK2 and PLK2. Dihydrobaicalein is a natural product that can be isolated from Scutellaria scandens .

HY-N1266

Scutebata B	Others	Others
Scutebata B (compound 4) is a neoclerodane diterpenoid iaolated from the whole plant of Scutellaria barbata. Scutebata B has cytotoxic activities with IC₅₀ values of 10.27～28.48 μM .

HY-N11484

5,6,7-Trihydroxyflavone-7-O-β-D-glucuronopyranoside	Others	Others
5,6,7-Trihydroxyflavone-7-O-β-D-glucuronopyranoside is a natural product that can be isolated from the root of Scutellaria repens Buch.-Ham. ex D. Don .

HY-N1083

Viscidulin III Ganhuangenin	Others	Cancer
Viscidulin III is a compound isolated from the roots of Scutellaria planipes (L.) . Viscidulin III can inhibit the proliferation of HL-60 (IC50= 17.4μM). Viscidulin III is a potential natural tumor inhibitor .

HY-N2481

Oroxylin A-7-O-glucuronide Oroxyloside; Oroxylin A-7-O-β-D-glucuronide	Prolyl Endopeptidase (PREP)	Neurological Disease
Oroxylin A-7-O-glucuronide (Oroxyloside; Oroxylin A-7-O-β-D-glucuronide) is a flavonoid glucuronide isolated from the dried root of Scutellaria baicalensis, with prolyl oligopeptidase (POP) inhibitory activity .

HY-N6624

Skullcapflavone II	Bacterial	Inflammation/Immunology
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG .

HY-N1672

5,7,2′,6′-Tetrahydroxyflavanone
5,7,2 ',6 '-Tetrahydroxyflavanone is an extract isolated from Scutellaria baicalensis. 5,7,2 ',6 '-Tetrahydroxyflavanone has significant antibacterial activity against gram-positive bacteria. 5,7,2 ',6 '-Tetrahydroxyflavanone can be used to study the treatment of inflammatory diseases .

HY-N7681

Taxifolin 7-O-β-D-glucoside Taxifolin 7-O-glucoside	Others	Others
Taxifolin 7-O-β-D-glucoside (Taxifolin 7-O-glucoside) is one of the main metabolites at the seed germination stage in Scutellaria baicalensis. Taxifolin 7-O-β-D-glucoside, a flavonoid, mainly exists in the episperm and participates in defending against pathogens and UV-damage .

HY-N1671

2',5,6',7-Tetraacetoxyflavanone	Others	Infection
2',5,6',7-Tetraacetoxyflavanone is an extract isolated from Scutellaria baicalensis. 2',5,6',7-Tetraacetoxyflavanone shows significant antibacterial activity against gram-positive bacteria. 2',5,6',7-Tetraacetoxyflavanone can be used to study the treatment of inflammatory diseases .

HY-N2036

Mosloflavone	Enterovirus Bacterial	Infection
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

HY-N0751

Scutellarin 5+ Cited Publications	STAT Akt HIV	Infection Cancer
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-N1904

4′-Hydroxywogonin 8-Methoxyapigenin
4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis .

HY-N8788

Baicalein 7-O-β-D-ethylglucuronide	Others	Inflammation/Immunology Cancer
Baicalein 7-O-β-D-ethylglucuronide is a natural flavone glycoside that can be extracted from Scutellaria baicalensis Georgi. Baicalein 7-O-β-D-ethylglucuronide has antioxidant activity. Baicalein 7-O-β-D-ethylglucuronide inhibits FeSO₄-Cys-induced lipid peroxidation of liver homogenate. Baicalein 7-O-β-D-ethylglucuronide also shows strong cytoprotective effect on H₂O₂-induced oxidative damage of human umbilical vein endothelial cells .

Norwogonin 5,7,8-Trihydroxyflavone	Infection Flavonoids Scutellaria baicalensis Georgi Classification of Application Fields Flavones Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields	Enterovirus
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC₅₀ of 31.83 μg/ml

Scutebarbatine Y	Structural Classification Terpenoids Labiatae Source classification Derris robusta Diterpenoids Plants	Others
Scutebarbatine Y is a neo-clerodane diterpenoid that can be isolated from Scutellaria barbata .

2',4'-Dihydroxy-2,3',6'-trimethoxychalcone	Flavonoids Chalcones Classification of Application Fields Labiatae Source classification Other Diseases Phenols Polyphenols Ulmus davidiana var. japonica (Rehd.)Nakai Plants Disease Research Fields	Others
2',4'-Dihydroxy-2,3',6'-trimethoxychalcone, a flavonoid, is a natural product that can be isolated from the roots of Scutellaria Luzonicatropical .

Oroxylin A 7-O-β-D-glucuronide methyl ester	Structural Classification Flavonoids Scutellaria baicalensis Georgi Flavones Labiatae Source classification Plants	Others
Oroxylin A 7-O-β-D-glucuronide methyl ester is a nature product that could be isolated form the roots of Scutellaria baicalensis Georgi .

Norwogonin-8-O-glucuronide	Structural Classification Scutellaria indica L. Flavonoids Flavones Labiatae Source classification Plants	Others
Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity .

5,7-Diacetoxy-8-methoxyflavone	Scutellaria baicalensis Georgi Flavones Labiatae Source classification Plants	Phosphodiesterase (PDE)
5,7-Diacetoxy-8-methoxyflavone is a natural product that could come from scutellaria genus plants. 5,7-Diacetoxy-8-methoxyflavone has inhibitory activity for cAMP phosphodiesterase .

6-O-Nicotinoylscutebarbatine G Scutebatin C	Structural Classification Alkaloids Other Alkaloids Labiatae Source classification Derris robusta Pyridine Alkaloids Plants	Others
6-O-Nicotinoylscutebarbatine G is an alkaloid that can be isolated from Scutellaria barbata.6-O-Nicotinoylscutebarbatine has cytotoxic activities against HONE-1, KB and HT29 cells with IC₅₀s of 3.1, 2.1 and 5.7 μM, respectively .

Viscidulin II	Structural Classification Flavonoids Scutellaria baicalensis Georgi Flavones Labiatae Source classification Plants	Others
Viscidulin II (FL6) is a flavone. Viscidulin II can be isolated from the root of Scutellaria baicalensis. Viscidulin II significantly suppresses P. acnes-induced IL-8 and IL-1β production in THP-1 cells .

Viscidulin I	Flavonols Flavonoids Artemisia tridentata Nutt. Classification of Application Fields Labiatae Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Others
Viscidulin I is found in Scutellaria baicalensis Georgi .

Dihydrobaicalin	Structural Classification Flavonoids Scutellaria baicalensis Georgi Flavones Labiatae Source classification Plants	Others
Dihydrobaicalin is a flavonoid glycoside, which can be isolated from American skullcap (Scutellaria lateriflora L.) .

Scutebata C	Structural Classification Terpenoids Labiatae Source classification Derris robusta Diterpenoids Plants	Others
Scutebata C is a neoclerodane diterpenoid isolated from Scutellaria barbata with weak cytotoxic activity .

Scutebata E	Structural Classification Terpenoids Labiatae Source classification Derris robusta Diterpenoids Plants	Others
Scutebata E is a new neoclerodane diterpenoid isolated from Scutellaria barbata with weak cytotoxic activity .

Chrysin-7-O-glucuronide 1 Publications Verification	Scutellaria baicalensis Georgi Classification of Application Fields Flavones Source classification Plants Oroxylum indicum (Linn.) Bentham ex Kurz Monophenols Flavonoids Labiatae Other Diseases Phenols Bignoniaceae Disease Research Fields	Others
Chrysin-7-O-glucuronide is a flavonoid extracted from Scutellaria baicalensis, with antioxidant activity .

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Scutellaria

Inhibitors & Agonists

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