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TCF12 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF15 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF19 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF20 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF21 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF23 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF23 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF25 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF25 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF3 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF4 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF7 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF7L1 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF7L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TCF7L2 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF7L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TC-F2 is a reversible non-covalent binding inhibitor of fatty acid amide hydrolase (FAAH) with an IC50 of 28 nM. FAAH is involved in many human diseases, particularly cancer, pain and inflammation as well as neurological, metabolic and cardiovascular disorders .
BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM .
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.
CCT 031374 hydrobromid is a potent inhibitor of β-catenin/transcription factor (TCF) complex signaling. CCT031374 inhibits TCF-dependent transcription of genes of Wnt signaling pathway. CCT 031374 has antitumor activity .
Toxoflavin- 13C4 is the 13C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Antibiotic properties.
β-catenin-IN-7 (Compound 9) is a β-catenin inhibitor. β-catenin-IN-7 inhibits the interaction between β-catenin and Tcf-4, and inhibits Wnt-dependent target gene expression. β-catenin-IN-7 has anti-cancer activity .
Eciskafusp alfa is a programmed cell death 1 (PDCD1, best known as PD-1) cis-targeted IL2v immunocytokine. Eciskafusp alfa preferentially targets antigen-specific stem-like PD-1+ TCF-1+ CD8+ T cells and differentiates them towards a novel population of better effectors. Eciskafusp alfa can be used for the research of cancer and chronic infections .
Pterostilbene-isothiocyanate (PTER-ITC) exhibits potent anticancereffects in vitro. Pterostilbene-isothiocyanate against human osteosarcoma cells by abrogating the β-catenin/TCF-4 interaction .
WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor.
Adavivint (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells .
Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells .
Hematein is a oxidation product of hematoxylin acted as a dye . Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells .
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .
UU-T01 is a selective inhibitor for β-Catenin/T-cell factor 4 protein-protein interaction (β-catenin/Tcf PPI) with an Ki value of 3.14 µM. UU-T01 is directly combined with β-catenin, and the KD value is 0.531 µM .
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM . UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells .
ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction.
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively .
FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K .
TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295) .
Eciskafusp alfa is a programmed cell death 1 (PDCD1, best known as PD-1) cis-targeted IL2v immunocytokine. Eciskafusp alfa preferentially targets antigen-specific stem-like PD-1+ TCF-1+ CD8+ T cells and differentiates them towards a novel population of better effectors. Eciskafusp alfa can be used for the research of cancer and chronic infections .
HNF 4 alpha, a nuclear transcription factor, forms homodimers to bind DNA. It regulates gene expression, including hepatocyte nuclear factor 1 alpha, impacting hepatic genes. Its involvement extends to liver, kidney, and intestinal development. Mutations associate with autosomal dominant non-insulin-dependent diabetes mellitus type I. The gene exhibits biased expression in the duodenum (RPKM 37.7) and colon (RPKM 32.8), among other tissues. HNF 4 alpha (HNF4A) Recombinant Protein,Human (C-His) is the recombinant human-derived HNF 4 alpha, expressed by HEK293 , with C-10*His labeled tag. The total length of HNF 4 alpha (HNF4A) Recombinant Protein,Human (C-His) is 474 a.a., with molecular weight of ~70-80 kDa.
The HGF gene encodes hepatocyte growth factor (HGF), a protein involved in organ regeneration, angiogenesis, and myelination. It is located in the extracellular space and serves as a biomarker for cholangiocarcinoma. Implicated in various diseases, HGF plays a crucial role in physiological and pathological conditions. It shows biased expression in the liver (RPKM 137.5), lung (RPKM 132.1), and other tissues. HGF Protein, Rat (HEK293) is the recombinant rat-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Rat (HEK293) is 696 a.a., with molecular weight of ~92 kDa.
HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and acts as a hepatotrophic factor for various tissues. As an activating ligand for MET receptor tyrosine kinase, HGF binds and promotes dimerization, activating MAPK signaling through TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Mouse (HEK293) is the recombinant mouse-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Mouse (HEK293) is 696 a.a., with molecular weight of ~93 kDa.
HGF protein is a potent hepatocyte mitogen that stimulates mature hepatocyte proliferation and exhibits multiple growth factor properties in different tissues. As a ligand of MET receptor tyrosine kinase, HGF initiates downstream signaling cascades upon binding, activating MAPK signaling after TMPRSS13 cleavage. HGF Protein, Canine (HEK293) is the recombinant canine-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Canine (HEK293) is 699 a.a., with molecular weight of ~79.9 kDa.
HGF Protein, a potent mitogen, stimulates mature hepatocyte growth and exhibits hepatotrophic properties for various tissues. It acts as an activating ligand for the receptor tyrosine kinase MET, promoting dimerization upon binding. Structurally, HGF Protein comprises alpha and beta chains linked by a disulfide bond. Additionally, it interacts with SRPX2, enhancing HGF's mitogenic activity. HGF Protein, Cynomolgus (HEK293) is the recombinant cynomolgus-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Cynomolgus (HEK293) is 728 a.a., with molecular weight of ~89 & 58 & 34 & 32 kDa, respectively.
HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and acts as a hepatotrophic factor for various tissues. As an activating ligand for MET receptor tyrosine kinase, HGF binds and promotes dimerization, activating MAPK signaling through TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Mouse (696a.a, HEK293, His) is the recombinant mouse-derived HGF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HGF Protein, Mouse (696a.a, HEK293, His) is 696 a.a., with molecular weight of (50-90) & (30-34) kDa, respectively.
Interleukin-8 (IL-8), also known as CXCL8 or NAP-1, is a pro-inflammatory CXC chemokine. IL-8 acts on human neutrophils via two receptors, CXCR1 and CXCR2. IL-8 has a conserved Glu-Leu-Arg (ELR) N-terminal motif, and is an agonist for CXCR1/CXCR2. IL-8 is produced by various cells including leukocytes, endothelial cells, and epithelial cells. IL-8/CXCL8 Protein, Human (77a.a, HEK293) is produced in HEK293 cells, and consists of 77 amino acids (A23-S99).
Interleukin-8 (IL-8), also known as CXCL8 or NAP-1, is a pro-inflammatory CXC chemokine. IL-8 acts on human neutrophils via two receptors, CXCR1 and CXCR2. IL-8 has a conserved Glu-Leu-Arg (ELR) N-terminal motif, and is an agonist for CXCR1/CXCR2. IL-8 is produced by various cells including leukocytes, endothelial cells, and epithelial cells. IL-8/CXCL8 Protein, Human (72a.a, HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 72 amino acids (S28-S99).
Interleukin-8 (IL-8), also known as CXCL8 or NAP-1, is a pro-inflammatory CXC chemokine. IL-8 acts on human neutrophils via two receptors, CXCR1 and CXCR2. IL-8 has a conserved Glu-Leu-Arg (ELR) N-terminal motif, and is an agonist for CXCR1/CXCR2. IL-8 is produced by various cells including leukocytes, endothelial cells, and epithelial cells. IL-8/CXCL8 Protein, Rhesus Macaque is produced in E.coil, and consists of 79 amino acids (A23-P101).
Toxoflavin- 13C4 is the 13C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Antibiotic properties.
TCF7L2/TCF4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 68 kDa, targeting to TCF7L2/TCF4. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.
HGF Antibody is an unconjugated, approximately 54/80 kDa, rabbit-derived, anti-HGF polyclonal antibody. HGF Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat, dog, pig, cow, horse, rabbit, sheep, guinea pig background without labeling.
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