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TOPK

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By Targets:	TOPK (8) Antibiotic (2) Apoptosis (3) Bacterial (2) Casein Kinase (1) CDK (1) JNK (1) PI3K (1) Proton Pump (2) VEGFR (1)
By Research Areas:	Cancer (7) Infection (2) Inflammation/Immunology (4) Metabolic Disease (1)

12

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

1

Antibodies

Targets Recommended: TOPK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101550

HI-TOPK-032

1 Publications Verification

TOPK Cancer

HI-TOPK-032 is a potent and specific TOPK inhibitor.

OTS514 2 Publications Verification	TOPK Apoptosis	Cancer
OTS514 is a highly potent *TOPK* inhibitor with an IC₅₀ of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells . OTS514 induces cell cycle arrest and apoptosis .

TOPK-p38/JNK-IN-1	JNK	Cancer
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active *TOPK-p38/JNK* signaling pathway inhibitor with the IC₅₀ value of 2.14 µM for NO production. TOPK-p38/JNK-IN-1 shows anti-inflammatory activities. TOPK-p38/JNK-IN-1 also inhibits phosphorylate downstream related proteins and avoids degradation of TOPK .

OTS514 hydrochloride	TOPK Apoptosis	Cancer
OTS514 hydrochloride is a highly potent *TOPK* inhibitor, which inhibits TOPK kinase activity with a median inhibitory concentration (IC₅₀) value of 2.6 nM. OTS514 hydrochloride strongly suppresses the growth of TOPK-positive cancer cells . OTS514 hydrochloride induces cell cycle arrest and apoptosis .

OTS964
OTS964 is an orally active, high affinity and selective *TOPK* inhibitor with an IC₅₀ of 28 nM . OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a K_d of 40 nM .

OTS964 hydrochloride Maximum Cited Publications 7 Publications Verification	TOPK CDK Apoptosis	Cancer
OTS964 hydrochloride is an orally active, high affinity and selective *TOPK* (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC₅₀ of 28 nM . OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a K_d of 40 nM .

Ilaprazole sodium IY-81149 sodium
Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H ⁺/K ⁺-ATPase in a dose-dependent manner with an IC₅₀ of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium is used for the research of gastric ulcers. Ilaprazole sodium is also a potent *TOPK* (T-lymphokine-activated killer cell-originated protein kinase) inhibitor .

Ilaprazole sodium hydrate IY-81149 sodium hydrate	Proton Pump TOPK	Inflammation/Immunology Cancer
Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor. Ilaprazole sodium hydrate irreversibly inhibits H ⁺/K ⁺-ATPase in a dose-dependent manner with an IC₅₀ of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium hydrate is used for the research of gastric ulcers. Ilaprazole sodium hydrate is also a potent *TOPK* (T-lymphokine-activated killer cell-originated protein kinase) inhibitor .

Ilaprazole IY-81149	Proton Pump TOPK	Inflammation/Immunology Cancer
Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H ⁺/K ⁺-ATPase in a dose-dependent manner with an IC₅₀ of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent *TOPK* (T-lymphokine-activated killer cell-originated protein kinase) inhibitor .

Cephradine 1 Publications Verification Cefradine; SQ-11436	Bacterial Antibiotic TOPK	Infection Inflammation/Immunology
Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of *TOPK* .

Cephradine monohydrate Cefradine monohydrate	Bacterial Antibiotic TOPK	Infection Inflammation/Immunology
Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of *TOPK* .

Orobol	Casein Kinase PI3K VEGFR	Metabolic Disease
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) .

Cat. No.	Compare	Product Name	Species	Source

	*PBK/TOPK* Protein, Human (sf9, His)** Lymphokine-activated killer T-cell-originated protein kinase; CT84; Nori-3; SPK; TOPK	Human	Sf9 insect cells
	PBK/TOPK Protein, a mitosis-specific kinase, phosphorylates MAP kinase p38, emphasizing its specific role in cell division. Implicated in lymphoid cell activation, PBK/TOPK has broader impacts on immune responses. When phosphorylated, it forms a complex with TP53, destabilizing TP53 and dampening the G2/M checkpoint in doxorubicin-induced DNA damage, highlighting its multifaceted functions in cell cycle control and genotoxic stress responses. PBK/TOPK Protein, Human (sf9, His) is the recombinant human-derived PBK/TOPK protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of PBK/TOPK Protein, Human (sf9, His) is 322 a.a., with molecular weight of 35-45 kDa.

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