Search Result

Results for "

carboxamide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Amino Acid Derivatives (2) Antibiotic (2) Antifolate (1) Apoptosis (7) Aryl Hydrocarbon Receptor (1) ATM/ATR (1) Bcr-Abl (1) Biochemical Assay Reagents (1) Ceramidase (1) COX (1) CXCR (2) Deubiquitinase (1) DNA/RNA Synthesis (1) Drug Metabolite (1) FLT3 (1) Fluorescent Dye (1) Fungal (1) Galectin (1) GCGR (2) HIV (1) Isotope-Labeled Compounds (6) Leukotriene Receptor (2) nAChR (1) Neuropeptide Y Receptor (2) NF-κB (3) Nucleoside Antimetabolite/Analog (6) Orthopoxvirus (1) Parasite (1) PGE synthase (1) Pim (1) Potassium Channel (1) Salt-inducible Kinase (SIK) (1) Sodium Channel (1)
By Research Areas:	Cancer (18) Endocrinology (1) Infection (6) Inflammation/Immunology (9) Metabolic Disease (4) Neurological Disease (8)

By Targets:

5-HT Receptor (1)

Amino Acid Derivatives (2)

Antibiotic (2)

Antifolate (1)

Apoptosis (7)

Aryl Hydrocarbon Receptor (1)

ATM/ATR (1)

Bcr-Abl (1)

Biochemical Assay Reagents (1)

Ceramidase (1)

COX (1)

CXCR (2)

Deubiquitinase (1)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

FLT3 (1)

Fluorescent Dye (1)

Fungal (1)

Galectin (1)

GCGR (2)

HIV (1)

Isotope-Labeled Compounds (6)

Leukotriene Receptor (2)

nAChR (1)

Neuropeptide Y Receptor (2)

NF-κB (3)

Nucleoside Antimetabolite/Analog (6)

Orthopoxvirus (1)

Parasite (1)

PGE synthase (1)

Pim (1)

Potassium Channel (1)

Salt-inducible Kinase (SIK) (1)

Sodium Channel (1)

By Research Areas:

Cancer (18)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (9)

Metabolic Disease (4)

Neurological Disease (8)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W012921

(R)-Pyrrolidine-2-carboxamide

Amino Acid Derivatives Others

(R)-Pyrrolidine-2-carboxamide is a proline derivative .
HY-133157

FAICAR

5-Formamidoimidazole-4-carboxamide ribotide
DNA/RNA Synthesis Others

FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide.
HY-W012748S

Piperidine-4-carboxamide-d9

Isotope-Labeled Compounds Others

Piperidine-4-carboxamide-d₉ is the deuterium labeled Piperidine-4-carboxamide[1].
HY-W102890S

Furan-2-carboxamide-d3

Isotope-Labeled Compounds Others

Furan-2-carboxamide-d₃ is the deuterium labeled Furan-2-carboxamide[1].
HY-W017413

(S)-Pyrrolidine-2-carboxamide hydrochloride

Amino Acid Derivatives Others

(S)-Pyrrolidine-2-carboxamide hydrochloride is a proline derivative .

(R)-Pyrrolidine-2-carboxamide	Amino Acid Derivatives	Others
(R)-Pyrrolidine-2-carboxamide is a proline derivative .

FAICAR 5-Formamidoimidazole-4-carboxamide ribotide	DNA/RNA Synthesis	Others
FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide.

*Piperidine-4-carboxamide-d9*	Isotope-Labeled Compounds	Others
Piperidine-4-carboxamide-d₉ is the deuterium labeled Piperidine-4-carboxamide[1].

*Furan-2-carboxamide-d3*	Isotope-Labeled Compounds	Others
Furan-2-carboxamide-d₃ is the deuterium labeled Furan-2-carboxamide[1].

*(S)-Pyrrolidine-2-carboxamide* hydrochloride**	Amino Acid Derivatives	Others
(S)-Pyrrolidine-2-carboxamide hydrochloride is a proline derivative .

HY-41461

5-Amino-3H-imidazole-4-Carboxamide 1 Publications Verification 5-Aminoimidazole-4-carboxamide; AICA
5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.

HY-113472S

N-Methyl-4-pyridone-3-carboxamide-d3

Isotope-Labeled Compounds Others

N-Methyl-4-pyridone-3-carboxamide-d₃ is deuterium labeled N-Methyl-4-pyridone-3-carboxamide.

*N-Methyl-4-pyridone-3-carboxamide-d3*	Isotope-Labeled Compounds	Others
N-Methyl-4-pyridone-3-carboxamide-d₃ is deuterium labeled N-Methyl-4-pyridone-3-carboxamide.

HY-152318

Adenosine-2-carboxamide	Nucleoside Antimetabolite/Analog	Others
Adenosine-2-carboxamide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-41461A

*5-Amino-3H-imidazole-4-carboxamide* hydrochloride** 1 Publications Verification 5-Aminoimidazole-4-carboxamide hydrochloride; AICA hydrochloride	Biochemical Assay Reagents	Others
5-Amino-3H-imidazole-4-carboxamide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-113472

N-Methyl-4-pyridone-3-carboxamide

Drug Metabolite Others

N-Methyl-4-pyridone-3-carboxamide is a metabolite of coffee pyridines .

N-Methyl-4-pyridone-3-carboxamide	Drug Metabolite	Others
N-Methyl-4-pyridone-3-carboxamide is a metabolite of coffee pyridines .

HY-W424788S

*N-(2,6-Dimethylphenyl)-1-isopropylpiperidine-2-carboxamide-d7*	Isotope-Labeled Compounds	Others
N-(2,6-Dimethylphenyl)-1-isopropylpiperidine-2-carboxamide-d₇ is the deuterium labeled N-(2,6-dimethylphenyl)-1-isopropylpiperidine-2-carboxamide[1].

HY-106048

Bredinin aglycone 5-Hydroxy-1H-imidazole-4-carboxamide; SM-108	Nucleoside Antimetabolite/Analog	Others
Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues .

HY-138698

FT206

Deubiquitinase Others

FT206 is an inhibitor of carboxamides as ubiquitin-specific protrase extracted from patent WO 2020033707 A1, example 11-1 .
HY-103592

ARN14974

Ceramidase Cancer

ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC₅₀=79 nM) .

FT206	Deubiquitinase	Others
FT206 is an inhibitor of carboxamides as ubiquitin-specific protrase extracted from patent WO 2020033707 A1, example 11-1 .

ARN14974	Ceramidase	Cancer
ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC₅₀=79 nM) .

HY-152685

4-Amino-1-(β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxamide	Nucleoside Antimetabolite/Analog	Others
4-Amino-1-(β-D-ribofurano syl)-7H-pyrrolo [2.3-d] pyrimidine-5-carboxamide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-163407

Galectin-3-IN-4	Galectin	Cancer
Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC₅₀ values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC₅₀ values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively .

HY-148766

VU661	Others	Metabolic Disease
VU661, a phenazine carboxamide, is a modulator of circadian rhythms to produce a period lengthening of the circadian rhythm. VU661 is a redox-active small molecule .

HY-17520

Penthiopyrad MTF-753	Fungal	Infection
Penthiopyrad (MTF-753) is a chiral carboxamide antifungal agent with a broad spectrum of fungicidal activity. Penthiopyrad can be used for controlling foliar and soil-borne plants diseases on a broad range of agricultural crops and turfgrass .

HY-147416

Vipoglanstat BI 1029539; GS-248; OX-MPI	PGE synthase	Infection
Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1). Vipoglanstat also has anti-inflammatory activity .

HY-13010S

Laquinimod-d5 ABR-215062-d₅	Isotope-Labeled Compounds Apoptosis NF-κB	Inflammation/Immunology
Laquinimod-d5 (ABR-215062-d5) is deuterium labeled Laquinimod. Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator that prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing-remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research .

HY-B0078

Dacarbazine Maximum Cited Publications 9 Publications Verification Imidazole carboxamide	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC₅₀ of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .

HY-B0078B

Dacarbazine hydrochloride Imidazole carboxamide hydrochloride	Antibiotic	Cancer
Dacarbazine hydrochloride is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine hydrochloride inhibits T and B lymphoblastic response, with IC₅₀ values of 50 and 10 μg/mL, respectively. Dacarbazine hydrochloride can be used for the research of metastatic malignant melanoma .

HY-15736

Sodium Channel inhibitor 1	Sodium Channel	Neurological Disease
Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.

HY-13010

Laquinimod 2 Publications Verification ABR-215062	NF-κB Apoptosis	Inflammation/Immunology
Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research .

HY-W062904

Laquinimod sodium ABR-215062 sodium	NF-κB Apoptosis	Neurological Disease Inflammation/Immunology
Laquinimod (ABR-215062) sodium, an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod sodium reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod sodium has the potential for relapsing remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research .

HY-13907

TCS 359 1 Publications Verification	FLT3	Cancer
TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent and selective FLT3 inhibitor with an IC₅₀ of 42 nM. TCS 359 inhibits MV4-11 cell proliferation with an IC₅₀ of 340 nM .

HY-128337

AN7973	Parasite	Infection
AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting agent candidate for treating cryptosporidiosis.

HY-B0078A

Dacarbazine citrate Imidazole carboxamide citrate	Apoptosis Antibiotic	Cancer
Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC₅₀ values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma .

HY-107981

LSN 3213128 1 Publications Verification	Antifolate	Cancer
LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC₅₀ of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity .

HY-151938

Reverse transcriptase-IN-3	HIV	Infection
Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains .

HY-100162

TOK-8801

Others Inflammation/Immunology

TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator.

TOK-8801	Others	Inflammation/Immunology
TOK-8801 is a synthesized dihydroimidazothiazole carboxamide and is under development as an immunomodulator.

HY-114570

Tiazofurin NSC 286193; Riboxamide	Nucleoside Antimetabolite/Analog Orthopoxvirus	Infection Cancer
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH) . Tiazofurin also has anti-orthopoxvirus and anti-variola activities .

HY-150252A

ATIC-IN-1 acetate	Others	Cancer
ATIC-IN-1 (compound 14) acetate is an inhibitor targeting to *Aminoimidazole carboxamide* ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization** with a K_i value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity via reduction in cell numbers and cell division rates .

HY-150252

ATIC-IN-1	Others	Cancer
ATIC-IN-1(compound 14) is an inhibitor targeting to *Aminoimidazole carboxamide* ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization** with a K_i value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates .

HY-135830

AHR antagonist 4	Aryl Hydrocarbon Receptor	Cancer
AHR antagonist 4 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 293, has an IC₅₀ of 82.2 nM. AHR antagonist 4 has anti-cancer effects .

HY-148038

5-HT3 antagonist 5	5-HT Receptor	Neurological Disease
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT₃ receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT₃ agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice .

HY-B0078S

Dacarbazine-d6 Imidazole carboxamide-d₆	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Dacarbazine-d₆ is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.

HY-149082

LTB4 antagonist 1	Leukotriene Receptor	Inflammation/Immunology
LTB4 antagonist 1, a carboxamide-acid compound, is a potent Leukotriene B4 (LTB4) antagonist with an IC₅₀ of 288 nM. LTB4 antagonist 1 has significant anti-inflammatory properties .

HY-149365

SIKs-IN-1	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .

HY-106628

Sudoxicam	COX	Inflammation/Immunology
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity .

HY-149083

LTB4 antagonist 2	Leukotriene Receptor	Inflammation/Immunology
LTB4 antagonist 2, a carboxamide-acid compound, is an antagonist of leukotriene B4 (LTB4) with potentially anti-inflammatory activity. LTB4 antagonist 2 shows good affinity for the LTB4 receptor with IC₅₀ of 439 nM .

HY-118911

ATM Inhibitor-10	ATM/ATR	Cancer
ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC₅₀: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors .

HY-P4154

Bevonescein ALM-488	Fluorescent Dye	Neurological Disease
Bevonescein (ALM-488) is a novel, intravenously-administrated fluorescein-conjugated peptide that binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves .

HY-P2962

Transglutaminase, Streptoverticillium mobaraense TG	Others	Infection Inflammation/Immunology
Transglutaminase, Streptoverticillium mobaraense (TG) is an enzyme that forms crosslinks between protein molecules. Transglutaminase catalyses the formation of an isopeptide bond between the group of γ-carboxamides of glutamine residues and the first-order ε-amine groups of different compounds. Transglutaminase is involved in many physiological processes, including coagulation, antibacterial immune reactions and photosynthesis .

HY-104027

ML402

Potassium Channel Neurological Disease

ML402, a thiophene-carboxamide, is a selective K_2P2.1(TREK-1) and K_2P10.1(TREK-2) activator. ML402 is inactive against K_2P4.1(TRAAK) .

ML402	Potassium Channel	Neurological Disease
ML402, a thiophene-carboxamide, is a selective K_2P2.1(TREK-1) and K_2P10.1(TREK-2) activator. ML402 is inactive against K_2P4.1(TRAAK) .

HY-P1103A

CTCE-9908 TFA	CXCR	Cancer
CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .

HY-P1103

CTCE-9908	CXCR	Cancer
CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .

HY-P2231A

Cotadutide acetate MEDI0382 acetate	GCGR	Metabolic Disease
Cotadutide (MEDI0382) acetate is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC₅₀ values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide acetate can be used in the research of obesity and type 2 diabetes (T2D) .

HY-P2231

Cotadutide MEDI0382	GCGR	Metabolic Disease
Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC₅₀ values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D) .

HY-15738

GNF-5 3 Publications Verification	Bcr-Abl	Cancer
GNF-5, the N-hydroxyethyl carboxamide analog of GNF-2, is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC₅₀ value of 0.22 µM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer .

Cat. No.	Product Name	Target	Research Area

HY-W012921

(R)-Pyrrolidine-2-carboxamide

Amino Acid Derivatives Others

(R)-Pyrrolidine-2-carboxamide is a proline derivative .

HY-P4154

Bevonescein ALM-488	Fluorescent Dye	Neurological Disease
Bevonescein (ALM-488) is a novel, intravenously-administrated fluorescein-conjugated peptide that binds nerve-associated connective tissue, labels peripheral nerves under real-time fluorescence imaging (FL) in living mice and human ex vivo nerve tissue. Bevonescein is a peptide-linked tracer which fluorescently labeled both intact and degenerated nerves .

HY-P1103

CTCE-9908	CXCR	Cancer
CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .

HY-W017413

(S)-Pyrrolidine-2-carboxamide hydrochloride

Amino Acid Derivatives Others

(S)-Pyrrolidine-2-carboxamide hydrochloride is a proline derivative .

HY-P1103A

CTCE-9908 TFA	CXCR	Cancer
CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .

HY-P2231A

Cotadutide acetate MEDI0382 acetate	GCGR	Metabolic Disease
Cotadutide (MEDI0382) acetate is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC₅₀ values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide acetate can be used in the research of obesity and type 2 diabetes (T2D) .

HY-P2231

Cotadutide MEDI0382	GCGR	Metabolic Disease
Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC₅₀ values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D) .

HY-P4757

N1-Glutathionyl-spermidine disulfide

Peptides Others

N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .
HY-P10026

Nisotirostide

LY-3457263
Peptides Metabolic Disease

Nisotirotide (LY-3457263) is a PYY analog agonist studied in type 2 diabetes and obesity .

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8) .

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8) .

HY-P5147

α-Conotoxin GID	nAChR	Neurological Disease
α-Conotoxin GID is a paralytic peptide neurotoxin and a selective antagonist of nAChR, with IC₅₀s of 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2), respectively. α-Conotoxin GID is small disulfide-rich peptide, with potential to inhibit chronic pain. α-Conotoxin GID contains a C-terminal carboxylate, thus substitution with a C-terminal carboxamide results in loss of α4β2 nAChR. α-Conotoxin GID can be isolated from the Conus species .

HY-P10016

Pegmolesatide HS-20039; EPO-018B	Peptides	Endocrinology
Pegmolesatide(HS-20039; EPO-018B) a synthetic peptide-based erythropoiesis-stimulating agent, can be used for ??the study of anemia in chronic kidney disease .

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