Search Result

Results for "

contraction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adenosine Receptor (2) Adenylate Cyclase (2) Adrenergic Receptor (13) Akt (2) Angiotensin Receptor (3) Antibiotic (2) Apoptosis (4) Bacterial (1) Biochemical Assay Reagents (3) Bombesin Receptor (1) Bradykinin Receptor (2) Calcium Channel (8) Cannabinoid Receptor (1) CD38 (1) Cholecystokinin Receptor (4) Cholinesterase (ChE) (1) Cyclic GMP-AMP Synthase (2) Cytochrome P450 (1) DAPK (1) Endogenous Metabolite (11) Endothelin Receptor (2) ERK (2) Fungal (1) GABA Receptor (2) GHSR (2) Glutathione S-transferase (1) Integrin (1) Isotope-Labeled Compounds (3) Leukotriene Receptor (4) Lipoxygenase (1) mAChR (9) Melatonin Receptor (1) mGluR (1) Motilin Receptor (6) Myosin (2) Na+/K+ ATPase (1) Neurokinin Receptor (4) NF-κB (1) NO Synthase (1) Opioid Receptor (2) Organoid (1) Oxytocin Receptor (6) P2X Receptor (2) Parasite (2) Phosphodiesterase (PDE) (1) PI3K (2) Pim (1) PKA (2) Potassium Channel (4) PPAR (1) Prostaglandin Receptor (11) RGS Protein (1) ROCK (1) SARS-CoV (1) Ser/Thr Protease (2) Sodium Channel (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (34) Endocrinology (29) Infection (5) Inflammation/Immunology (23) Metabolic Disease (31) Neurological Disease (37)

By Targets:

5-HT Receptor (3)

Adenosine Receptor (2)

Adenylate Cyclase (2)

Adrenergic Receptor (13)

Akt (2)

Angiotensin Receptor (3)

Antibiotic (2)

Apoptosis (4)

Bacterial (1)

Biochemical Assay Reagents (3)

Bombesin Receptor (1)

Bradykinin Receptor (2)

Calcium Channel (8)

Cannabinoid Receptor (1)

CD38 (1)

Cholecystokinin Receptor (4)

Cholinesterase (ChE) (1)

Cyclic GMP-AMP Synthase (2)

Cytochrome P450 (1)

DAPK (1)

Endogenous Metabolite (11)

Endothelin Receptor (2)

ERK (2)

Fungal (1)

GABA Receptor (2)

GHSR (2)

Glutathione S-transferase (1)

Integrin (1)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (4)

Lipoxygenase (1)

mAChR (9)

Melatonin Receptor (1)

mGluR (1)

Motilin Receptor (6)

Myosin (2)

Na+/K+ ATPase (1)

Neurokinin Receptor (4)

NF-κB (1)

NO Synthase (1)

Opioid Receptor (2)

Organoid (1)

Oxytocin Receptor (6)

P2X Receptor (2)

Parasite (2)

Phosphodiesterase (PDE) (1)

PI3K (2)

Pim (1)

PKA (2)

Potassium Channel (4)

PPAR (1)

Prostaglandin Receptor (11)

RGS Protein (1)

ROCK (1)

SARS-CoV (1)

Ser/Thr Protease (2)

Sodium Channel (2)

By Research Areas:

Cancer (5)

Cardiovascular Disease (34)

Endocrinology (29)

Infection (5)

Inflammation/Immunology (23)

Metabolic Disease (31)

Neurological Disease (37)

137

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101679

YM-58790	mAChR	Neurological Disease
YM-58790 is a potent antagonist of mAChR. YM-58790 binds M1, M2, M3 with K_i values of 28 nM, 260 nM, and 15 nM. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction in rats .

HY-P1233

ANQ-11125	Motilin Receptor	Metabolic Disease
ANQ-11125 is a potent and selective antagonist of motilin, with the pK_d of 8.24. ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit .

HY-134092

N-Methyl Leukotriene C4 N-Methyl-LTC4	Others	Inflammation/Immunology
N-Methyl Leukotriene C4 stimulates contraction of airway smooth muscle in animals, with efficacy varying by tissue and species. For example, it can stimulate the lungs of bullfrogs to contract .

HY-P1233A

ANQ-11125 TFA	Motilin Receptor	Metabolic Disease
ANQ-11125 TFA is a potent and selective antagonist of motilin, with the pK_d of 8.24. ANQ-11125 TFA blocks motilide-induced contractions in vitro in the rabbit .

HY-P3092

Phyllomedusin	Neurokinin Receptor	Neurological Disease
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus .

HY-P2034

Cargutocin

Oxytocin Receptor Endocrinology

Cargutocin, an oxytocin analogue, targets the oxytocin receptor and acts as a uterine contraction agent .

Cargutocin	Oxytocin Receptor	Endocrinology
Cargutocin, an oxytocin analogue, targets the oxytocin receptor and acts as a uterine contraction agent .

HY-P2168

Demoxytocin	Oxytocin Receptor	Endocrinology
Demoxytocin, a heterodetic cyclic peptide, is an analog of oxytocin. Demoxytocin affects the permeability of the cell membrane, increasing the content of calcium ions in smooth muscle cells, increasing its contraction. Demoxytocin also stimulates the contraction of smooth muscles of the uterus. Demoxytocin has the function of oxytocin. Demoxytocin can be used to research stimulation of labor in cases of premature rupture .

HY-113758

LY 163443	Leukotriene Receptor	Inflammation/Immunology
LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4 .

HY-101679A

YM-58790 free base	mAChR	Neurological Disease
YM-58790 free base is a potent antagonist of mAChR. YM-58790 free base binds M1, M2, M3 with K_i values of 28 nM, 260 nM, and 15 nM. YM-58790 free base exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction in rats .

HY-P3433

Sarafotoxin S6b	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the K_i values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively .

HY-N1551

Przewaquinone A	Others	Cardiovascular Disease
Przewaquinone A, a lipophilic diterpene quinone present only in Salvia przewalskii, induces a potent inhibitory action on vascular contraction .

HY-118388

AS604872	Prostaglandin Receptor	Endocrinology
AS604872 is an orally active, potent and selective prostaglandin F2α receptor (FP) antagonist with a K_i of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour .

HY-130138A

(5S,6R)-DiHETE	Others	Inflammation/Immunology
(5S,6R)-DiHETE is an enantiomer of (5,6)-DiHETEs. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction? with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-157495

EP3 antagonist 6	Prostaglandin Receptor	Endocrinology
EP3 antagonist 6 (compound 5) is a potent, orally and selective EP3 receptor antagonist, with an IC₅₀ of 1.9 nM. EP3 antagonist 6 can inhibits PGE2-induced (HY-101952) uterine contraction in pregnant rats .

HY-B0452A

Ritodrine DU21220	Adrenergic Receptor	Endocrinology
Ritodrine (DU21220) is a potent and orally active β-adrenergic agonist. Ritodrine decreases preterm delivery and uterine contraction. Ritodrine has the potential for the research of preterm labor .

HY-114920

Piprofurol	Calcium Channel	Cardiovascular Disease
Piprofurol is a calcium channel inhibitor. Piprofurol inhibits the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta in a concentration-dependent manner and relaxes the K ⁺-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC₅₀ of 5 μM .

HY-106234

ZP 120C	Opioid Receptor	Cardiovascular Disease Neurological Disease
ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia .

HY-A0195

Carboprost tromethamine	Prostaglandin Receptor	Endocrinology
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F_2α. Carboprost tromethamine can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery .

HY-Y0413

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

HY-P2700

µ-Conotoxin GIIIB	Sodium Channel	Neurological Disease
μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a Na_V1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction .

HY-103212

Azepexole dihydrochloride B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pK_is of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively . Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC₅₀= 78.72 nM) .

HY-130138B

(5S,6R)-DiHETEs (5S,6R)-(11E)-DiHETE	Others	Inflammation/Immunology
(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-103212A

Azepexole hydrochloride B-HT 933 hydrochloride; Oxazoloazepin hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pK_i of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC₅₀ of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy .

HY-P3516

Barusiban FE-200440	Oxytocin Receptor	Endocrinology
Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (K_i=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research .

HY-15008

L-368,899	Oxytocin Receptor	Endocrinology
L-368,899 is an orally active and selective OT (oxytocin ) receptor antagonist, with IC₅₀s of 8.9 and 26 nM for uterus of rat and human, respectively. L-368,899 can cross the blood-brain barrier (BBB). L-368,899 inhibits oxytocin-stimulated uterine contractions in rats and can be used in study of preterm labor .

HY-150270

NP-1815-PX	P2X Receptor	Neurological Disease Inflammation/Immunology
NP-1815-PX is a potent and selective P2X4R antagonist. NP-1815-PX has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions .

HY-150270A

NP-1815-PX sodium	P2X Receptor	Neurological Disease Inflammation/Immunology
NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions .

HY-128428

Carboprost 15(S)-15-Methyl Prostaglandin F2α; 15-Methyl-PGF2α	Prostaglandin Receptor	Endocrinology
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .

HY-103204

RS100329 hydrochloride	Adrenergic Receptor	Endocrinology
RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pK_i values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia .

HY-128428R

Carboprost (Standard)		Endocrinology
Carboprost (Standard) is the analytical standard of Carboprost. This product is intended for research and analytical applications. Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-P3849

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) LMN-NKA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues .

HY-106077

Meteneprost

U 46785
Others Others

Meteneprost (U 46785) is a cervical dilator that stimulates uterine contractions and dilates the cervical canal.
HY-106077A

Meteneprost potassium

U 46785 potassium
Others Others

Meteneprost (U 46785) potassium is a cervical dilator that stimulates uterine contractions and dilates the cervical canal.

Meteneprost U 46785	Others	Others
Meteneprost (U 46785) is a cervical dilator that stimulates uterine contractions and dilates the cervical canal.

Meteneprost potassium U 46785 potassium	Others	Others
Meteneprost (U 46785) potassium is a cervical dilator that stimulates uterine contractions and dilates the cervical canal.

HY-W127502

1-Hexadecylglycero-3-phosphate 1-Hex-GPA	Biochemical Assay Reagents	Others
1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group in the sn-1 position. LPA binds to five different G protein-coupled receptors and mediates a variety of biological responses, including cell proliferation, smooth muscle contraction, platelet aggregation, neurite contraction, and cell motility.

HY-P1541

Motilin, canine Motilin (canine)	Motilin Receptor	Metabolic Disease
Motilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.

HY-108991

T-0509 (-)-T-0509	Adrenergic Receptor	Cardiovascular Disease
T-0509 ((-)-T-0509) is a selective full agonist of the β₁ receptor. T-0509 activates the cAMP signaling pathway through the β₁ receptor and enhances myocardial contractility .

HY-U00135

Calcium channel-modulator-1

Calcium Channel Cardiovascular Disease

Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC₅₀ of 0.8 μM.

Calcium channel-modulator-1	Calcium Channel	Cardiovascular Disease
Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC₅₀ of 0.8 μM.

HY-113331

Thromboxane B2	Others	Inflammation/Immunology
Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation.

HY-N10549

Gigantol	Others	Others
Gigantol is a natural product that could be isolated from Cymbidium giganteum. Gigantol is a potent inhibitor of the spontaneous contractions of the guinea-pig ileum .

HY-111587

Ifenprodil glucuronide	Others	Cardiovascular Disease
Ifenprodil glucuronide is a derivative of Ifenprodil. Ifenprodil is a vasodilator and an inhibitor of platelet aggregation, and Ifenprodil glucuronide has no effect on platelet aggregation and arterial contraction .

HY-136474

Amidephrine (±)-Amidephrine	Adrenergic Receptor	Endocrinology
Amidephrine is a selective agonist of alpha 1-adrenoceptor. Amidephrine inhibits inhibits monopulse field contraction of the vas deferens epithelium and prostate gland .

HY-N7527

Baccatin VI	Others	Neurological Disease
Baccatin VI is a natural taxoid with antinociceptive activities. Baccatin VI possesses significant antinociceptive activity against p-Benzoquinone-induced abdominal contractions .

HY-U00127

Pyridazinediones-derivative-1	Others	Neurological Disease
Pyridazinediones-derivative-1 has potential in treating neurodegenerative disorders. It shows an ED₅₀ of 2.1 μM for inhibiting glutamate-induced contractions of isolated guineapig ileum.

HY-D0885B

Phosphocreatine disodium 1 Publications Verification Disodium creatine phosphate	Endogenous Metabolite	Metabolic Disease
Phosphocreatine disodium, one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

HY-121966

Riparin Riparin III	Others	Cancer
Riparin is a nonspecific smooth muscle relaxant. Riparin inhibits CaCl2-induced contractions in a reversible and non-competitive manner and can be used in spasmolytic studies .

HY-128878

Dexloxiglumide	Cholecystokinin Receptor	Metabolic Disease Endocrinology
Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist . Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8) .

HY-103281

Litorin	Bombesin Receptor	Metabolic Disease
Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo .

HY-P10006

Leumorphin, human	Opioid Receptor	Neurological Disease
Leumorphin, human is a potent kappa opioid receptor (κ opioid receptor) agonist. Leumorphin, human inhibits the contraction of the myenteric plexus-longitudinal muscle preparation of the guinea pig ileum .

HY-148533

β2AR agonist /M-receptor antagonist-1	mAChR Adrenergic Receptor	Neurological Disease
β2AR agonist /M-receptor antagonist-1 is a potent dual muscarinic antagonist/beta 2 agonist (MABA). β2AR agonist /M-receptor antagonist-1 potently relaxes either Carbachol (HY-B1208)-induced contraction, in the absence (MABA) or presence of Propranolol (M3; HY-B1208), or Histamine (HY-B1204)-induced contraction (β2) .

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library

1,276 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1,276 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

HY-L166

Ion Channel Compound Library

1,129 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,129 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P3524

GRGESP	Peptides	Others
GRGESP is a collagen gel contraction inhibitor. GRGESP inhibits the spreading of human fibroblasts inside collagen gels and markedly decreased gel contraction. GRGDSP can be used for the research of connective tissue morphogenesis .

HY-P1233

ANQ-11125	Motilin Receptor	Metabolic Disease
ANQ-11125 is a potent and selective antagonist of motilin, with the pK_d of 8.24. ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit .

HY-P1233A

ANQ-11125 TFA	Motilin Receptor	Metabolic Disease
ANQ-11125 TFA is a potent and selective antagonist of motilin, with the pK_d of 8.24. ANQ-11125 TFA blocks motilide-induced contractions in vitro in the rabbit .

HY-P4182

Schistoflrfamide	Peptides	Neurological Disease
Schistoflrfamide, a FMRFamide-related peptide, is an inhibitory neuropeptide. Schistoflrfamide decreases the amplitude and frequency of myogenic contractions and reduce basal tension visceral muscle .

HY-P3847

Tyr0-Neurokinin B

Tyr-NKB
Peptides Neurological Disease

Tyr0-Neurokinin B (Tyr-NKB) is an analogue of Neurokinin B. Tyr0-Neurokinin B can exerts contractions in bladder .

HY-P3092

Phyllomedusin	Neurokinin Receptor	Neurological Disease
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus .

HY-P2034

Cargutocin

Oxytocin Receptor Endocrinology

Cargutocin, an oxytocin analogue, targets the oxytocin receptor and acts as a uterine contraction agent .

HY-P2168

Demoxytocin	Oxytocin Receptor	Endocrinology
Demoxytocin, a heterodetic cyclic peptide, is an analog of oxytocin. Demoxytocin affects the permeability of the cell membrane, increasing the content of calcium ions in smooth muscle cells, increasing its contraction. Demoxytocin also stimulates the contraction of smooth muscles of the uterus. Demoxytocin has the function of oxytocin. Demoxytocin can be used to research stimulation of labor in cases of premature rupture .

HY-P3651

Cholecystokinin (26-33) (free acid) CCK (26-33) (free acid)	Peptides	Metabolic Disease
Cholecystokinin (26-33) (CCK (26-33)) free acid is a cholecystokinin (CCK) fragment. Cholecystokinin (26-33) free acid can reduce food intake and gallbladder contraction .

HY-P3433

Sarafotoxin S6b	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the K_i values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively .

HY-P3652

Cholecystokinin-33 (swine)	Peptides	Metabolic Disease
Cholecystokinin-33 (swine) is a cholecystokinin (CCK) fragment. Cholecystokinin-33 (swine) can reduce food intake and gallbladder contraction .

HY-P2636

Cholecystokinin Precursor (24-32) (rat) Prepro CCK Fragment V-9-M	Peptides	Metabolic Disease
Cholecystokinin Precursor (24-32) (rat) is a cholecystokinin precursor that can be expressed in the heart, lungs, and kidneys as well as in the gastrointestinal tract and brain. Cholecystokinin is a brain-gut peptide that stimulates gallbladder contraction and pancreatic exocrine secretion and also acts as a neurotransmitter .

HY-106234

ZP 120C	Opioid Receptor	Cardiovascular Disease Neurological Disease
ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia .

HY-P2700

µ-Conotoxin GIIIB	Sodium Channel	Neurological Disease
μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a Na_V1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction .

HY-P10346

smMLCK peptide Smooth-Muscle Myosin Light-Chain Kinase (796-815)	Peptides	Cardiovascular Disease Inflammation/Immunology
smMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK). The smMLCK peptide mimics the substrate and competitively inhibits the binding of the actual substrate to the enzyme, thereby inhibiting the kinase activity. This inhibition prevents the phosphorylation of the myosin light chain, thus inhibiting muscle contraction .

HY-P3516

Barusiban FE-200440	Oxytocin Receptor	Endocrinology
Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (K_i=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research .

HY-P3849

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) LMN-NKA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues .

HY-P1541

Motilin, canine Motilin (canine)	Motilin Receptor	Metabolic Disease
Motilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.

HY-125295

Leucokinin I	Peptides	Others
Leucokinin I is a peptide that stimulates contraction of the anterior midgut and hindgut muscles involved in feeding in Rhodnius prolixus but not absorption in the anterior midgut .

HY-P2709

Rigin

Tetrapeptide-3; GQPR
Peptides Others

Rigin (Tetrapeptide-3; GQPR) is a bioactive peptide with anti-wrinkle effect and has been reported used as a cosmetic ingredient .
HY-P0065

Acetyl octapeptide-1

Peptides Others

Acetyl octapeptide-1 is a bioactive peptide with anti-wrinkle effect and has been reported used as a cosmetic ingredient .

HY-103281

Litorin	Bombesin Receptor	Metabolic Disease
Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo .

HY-P10006

Leumorphin, human	Opioid Receptor	Neurological Disease
Leumorphin, human is a potent kappa opioid receptor (κ opioid receptor) agonist. Leumorphin, human inhibits the contraction of the myenteric plexus-longitudinal muscle preparation of the guinea pig ileum .

HY-P2563

[Tyr(P)4] Angiotensin II	Angiotensin Receptor	Metabolic Disease
[Tyr(P)4] Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels .

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-P1564

[Sar1, Ile8]-Angiotensin II	Angiotensin Receptor	Cardiovascular Disease Endocrinology
[Sar1, Ile8]-Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.

HY-P0004A

Lysipressin acetate 2 Publications Verification Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-P1564A

[Sar1, Ile8]-Angiotensin II TFA AngiotensinII TFA; Angiotensin 2 TFA	Angiotensin Receptor	Others
[Sar1, Ile8]-Angiotensin II (TFA) is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.

HY-103283

Neuromedin C (porcine) GRP(18-27) (porcine)	Biochemical Assay Reagents	Neurological Disease
Neuromedin C porcine (GRP, 18-27, porcine) is a bombesin-like neuropeptide that can be obtained from porcine spinal cord. Neuromedin C porcine exhibits a potent contractile activity on rat uterus in the characteristic manner of bombesin. Neuromedin C porcine has research potential for neurological-related diseases .

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra .

HY-135108

QWF Peptide	Neurokinin Receptor	Neurological Disease
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM .

HY-P10268

Neuropeptide K (human, porcine, rat)	Peptides	Neurological Disease
Neuropeptide K, human, porcine, rat exhibits bioactivity in gallbladder contraction, protein extravasation, hypotension and brcnchial smooth muscle spasm. Neuropeptide K, human, porcine, rat is concentrated in brain and acts as tachykinin neuromessenger .

HY-P3563

[Lys4] Sarafotoxin S6c	Endothelin Receptor	Cardiovascular Disease
[Lys4] Sarafotoxin S6c, a sarafotoxin analogue, is a potent and partial agonist of endothelin receptor. [Lys4] Sarafotoxin S6c elicits contraction of pig coronary artery, with an EC₅₀ of 1.5 nM .

HY-P0206

Bradykinin Maximum Cited Publications 9 Publications Verification	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease	Cardiovascular Disease Endocrinology
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P0206A

Bradykinin acetate	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease	Cardiovascular Disease Endocrinology
Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P5493

D-Arg-[Hyp3,Thi5,8,D-Phe7]-Bradykinin	Peptides	Others
D-Arg-[Hyp3,Thi5,8,D-Phe7]-Bradykinin is a biological active peptide. (inhibited bradykinin-induced contractions concentration dependently; bradykinin B2 receptor antagonist)

HY-P10041

Obestatin(11-23)mouse, rat	Peptides	Metabolic Disease
Obestatin(11-23)mouse, rat is a polypeptide involved in regulating energy balance and inhibiting eating. Obestatin(11-23)mouse, rat causes reduced food intake, body weight, and jejunal contractions in rodents .

HY-P3680

[Nle13]-Motilin

Motilin Receptor Neurological Disease

[Nle13]-Motilin, a motilin analogue, is a motilin receptor agonist .

HY-P5494

DPc10	Peptides	Others
DPc10 is a biological active peptide. (This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.)

HY-106323

[Leu13]-Motilin KW-5139	Motilin Receptor	Metabolic Disease
[Leu13]-Motilin (KW-5139) is a motilin analogue. [Leu13]-Motilin stimulates gastrointestinal motility in the rabbit. [Leu13]-Motilin causes concentration-dependent contractions of the gastric antrum, duodenum, jejunum, ileum and the descending colon in vitro .

HY-108055

Urantide	Peptides	Cardiovascular Disease
Urantide is a selective and competitive urotensin-II (UT) receptor antagonist peptide (pKB=8.3) that blocks human urotensin-II (hU-II)-induced contractions in rat thoracic aorta ex vivo. Urantide can be used to study the (patho)physiological role of hU-II in the mammalian cardiovascular system .

HY-P3617

Glucagon (22-29)	Peptides	Metabolic Disease
Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca ²⁺ pump in liver plasma membranes independently of adenylate cyclase activation .

HY-P3217

[Asp5]-Oxytocin	Oxytocin Receptor	Endocrinology
[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin causes uterine contractions in vitro, enhanced by Mg ²⁺. [Asp5]-Oxytocin has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .

HY-P3217A

[Asp5]-Oxytocin acetate	Oxytocin Receptor	Endocrinology
[Asp5]-Oxytocin acetate is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin acetate causes uterine contractions in vitro, enhanced by Mg ²⁺. [Asp5]-Oxytocin acetate has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic .

HY-P1767

Prepro VIP (81-122), human	Peptides	Cardiovascular Disease
Prepro VIP (81-122), human is a prepro-vasoactive intestinal polypeptide (VIP) derived peptide, corresponding to residues 81-122. Peptide histidine valine 42 (PHV-42) has been designated to correspond exactly to Prepro VIP (81-122), which reduces both the force and frequency of spontaneous contractions of isolated rat uterus .

HY-P1306

Obestatin(rat)	GHSR	Cardiovascular Disease Inflammation/Immunology
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities .

HY-P3545

5-Valine-angiotensin I	Peptides	Cardiovascular Disease
5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone .

HY-P10034

Pheromonotropin (pseudaletia separata) Pss-PT	Peptides	Endocrinology
Pheromonotropin (Pseudaletia separata) (Pss-PT) is an armyworm (Pseudaletia separata) pheromone with the C-terminal pentapeptide FXPRL-amide. Pheromonotropin (Pseudaletia separata) belongs to the PK/PBAN family and stimulates sex pheromone biosynthesis in moths, mediating feeding (intestinal muscle contraction), development (embryonic diapause, pupal diapause, and pupation), and defense against natural enemy insects wait .

HY-P1306A

Obestatin(rat) TFA	GHSR	Cardiovascular Disease Inflammation/Immunology
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities .

HY-P0084

Cyclic somatostatin SRIF-14; Somatostatin-14	Peptides	Cardiovascular Disease Neurological Disease
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC₅₀ value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1551

Przewaquinone A	Natural Products Labiatae Source classification Diterpenoids Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Przewaquinone A, a lipophilic diterpene quinone present only in Salvia przewalskii, induces a potent inhibitory action on vascular contraction .

HY-N10549

Gigantol	Structural Classification Natural Products Classification of Application Fields Orchidaceae Other Diseases Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.	Others
Gigantol is a natural product that could be isolated from Cymbidium giganteum. Gigantol is a potent inhibitor of the spontaneous contractions of the guinea-pig ileum .

HY-N12840

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-N7527

Baccatin VI	Structural Classification Natural Products Neurological Disease Classification of Application Fields Gibberellins Source classification Taxaceae Phytohormone Plants Disease Research Fields Taxus baccata L. Agricultural Research	Others
Baccatin VI is a natural taxoid with antinociceptive activities. Baccatin VI possesses significant antinociceptive activity against p-Benzoquinone-induced abdominal contractions .

HY-P2709

Rigin Tetrapeptide-3; GQPR	Structural Classification Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Other Diseases Cosmetic Research Endogenous metabolite Disease Research Fields	Others
Rigin (Tetrapeptide-3; GQPR) is a bioactive peptide with anti-wrinkle effect and has been reported used as a cosmetic ingredient .

HY-D0885B

Phosphocreatine disodium 1 Publications Verification Disodium creatine phosphate	Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phosphocreatine disodium, one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

HY-103281

Litorin	Alkaloids Classification of Application Fields Animals Source classification Metabolic Disease Plants Solanaceae Disease Research Fields Datura metel Linn. Indole Alkaloids	Bombesin Receptor
Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo .

HY-N8493

Mycalolide B	Alkaloids Structural Classification Classification of Application Fields Animals Other Alkaloids Source classification Other Diseases Disease Research Fields	Antibiotic
Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg ²⁺-ATPase activity in the absence of Ca ²⁺ .

HY-N3320

Marmin	Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants Aegle marmelos (L.) Correa	Others
Marmin is a coumarin, that can be isolated from the immature bark of Aegle marmelos Correa. Marmin antagonizes the Histamine (HY-B1204)-induced contraction in competitive manner .

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Structural Classification Monophenols Classification of Application Fields Animals Source classification Other Diseases Phenols Disease Research Fields	Adenylate Cyclase
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-101952

Prostaglandin E2 Maximum Cited Publications 25 Publications Verification PGE2; Dinoprostone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Endocrinology	Organoid Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-D0885

Phosphocreatine Creatine phosphate; Creatinephosphoric acid	Structural Classification Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phosphocreatine, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction ..

HY-D0885C

Phosphocreatine dipotassium Creatine phosphate (dipotassium); Creatinephosphoric acid (dipotassium)	Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phosphocreatine dipotassium, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

HY-D0885A

Sodium creatine phosphate dibasic tetrahydrate Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate	Structural Classification Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

HY-P0206

Bradykinin 5+ Cited Publications	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-N4080

Cyclobuxine D	other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Steroids	mAChR
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba ⁺⁺−induced contraction of the longitudinal muscle isolated from the rabbit jejunum .

HY-B2134

Casanthranol	Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Others
Casanthranol is a concentrated mixture of anthranol glycosides from cascara sagrada (dried bark of Rhamnus p.) and used as a laxative in constipation and various medical conditions, stimulant laxative Casanthranol encourages bowel movements by acting on the intestinal wall to increase muscle contractions .

HY-W017277

(+)-Menthol D-Menthol	Natural Products Labiatae Source classification Erythrina poeppigiana Plants	Others
(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Structural Classification Alkaloids Source classification Cocculus laurifolius DC. Plants Isoquinoline Alkaloids Menispermaceae	Endogenous Metabolite
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

HY-101952R

Prostaglandin E2 (Standard) PGE2(Standard); Dinoprostone (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Endocrinology	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E2 (Standard) is the analytical standard of Prostaglandin E2. This product is intended for research and analytical applications. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-N0584B

Anisodamine hydrochloride 6-Hydroxyhyoscyamine hydrochloride	Structural Classification Alkaloids Pyrrole Alkaloids Anisodus tanguticus (Maxinowicz) Pascher Source classification Plants Solanaceae	Adrenergic Receptor
Anisodamine hydrochloride is an anticholinergic and α1 adrenergic receptor antagonist. Anisodamine hydrochloride can be used for improving blood flow in circulatory disorders such as septic shock, Anisodamine hydrochloride displays a spectrum of pharmacological effects similar to Atropine (HY-B1205) and Sopolamine (HY-B2065) including inhibition of salivation, gastrointestinal and sweat secretion, gastrointestinal motility, respiratory secretion and urinary bladder contraction in vivo .

HY-B1671

(+)-Kavain	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-14578

Taxiresinol	Structural Classification Source classification Taxaceae Lignans Phenylpropanoids Plants Taxus baccata L.	Others
Taxiresinol is an orally active and potent lignan, that can be isolated from the heartwood of Taxus baccata. Taxiresinol shows significant antinociceptive activity .

Cat. No.	Product Name	Chemical Structure

HY-101952S

Prostaglandin E2-d4
Prostaglandin E2-d₄ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-113331S

Thromboxane B2-d4
Thromboxane B2-D4 is the deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation .

HY-101952S1

Prostaglandin E2-d9
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-B0267BS

Oxybutynin-d5 hydrochloride

Oxybutynin-d₅ hydrochloride is deuterated labeled (R)-Oxybutynin hydrochloride (HY-B0267B). (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction . (R)-Oxybutynin hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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