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Results for "

diarrhea

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Adrenergic Receptor (2) Antibiotic (4) Apoptosis (1) Autophagy (3) Bacterial (3) Calcium Channel (2) CFTR (1) CMV (1) COX (1) DNA/RNA Synthesis (4) Fungal (2) Glucosidase (1) GLUT (2) Guanylate Cyclase (1) HCV (1) HSV (2) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Mitophagy (2) Nucleoside Antimetabolite/Analog (1) Parasite (3) PI4K (1) TNF Receptor (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (15) Inflammation/Immunology (6) Metabolic Disease (4)

By Targets:

Acyltransferase (1)

Adrenergic Receptor (2)

Antibiotic (4)

Apoptosis (1)

Autophagy (3)

Bacterial (3)

Calcium Channel (2)

CFTR (1)

CMV (1)

COX (1)

DNA/RNA Synthesis (4)

Fungal (2)

Glucosidase (1)

GLUT (2)

Guanylate Cyclase (1)

HCV (1)

HSV (2)

Influenza Virus (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Mitophagy (2)

Nucleoside Antimetabolite/Analog (1)

Parasite (3)

PI4K (1)

TNF Receptor (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (1)

Infection (15)

Inflammation/Immunology (6)

Metabolic Disease (4)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149276

SLC26A3-IN-2	GLUT	Metabolic Disease
SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC₅₀=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea .

HY-155181

hCES2-IN-1	Others	Cancer
hCES2-IN-1 (Compound 24) is a reversible and selective hCES2 inhibitor (IC₅₀: 6.72 μM). hCES2-IN-1 reduces the level of hCES2 in living cells. hCES2-IN-1 is effective against Irinotecan (HY-16562)-induced delayed diarrhea and DSS-induced ulcerative colitis .

HY-155228

LK-44	Others	Inflammation/Immunology
hCES2A-IN-2 (Compound 44) is an orally active human carboxylesterase 2 (hCES2A) inhibitor (IC₅₀: 5.02 μM). hCES2A-IN-2 improves Irinotecan (HY-16562)-induced delayed diarrhea .

HY-P5077

Guanylin (mouse, rat)	Guanylate Cyclase	Metabolic Disease
Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) can be used for the research of diarrhea .

HY-149802

SLC26A3-IN-1	GLUT	Metabolic Disease
SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC₅₀=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea .

HY-131976

BVDV-IN-1	DNA/RNA Synthesis	Infection
BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of *bovine viral diarrhea* virus (BVDV), with an EC₅₀** of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC) .

HY-B0418AS

Loperamide-d6 hydrochloride R-18553-d6 hydrochloride
Loperamide-d₆ (hydrochloride) is a deuterium labeled Loperamide hydrochloride. Loperamide hydrochloride is an opioid receptor agonist for the treatment of diarrhea[1].

HY-105099

Rifalazil KRM-1648; ABI-1648	DNA/RNA Synthesis Bacterial	Infection Inflammation/Immunology
Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase . Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml . Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB) .

HY-107358A

Lidamidine hydrochloride

WHR-1142A
Adrenergic Receptor Others

Lidamidine hydrochloride (WHR-1142A) is an α2-adrenergic receptor agonist and antidiarrheal agent .

Lidamidine hydrochloride WHR-1142A	Adrenergic Receptor	Others
Lidamidine hydrochloride (WHR-1142A) is an α2-adrenergic receptor agonist and antidiarrheal agent .

HY-14603

Clioquinol 2 Publications Verification Iodochlorohydroxyquinoline	Fungal Autophagy Mitophagy Antibiotic Parasite	Infection Cancer
Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic .

HY-138594

5'-O-TBDMS-N2-ibu-dG	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
5'-O-TBDMS-N2-ibu-dG is a nucleoside derivative and can be used for lead compounds synthesis with anti-bovine viral diarrhea virus activity .

HY-107358

Lidamidine

WHR-1142A free base
Adrenergic Receptor Metabolic Disease

Lidamidine (WHR-1142A free base) is an α2-adrenergic receptor agonist and antidiarrheal agent .

Lidamidine WHR-1142A free base	Adrenergic Receptor	Metabolic Disease
Lidamidine (WHR-1142A free base) is an α2-adrenergic receptor agonist and antidiarrheal agent .

HY-14603R

Clioquinol (Standard) Iodochlorohydroxyquinoline (Standard)	Fungal Autophagy Mitophagy Antibiotic Parasite	Infection Cancer
Clioquinol (Standard) is the analytical standard of Clioquinol. This product is intended for research and analytical applications. Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic .

HY-111613

Pinaverium bromide 3 Publications Verification	Calcium Channel	Cancer
Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients .

HY-135319

Strictinin	Others	Infection
Strictinin is a phenolic compound isolated from Pu'er teas. Strictinin has potential antiviral, antibacterial and laxative activities. Strictinin occurs by accelerating intestinal transit rather than enhancing gastric emptying, increasing food intake, or inducing diarrhea in rats.

HY-N1372

(R)-Fangchinoline Thalrugosine; Thaligine	Bacterial Antibiotic	Infection Cardiovascular Disease Inflammation/Immunology Cancer
(R)-Fangchinoline (Thalrugosine), a alkaloids from Stephania tetrandra，exhibits antimicrobial and hypotensive activity. The roots and stems of several plants from genus Stephania are all used as traditional Chinese medicine and have been used for treatment of fever, diarrhea, dyspepsia and urinary disease .

HY-114621

DB772

Others Infection

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity .
HY-114621A

DB772 hydrate

Others Infection

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity .

DB772	Others	Infection
DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity .

DB772 hydrate	Others	Infection
DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity .

HY-103583

KDU731	PI4K Parasite	Infection
KDU731, an orally active C. parvum PI4K inhibitor with an IC₅₀ value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo . KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety .

HY-111613S

Pinaverium bromide-d4	Isotope-Labeled Compounds Calcium Channel	Others
Pinaverium bromide-d₄ is deuterium labeled Pinaverium bromide. Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].

HY-13234

Rifaximin 1 Publications Verification	Bacterial Antibiotic DNA/RNA Synthesis	Infection Cancer
Rifaximin, a gastrointestinal-selective antibiotic, binds the β-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of bacterial RNA synthesis. Rifaximin susceptibility is higher against Gram-positive strains (MIC: 0.03-5 mg/ml) compared to Gram-negative bacteria (MIC: 8-50 mg/mL) .

HY-N1067

Xanthohumol Maximum Cited Publications 8 Publications Verification	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against *bovine viral diarrhea* virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV)**.

HY-N2584A

Isoxanthohumol 1 Publications Verification	HSV	Infection Cancer
Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and *bovine viral diarrhea* virus (BVDV)** .

HY-12633

GS-6620	HCV	Inflammation/Immunology
GS-6620 is?potent and selective pangenotype HCV inhibitor against HCV replicons of genotypes 1 to 6 (EC₅₀: 0.048 to 0.68 μM). GS-6620 shows limited activities against other viruses, maintaining only some of its activity against the closely related bovine viral diarrhea virus (EC₅₀, 1.5 μM) .

HY-126360

Oxazolone	TNF Receptor Interleukin Related	Inflammation/Immunology
Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins .

HY-139663

IHVR-17028	Glucosidase	Infection
IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC₅₀ values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC₅₀ of 0.24 μM. IHVR-17028 can be used for infectious diseases research .

HY-19778

(R)-BPO-27 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology
(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC₅₀ of 4 nM.

Guanylin (mouse, rat)	Guanylate Cyclase	Metabolic Disease
Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) can be used for the research of diarrhea .

Lagatide BN 52080	Peptides	Infection
Lagatide (BN 52080), a heptapeptide, is a short C-terminal analog of sorbin. Lagatide has proabsorptive and antisecretory effect in the different parts of the intestine. Lagatide can be used for the research of chronic diarrhea .

Cat. No.	Product Name	Category	Target	Chemical Structure