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Results for "

synthetase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (20) Acyltransferase (1) Antibiotic (16) Antifolate (1) Apoptosis (11) Autophagy (4) Bacterial (33) Biochemical Assay Reagents (1) Calcium Channel (4) Caspase (3) CDK (1) COX (5) Cytochrome P450 (1) DNA/RNA Synthesis (8) Endogenous Metabolite (19) Ferroptosis (4) Fungal (3) Glutathione S-transferase (1) HIV (5) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (7) Lipoxygenase (2) Mitochondrial Metabolism (1) Mitophagy (3) NF-κB (3) Nucleoside Antimetabolite/Analog (5) p38 MAPK (3) Parasite (15) PARP (3) PGE synthase (4) Potassium Channel (2) Prostaglandin Receptor (3) RSV (1) Sialyltransferase (1) Sodium Channel (4) TGF-beta/Smad (4) Thrombin (1) TNF Receptor (1) Virus Protease (3)
By Research Areas:	Cancer (39) Cardiovascular Disease (9) Endocrinology (2) Infection (77) Inflammation/Immunology (28) Metabolic Disease (16) Neurological Disease (3)
Click Chemistry:	Azide (3) Alkynes (1)

145

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Aminoacyl-tRNA Synthetase Methionine Adenosyltransferase (MAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152149

*CTP Synthetase-IN-1*	DNA/RNA Synthesis	Inflammation/Immunology
CTP Synthetase-IN-1 is a potent, orally active *cytidine 5'-triphosphate synthetase* (CTPS) inhibitor with IC₅₀*s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase*-IN-1 has anti-inflammatory effects .

HY-147674

*Isoleucyl tRNA synthetase-IN-2*	Aminoacyl-tRNA Synthetase	Infection
Isoleucyl tRNA synthetase-IN-2 (compound 36a) is a potent and selective *isoleucyl-tRNA synthetase* (IleRS) inhibitor, with a K_i,app** of 114 nM .

HY-151149

*Trypanothione synthetase-IN-4*	Parasite	Infection
Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC₅₀ value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis .

HY-151150

*Trypanothione synthetase-IN-2*	Parasite	Infection
Trypanothione synthetase-IN-2 (Compound 3) is a competitive Leishmania infantum *trypanothione synthetase* (TryS) inhibitor with an IC₅₀** of 5.4 μM when triamine spermidine is as polyamine S .

HY-151148

*Trypanothione synthetase-IN-1*	Parasite	Infection
Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum *trypanothione synthetase* (TryS) inhibitor with an IC₅₀** of 14.8 μM when triamine spermidine is as polyamine S .

HY-E70233

*Histidyl-tRNA synthetase, human*	Others	Inflammation/Immunology
Histidyl-tRNA synthetase, human is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. Histidyl-tRNA synthetase has been found to act as a particularly important antigen in autoimmune diseases such as rheumatic arthritis or myositis .

HY-151151

*Trypanothione synthetase-IN-3*	Parasite	Infection
Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic *Trypanothione synthetase* (TryS) inhibitor (K_i*: 0.8 μM). Trypanothione synthetase-IN-3 can be used in the study of parasites, such as L. infantum* .

HY-E70121

Succinyl-CoA synthetase	Others	Others
Succinyl-CoA synthetase catalyzes the only substrate-level phosphoryl-ation step in the tricarboxylic acid cycle. Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism .

HY-108939

*Aminoacyl tRNA synthetase-IN-1* 1 Publications Verification	Bacterial Aminoacyl-tRNA Synthetase	Infection
Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor.

HY-147643

*Aminoacyl tRNA synthetase-IN-2*	Aminoacyl-tRNA Synthetase	Infection
Aminoacyl tRNA synthetase-IN-2 (Compound 14) is an *aminoacyl-tRNA synthetase* (aaRS)** inhibitor. Aminoacyl tRNA synthetase-IN-2 can be used for development of a new family of antibiotics .

HY-P2832

Acyl coenzyme A synthetase ACS	Endogenous Metabolite	Metabolic Disease
Acyl coenzyme A synthetase (ACS), namely acetyl coenzyme A synthetase, is often used in biochemical research. Acyl coenzyme A synthetase can catalyze the activation of fatty acids by coenzyme A through a two-step thioesterification reaction to produce acyl coenzyme A, and then participate in a variety of anabolic and catabolic lipid metabolism pathways, and participate in the TCA cycle in aerobic respiration .

HY-E70024

*CMP-sialic acid synthetase* (NmCSS)**	Sialyltransferase	Others
CMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases .

HY-162134

*Trypanothione synthetase-IN-5*	Parasite	Infection
Trypanothione synthetase-IN-5 (compound 9) is a trypanothione reductase (TR) inhibitor, with an IC₅₀ of 20.5 μM for Leishmania infantum TR. Trypanothione synthetase-IN-5 also has inhibitory activity for human glutathione reductase (hGR), with an IC₅₀ of 62.4 μM .

HY-145555

Bersiporocin DWN12088	DNA/RNA Synthesis	Inflammation/Immunology
Bersiporocin is a prolyl-tRNA synthetase inhibitor. Bersiporocin has an IC₅₀ of ≤100 nM for phosphoribosylpyrophosphate synthetase (PRS). Bersiporocin can be used for the research of antifibrotic .

HY-146264

Antibacterial agent 91	Aminoacyl-tRNA Synthetase Bacterial	Infection
Antibacterial agent 91 (Compound 36b) is a triple-site *aminoacyl-tRNA synthetase* (aaRS) inhibitor with an IC₅₀** of 2.10 μM against Salmonella enterica threonyl-tRNA synthetase (SeThrRS). Antibacterial agent 91 exhibits antibacterial activities .

HY-146265

Antibacterial agent 92	Aminoacyl-tRNA Synthetase Bacterial	Infection
Antibacterial agent 92 (Compound 36k) is a triple-site *aminoacyl-tRNA synthetase* (aaRS) inhibitor with an IC₅₀** of 0.58 μM against Salmonella enterica threonyl-tRNA synthetase (SeThrRS). Antibacterial agent 92 exhibits antibacterial activities .

HY-E70346

S-Adenosylmethionine synthetase	Endogenous Metabolite	Others
S-Adenosylmethionine synthetase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-162371

NRPSs-IN-1	Others	Infection
NRPSs-IN-1 (Compound 7) is a cell-penetrating inhibitor of non-ribosomal peptide synthetase (NRPSs). NRPSs-IN-1 K inhibits gramicidin S synthetase A (GrsA) with a K_d value of 16.6 nM .

HY-129614

LG 82-4-01

Prostaglandin Receptor Metabolic Disease

LG 82-4-01 is a thromboxane (TX) synthetase specific inhibitor, with an IC₅₀ of 1.3 μM .
HY-W173220

Clopirac

PGE synthase Inflammation/Immunology

Clopirac is a potent and orally active inhibitor of prostaglandin synthetase. Clopirac is an anti-inflammatory agent .
HY-B2063

Chlorobenzuron

Others Infection

Chlorobenzuron is a chitin synthetase inhibitor, acts as an insecticide. Chlorobenzuron can inhibit larvae development and pupate .

LG 82-4-01	Prostaglandin Receptor	Metabolic Disease
LG 82-4-01 is a thromboxane (TX) synthetase specific inhibitor, with an IC₅₀ of 1.3 μM .

Clopirac	PGE synthase	Inflammation/Immunology
Clopirac is a potent and orally active inhibitor of prostaglandin synthetase. Clopirac is an anti-inflammatory agent .

Chlorobenzuron	Others	Infection
Chlorobenzuron is a chitin synthetase inhibitor, acts as an insecticide. Chlorobenzuron can inhibit larvae development and pupate .

HY-E70243

Tigloyl-CoA Tiglyl-coenzyme A	Others	Metabolic Disease
Tigloyl-CoA (Tiglyl-coenzyme A) is an intermediate product of isoleucine metabolism. Tigloyl-CoA is an inhibitor of N-acetylglutamate synthetase .

HY-147671

CB 168

Aminoacyl-tRNA Synthetase Infection

CB 168 is a potent and selective aminoacyl-sulfamoyl aryltetrazole inhibitor targeting isoleucyl-tRNA synthetase (IleRS) .
HY-136461

Polyoxin D

Polyoxorim
Fungal Antibiotic Infection

Polyoxin D (Polyoxorim), a polyoxin antibiotic fungicide, is a potent chitin synthetase inhibitor .
HY-156050

Thioacetamide-S-oxide

Others Metabolic Disease

Thioacetamide-S-oxide, a Thiocetamide metabolite, is a δ-aminolevulinic acid (ALA) synthetase inhibitor .
HY-147381

MetRS-IN-1

Others Others

MetRS-IN-1 (Compound 27) is an E. coli methionyl-tRNA synthetase (MetRS) inhibitor (IC₅₀=237 nM) .
HY-147672

IleRS-IN-1

Aminoacyl-tRNA Synthetase Infection

IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a K_i,app of 88 nM .

CB 168	Aminoacyl-tRNA Synthetase	Infection
CB 168 is a potent and selective aminoacyl-sulfamoyl aryltetrazole inhibitor targeting *isoleucyl-tRNA synthetase* (IleRS)** .

Polyoxin D Polyoxorim	Fungal Antibiotic	Infection
Polyoxin D (Polyoxorim), a polyoxin antibiotic fungicide, is a potent chitin synthetase inhibitor .

Thioacetamide-S-oxide	Others	Metabolic Disease
Thioacetamide-S-oxide, a Thiocetamide metabolite, is a δ-aminolevulinic acid (ALA) synthetase inhibitor .

MetRS-IN-1	Others	Others
MetRS-IN-1 (Compound 27) is an E. coli methionyl-tRNA synthetase (MetRS) inhibitor (IC₅₀=237 nM) .

IleRS-IN-1	Aminoacyl-tRNA Synthetase	Infection
IleRS-IN-1 (compound 11) is a potent and selective *isoleucyl-tRNA synthetase* (IleRS) inhibitor, with a K_i,app** of 88 nM .

HY-106691

Pirmagrel CGS-13080	Thrombin	Endocrinology
Pirmagrel is a thrombin synthetase inhibitor. Pirmagrel has inhibitory effects on thrombin secretion stimulated by lipopolysaccharide (HY-D1056) .

HY-117029

NAAD sodium Deamido nad sodium	Endogenous Metabolite	Metabolic Disease
NAAD sodium (Deamido nad sodium), a functional NAD ⁺ precursor, is the substrate of glutamine-dependent NAD ⁺ synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases .

HY-146263

ThrRS-IN-3	Bacterial	Infection
ThrRS-IN-3 (compound 36j) is a highly potent *threonyl-tRNA synthetase* (ThrRS) inhibitor, with an IC₅₀ value of 19 nM and a K_d** of 34 nM for Salmonella enterica ThrRS. ThrRS-IN-3 has antibacterial activities .

HY-151880

Antibacterial agent 124	DNA/RNA Synthesis	Infection
Antibacterial agent 124 (Compound 3) is a potent bacterial *prolyl-tRNA synthetase* (ProRS) inhibitor with an IC₅₀** of 0.18 μM against Staphylococcus aureus ProRS (SaProRS) .

HY-142031

4-Piperidinecarboxamide	Bacterial	Infection
4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor. 4-Piperidinecarboxamide is a promising anti-tuberculosis (TB) agent .

HY-134648

Ganfeborole GSK656 free base; GSK3036656 free base; GSK070 free base	Bacterial	Infection
Ganfeborole (GSK656 free base) is a potent, selective and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase, with an IC₅₀ of 0.20 μM. Ganfeborole can be used for the research of tuberculosis .

HY-W051513

2-Methylquinazolin-4-ol	PARP	Others
2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a K_i of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM .

HY-141699

FATP1-IN-1	Others	Metabolic Disease
FATP1-IN-1 (compound 5k) is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC₅₀ values of 0.046 μM or 0.60 μM, respectively .

HY-130718

ThrRS-IN-1	Bacterial	Infection Cancer
ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC₅₀ of 1.4 µM and a K_d of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNA ^Thr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities .

HY-B0212

Sulfapyridine	Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits *recombinant P. carinii* dihydropteroate synthetase (DHPS) with an IC₅₀** of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

HY-136128

H3B-120	Potassium Channel	Cancer
H3B-120 is a highly selective, competitive and allosteric *carbamoyl phosphate synthetase* 1 (CPS1) inhibitor with an IC₅₀ of 1.5 μM and a K_i** of 1.4 μM. H3B-120 has anti-cancer activity .

HY-160127

SerSA

Others Others

SerSA is a potent inhibitor of seryl-tRNA synthetases. SerSA inhibits EcSerRS, SaSerRS and HsSerRS with IC₅₀s of 0.21, 0.23 and 2.17 μM, respectively .

SerSA	Others	Others
SerSA is a potent inhibitor of seryl-tRNA synthetases. SerSA inhibits EcSerRS, SaSerRS and HsSerRS with IC₅₀s of 0.21, 0.23 and 2.17 μM, respectively .

HY-105024

FPL 62064	Lipoxygenase COX	Inflammation/Immunology
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC₅₀ values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity .

HY-163457

Antileishmanial agent-27	Aminoacyl-tRNA Synthetase Parasite	Infection
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of *arginyl-tRNA synthetases* (ArgRSs)*. Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani* (LdArgRS) than its human counterpart (HsArgRS), with IC₅₀ values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .

HY-117651

2-Fluoropalmitic acid	Acyltransferase	Cancer
2-Fluoropalmitic acid, an acyl-CoA synthetase inhibitor, acts as a candidate anti-glioma agent. 2-Fluoropalmitic acid suppresses the viability and stem-like phenotype of glioma stem cells (GSCs). 2-Fluoropalmitic acid also inhibits proliferation and invasion of glioma cell lines .

HY-104032

Ac-CoA Synthase Inhibitor1 3 Publications Verification	RSV	Infection Metabolic Disease
Ac-CoA Synthase Inhibitor1 is a potent, reversible *acetate-dependent acetyl-CoA synthetase* 2 (ACSS2) inhibitor with an IC₅₀ of 0.6 µM . Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV)** .

HY-139180

PRGL493 2 Publications Verification	Others	Cancer
PRGL493 is a potent and selective *long-chain acyl-CoA synthetase* 4 (ACSL4)** inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research .

HY-147878

Antibacterial agent 111	Bacterial	Infection
Antibacterial agent 111 (Compound 3) is an antibacterial agent with MIC values of 3.90 μg/mL and 0.49 μg/mL against B. cereus and K. pneumonia, respectively. Antibacterial agent 111 firmly binds with tyrosyl-tRNA synthetase residues .

HY-N6707

Triacsin C 3 Publications Verification WS 1228A; FR 900190	Parasite	Infection
Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C is found to be highly effective against rotavirus replication .

HY-10446

Pralatrexate 4 Publications Verification	Antifolate Apoptosis	Cancer
Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K_i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment . Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100283

CGS 15435	Others	Inflammation/Immunology Endocrinology
CGS 15435, a potent thromboxane (TxA₂) synthetase inhibitor with an IC₅₀ of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI₂ synthetase and lipoxygenase enzymes.

HY-115440

CRS3123 dihydrochloride REP-3123 dihydrochloride	Bacterial Antibiotic	Infection
CRS3123 (REP-3123) dihydrochloride, a fully synthetic antibacterial agent, potently inhibits methionyl-tRNA synthetase (MetRS) of Clostridioides difficile, inhibiting Clostridioides difficile toxin production and spore formation. CRS3123 dihydrochloride is an oral agent for the research of Clostridioides difficile infection (CDI) .

HY-14654

Aspirin 15+ Cited Publications Acetylsalicylic Acid; ASA	COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis .

Cat. No.	Product Name	Type

HY-P2749

Glutamine synthetase	Biochemical Assay Reagents
Glutamine synthetase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2832

Acyl coenzyme A synthetase

ACS

Biochemical Assay Reagents

Acyl coenzyme A synthetase (ACS), namely acetyl coenzyme A synthetase, is often used in biochemical research. Acyl coenzyme A synthetase can catalyze the activation of fatty acids by coenzyme A through a two-step thioesterification reaction to produce acyl coenzyme A, and then participate in a variety of anabolic and catabolic lipid metabolism pathways, and participate in the TCA cycle in aerobic respiration .

HY-P2827

Acetyl-CoA synthetase ACS	Biochemical Assay Reagents
Acetyl-CoA synthetase (ACS) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-E70048

beta-1,3-N-Acetylgalactosaminyltransferase (LgtD) Gb4 synthetase	Biochemical Assay Reagents
beta-1,3-N-Acetylgalactosaminyltransferase (LgtD) (Gb4 synthetase) expressed by mature/activated B cells .

HY-125139

omega-3 Arachidonic acid ethyl ester

ω-3 Arachidonic acid ethyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester

Biochemical Assay Reagents

omega-3 Arachidonic Acid ethyl ester is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-117029

NAAD sodium Deamido nad sodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NAAD sodium (Deamido nad sodium), a functional NAD ⁺ precursor, is the substrate of glutamine-dependent NAD ⁺ synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases .

HY-W051513

2-Methylquinazolin-4-ol	Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	PARP
2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a K_i of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM .

HY-N6707

Triacsin C 3 Publications Verification WS 1228A; FR 900190	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Parasite
Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C is found to be highly effective against rotavirus replication .

HY-W015444

2-Hydroxyoctanoic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Hydroxyoctanoic acid is a medium chain acyl-CoA synthetase inhibitor with a K_i of 500 μM .

HY-N7128

Flavanone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Plants Sophora flavescens Aiton Disease Research Fields Cancer	Cytochrome P450
Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase) .

HY-D0186

2'-Deoxyuridine	Infection Structural Classification Natural Products Microorganisms Immune System Disorder Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

HY-P1975

Aureobasidin A 1 Publications Verification Basifungin	Infection Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics	Fungal Parasite
Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity .

HY-130043

11-O-Methylpseurotin A	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology	Others
11-O-Methylpseurotin A is a compound of mixed polyketide synthase–nonribosomal peptide synthetase (PKS/NRPS) origin. 11-O-Methylpseurotin A selectively inhibits a Hof1 deletion strain .

HY-B0711R

Carglumic Acid (Standard) N-Carbamyl-L-glutamic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
Carglumic Acid (Standard) is the analytical standard of Carglumic Acid. This product is intended for research and analytical applications. Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a *carbamoyl phosphate synthetase* 1 (CPS1**) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

HY-112052

Aminomalonic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (K_i= 0.0023 M) and mouse pancreas (K_i= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis .

HY-163178

Bisabosqual A	Structural Classification Natural Products Microorganisms Source classification	Apoptosis Autophagy
Bisabosqual A, a potent *asparagine synthetase* (ASNS) inhibitor, with an IC₅₀ of 10.7 μM. Bisabosqual A can covalently modify the K556 site of ASNS protein. Bisabosqual A promotes oxidative stress and apoptosis, while inhibiting autophagy**, cell migration and epithelial-mesenchymal transition (EMT), impeding cancer cell development .

HY-90006

5-Fluorouracil Maximum Cited Publications 183 Publications Verification 5-FU	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite
5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-90006R

5-Fluorouracil (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite
5-Fluorouracil (Standard) is the analytical standard of 5-Fluorouracil. This product is intended for research and analytical applications. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .

HY-N1584

Halofuginone 5+ Cited Publications RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584A

Halofuginone hydrobromide 5+ Cited Publications RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N6742

Borrelidin 1 Publications Verification Treponemycin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Anti-parasitic Antibacterial Disease Research Disease Research Fields	CDK Parasite Apoptosis Antibiotic
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC₅₀ of 24 μM . Borrelidin is a potent angiogenesis inhibitor, with an IC₅₀ of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells . Borrelidin has strong antimalarial activities, with IC₅₀s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively .

HY-N1584AR

Halofuginone hydrobromide (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Source classification Saxifragaceae Plants	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

Species:	Human (15) Mouse (2) E.coli (3)
Tag:	His (19) SUMO (3) Tag Free (1)
Source:	HEK293 (1) Sf9 insect cells (3) E. coli (16)

Cat. No.	Compare	Product Name	Species	Source

HY-P70360

	*Glutathione synthetase/GSS Protein, Human (His)* rHuGlutathione synthetase/GSS, His; Glutathione synthetase; GSH synthetase; GSH-S; Glutathione Synthase; GSS	Human	E. coli
	Glutathione synthase/GSS protein catalyzes the ATP-dependent synthesis of glutathione from gamma-glutamylcysteine and glycine. Glutathione synthetase/GSS Protein, Human (His) is the recombinant human-derived Glutathione synthetase/GSS protein, expressed by E. coli , with C-6*His labeled tag. The total length of Glutathione synthetase/GSS Protein, Human (His) is 473 a.a., with molecular weight of ~55.0 kDa.

HY-P70294

	*Glutamine synthetase/GLUL Protein, Human (His)* rHuGlutamine synthetase/GLUL, His; Glutamine synthetase; GS; Glutamate Decarboxylase; Glutamate--Ammonia Ligase; GLUL; GLNS	Human	E. coli
	GLUL proteins catalyze the conversion of glutamate and ammonia to glutamine. Glutamine synthetase/GLUL Protein, Human (His) is the recombinant human-derived Glutamine synthetase/GLUL protein, expressed by E. coli , with C-6*His labeled tag. The total length of Glutamine synthetase/GLUL Protein, Human (His) is 372 a.a., with molecular weight of 40-50 kDa.

HY-P71445

	CPS1/CPSase I Protein, Human (His) Carbamoyl phosphate synthase; Carbamoyl phosphate synthase mitochondrial; Carbamoyl phosphate synthase; Carbamoyl phosphate synthetase 1; Carbamoyl phosphate synthetase 1 mitochondrial; Carbamoyl phosphate synthetase I; Carbamoyl-phosphate synthase [ammonia]; Carbamoyl-phosphate synthetase I; Carbamoylphosphate synthase; Carbamoylphosphate synthetase 1; Carbamoylphosphate synthetase I; CPS 1; Cps1; CPSase 1; CPSase I; CPSASE1; mitochondrial; MS738	Human	E. coli
	The CPS1/CPSase I protein is critical in participating in the urea cycle and is essential for the elimination of excess ammonia in urea-bearing animals. This essential enzyme converts toxic ammonia (a byproduct of amino acid catabolism) into urea, promoting safe excretion. CPS1/CPSase I Protein, Human (His) is the recombinant human-derived CPS1/CPSase I protein, expressed by E. coli , with N-His labeled tag. The total length of CPS1/CPSase I Protein, Human (His) is 147 a.a., with molecular weight of ~20.5 kDa.

HY-P71642

	*Acetyl-CoA synthetase* 1/AceCS Protein, Mouse (His)** Acss2; Acas2; Acecs1Acetyl-coenzyme A synthetase; cytoplasmic; EC 6.2.1.1; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1	Mouse	E. coli
	Acetyl-CoA synthetase 1/AceCS Protein, Mouse (His) is an enzyme that converts acetate to acetyl-CoA, which supplies acetyl-CoA for tumor cells by capturing acetate as a carbon source under stressed conditions.

HY-P701922

	ACSS2 Protein, Human ACSS2; Acetyl-coenzyme A synthetase; cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase	Human	E. coli
	The ACSS2 protein plays a key role in catalyzing the synthesis of acetyl-CoA from short-chain fatty acids, with acetate being the preferred substrate. Although acetate is efficiently utilized, ACSS2 can also process propionate, albeit with significantly lower affinity. ACSS2 Protein, Human is the recombinant human-derived ACSS2 protein, expressed by E. coli , with tag free. The total length of ACSS2 Protein, Human is 700 a.a., .

HY-P701923

	ACSS2 Protein, Human (His) ACSS2; Acetyl-coenzyme A synthetase; cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase	Human	E. coli
	The ACSS2 protein plays a key role in catalyzing the synthesis of acetyl-CoA from short-chain fatty acids, with acetate being the preferred substrate. Although acetate is efficiently utilized, ACSS2 can also process propionate, albeit with significantly lower affinity. ACSS2 Protein, Human (His) is the recombinant human-derived ACSS2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ACSS2 Protein, Human (His) is 700 a.a., .

HY-P71098

	Tryptophan Synthase Protein, E.coli (His) Tryptophan synthetase; Tryptophan synthase	E.coli	E. coli
	The TrpA protein, especially its α subunit, plays a crucial role in catalyzing the aldol cleavage of indole glycerol phosphate to produce indole and glyceraldehyde 3-phosphate. This enzymatic activity highlights the importance of TrpA in the tryptophan biosynthetic pathway, providing an essential component of cellular processes. Tryptophan Synthase Protein, E.coli (His) is a recombinant protein dimer complex containing E. coli-derived Tryptophan Synthase protein, expressed by E. coli , with N-6*His labeled tag. Tryptophan Synthase Protein, E.coli (His), has molecular weight of 28 & 40-50 kDa, respectively.

HY-P70362

	MTHFS Protein, Human (His) rHu5-formyltetrahydrofolate cyclo-ligase/MTHFS, His; 5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetase	Human	E. coli
	MTHFS proteins play a critical role in tetrahydrofolate metabolism and help regulate carbon flow within the folate-dependent one-carbon metabolic network. This network is critical for providing the carbon units required for purine, thymidine, and amino acid biosynthesis. MTHFS Protein, Human (His) is the recombinant human-derived MTHFS protein, expressed by E. coli , with C-6*His labeled tag. The total length of MTHFS Protein, Human (His) is 203 a.a., with molecular weight of ~28.0 kDa.

HY-P74435

	AACS Protein, Human (sf9, His) Acetoacetyl-CoA synthetase; AACS; ACSF1	Human	Sf9 insect cells
	AACS proteins play a key role in cellular metabolism by converting acetoacetate in the cytoplasm into acetoacetyl-CoA (by similarity). As a ketone body utilizing enzyme, AACS helps synthesize essential cellular components including cholesterol and fatty acids (by similarity). AACS Protein, Human (sf9, His) is the recombinant human-derived AACS protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P71134

	WARS Protein, Human (His) WARS also known as Tryptophanyl-tRNA synthetase; Interferon-induced protein 53.	Human	E. coli
	WARS includes isomer 1, isomer 2, T1-TrpRS and T2-TrpRS, and has aminoacylation activity, except T2-TrpRS. Unlike isoform 1, isoform 2, T1-TrpRS and T2-TrpRS, exhibit vasostatic activity. WARS Protein, Human (His) is the recombinant human-derived WARS protein, expressed by E. coli , with N-6*His labeled tag. The total length of WARS Protein, Human (His) is 471 a.a., with molecular weight of ~60.0 kDa.

HY-P70840

	KARS Protein, Human (HEK293, His) Lysine--tRNA Ligase; Lysyl-tRNA synthetase; LysRS; KARS; KIAA0070	Human	HEK293
	The KARS protein promotes attachment of amino acids to its cognate tRNA through a two-step reaction, inducing immune responses through monocyte/macrophage activation. In microbial infections, it interacts with the HIV-1 GAG protein to enable selective tRNA(3)(Lys) packaging to initiate reverse transcription. KARS Protein, Human (HEK293, His) is the recombinant human-derived KARS protein, expressed by HEK293 , with C-6*His labeled tag. The total length of KARS Protein, Human (HEK293, His) is 596 a.a., with molecular weight of 70-90 kDa.

HY-P75517

	*Alanyl-tRNA synthetase* Protein, Human (sf9, His)** Alanine--tRNA ligase, cytoplasmic; AlaRS; AARS1; AARS	Human	Sf9 insect cells
	The Alanyl-tRNA synthetase protein facilitates a two-step process, activating alanine with ATP to form Ala-AMP and transferring it to the acceptor end of tRNA(Ala). Additionally, it corrects incorrectly charged tRNA(Ala) through its editing domain. Alanyl-tRNA synthetase Protein, Human (sf9, His) is the recombinant human-derived Alanyl-tRNA synthetase protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Alanyl-tRNA synthetase Protein, Human (sf9, His) is 968 a.a., with molecular weight of ~109.2 kDa.

HY-P75567

	AARS1 Protein, Mouse (sf9, His) Alanine--tRNA ligase, cytoplasmic; Alanyl-tRNA synthetase; AlaRS; Sti; Aars	Mouse	Sf9 insect cells
	AARS1, a pivotal enzyme in protein synthesis, plays a crucial role in the attachment of alanine to tRNA(Ala) through a two-step process. Initially, alanine undergoes activation by ATP to form Ala-AMP, and subsequently, it is transferred to the acceptor end of tRNA(Ala). Beyond its primary aminoacylation function, AARS1 boasts an editing domain that enables the correction of incorrectly charged tRNA(Ala), underscoring its role in maintaining the fidelity of the translation process. This dual functionality highlights AARS1's significance in ensuring the accuracy and integrity of the protein synthesis machinery. AARS1 Protein, Mouse (sf9, His) is the recombinant mouse-derived AARS1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of AARS1 Protein, Mouse (sf9, His) is 968 a.a., with molecular weight of ~108 kDa.

HY-P700595

	PRPS1 Protein, Human (His-SUMO) PRPS1; phosphoribosyl pyrophosphate synthetase 1; deafness, X linked 2, perceptive, congenital , DFN2; ribose-phosphate pyrophosphokinase 1; CMTX5; DFNX1; PRS I; ribose phosphate diphosphokinase 1	Human	E. coli
	The PRPS1 protein plays a crucial role in catalyzing the synthesis of phosphoribosyl pyrophosphate (PRPP), a key intermediate in nucleotide synthesis. By promoting the conversion of ribose 5-phosphate and ATP to PRPP, PRPS1 contributes to the availability of PRPP in various cellular processes, including de novo biosynthesis of purine and pyrimidine nucleotides. PRPS1 Protein, Human (His-SUMO) is the recombinant human-derived PRPS1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P76131

	AARSD1 Protein, Human (His) Alanyl-tRNA editing protein Aarsd1; Alanyl-tRNA synthetase domain-containing protein 1; AARSD1	Human	E. coli
	AARSD1 Protein actively functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). AARSD1 Protein, Human (His) is the recombinant human-derived AARSD1 protein, expressed by E. coli , with N-His labeled tag. The total length of AARSD1 Protein, Human (His) is 350 a.a., with molecular weight of ~40 KDa.

HY-P702154

	birA Protein, E.coli (His) birA; Bifunctional ligase/repressor BirA; Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] ligase; Biotin--protein ligase; Biotin-[acetyl-CoA carboxylase] synthetase	E.coli	E. coli
	The birA protein has the dual role of biotin ligase and biotin operon repressor. In the presence of ATP, it activates biotin to form the BirA-biotinyl-5'-adenylate complex. birA Protein, E.coli (His) is the recombinant E. coli-derived birA protein, expressed by E. coli , with N-6*His labeled tag. The total length of birA Protein, E.coli (His) is 321 a.a., .

HY-P72193

	FDFT1 Protein, Human (His) DGPT; ERG9; Farnesyl diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT_HUMAN; FDFT1; FPP:FPP farnesyltransferase; SQS; Squalene synthase; Squalene synthetase; SS	Human	E. coli
	FDFT1 is a key enzyme in cellular metabolism responsible for coordinating the condensation of two farnesyl pyrophosphate (FPP) molecules, a key step in sterol biosynthesis. The process proceeds in two distinct steps: First, two FPP molecules react to form the stable squalene diphosphate intermediate (PSQPP), releasing protons and inorganic diphosphate. FDFT1 Protein, Human (His) is the recombinant human-derived FDFT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FDFT1 Protein, Human (His) is 416 a.a., with molecular weight of ~52 kDa.

HY-P71511

	Gamma-GCS Protein, E.coli (His-SUMO) gshA; gsh-I; b2688; JW2663Glutamate--cysteine ligase; EC 6.3.2.2; Gamma-ECS; GCS; Gamma-glutamylcysteine synthetase	E.coli	E. coli
	Gamma-GCS protein is a key enzyme in sulfur metabolism and initiates glutathione synthesis by catalyzing the incorporation of L-cysteine and L-glutamic acid. This important molecule critical for cellular antioxidant defense is synthesized through a critical 1/2 step facilitated by γ-GCS. Gamma-GCS Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Gamma-GCS protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P71538

	AIMP2 Protein, Human (His) Aimp2; AIMP2_HUMAN; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 ; ARS interacting multi functional protein 2 ; JTV 1; JTV 1 protein; JTV1; JTV1 gene; Multisynthase complex auxiliary component p38; Multisynthetase complex auxiliary component p38; P38; PRO0992; Protein JTV 1; Protein JTV-1; tRNA synthetase COFACTOR p38	Human	E. coli
	AIMP2 Protein, Human (His) plays a primary role in the initiation of α-synuclein (aSyn) aggregation.

HY-P72096

	ATP5F1A Protein, Human (His-SUMO) ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase subunit alpha; ATP synthase subunit alpha mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; 1; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; non-cardiac muscle-like 2; ATP sythase F1 ATPase; alpha subunit; ATP5A; Atp5a1; ATP5AL2; ATPA_HUMAN; ATPM; Epididymis secretory sperm binding protein Li 123m; hATP1; HEL-S-123m; MC5DN4; mitochondrial; Mitochondrial ATP synthetase; Mitochondrial ATP synthetase oligomycin resistant; Modifier of Min 2; Modifier of Min 2 mouse homolog; Modifier of Min 2; mouse; homolog of; MOM2; OMR; ORM; OTTHUMP00000163475	Human	E. coli
	ATP5F1A is an important component of mitochondrial ATP synthase (complex V) that coordinates ATP production from ADP by utilizing the transmembrane proton gradient. As part of the F-type ATPase, the α and β subunits of ATP5F1A form the catalytic core to achieve ATP hydrolysis. ATP5F1A Protein, Human (His-SUMO) is the recombinant human-derived ATP5F1A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of ATP5F1A Protein, Human (His-SUMO) is 510 a.a., with molecular weight of ~71.2 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0242S1

Sulfanilamide-d4

Sulfanilamide-d₄ is the deuterium labeled Sulfanilamide. Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

HY-B0946S1

Sulfamonomethoxine-d3
Sulfamonomethoxine-d₃ is the deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.

HY-B0946S

Sulfamonomethoxine-d4
Sulfamonomethoxine-d₄ is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate[1].

HY-B0946S2

Sulfamonomethoxine-13C6
Sulfamonomethoxine- ¹³C₆ is the ¹³C₆ labeled Sulfamonomethoxine. Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.

HY-B0946S3

Sulfamonomethoxine-d3-1
Sulfamonomethoxine-d₃-1 is the deuterium labeled Sulfamonomethoxine[1]. Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate[2].

HY-D0186S5

2'-Deoxyuridine-d
2'-Deoxyuridine-d is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]<

HY-D0186S4

2'-Deoxyuridine-d2
2'-Deoxyuridine-d₂ is the deuterium labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S

2'-Deoxyuridine-1′-13C
2'-Deoxyuridine-1′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S1

2'-Deoxyuridine-2′-13C
2'-Deoxyuridine-2′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S2

2'-Deoxyuridine-3′-13C
2'-Deoxyuridine-3′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S3

2'-Deoxyuridine-5′-13C
2'-Deoxyuridine-5′- ¹³C is the ¹³C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]

HY-D0186S8

2'-Deoxyuridine-d2-1
2'-Deoxyuridine-d₂-1 is the deuterium labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

HY-D0186S7

2'-Deoxyuridine-13C,15N2
2'-Deoxyuridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

HY-90006S

5-Fluorouracil-d1
5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

HY-90006S2

5-Fluorouracil-15N2
5-Fluorouracil- ¹⁵N₂ is the ¹⁵N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

HY-90006S1

5-Fluorouracil-13C,15N2

5-Fluorouracil- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

HY-90006S3

5-Fluorouracil-13C4,15N2

5-Fluorouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80411

	*Glutathione Synthetase* Antibody**	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Glutathione Synthetase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Glutathione Synthetase. It can be used for WB,ICC,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80550

	*Asparagine Synthetase* Antibody** TS11; ASNSD; ASNS; Asparagine synthetase [glutamine-hydrolyzing]	WB, IHC-P	Human, Rat
	Asparagine Synthetase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 64 kDa, targeting to Asparagine Synthetase. It can be used for WB,IHC-P assays with tag free, in the background of Human, Rat.

HY-P80408

	*Glutamine Synthetase* Antibody (YA751)**	WB, IHC-P, FC	Human, Mouse
	Glutamine Synthetase Antibody (YA751) is a non-conjugated and Mouse origined monoclonal antibody about 42 kDa, targeting to Glutamine Synthetase. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80691

	*Glutamine Synthetase* Antibody (YA405)** GLNA; GS; GLUL; GLNS; PIG43; PIG59; Glutamine synthetase	WB	Mouse, Rat
	Glutamine Synthetase Antibody (YA405) is a non-conjugated and Rabbit origined monoclonal antibody about 42 kDa, targeting to Glutamine Synthetase. It can be used for WB assays with tag free, in the background of Mouse, Rat.

HY-P83057

Citrate Synthetase Antibody (YA2802)

Citrate synthase; Citrate synthase; mitochondrial; Cs
WB, IHC-F, IHC-P, ICC/IF, IP Human, Rat

HY-P81072

	LIAS Antibody HUSSY 01; LAS; LIP 1; Lip syn; LIP1; Lipoate synthase; Lipoic acid synthetase; Lipoic acid synthetase mitochondrial; Lipoyl synthase, mitochondrial; LS; MGC23245.	ELISA, IHC-P, ICC/IF	Mouse
	LIAS Antibody is an unconjugated, rabbit-derived, anti-LIAS polyclonal antibody. LIAS Antibody can be used for: ELISA, IHC-P, ICC, IF, expriments in mouse and predicted: human, rat, chicken, dog, pig, cow, horse, rabbit, sheep background without labeling.

HY-P82238

ACSS2 Antibody (YA1983)

ACSS2; ACSA; ACAS2; AceCS; MYH7B; Acetyl CoA synthetase
WB Human
HY-P83153

GCLC Antibody (YA2898)

GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase
WB Human, Mouse, Rat

HY-P81662

	GCLM Antibody (YA1407) GCLM; GLCLR; Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-131033

L-Azidonorleucine hydrochloride		Azide
L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants . L-Azidonorleucine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-10446

Pralatrexate 4 Publications Verification		Alkynes
Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a K_i of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment . Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111434

UAA crosslinker 1		Azide
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-111434A

UAA crosslinker 1 hydrochloride		Azide
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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