β1-integrin

By Targets:	Integrin (23) Apoptosis (2) FAK (1) Nuclear Hormone Receptor 4A/NR4A (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (8) Metabolic Disease (2)

Targets Recommended: Integrin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13306

Pyrintegrin 3 Publications Verification	Integrin	Metabolic Disease
Pyrintegrin is an *β1-integrin* agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated *integrin* signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic ^[1] .

HY-48959

*α7β1 integrin* modulator-1**	Integrin	Metabolic Disease
α7β1 integrin modulator-1 is a potent α7β1 integrin modulator. α7β1 integrin modulator-1 has the potential for the research of muscular dystrophy ^[1].

HY-139702

*α5β1 integrin* agonist-1**	Integrin	Cancer
α5β1 integrin agonist-1, acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death.

HY-100506

GLPG0187 Maximum Cited Publications 6 Publications Verification	Integrin	Cancer
GLPG0187 is a broad spectrum *integrin* receptor antagonist with antitumor activity; inhibits α_vβ₁-integrin with an IC₅₀ of 1.3 nM ^[1]. GLPG0187 inhibits migrasome biogenesis without cytotoxicity .

HY-P1868

*α2β1 Integrin* Ligand Peptide** DGEA peptide	Integrin	Infection
α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors ^[1].

HY-P1868A

*α2β1 Integrin* Ligand Peptide TFA** 2 Publications Verification DGEA peptide TFA	Integrin	Others
α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors ^[1].

HY-134130

Integrin modulator 1	Integrin	Inflammation/Immunology
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC₅₀ of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC₅₀ of 12.9 nM ^[1].

HY-111413

c(phg-isoDGR-(NMe)k)

Integrin Cancer

c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM ^[1].
HY-111413A

c(phg-isoDGR-(NMe)k) TFA

Integrin Cancer

c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM ^[1].

c(phg-isoDGR-(NMe)k)	Integrin	Cancer
c(phg-isoDGR-(NMe)k) is a selective and potent *α5β1-integrin* ligand with an IC₅₀ of 2.9 nM ^[1].

c(phg-isoDGR-(NMe)k) TFA	Integrin	Cancer
c(phg-isoDGR-(NMe)k) TFA is a selective and potent *α5β1-integrin* ligand with an IC₅₀ of 2.9 nM ^[1].

HY-P2267

LDV 1 Publications Verification	Integrin	Others
LDV is a non-fluorescent analog of LDV-FITC. LDV is a α4β1 integrin (VLA-4) ligand, and binds α4β1 integrin in leukemia cells ^[1] .

HY-136214

R-BC154 acetate	Integrin	Inflammation/Immunology Cancer
R-BC154 acetate is a selective fluorescent *α₉β₁* integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity ^[1].

HY-P5038

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) c(GRGDSP)	Integrin	Cancer
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 *integrin* ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells ^[1].

HY-P1188

LDV-FITC	Integrin	Cancer
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (K_d: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn ²⁺ respectively). LDV-FITC can be used to detect α4β1 integrin affinity ^[1] .

HY-150124

K34c

Integrin Cancer

K34c is a potent and selective α5β1 integrin antagonist. K34c can be used for glioblastoma research ^[1].

K34c	Integrin	Cancer
K34c is a potent and selective α5β1 integrin antagonist. K34c can be used for glioblastoma research ^[1].

HY-108831

Natalizumab 2 Publications Verification	Integrin	Inflammation/Immunology
Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses ^[1].

HY-P5929

VnP-16	Integrin FAK	Inflammation/Immunology
VnP-16 can promote bone formation by accelerating osteoblast differentiation and activity through direct interaction with β1 integrin followed by FAK activation ^[1].

HY-108831A

Natalizumab (Solution) 2 Publications Verification	Integrin	Inflammation/Immunology
Natalizumab (Solution) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses ^[1].

HY-100445

αvβ1 integrin-IN-1

αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC₅₀ of 0.63 nM. Antifibrotic effects ^[1].
HY-123802

BIO7662

Integrin Cancer

BIO7662 is a specific α4β1 antagonist. BIO7662 can be used to study α4β1 integrin-ligand interactions ^[1] .

*αvβ1 integrin-IN-1*
αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC₅₀ of 0.63 nM. Antifibrotic effects ^[1].

BIO7662	Integrin	Cancer
BIO7662 is a specific *α4β1* antagonist. BIO7662 can be used to study α4β1 integrin-ligand interactions ^[1] .

HY-100445A

*αvβ1 integrin-IN-1 TFA* 3 Publications Verification	Integrin	Cardiovascular Disease Cancer
αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC₅₀ of 0.63 nM. Antifibrotic effects ^[1].

HY-N2587

Irigenin	Integrin Apoptosis	Cancer
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking *α9β1* and *α4β1* integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells ^[1].

HY-15770

TR-14035 4 Publications Verification	Integrin	Inflammation/Immunology
TR-14035 is a orally active dual *α₄β₇/α₄β₁ integrin* antagonist, with IC₅₀ s of 7 nM and 87 nM for α₄β₇ and α₄β₁, respectively. TR-14035 can be used for the research of inflammation and autoimmune diseases ^[1] .

HY-137561

Bexotegrast PLN-74809	Integrin	Inflammation/Immunology
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with K_d of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC₅₀ values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung ^[1] .

HY-112055

DIM-C-pPhOH 4 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis	Cancer
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively ^[1].

HY-129453

BOP sodium	Integrin	Inflammation/Immunology
BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with K_d values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins ^[1] .

Cat. No.	Product Name	Type

HY-111413A

c(phg-isoDGR-(NMe)k) TFA

Biochemical Assay Reagents

c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM ^[1].
HY-111413

c(phg-isoDGR-(NMe)k)

Biochemical Assay Reagents

c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC₅₀ of 2.9 nM ^[1].

c(phg-isoDGR-(NMe)k) TFA	Biochemical Assay Reagents
c(phg-isoDGR-(NMe)k) TFA is a selective and potent *α5β1-integrin* ligand with an IC₅₀ of 2.9 nM ^[1].

c(phg-isoDGR-(NMe)k)	Biochemical Assay Reagents
c(phg-isoDGR-(NMe)k) is a selective and potent *α5β1-integrin* ligand with an IC₅₀ of 2.9 nM ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P1868A

*α2β1 Integrin* Ligand Peptide TFA** 2 Publications Verification DGEA peptide TFA	Integrin	Others
α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors ^[1].

HY-P2267

LDV 1 Publications Verification	Integrin	Others
LDV is a non-fluorescent analog of LDV-FITC. LDV is a α4β1 integrin (VLA-4) ligand, and binds α4β1 integrin in leukemia cells ^[1] .

HY-P1868

*α2β1 Integrin* Ligand Peptide** DGEA peptide	Integrin	Infection
α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors ^[1].

HY-P5038

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) c(GRGDSP)	Integrin	Cancer
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 *integrin* ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells ^[1].

HY-P1188

LDV-FITC	Integrin	Cancer
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (K_d: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn ²⁺ respectively). LDV-FITC can be used to detect α4β1 integrin affinity ^[1] .

HY-P5929

VnP-16	Integrin FAK	Inflammation/Immunology
VnP-16 can promote bone formation by accelerating osteoblast differentiation and activity through direct interaction with β1 integrin followed by FAK activation ^[1].

Cat. No.	Product Name	Target	Research Area

HY-108831

Natalizumab 2 Publications Verification	Integrin	Inflammation/Immunology
Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses ^[1].

HY-108831A

Natalizumab (Solution) 2 Publications Verification	Integrin	Inflammation/Immunology
Natalizumab (Solution) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2587

Irigenin	Flavonoids Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Isoflavones Cancer	Integrin Apoptosis
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking *α9β1* and *α4β1* integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells ^[1].

Species:	Human (7) Mouse (2)
Tag:	His (9) Avi (3) Flag (1)
Source:	HEK293 (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P700752

	Integrin alpha 2 beta 1 Protein, Human (HEK293, His) α2β1; integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; VLA-2, GPIa-IIa, CD49b; integrin alpha A1 β 1; alpha A1 β 1; β 1	Human	HEK293
	ITGA2 Protein, a transmembrane receptor, is involved in cell adhesion, platelet aggregation, and tumor metastasis. Dysregulation of ITGA2 Protein has been associated with various disorders, including thrombosis and cancer. Targeting ITGA2 Protein may offer potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting blood clot formation, and preventing tumor metastasis. Integrin alpha 2 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 2 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2 beta 1 Protein, Human (HEK293, His), has molecular weight of 110-140 kDa.

HY-P700764

Integrin alpha 6 beta 1 Protein, Human (HEK293, His-Avi)

α6β1; integrin alpha 6 beta 1; ITGA6&ITGB1; integrin alpha 6 β 1
Human HEK293
HY-P702621

Integrin alpha 6 beta 1 Protein, Human (Biotinylated, HEK293, His, Avi)

α6β1; integrin alpha 6 beta 1; ITGA6&ITGB1; integrin alpha 6 β 1
Human HEK293

HY-P700750

	Integrin alpha 10 beta 1 Protein, Human (HEK293, His) integrin alpha 10 beta 1; ITGA10&ITGB1; α10β1	Human	HEK293
	Integrin alpha-10/beta-1, a collagen-specific receptor, crucially mediates cell interactions with the extracellular matrix. Comprising alpha-10 and beta-1 subunits, their stable association forms a heterodimeric complex. This interaction facilitates adhesion and signaling events, influencing essential aspects of cell behavior and tissue organization. Understanding Integrin alpha-10/beta-1's nuances provides insights into its significance in mediating cell-matrix interactions, offering implications in physiological and pathological contexts. Integrin alpha 10 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha 10 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 10 beta 1 Protein, Human (HEK293, His), has molecular weight of 140-160 kDa (ITGA10) & 100-130 kDa (ITGB), respectively.

HY-P700751

	Integrin alpha 10 beta 1 Protein, Mouse (HEK293, His) integrin alpha 10 beta 1; ITGA10&ITGB1; α10β1	Mouse	HEK293
	Integrin alpha 10 beta 1 Protein, within the integrin alpha chain family, is emphasized. Integrin alpha 10 beta 1 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha 10 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 10 beta 1 Protein, Mouse (HEK293, His), has molecular weight of 140-170 kDa (ITGA10) & 100-130 kDa (ITGB), respectively.

HY-P73872

	Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His) CD49e; FNRA; integrin alpha 5 beta 1; integrin alpha-F; VLA-5; ITGB1; CD29	Human	HEK293
	ITGA5, a versatile receptor, interacts with diverse ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, Human metapneumovirus, and soluble CD40LG. Recognizing the R-G-D sequence, ITGA5 mediates cell adhesion through distinct binding sites. Notably, it binds PLA2G2A at a separate site, inducing conformational changes enhancing ligand binding. ITGA5's role in IL1B signaling, microbial infection, and CD40/CD40LG signaling highlights its multifunctionality in cellular processes and signaling pathways. Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein, expressed by HEK293, with C-Flag, C-10*His labeled tag. Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His), has molecular weight of ~101.35 kDa.

HY-P700755

	Integrin alpha 5 beta 1 Protein, Human (Biotinylated, HEK293, His-Avi) integrin alpha 5 beta 1; VLA-5; ITGA5&ITGB1; integrin alpha 5 β 1; α5β1	Human	HEK293
	ITGA5, a versatile receptor, interacts with diverse ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, Human metapneumovirus, and soluble CD40LG. Recognizing the R-G-D sequence, ITGA5 mediates cell adhesion through distinct binding sites. Notably, it binds PLA2G2A at a separate site, inducing conformational changes enhancing ligand binding. ITGA5's role in IL1B signaling, microbial infection, and CD40/CD40LG signaling highlights its multifunctionality in cellular processes and signaling pathways. Integrin alpha 5 beta 1 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein, expressed by HEK293, with C-Avi, C-His labeled tag. Integrin alpha 5 beta 1 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 110-140 kDa.

HY-P700756

	Integrin alpha A1 beta 1 Protein, Human (HEK293, His) integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; integrin alpha A1 β 1; alpha A1 β 1; β 1	Human	HEK293
	ITGA1 Protein, a cell surface receptor, plays a crucial role in cell adhesion, migration, and tissue development. Dysregulation of ITGA1 Protein has been linked to various diseases, including cancer and fibrosis. Targeting ITGA1 Protein may provide potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting tumor growth, and preventing tissue fibrosis. Integrin alpha A1 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha A1 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Human (HEK293, His), has molecular weight of 160-200 kDa.

HY-P700757

	Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His) integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; integrin alpha A1 β 1; alpha A1 β 1; β 1	Mouse	HEK293
	Integrin alpha-1/beta-1, a receptor for laminin and collagen, recognizes the proline-hydroxylated sequence G-F-P-G-E-R within collagen. This integral protein negatively regulates EGF-stimulated cell growth and forms a heterodimeric complex with beta-1, interacting with the small GTPase RAB21. Through its cytoplasmic domain, Integrin alpha-1/beta-1 engages with PTPN2, activating phosphatase activity towards EGFR, exerting a negative regulatory influence on EGF signaling, highlighting its multifaceted role in cellular responses. Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha A1 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His), has molecular weight of 140-200 kDa (ITGA1) & 100-115 kDa (ITGB1), respectively.


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