2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage Autophagy Apoptosis
  3. Estrogen Receptor/ERR HSP Autophagy Apoptosis
  4. Tamoxifen-d5

Tamoxifen-d5  (Synonyms: ICI 47699-​d5; (Z)-Tamoxifen-d5; trans-Tamoxifen-d5)

Cat. No.: HY-13757AS Purity: 99.99%
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Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

For research use only. We do not sell to patients.

Tamoxifen-d<sub>5</sub> Chemical Structure

Tamoxifen-d5 Chemical Structure

CAS No. : 157698-32-3

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1 mg USD 320 In-stock
5 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Tamoxifen-d5:

Tamoxifen-d5 Related Antibodies

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Description

Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

IC50 & Target[1][2]

Estrogen receptor

 

HSP90

 

Molecular Weight

376.55

Formula

C26H24D5NO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C([2H])([2H])/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (221.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6557 mL 13.2784 mL 26.5569 mL
5 mM 0.5311 mL 2.6557 mL 5.3114 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6557 mL 13.2784 mL 26.5569 mL 66.3922 mL
5 mM 0.5311 mL 2.6557 mL 5.3114 mL 13.2784 mL
10 mM 0.2656 mL 1.3278 mL 2.6557 mL 6.6392 mL
15 mM 0.1770 mL 0.8852 mL 1.7705 mL 4.4261 mL
20 mM 0.1328 mL 0.6639 mL 1.3278 mL 3.3196 mL
25 mM 0.1062 mL 0.5311 mL 1.0623 mL 2.6557 mL
30 mM 0.0885 mL 0.4426 mL 0.8852 mL 2.2131 mL
40 mM 0.0664 mL 0.3320 mL 0.6639 mL 1.6598 mL
50 mM 0.0531 mL 0.2656 mL 0.5311 mL 1.3278 mL
60 mM 0.0443 mL 0.2213 mL 0.4426 mL 1.1065 mL
80 mM 0.0332 mL 0.1660 mL 0.3320 mL 0.8299 mL
100 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.6639 mL
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Tamoxifen-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tamoxifen-d5157698-32-3ICI 47699-​d5(Z)-Tamoxifen-d5trans-Tamoxifen-d5Estrogen Receptor/ERRHSPAutophagyApoptosisHeat shock proteinsestrogenmodulatorSERMbreastboneliveruterineHsp90chaperoneATPaseInhibitorinhibitorinhibit

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