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  4. Thiethylperazine dimaleate

Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects.

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Thiethylperazine dimaleate Chemical Structure

Thiethylperazine dimaleate Chemical Structure

CAS No. : 1179-69-7

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Based on 1 publication(s) in Google Scholar

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Thiethylperazine dimaleate Related Antibodies

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Description

Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].

IC50 & Target

D2 Receptor

 

H1 Receptor

 

In Vitro

Thiethylperazine could enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thiethylperazine dimaleate Related Antibodies
In Vivo

Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days; young APP/PS1 mice) treatment significantly reduces Aβ42 levels in APP/PS1 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice[2]
Dosage: 3 mg/kg
Administration: Intramuscular injection; twice daily; for 30 days
Result: Significantly reduced Aβ42 levels in APP/PS1 mice.
Molecular Weight

631.76

Formula

C30H37N3O8S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (197.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5829 mL 7.9144 mL 15.8288 mL
5 mM 0.3166 mL 1.5829 mL 3.1658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5829 mL 7.9144 mL 15.8288 mL 39.5720 mL
5 mM 0.3166 mL 1.5829 mL 3.1658 mL 7.9144 mL
10 mM 0.1583 mL 0.7914 mL 1.5829 mL 3.9572 mL
15 mM 0.1055 mL 0.5276 mL 1.0553 mL 2.6381 mL
20 mM 0.0791 mL 0.3957 mL 0.7914 mL 1.9786 mL
25 mM 0.0633 mL 0.3166 mL 0.6332 mL 1.5829 mL
30 mM 0.0528 mL 0.2638 mL 0.5276 mL 1.3191 mL
40 mM 0.0396 mL 0.1979 mL 0.3957 mL 0.9893 mL
50 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7914 mL
60 mM 0.0264 mL 0.1319 mL 0.2638 mL 0.6595 mL
80 mM 0.0198 mL 0.0989 mL 0.1979 mL 0.4946 mL
100 mM 0.0158 mL 0.0791 mL 0.1583 mL 0.3957 mL
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Thiethylperazine dimaleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiethylperazine dimaleate1179-69-7Dopamine ReceptorHistamine ReceptorBacterialAmyloid-ββ-amyloid peptideAβAbetaAnti-emeticphenothiazineD2-receptorH1-receptorpregnancycleftAlzheimerdiseaseAβ42ABCC1antipsychoticInhibitorinhibitorinhibit

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