2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Upidosin

Upidosin  (Synonyms: Rec 15/2739; Recordati 15/2739; SB 216469)

Cat. No.: HY-106954 Purity: 99.58%
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Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction.

For research use only. We do not sell to patients.

Upidosin Chemical Structure

Upidosin Chemical Structure

CAS No. : 152735-23-4

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Upidosin Related Antibodies

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Description

Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction[1].

In Vitro

Upidosin is one of the most potent compounds action on the prostate with comparing the apparent pKB values, but its potency is slightly lower than that of tamsulosin and is higher than the potencies of prazosin, terazosin and 5-methylurapidil[2].
Upidosin shows binding affinities to cloned humanα1A, humanα1B, humanα1D adrenoceptors with pKi value of 9.0, 7.5 and 8.6, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Upidosin Related Antibodies
In Vivo

Upidosin shows greater selectivity than any other α-1 AR antagonist terazosin and tamsulosin in the anesthetized dog[1].
Upidosin (1-300 μg/kg; i.v.) is a more potent antagonist of phenylephrine mediated increases in prostatic pressure with a pA2 value of 8.74 compared to blood pressure with a pA2 value of 7.51[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

511.61

Formula

C31H33N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=CC=C1)=C1N(CC2)CCN2CCCNC(C3=C4C(C(C(C)=C(C5=CC=CC=C5)O4)=O)=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (488.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9546 mL 9.7731 mL 19.5461 mL
5 mM 0.3909 mL 1.9546 mL 3.9092 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9546 mL 9.7731 mL 19.5461 mL 48.8653 mL
5 mM 0.3909 mL 1.9546 mL 3.9092 mL 9.7731 mL
10 mM 0.1955 mL 0.9773 mL 1.9546 mL 4.8865 mL
15 mM 0.1303 mL 0.6515 mL 1.3031 mL 3.2577 mL
20 mM 0.0977 mL 0.4887 mL 0.9773 mL 2.4433 mL
25 mM 0.0782 mL 0.3909 mL 0.7818 mL 1.9546 mL
30 mM 0.0652 mL 0.3258 mL 0.6515 mL 1.6288 mL
40 mM 0.0489 mL 0.2443 mL 0.4887 mL 1.2216 mL
50 mM 0.0391 mL 0.1955 mL 0.3909 mL 0.9773 mL
60 mM 0.0326 mL 0.1629 mL 0.3258 mL 0.8144 mL
80 mM 0.0244 mL 0.1222 mL 0.2443 mL 0.6108 mL
100 mM 0.0195 mL 0.0977 mL 0.1955 mL 0.4887 mL
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Upidosin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Upidosin152735-23-4Rec 15/2739 Recordati 15/2739 SB 216469SB216469SB 216469SB-216469Adrenergic ReceptorBeta Receptorurethraprostateear arteryaorta[3H]prazosinprostatic pressuredogInhibitorinhibitorinhibit

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