2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. Y-33075 hydrochloride

Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.

For research use only. We do not sell to patients.

Y-33075 hydrochloride Chemical Structure

Y-33075 hydrochloride Chemical Structure

CAS No. : 471843-75-1

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Y-33075 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Y-33075 hydrochloride purchased from MedChemExpress. Usage Cited in: PLoS One. 2023 Jan 31;18(1):e0270288.  [Abstract]

    Y-27632 (10, 100 nM and 10, 100 µM; 24 h) decreases phosphorylation of MLC starting at a concentration of 100 nM in HSCs.

    Y-33075 hydrochloride purchased from MedChemExpress. Usage Cited in: Neurotox Res. 2013 Apr;23(3):238-48.  [Abstract]

    Effect of Y39983 on glutamate-treated HT22 cell viability.

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    Description

    Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.

    In Vitro

    Y-33075 hydrochloride (Y-39983) (10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983[2].
    Y-33075 hydrochloride (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca2+-free solutions. Y-33075 hydrochloride (10 μM) shows no effect on the [Ca2+]i increase with the high-potassium (high-K) solution[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Y-33075 hydrochloride Related Antibodies
    Molecular Weight

    316.79

    Formula

    C16H17ClN4O
    CAS No.
    SMILES

    O=C(C1=CC=C([C@@H](C)N)C=C1)NC2=C3C(NC=C3)=NC=C2.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Y-33075 hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Y-33075471843-75-1Y-39983Y33075Y 33075Y39983Y 39983ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKROCK?InhibitorRGCretinal ganglion celloptic nerveInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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