Zagociguat (Synonyms: CY-6463; IW-6463)

Cat. No.: HY-145607 Purity: 99.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Zagociguat is the stimulator of soluble guanylate cyclase. Zagociguat increases nitric oxide (NO) signaling leading to an increase in cyclic guanosine monophosphate production. Zagociguat has the potential for the research of noncentral nervous system (CNS) disorders.

For research use only. We do not sell to patients.

Zagociguat Chemical Structure

CAS No. : 2201048-82-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 330	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 330	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

Soluble Guanylate Cyclase^[1]

Molecular Weight

362.28

Formula

C₁₆H₁₀F₄N₆

CAS No.

2201048-82-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=C(CC2=NC(C3=NN=C(C(F)(F)F)N3)=CN4C=CN=C24)C=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (690.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7603 mL	13.8015 mL	27.6030 mL
5 mM	0.5521 mL	2.7603 mL	5.5206 mL
10 mM	0.2760 mL	1.3801 mL	2.7603 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Debra J. Wallace, et al. Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases. Org Process Res Dev. 2021;25(10):2288-2299.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7603 mL	13.8015 mL	27.6030 mL	69.0074 mL
	5 mM	0.5521 mL	2.7603 mL	5.5206 mL	13.8015 mL
	10 mM	0.2760 mL	1.3801 mL	2.7603 mL	6.9007 mL
	15 mM	0.1840 mL	0.9201 mL	1.8402 mL	4.6005 mL
	20 mM	0.1380 mL	0.6901 mL	1.3801 mL	3.4504 mL
	25 mM	0.1104 mL	0.5521 mL	1.1041 mL	2.7603 mL
	30 mM	0.0920 mL	0.4600 mL	0.9201 mL	2.3002 mL
	40 mM	0.0690 mL	0.3450 mL	0.6901 mL	1.7252 mL
	50 mM	0.0552 mL	0.2760 mL	0.5521 mL	1.3801 mL
	60 mM	0.0460 mL	0.2300 mL	0.4600 mL	1.1501 mL
	80 mM	0.0345 mL	0.1725 mL	0.3450 mL	0.8626 mL
	100 mM	0.0276 mL	0.1380 mL	0.2760 mL	0.6901 mL

Zagociguat Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zagociguat2201048-82-8CY-6463 IW-6463CY6463CY 6463IW6463IW 6463IW-6463Guanylate Cyclasesoluble guanylate cyclasenitric oxideNOnoncentral nervous system (CNS) disordersInhibitorinhibitorinhibit

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Zagociguat (Synonyms: CY-6463; IW-6463)

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Zagociguat Related Antibodies

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Complete Stock Solution Preparation Table

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