2. Stem Cell/Wnt
  3. β-catenin Wnt
  4. β-catenin-IN-3

β-catenin-IN-3 (compound C2) is a potent and selective β-catenin inhibitor with a KD value of 54.96 nM. β-catenin-IN-3 acts by targeting a cryptic allosteric modulation site of β-catenin. β-catenin-IN-3 can significantly reduce viability of β-catenin-driven cancer cells.

For research use only. We do not sell to patients.

β-catenin-IN-3 Chemical Structure

β-catenin-IN-3 Chemical Structure

CAS No. : 1005288-15-2

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Based on 1 publication(s) in Google Scholar

β-catenin-IN-3 Related Antibodies

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Description

β-catenin-IN-3 (compound C2) is a potent and selective β-catenin inhibitor with a KD value of 54.96 nM. β-catenin-IN-3 acts by targeting a cryptic allosteric modulation site of β-catenin. β-catenin-IN-3 can significantly reduce viability of β-catenin-driven cancer cells[1].

IC50 & Target

KD: 54.96 nM (β-catenin)[1]
Molecular Weight

484.25

Formula

C19H20Br2N2OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

S=C(N/C=C/C(C=C1Br)=C(C(Br)=C1)O)NC(C2)C3C(C=CC4)C4C2C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation

Purity: 98.03%

COA (247 KB) HNMR (229 KB) LCMS (114 KB)

Handling Instructions (2659 KB)
References
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β-catenin-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-catenin-IN-31005288-15-2β-cateninWntBeta cateninAnticancerWnt pathwayβ-catenin-driven cancer cellsInhibitorinhibitorinhibit

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