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Signaling Pathway

ADL-5859

HY-13044

(ADL5859; ADL 5859)

ADL-5859

ADL-5859 Chemical Structure

ADL5859 is a _delta_-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor _kappa_, _mu_, and weak inhibitory activity at the hERG channel.

Price and Availability of ADL-5859

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Size Price Stock Quantity
10 mM * 1 mL $145 In-stock
5 mg $132 In-stock
10 mg $220 In-stock
50 mg $770 In-stock
100 mg $1260 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL €142 In-stock
5 mg €129 In-stock
10 mg €216 In-stock
50 mg €755 In-stock
100 mg €1235 In-stock
200 mg Get quote
500 mg Get quote

Discount Prices Available for Larger Orders.

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ADL-5859 Data Sheet

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    Purity: 99.69%

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    DataSheet

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    MSDS

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    COA

Related Compound Libraries

Inhibitor Kit

Biological Activity of ADL-5859

ADL5859 is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel.
IC50 value: 0.8 nM(Ki)
Target: δ-opioid receptor
ADL-5859 (ADL5859) is an δ-opioid receptor agonist (Ki=0.84 nM, EC50=20 nM). ADL-5859 (ADL5859)  is an agonist agent that selectively stimulates the δ-opioid receptor with potential application in a wide range of inflammatory, neuropathic and acute pain conditions. In addition, Delta agonists are thought to modulate other biological processes that may manifest themselves in disease states or conditions such as overactive bladder and depression.ADL-5859  (ADL5859)  is useful for inflammatory, neuropathic and acute pain conditions.

Chemical Information

M.Wt 428.95 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C24H29ClN2O3
CAS No 850173-95-4
Solvent & Solubility

DMSO ≥84mg/mL Water ≥10mg/mL Ethanol ≥0.8mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.3313 mL 11.6564 mL 23.3127 mL
5 mM 0.4663 mL 2.3313 mL 4.6625 mL
10 mM 0.2331 mL 1.1656 mL 2.3313 mL

Clinical Information of ADL-5859

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
ADL-5859 Adolor Corp Pain 31-OCT-09 30-JUN-10 Phase 2 20-AUG-10
Adolor Corp Diabetic neuropathy 30-NOV-07 31-AUG-08 Phase 2 13-SEP-13
Adolor Corp Pain 30-JUN-07 01-SEP-07 Phase 2 14-SEP-13
Adolor Corp Peripheral neuropathy 30-NOV-07 31-AUG-08 Phase 2 13-SEP-13
Adolor Corp Rheumatoid arthritis 31-OCT-07 30-SEP-08 Phase 2 30-APR-12
Adolor Corp Neuropathic pain 30-NOV-07 31-AUG-08 Phase 2 13-SEP-13

References on ADL-5859

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