1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

ADL-5859 (Synonyms: ADL5859; ADL 5859)

Cat. No.: HY-13044 Purity: 98.81%
Handling Instructions

ADL5859 is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel.

For research use only. We do not sell to patients.
ADL-5859 Chemical Structure

ADL-5859 Chemical Structure

CAS No. : 850173-95-4

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $145 In-stock
5 mg $132 In-stock
10 mg $220 In-stock
50 mg $770 In-stock
100 mg $1260 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

ADL5859 is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel. IC50 value: 0.8 nM(Ki) Target: δ-opioid receptor ADL-5859 (ADL5859) is an δ-opioid receptor agonist (Ki=0.84 nM, EC50=20 nM). ADL-5859 (ADL5859) is an agonist agent that selectively stimulates the δ-opioid receptor with potential application in a wide range of inflammatory, neuropathic and acute pain conditions. In addition, Delta agonists are thought to modulate other biological processes that may manifest themselves in disease states or conditions such as overactive bladder and depression.ADL-5859 (ADL5859) is useful for inflammatory, neuropathic and acute pain conditions.

Clinical Trial
Sponsor Condition Start Date Phase
Adolor Corp Pain 2009-10-31 Phase 2
Adolor Corp Rheumatoid arthritis 2007-10-31 Phase 2
Adolor Corp Diabetic neuropathy 2007-11-30 Phase 2
Adolor Corp Peripheral neuropathy 2007-11-30 Phase 2
Adolor Corp Neuropathic pain 2007-11-30 Phase 2
Adolor Corp Pain 2007-06-30 Phase 2
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.3313 mL 11.6564 mL 23.3127 mL
5 mM 0.4663 mL 2.3313 mL 4.6625 mL
10 mM 0.2331 mL 1.1656 mL 2.3313 mL
M.Wt

428.95

Formula

C₂₄H₂₉ClN₂O₃

CAS No.

850173-95-4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

Purity: 98.81%

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Product Name:
ADL-5859
Cat. No.:
HY-13044
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