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Products are for research use only. Not for human use. We do not sell to patients.
(ADL5859; ADL 5859)
ADL-5859 Chemical Structure
Protease Inhibitor Cocktail
protease inhibitor cocktails are used in mammalian cell lysates or tissue extracts to increase protein stability.
ADL5859 is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel.
IC50 value: 0.8 nM(Ki)
Target: δ-opioid receptor
ADL-5859 (ADL5859) is an δ-opioid receptor agonist (Ki=0.84 nM, EC50=20 nM). ADL-5859 (ADL5859) is an agonist agent that selectively stimulates the δ-opioid receptor with potential application in a wide range of inflammatory, neuropathic and acute pain conditions. In addition, Delta agonists are thought to modulate other biological processes that may manifest themselves in disease states or conditions such as overactive bladder and depression.ADL-5859 (ADL5859) is useful for inflammatory, neuropathic and acute pain conditions.
|M.Wt||428.95||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO ≥84mg/mL Water ≥10mg/mL Ethanol ≥0.8mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.3313 mL||11.6564 mL||23.3127 mL|
|5 mM||0.4663 mL||2.3313 mL||4.6625 mL|
|10 mM||0.2331 mL||1.1656 mL||2.3313 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|ADL-5859||Adolor Corp||Pain||31-OCT-09||30-JUN-10||Phase 2||20-AUG-10|
|Adolor Corp||Diabetic neuropathy||30-NOV-07||31-AUG-08||Phase 2||13-SEP-13|
|Adolor Corp||Pain||30-JUN-07||01-SEP-07||Phase 2||14-SEP-13|
|Adolor Corp||Peripheral neuropathy||30-NOV-07||31-AUG-08||Phase 2||13-SEP-13|
|Adolor Corp||Rheumatoid arthritis||31-OCT-07||30-SEP-08||Phase 2||30-APR-12|
|Adolor Corp||Neuropathic pain||30-NOV-07||31-AUG-08||Phase 2||13-SEP-13|
. Le Bourdonnec B et al. Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859) J Med Chem. 2008 Oct 9;51(19):5893-6.
. Le Bourdonnec B, et al. Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).J Med Chem. 2009 Sep 24;52(18):5685-702.
. Le Bourdonnec B, Windh RT, Ajello CW, Leister LK, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Christ DD, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE. Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).J Med Chem. 2008 Oct 9;51(19):5893-6. Epub 2008 Sep 13.
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