Cytochrome P450 Inhibitors

CYP1

CYP2

CYP3

CYP4

CYP11

CYP17

Aromatase/CYP19A1

CYP26

CYP51

CYP2D6

CYP3A4

CYP17A1

Cytochrome P450 Inducers, Inhibitors, Activators & Modulators

Product Name	CYP1	CYP2	CYP3	CYP4	CYP11	CYP17	Aromatase/CYP19A1	CYP26	CYP51	CYP2D6	CYP3A4	CYP17A1	Purity
Verapamil			CYP3										99.96%
Fenofibrate		CYP2C19, IC₅₀: 0.2 μM CYP2B6, IC₅₀: 0.7 μM CYP2C9, IC₅₀: 9.7 μM CYP2C8, IC₅₀: 4.8 μM	CYP3A4, IC₅₀: 142.1 μM										99.93%
Apigenin		CYP2											99.58%
Ketoconazole			CYP3	CYP4									99.64%
1-Aminobenzotriazole		CYP2	CYP3										99.88%
NN1177 TFA											CYP3A4
Letrozole							Aromatase						99.91%
Cepharanthine		CYP2E1, IC₅₀: 25.62 μM CYP2C9, IC₅₀: 24.57 μM	CYP3A4, IC₅₀: 16.29 μM										99.91%
Abiraterone acetate						CYP17							99.96%
Clarithromycin			CYP3										99.90%
Diosmetin	CYP1												99.80%
Fomepizole		CYP2E1											99.67%
Gemfibrozil 1-O-β-glucuronide		CYP2C8, IC₅₀: 4.07 μM											99.88%
Salvianolic acid C		CYP2C8, Ki: 4.82 μM CYP2J2, Ki: 5.75 μM											99.94%
Talarozole								CYP26					99.61%
HET0016				CYP4									99.77%
(S)-Mephenytoin		CYP2											99.81%
Cobicistat			CYP3										99.77%
Anastrozole							Aromatase						99.99%
Sulfaphenazole		CYP2C9											99.83%
Gemfibrozil	CYP1A2, Ki: 82 μM	CYP2C9, Ki: 5.8 μM CYP2C19, Ki: 24 μM CYP2C8, Ki: 69 μM											99.91%
Exemestane							Aromatase						99.92%
Alpha-Naphthoflavone							Aromatase						98.54%
Troleandomycin			CYP3										≥98.0%
Clobetasol propionate			CYP3A5, IC₅₀: 0.206 μM CYP3A4, IC₅₀: 15.6 μM										99.85%
Galangin	CYP1												99.96%
Isavuconazole			CYP3										99.99%
Oleuropein							Aromatase						99.05%
Ginsenoside Rd	CYP1A2, IC₅₀: 78.4 μM	CYP2D6, IC₅₀: 58 μM CYP2C9, IC₅₀: 85.1 μM	CYP3A4, IC₅₀: 81.7 μM										98.07%
Clopidogrel hydrogen sulfate		CYP2B6, IC₅₀: 18.2 nM CYP2C19, IC₅₀: 524 nM											99.43%
TMS	CYP1B1, IC₅₀: 6 nM CYP1A1, IC₅₀: 300 nM CYP1A2, IC₅₀: 3.1 μM CYP1B1, Ki: 3 nM												98.61%
Atazanavir sulfate			CYP3										99.94%
Phillyrin	CYP1	CYP2											98.99%
AS1810722			CYP3A4										98.14%
Endoxifen hydrochloride							Aromatase						98.75%
BMS-986202		CYP2C19, IC₅₀: 14 μM											99.92%
5,7-Dimethoxyflavone			CYP3A										99.86%
Ginsenoside C-K		CYP2C9, IC₅₀: 32 μM CYP2A6, IC₅₀: 63.6 μM											≥98.0%
Schisandrol B		CYP2	CYP3A										99.99%
Clomethiazole		CYP2											99.75%
7-Ethoxyresorufin	CYP1												98.96%
K777			CYP3										99.77%
Bergaptol			CYP3										99.44%
Olivetol		CYP2											99.81%
Schisandrin A			CYP3A, IC₅₀: 6.6 μM										99.83%
Chlorzoxazone		CYP2											99.84%
Gentiopicroside		CYP2											99.52%
Fadrozole							Aromatase						99.69%
Tetrahydrocurcumin		CYP2C9	CYP3A4										99.43%
Dihydromethysticin			CYP3										99.94%
Cecropin B			CYP3										98.07%
APD668		CYP2C9, Ki: 0.1 μM											99.10%
Tebuconazole									CYP51				99.66%
Oxiconazole nitrate			CYP3A4 CYP3										≥98.0%
Seviteronel						CYP17							99.83%
Casopitant mesylate			CYP3A4										99.84%
Mefentrifluconazole									CYP51A, Kd: 0.5 nM				99.61%
AZD7325	CYP1A2		CYP3A4										99.27%
Fadrozole hydrochloride							Aromatase						99.22%
LKY-047		CYP2J2, IC₅₀: 1.7 μM											98.85%
CYP3cide			CYP3A4, EC₅₀: 30 nM CYP3A5, EC₅₀: 17 μM CYP3A7, EC₅₀: 71 μM										99.46%
Harmalol hydrochloride	CYP1												99.72%
Ginsenoside F1		CYP2	CYP3A4 CYP3										≥99.0%
Atazanavir			CYP3										99.23%
Cephaeline dihydrochloride		CYP2											99.84%
Isosilybin			CYP3										99.82%
Cedrol		CYP2	CYP3										≥98.0%
2-Phenyl-2-(1-piperidinyl)propane	CYP1A2, IC₅₀: >300 μM	CYP2B6, IC₅₀: 5.1 μM CYP2B6, Ki: 5.6 μM CYP2D6, IC₅₀: 74 μM CYP2A6, IC₅₀: >300 μM CYP2C8, IC₅₀: >300 μM CYP2C9, EC₅₀: >300 μM CYP2C19, IC₅₀: >300 μM CYP2E1, IC₅₀: >300 μM	CYP3A, IC₅₀: 200 μM										99.81%
PC945									CYP51A, IC₅₀: 0.23 μM CYP51B, IC₅₀: 0.22 μM				99.27%
Endoxifen							Aromatase						99.42%
AMG-208			CYP3A4, IC₅₀: 32 μM										99.86%
Dihydrolanosterol									CYP51				99.56%
β-Apo-8'-carotenal	CYP1A1 CYP1A2
2,6-Dimethylquinoline	CYP1A2, IC₅₀: 3.3 μM	CYP2B6, IC₅₀: 480 μM											99.51%
Carbosulfan	CYP1	CYP2	CYP3										≥98.0%
ACP-5862		CYP2C8	CYP3A4										98.41%
Ezutromid	CYP1												98.10%
Dapaconazole								CYP26, IC₅₀: 1.4 μM					98.95%
Linderane		CYP2											99.61%
TP0472993				CYP4A11, IC₅₀: 140 nM CYP4F2, IC₅₀: 40 nM									98.69%
MS-PPOH		CYP2											99.27%
BI 689648					CYP11								99.20%
Nampt-IN-5			CYP3, IC₅₀: 0.7 nM										98.02%
Liarozole								CYP26, IC₅₀: 7 μM					98.83%
Friedelin		CYP2	CYP3										≥99.0%
Obtusifoliol									CYP51				99.86%
Fenofibrate (Standard)		CYP2B6 CYP2C19 CYP2C8 CYP2C9	CYP3A4										99.91%
Orteronel						CYP17							99.70%
Dagrocorat		CYP2D6	CYP3A										99.90%
Phortress	CYP1												99.25%
Tetrahydropiperine	CYP1A1, IC₅₀: 23 μM												99.45%
Quilseconazole									CYP51				98.98%
Nonsteroidal aromatase inhibitor 1							Aromatase						98.88%
Flavanone							Aromatase						99.84%
Letrozole-d₄							Aromatase						99.82%
Pradefovir mesylate			CYP3										99.89%
α-Terpinyl acetate		CYP2B6, Kd: 5.4  μM
N-Nornuciferine		CYP2											99.82%
(R)-(+)-Aminoglutethimide							Aromatase
Exemestane (Standard)							Aromatase						99.63%
1'-Hydroxy bufuralol		CYP2
Eriodictyol chalcone							Aromatase
ε-Viniferin	CYP1A2, Ki: 5 μM ((EROD))	CYP2B6, Ki: 3 μM ((BROD)) CYP2A6, Ki: 60 μM ((COH)) CYP2E1, IC₅₀: 25 μM ((CHZ))	CYP3A4, Ki: 10 μM ((TST))	CYP4A, IC₅₀: 15 μM ((LwOH))									≥98.0%
SDZ285428									CYP51				98.00%
Dagrocorat hydrochloride		CYP2D6	CYP3A										99.85%
Nicotelline								CYP26, Ki: ≥300 μM					99.92%
Gemfibrozil (Standard)	CYP1A2	CYP2C19 CYP2C8 CYP2C9											99.90%
CYP11B2-IN-1					CYP11B2, IC₅₀: 2.3 nM CYP11B1, IC₅₀: 142 nM								99.83%
Revexepride			CYP3A4										99.84%
Liarozole dihydrochloride								CYP26, IC₅₀: 7 μM					≥99.0%
Resorufin methyl ether	CYP1												99.75%
SR9186			CYP3										98.06%
Seviteronel (R enantiomer)						CYP17							98.82%
6',7'-Dihydroxybergamottin			CYP3A4										≥99.0%
Abiraterone decanoate						CYP17
IHMT-PI3Kδ-372		CYP2C9, IC₅₀: 2.7 μM											99.75%
BMS-819881			CYP3A4, EC₅₀: 13 μM
BMS-986339		CYP2C8, IC₅₀: 8 μM CYP2C9, IC₅₀: 13.5 μM
Fadrozole hydrochloride hemihydrate							Aromatase
Anastrozole-d₁₂							Aromatase
Endoxifen-d₅							Aromatase
CYP3A4-IN-2			CYP3A4, IC₅₀: 0.055 μM
Clarithromycin (Standard)			CYP3
CYP11B1-IN-2	CYP1A2, IC₅₀: >10 μM	CYP2C9, IC₅₀: >10 μM CYP2C19, IC₅₀: >10 μM CYP2D6, IC₅₀: >10 μM CYP2E1, IC₅₀: >10 μM	CYP3A4, IC₅₀: >10 μM		CYP11B1, IC₅₀: 9 ± 2 nM (human CYP11B1) CYP11B1, IC₅₀: 25 nM (rat CYP11B1) CYP11B2, IC₅₀: 1121 ± 237 nM
Antitumor agent-88	CYP1A1, Ki: 1.4 μM
17-HETE	CYP1B1
SYN20028567							Aromatase
CYP4Z1-IN-1		CYP2D6, IC₅₀: >10 000 nM CYP2C9, IC₅₀: >10 000 nM	CYP3A4, IC₅₀: >10 000 nM	CYP4Z1, IC₅₀: 41.8 ± 1.4 nM CYP4F11, IC₅₀: 291.3 ± 46 nM CYP4F12, IC₅₀: 1598.3 ± 5 nM
ONT-993		CYP2D6, IC₅₀: 7.9 μM
ML252	CYP1A2, IC₅₀: 6.1 μM	CYP2C9, IC₅₀: 18.9 μM CYP2D6, IC₅₀: 19.9 μM	CYP3A4, IC₅₀: 3.9 μM
CYP3A4-IN-3			CYP3A4, IC₅₀: 0.075 μM
Diosmetin (Standard)	CYP1
hCYP3A4 Fluorogenic substrate 1			CYP3A4, Km: 0.36 μM										99.27%
CYP1B1-IN-2	CYP1B1, IC₅₀: 0.52 nM CYP1A1, IC₅₀: 16.7 nM CYP1A2, IC₅₀: 94.2 nM
Ginsenoside C-K (Standard)		CYP2A6 CYP2C9
CYP1B1-IN-5	CYP1B1, IC₅₀: 4.7 nM CYP1A1, IC₅₀: 190.7 nM CYP1A2, IC₅₀: 585.7 nM
FGFR-IN-10		CYP2C9, IC₅₀: 3.33 μM CYP2C19, IC₅₀: 18.75 μM CYP2D6, IC₅₀: 4.34 μM	CYP3A4, IC₅₀: 0.69 μM
CYP17A1/HDAC6-IN-1												CYP17A1, IC₅₀: 0.284 μM
Ginsenoside Rd (Standard)	CYP1A2	CYP2C9 CYP2D6	CYP3A4
Isolimonexic acid							Aromatase
HIV-1 inhibitor-40		CYP2C9, IC₅₀: 5.16 μM CYP2C19, IC₅₀: 4.51 μM
Abiraterone acetate (Standard)						CYP17							99.85%
Anticancer agent 78							Aromatase
CYP3A4-IN-1			CYP3A4, IC₅₀: 0.085 μM
CYP51/HDAC-IN-1									CYP51
Exemestane-¹³C₃							Aromatase
Kushenol K			CYP3A4, Ki: 1.35 μM
CYP1B1-IN-3	CYP1B1, IC₅₀: 6.6 nM CYP1A1, IC₅₀: 347.3 nM CYP1A2, IC₅₀: >10000 nM
Antitumor agent-87	CYP1A1, Ki: 0.23 μM
DL-Acetylshikonin	CYP1A2, IC₅₀: 4.0 μM	CYP2A6, IC₅₀: 3.8 μM CYP2B6, IC₅₀: 2.0 μM CYP2C8, IC₅₀: 1.4 μM CYP2C9, IC₅₀: 3.3 μM CYP2C19, IC₅₀: 2.5 μM CYP2D6, IC₅₀: 2.5 μM CYP2E1, IC₅₀: 2.7 μM CYP2J2, IC₅₀: 3.3 μM	CYP3A, IC₅₀: 2.3 μM
Exemestane-d₂							Aromatase
5,7,2',6'-Tetrahydroxyflavone			CYP3A4, IC₅₀: 7.8 μM
IDO1-IN-19		CYP2C9, IC₅₀: 8.64 μM											98.52%
7-Ethoxy-4-methylcoumarin	CYP1A1	CYP2B6 CYP2B4											99.44%
CYP1B1-IN-4	CYP1B1, IC₅₀: 0.2 nM CYP1A1, IC₅₀: 3.98 μM												99.09%
Aromatase-IN-3							Aromatase, IC₅₀: 54 nM
YM511							Aromatase						99.73%
Exemestane-d₃							Aromatase
Apigenin (Standard)		CYP2
Nav1.7-IN-8		CYP2C9, IC₅₀: 0.17 μM	CYP3A4, IC₅₀: 0.077 μM
Galangin (Standard)	CYP1
JNK-IN-14										CYP2D6, IC₅₀: 26.7 ± 0.5 nM	CYP3A4, IC₅₀: 383.0 ± 1. nM
Fenofibrate-d₆		CYP2	CYP3
Oxiconazole			CYP3A4
Tetrahydrocurcumin-d₆		CYP2	CYP3
Antibacterial agent 132							Aromatase
CYP4A11/CYP4F2-IN-1				CYP4A11, IC₅₀: 19 nM CYP4F2, IC₅₀: 17 nM									99.82%
7-Hydroxyflavanone							Aromatase
Phortress free base	CYP1
Tabimorelin			CYP3A4
hCYP3A4-IN-1			CYP3A4, IC₅₀: 43.93 nM
Monoamine oxidase/Aromatase-IN-1							Aromatase
RO6889678			CYP3A4
CYP51/PD-L1-IN-4									CYP51, IC₅₀: 0.17 ± 0.0 μM
Azamulin			CYP3A, IC₅₀: 0.03-0.24 μM
Tabimorelin hemifumarate			CYP3A4
Aromatase-IN-2							Aromatase						99.83%
Chlorzoxazone (Standard)		CYP2
Ranitidine		CYP2C19 CYP2C9
17(S)-HETE	CYP1B1
Licopyranocoumarin			CYP3A4, IC₅₀: 32 μM
Methysticin	CYP1A1
Org30958							Aromatase

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