2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. NSC 23766

NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment.

For research use only. We do not sell to patients.

NSC 23766 Chemical Structure

NSC 23766 Chemical Structure

CAS No. : 733767-34-5

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Customer Review

Based on 31 publication(s) in Google Scholar

Other Forms of NSC 23766:

NSC 23766 Related Antibodies

Top Publications Citing Use of Products

29 Publications Citing Use of MCE NSC 23766

WB
IF

    NSC 23766 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2022 Dec 19.  [Abstract]

    NSC23766 (NSC; 1.5 mg/kg/day; i.p.) in combination with FX11(1 mg/kg/day; i.p.) for 2-3 weeks, displays a pronounced inhibitory effect on lung metastasis of Hs578T cells (fig c) and 4T1 cells (fig d).

    NSC 23766 purchased from MedChemExpress. Usage Cited in: J Cell Commun Signal. 2022 Dec 12.  [Abstract]

    The inhibition of the endogenous Rac1-GTP production using NSC23766 (NSC) does not afect the expression of Rac1-GTP in HSC cells.

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    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment.

    In Vitro

    NSC 23766 (100 μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased[2]. NSC23766 (50 μM) plus 100 ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles[3]. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    NSC 23766 Related Antibodies
    In Vivo

    NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    421.58

    Formula

    C24H35N7
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    NC1=CC(C)=NC2=CC=C(NC3=NC(NC(C)CCCN(CC)CC)=NC(C)=C3)C=C12
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (237.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3720 mL 11.8601 mL 23.7203 mL
    5 mM 0.4744 mL 2.3720 mL 4.7441 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    Purity & Documentation
    References
    Kinase Assay
    [4]

    Briefly, fresh spinal cord tissue of the lumbar enlargement is homogenised in the presence of protease and phosphatase inhibitors and lysed with buffer. After being centrifuged at 12,000× g for 5 min at 4°C, the supernatants are collected and incubated with PAK-PBD beads at 4°C on a rotator for 1 h and then the beads are pelleted through centrifugation at 5000× g for 3 min at 4°C. The resulting pellet is resuspended in LaemmLi buffer and boiled for 2 min. The bead samples are subjected to Western blot analysis. Total Rac1 in each sample is also determined by Western blot analysis.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    Balb/c control and NOD mice are at 7 weeks of age and are divided into four groups (n=8/group). At 8 weeks of age two groups of experimental animals (Balb/c and NOD) receive NSC23766 (2.5 mg/kg/day, i.p./daily) and other two groups, which serve as control Balb/c and NOD mice and receive equal volume of saline. The body weights and blood glucose are monitored every week for 34 weeks.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3720 mL 11.8601 mL 23.7203 mL 59.3007 mL
    5 mM 0.4744 mL 2.3720 mL 4.7441 mL 11.8601 mL
    10 mM 0.2372 mL 1.1860 mL 2.3720 mL 5.9301 mL
    15 mM 0.1581 mL 0.7907 mL 1.5814 mL 3.9534 mL
    20 mM 0.1186 mL 0.5930 mL 1.1860 mL 2.9650 mL
    25 mM 0.0949 mL 0.4744 mL 0.9488 mL 2.3720 mL
    30 mM 0.0791 mL 0.3953 mL 0.7907 mL 1.9767 mL
    40 mM 0.0593 mL 0.2965 mL 0.5930 mL 1.4825 mL
    50 mM 0.0474 mL 0.2372 mL 0.4744 mL 1.1860 mL
    60 mM 0.0395 mL 0.1977 mL 0.3953 mL 0.9883 mL
    80 mM 0.0297 mL 0.1483 mL 0.2965 mL 0.7413 mL
    100 mM 0.0237 mL 0.1186 mL 0.2372 mL 0.5930 mL
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    NSC 23766 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NSC 23766733767-34-5NSC23766NSC-23766RasInhibitorinhibitorinhibit

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