2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. AG 538

AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM.

For research use only. We do not sell to patients.

AG 538 Chemical Structure

AG 538 Chemical Structure

CAS No. : 133550-18-2

Size Price Stock Quantity
5 mg USD 300 In-stock
10 mg USD 450 In-stock
25 mg USD 790 In-stock
50 mg USD 1100 In-stock
100 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].

Molecular Weight

297.26

Formula

C16H11NO5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#C/C(C(C1=CC=C(O)C(O)=C1)=O)=C\C2=CC=C(O)C(O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (336.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3641 mL 16.8203 mL 33.6406 mL
5 mM 0.6728 mL 3.3641 mL 6.7281 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3641 mL 16.8203 mL 33.6406 mL 84.1015 mL
5 mM 0.6728 mL 3.3641 mL 6.7281 mL 16.8203 mL
10 mM 0.3364 mL 1.6820 mL 3.3641 mL 8.4101 mL
15 mM 0.2243 mL 1.1214 mL 2.2427 mL 5.6068 mL
20 mM 0.1682 mL 0.8410 mL 1.6820 mL 4.2051 mL
25 mM 0.1346 mL 0.6728 mL 1.3456 mL 3.3641 mL
30 mM 0.1121 mL 0.5607 mL 1.1214 mL 2.8034 mL
40 mM 0.0841 mL 0.4205 mL 0.8410 mL 2.1025 mL
50 mM 0.0673 mL 0.3364 mL 0.6728 mL 1.6820 mL
60 mM 0.0561 mL 0.2803 mL 0.5607 mL 1.4017 mL
80 mM 0.0421 mL 0.2103 mL 0.4205 mL 1.0513 mL
100 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.8410 mL
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AG 538 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG 538133550-18-2AG538AG-538IGF-1RInsulin-like growth factor-1 receptorIGF-1 receptor kinaseInhibitorinhibitorinhibit

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