2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. FAK-IN-10

FAK-IN-10 is an inhibitor of FAK with an IC50 of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC50s of 4.23 and 0.78 μM,respectively.

For research use only. We do not sell to patients.

FAK-IN-10 Chemical Structure

FAK-IN-10 Chemical Structure

CAS No. : 491839-65-7

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5 mg USD 170 In-stock
10 mg USD 270 In-stock
25 mg USD 460 In-stock
50 mg USD 645 In-stock
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Description

FAK-IN-10 is an inhibitor of FAK with an IC50 of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC50s of 4.23 and 0.78 μM,respectively[1].

Molecular Weight

376.23

Formula

C15H10BrN3O2S
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C(CSC1=NN=C(C2=CC=NC=C2)O1)C3=CC=C(C=C3)Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (53.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6579 mL 13.2897 mL 26.5795 mL
5 mM 0.5316 mL 2.6579 mL 5.3159 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6579 mL 13.2897 mL 26.5795 mL 66.4487 mL
5 mM 0.5316 mL 2.6579 mL 5.3159 mL 13.2897 mL
10 mM 0.2658 mL 1.3290 mL 2.6579 mL 6.6449 mL
15 mM 0.1772 mL 0.8860 mL 1.7720 mL 4.4299 mL
20 mM 0.1329 mL 0.6645 mL 1.3290 mL 3.3224 mL
25 mM 0.1063 mL 0.5316 mL 1.0632 mL 2.6579 mL
30 mM 0.0886 mL 0.4430 mL 0.8860 mL 2.2150 mL
40 mM 0.0664 mL 0.3322 mL 0.6645 mL 1.6612 mL
50 mM 0.0532 mL 0.2658 mL 0.5316 mL 1.3290 mL
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FAK-IN-10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK-IN-10491839-65-7FAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseMCF-7A431Skin cancerInhibitorinhibitorinhibit

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