1. Gene
  2. MICAL1 - microtubule associated monooxygenase, calponin and LIM domain containing 1 Gene

MICAL1 - microtubule associated monooxygenase, calponin and LIM domain containing 1 Gene

Homo sapiens

Also known as MICAL; NICAL; MICAL-1

Gene ID: 64780 | Gene type: protein coding

About MICAL1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:109,444,062-109,465,968 (from NCBI)

This gene has 8 transcripts (splice variants), 198 orthologues, 36 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 31.4), lymph node (RPKM 25.8) and 23 other tissues.

Summary

This gene encodes an Enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

MICAL1 Products(3)

mRNA Protein Name
NM_001159291.2 NP_001152763.1 [F-actin]-monooxygenase MICAL1 isoform 2
NM_001286613.2 NP_001273542.1 [F-actin]-monooxygenase MICAL1 isoform 3
NM_022765.4 NP_073602.3 [F-actin]-monooxygenase MICAL1 isoform 1

MICAL1 Protein Structure

FAD_binding_3

FAD_binding_3: FAD binding domain (85 - 122)

CH

CH: Calponin homology (CH) domain (512 - 610)

LIM

LIM: LIM domain (697 - 750)

DUF3585

DUF3585: Protein of unknown function (DUF3585) (926 - 1059)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1067 a.a.
Protein Preferred Names Protein Names

[F-actin]-monooxygenase MICAL1

NEDD9-interacting protein with calponin homology and LIM domains

Related Diseases

Diseases Alias
Epilepsy, Familial Temporal Lobe, 1

ETL1

Adpeaf

Adlte

Epilepsy, Partial, With Auditory Features

Autosomal Dominant Partial Epilepsy With Auditory Features

Epilepsy, Lateral Temporal Lobe, Autosomal Dominant

Familial Temporal Lobe Epilepsy 1

Partial Epilepsy With Auditory Features

Autosomal Dominant Lateral Temporal Lobe Epilepsy

Lateral Temporal Lobe Epilepsy Autosomal Dominant

Epilepsy, Temporal Lobe, Familial, Type 1

Epilepsy, Familial Temporal Lobe, 7

Familial Temporal Lobe Epilepsy 7

ETL7

Epilepsy, Temporal Lobe, Familial, Type 7

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British

Fbd

Presenile Dementia With Spastic Ataxia

Familial British Dementia

Abri Amyloidosis

Cerebral Amyloid Angiopathy, British Type

Itm2b-Related Cerebral Amyloid Angiopathy 1

Familial Dementia, British Type

Cerebral Amyloid Angiopathy, Itm2b-Related 1

CAA-ITM2B1

Cerebral Amyloid Angiopathy British Type

Dementia, Familial, British

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus MICAL1 VGNC VGNC:63493
Bos taurus MICAL1 VGNC VGNC:31457
Mus musculus MICAL1 MGD MGI:2385847
Rattus norvegicus MICAL1 RGD RGD:1309386
Canis familiaris MICAL1 VGNC VGNC:49758
Macaca mulatta MICAL1 VGNC VGNC:74547