2. Protein Tyrosine Kinase/RTK
  3. ROS Kinase
  4. ROS kinases-IN-1

ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity.

For research use only. We do not sell to patients.

ROS kinases-IN-1 Chemical Structure

ROS kinases-IN-1 Chemical Structure

CAS No. : 370096-57-4

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Based on 1 publication(s) in Google Scholar

ROS kinases-IN-1 Related Antibodies

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Description

ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity[1].

IC50 & Target

IC50: 1.22 μM (ROS kinase)[1]
In Vitro

ROS kinases-IN-1 (1-100 μM; 1 d) inhibits the growth of cervical cancer cell and glioblastoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ROS kinases-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa, U138, U87, LN18, and U118 cells
Concentration: 1, 10, and 100 μM
Incubation Time: one day
Result: Showed EC50s for HeLa, U138, U87, LN18, and U118 cells of 20, 8, 8, 12, and 7 μM, respectively.
Molecular Weight

328.37

Formula

C20H16N4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NN=C(C)/C1=C\C2=CN(C3=CC=CC=C3)N=C2C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (63.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0453 mL 15.2267 mL 30.4535 mL
5 mM 0.6091 mL 3.0453 mL 6.0907 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0453 mL 15.2267 mL 30.4535 mL 76.1336 mL
5 mM 0.6091 mL 3.0453 mL 6.0907 mL 15.2267 mL
10 mM 0.3045 mL 1.5227 mL 3.0453 mL 7.6134 mL
15 mM 0.2030 mL 1.0151 mL 2.0302 mL 5.0756 mL
20 mM 0.1523 mL 0.7613 mL 1.5227 mL 3.8067 mL
25 mM 0.1218 mL 0.6091 mL 1.2181 mL 3.0453 mL
30 mM 0.1015 mL 0.5076 mL 1.0151 mL 2.5378 mL
40 mM 0.0761 mL 0.3807 mL 0.7613 mL 1.9033 mL
50 mM 0.0609 mL 0.3045 mL 0.6091 mL 1.5227 mL
60 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2689 mL
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ROS kinases-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROS kinases-IN-1370096-57-4ROS Kinaseanti-tumor activityHeLaU138U87LN18U118Inhibitorinhibitorinhibit

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