2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Spiclomazine

Spiclomazine  (Synonyms: Clospirazine)

Cat. No.: HY-154313 Purity: 99.95%
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Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models.

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Spiclomazine Chemical Structure

Spiclomazine Chemical Structure

CAS No. : 24527-27-3

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Based on 1 publication(s) in Google Scholar

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Description

Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].

IC50 & Target[1]

KRAS(G12C)

 

Molecular Weight

446.03

Formula

C22H24ClN3OS2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (280.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2420 mL 11.2100 mL 22.4200 mL
5 mM 0.4484 mL 2.2420 mL 4.4840 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2420 mL 11.2100 mL 22.4200 mL 56.0500 mL
5 mM 0.4484 mL 2.2420 mL 4.4840 mL 11.2100 mL
10 mM 0.2242 mL 1.1210 mL 2.2420 mL 5.6050 mL
15 mM 0.1495 mL 0.7473 mL 1.4947 mL 3.7367 mL
20 mM 0.1121 mL 0.5605 mL 1.1210 mL 2.8025 mL
25 mM 0.0897 mL 0.4484 mL 0.8968 mL 2.2420 mL
30 mM 0.0747 mL 0.3737 mL 0.7473 mL 1.8683 mL
40 mM 0.0561 mL 0.2803 mL 0.5605 mL 1.4013 mL
50 mM 0.0448 mL 0.2242 mL 0.4484 mL 1.1210 mL
60 mM 0.0374 mL 0.1868 mL 0.3737 mL 0.9342 mL
80 mM 0.0280 mL 0.1401 mL 0.2803 mL 0.7006 mL
100 mM 0.0224 mL 0.1121 mL 0.2242 mL 0.5605 mL
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Spiclomazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spiclomazine24527-27-3ClospirazineRasSerum-starved MIA PaCa-2CFPAC-1BxPC-3pancreatic cancerInhibitorinhibitorinhibit

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