2. Protein Tyrosine Kinase/RTK
  3. Src
  4. Saracatinib difumarate

Saracatinib difumarate  (Synonyms: AZD0530 difumarate)

Cat. No.: HY-10234A Purity: 99.24%
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Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. .

For research use only. We do not sell to patients.

Saracatinib difumarate Chemical Structure

Saracatinib difumarate Chemical Structure

CAS No. : 893428-72-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 102 In-stock
Solution
10 mM * 1 mL in DMSO USD 102 In-stock
Solid
5 mg USD 75 In-stock
10 mg USD 120 In-stock
25 mg USD 230 In-stock
50 mg USD 370 In-stock
100 mg USD 590 In-stock
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Based on 30 publication(s) in Google Scholar

Other Forms of Saracatinib difumarate:

Saracatinib difumarate Related Antibodies

Top Publications Citing Use of Products

    Saracatinib difumarate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 17;8(1):66.  [Abstract]

    Saracatinib (10 μM) reduces BLK-mediated FAM83A tyrosine phosphorylation in HEK293T cells.

    Saracatinib difumarate purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2019 Apr;23(4):2399-2409.  [Abstract]

    Immunoblot analysis of p-JNK1/2 (T183/Y185) in HepG2 cells treated with saracatinib (10 μM, 12 h) and PP1 (10 μM, 2 h).

    Saracatinib difumarate purchased from MedChemExpress. Usage Cited in: Arch Biochem Biophys. 2018 May 1;645:54-60.  [Abstract]

    SK-BR-3, MCF-7, and MDA-MB-231 cells are treated with 1 μM Saracatinib for 48 h. After treatment, the Src protein expression is determined by western blot.

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    Description

    Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. [1].

    IC50 & Target

    IC50: 2.7 nM (Src), 30 nM (v-Abl), 66 nM (EGFR), 200 nM (c-Kit)[1]
    Molecular Weight

    774.17

    Formula

    C35H40ClN5O13
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    ClC1=CC=C2C(OCO2)=C1NC3=C4C(OC5CCOCC5)=CC(OCCN6CCN(C)CC6)=CC4=NC=N3.OC(/C=C/C(O)=O)=O.OC(/C=C/C(O)=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 83.33 mg/mL (107.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2917 mL 6.4585 mL 12.9171 mL
    5 mM 0.2583 mL 1.2917 mL 2.5834 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.2917 mL 6.4585 mL 12.9171 mL 32.2926 mL
    5 mM 0.2583 mL 1.2917 mL 2.5834 mL 6.4585 mL
    10 mM 0.1292 mL 0.6459 mL 1.2917 mL 3.2293 mL
    15 mM 0.0861 mL 0.4306 mL 0.8611 mL 2.1528 mL
    20 mM 0.0646 mL 0.3229 mL 0.6459 mL 1.6146 mL
    25 mM 0.0517 mL 0.2583 mL 0.5167 mL 1.2917 mL
    30 mM 0.0431 mL 0.2153 mL 0.4306 mL 1.0764 mL
    40 mM 0.0323 mL 0.1615 mL 0.3229 mL 0.8073 mL
    50 mM 0.0258 mL 0.1292 mL 0.2583 mL 0.6459 mL
    60 mM 0.0215 mL 0.1076 mL 0.2153 mL 0.5382 mL
    80 mM 0.0161 mL 0.0807 mL 0.1615 mL 0.4037 mL
    100 mM 0.0129 mL 0.0646 mL 0.1292 mL 0.3229 mL
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    Saracatinib difumarate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Saracatinib difumarate893428-72-3AZD0530 difumarateSrcInhibitorinhibitorinhibit

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