Search Result
Results for "
AhR
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
10
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-141609
-
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Aryl Hydrocarbon Receptor
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Cancer
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AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. AHR antagonist 5 free base effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases .
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- HY-144339
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Aryl Hydrocarbon Receptor
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Others
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AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis .
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- HY-128229
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- HY-135671
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Aryl Hydrocarbon Receptor
VEGFR
Estrogen Receptor/ERR
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Endocrinology
Cancer
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AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus .
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- HY-135830
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Aryl Hydrocarbon Receptor
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Cancer
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AHR antagonist 4 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 293, has an IC50 of 82.2 nM. AHR antagonist 4 has anti-cancer effects .
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- HY-112628
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AhR antagonist 7
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Aryl Hydrocarbon Receptor
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Cancer
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CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of 1.4 nM .
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-
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- HY-119960
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COX
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Inflammation/Immunology
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AHR-10037 is a non-steroidal anti-inflammatory agent with low gastric toxicity. AHR-10037 is a prodrug converted in vivo to a cyclooxygenase inhibitor .
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- HY-116638
-
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Lipoxygenase
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Endocrinology
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AHR-5333 is a selective human blood neutrophil 5-lipoxygenase inhibitor. AHR-5333 exhibits potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity .
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- HY-106487
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-
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- HY-135831
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Aryl Hydrocarbon Receptor
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Cancer
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AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1, with IC50s of 0.885 and 2.03 nM for human and mouse AhR .
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-
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- HY-114682
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AhR 2277 (free base)
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Others
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Neurological Disease
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Lenperone (AHR 2277 free?base) has antipsychotic effect. Lenperone improves depressive symptoms .
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-
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- HY-W338764
-
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Apoptosis
Aryl Hydrocarbon Receptor
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Cancer
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AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research .
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- HY-114682A
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AhR 2277
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Dopamine Receptor
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Neurological Disease
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Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research .
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- HY-136220
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Aryl Hydrocarbon Receptor
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Cancer
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AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 .
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- HY-155505
-
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Aryl Hydrocarbon Receptor
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Inflammation/Immunology
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AHR agonist 4 (compound 24e) is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-17357
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- HY-136220A
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Aryl Hydrocarbon Receptor
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Cancer
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AHR antagonist 5 hemimaleate, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist, has an IC50 of < 0.5 µΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 (WO2018195397, example 39) .
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- HY-111449
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AhR antagonist 1
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Aryl Hydrocarbon Receptor
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Inflammation/Immunology
Cancer
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BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses .
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- HY-RS00483
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Small Interfering RNA (siRNA)
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Others
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AHR Human Pre-designed siRNA Set A contains three designed siRNAs for AHR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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AHR Human Pre-designed siRNA Set A
AHR Human Pre-designed siRNA Set A
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- HY-B0678
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-
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- HY-130270
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E3 Ligase Ligand-Linker Conjugates 57
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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AhR Ligand-Linker Conjugates 1 (E3 Ligase Ligand-Linker Conjugates 57) incorporates an IAP ligand for the E3 ubiquitin ligase, and a SNIPER linker. AhR Ligand-Linker Conjugates 1 can be used to design SNIPER .
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- HY-101802
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- HY-U00010
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-
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- HY-101745
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-
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- HY-129305
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AhR-9377
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Serotonin Transporter
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Neurological Disease
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Tampramine fumarate is a potent, selective, noncompetitive NE reuptake inhibitor. Tampramine fumarate has antidepressant activity. Tampramine fumarate can be used in research of depression .
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- HY-111157
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- HY-B0678R
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AhR438 (Standard); NSC170959 (Standard)
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Others
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Neurological Disease
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Metaxalone (Standard) is the analytical standard of Metaxalone. This product is intended for research and analytical applications.
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- HY-125926S
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- HY-17357S
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AhR-9434-d5; AL-6515-d5
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COX
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Others
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Nepafenac-d5 is the deuterium labeled Nepafenac, which is a selective COX-2 inhibitor.
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- HY-B0678S1
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- HY-118438
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Aryl Hydrocarbon Receptor
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Inflammation/Immunology
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10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations .
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- HY-135829
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Aryl Hydrocarbon Receptor
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Cancer
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BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment .
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- HY-W015273A
-
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Endogenous Metabolite
Ferroptosis
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Metabolic Disease
Cancer
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Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis
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- HY-117532
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PCB 118
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Pyroptosis
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Cancer
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PenCB (PCB 118) could induces pyroptosis by priming and activating NFκB-dependent NLRP3 inflammasome. PCB 118 induces oxidative stress and pyroptosis are dependent on Aryl hydrocarbon receptor (AhR) activation and subsequent cytochrome P450 1A1 upregulation .
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- HY-117102
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Aryl Hydrocarbon Receptor
Checkpoint Kinase (Chk)
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Cancer
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ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines .
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- HY-W014502
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Aryl Hydrocarbon Receptor
Endogenous Metabolite
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Cancer
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D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR) .
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- HY-N12537A
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Aryl Hydrocarbon Receptor
PD-1/PD-L1
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Cancer
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(2R,3S)-PD-1/PD-L1-IN-38 (Compound (±)-13e) is an orally active Ah receptor (AhR) antagonist with in vivo and in vitro anticancer activity. (2R,3S)-PD-1/PD-L1-IN-38 promotes the secretion of INF-γ by CD8 +T cells and inhibits the signal transduction of PD-1/PD-L1 .
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- HY-12545
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PbTx-3
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Sodium Channel
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Inflammation/Immunology
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Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na + channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na + channels, inhibits the inactivation of Na + channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .
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- HY-18619
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YL-109
1 Publications Verification
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Aryl Hydrocarbon Receptor
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Cancer
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YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness .
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- HY-B0845
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-
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- HY-102023
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GNF351
3 Publications Verification
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Aryl Hydrocarbon Receptor
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Others
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GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes .
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- HY-19317
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- HY-111450
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Aryl Hydrocarbon Receptor
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Cancer
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CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .
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- HY-B0678S
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- HY-104026B
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- HY-103220
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- HY-15972
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Fungal
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Inflammation/Immunology
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UM729 is a new pyrimidoindole, which has an additive effect
with AhR antagonists in preventing differentiation in most AML
specimens; collaborates with Ahr suppressors in preventing AML cell differentiation.
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- HY-122208
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Others
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Inflammation/Immunology
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SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist) .
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- HY-114740
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- HY-103222
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3',4'-Dimethoxy-αNF
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Aryl Hydrocarbon Receptor
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Inflammation/Immunology
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DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent .
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- HY-12684
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Aryl Hydrocarbon Receptor
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Cancer
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CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR).
CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM .
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- HY-12451
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- HY-104026CS
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- HY-15001
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- HY-N10123
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- HY-118780
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- HY-100242
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YH439
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Aryl Hydrocarbon Receptor
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Others
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Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.
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- HY-104026BS
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- HY-135750
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VAF347
2 Publications Verification
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Aryl Hydrocarbon Receptor
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Inflammation/Immunology
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VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14 +CD11b + monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects .
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- HY-N0178
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- HY-130269
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β-NF-CH2-OH
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Ligands for E3 Ligase
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Cancer
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β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .
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- HY-111441
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Chrysene-1,4-dione
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Aryl Hydrocarbon Receptor
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Cancer
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1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).
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- HY-112629
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- HY-112627
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- HY-103223
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NSC 710305
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Cytochrome P450
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Cancer
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Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1 .
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- HY-130256
-
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PROTACs
Epigenetic Reader Domain
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Cancer
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β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity .
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- HY-109044
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- HY-N10295
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Aryl Hydrocarbon Receptor
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Inflammation/Immunology
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Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 + T cells and CD11b + macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA . Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM .
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- HY-15484
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Pifithrin hydrobromide; PFTα hydrobromide
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MDM-2/p53
Aryl Hydrocarbon Receptor
Ferroptosis
Apoptosis
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Cancer
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Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
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- HY-N4095
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- HY-N6264
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- HY-N0586A
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(+)-Laurelliptine hydrochloride
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Adenosine Receptor
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Inflammation/Immunology
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Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .
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- HY-N0586
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(+)-Laurelliptine
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Adenosine Receptor
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Inflammation/Immunology
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Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .
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- HY-16031B
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NSC710464 dihydrochloride
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HIF/HIF Prolyl-Hydroxylase
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Cancer
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AFP464 (dihydrochloride) (NSC710464 (dihydrochloride)) is the hydrochloride form of AFP464 and is a potent HIF-1α inhibitor with an IC50 value of 0.25 μM. It is also an activator of aryl hydrocarbon receptor (AhR).
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- HY-16031
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NSC710464 free base
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HIF/HIF Prolyl-Hydroxylase
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Cancer
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AFP464 free base (NSC710464 free base), is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.
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- HY-134217
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Aryl Hydrocarbon Receptor
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Cancer
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KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity .
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- HY-B0311
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(S)-(-)-Carbidopa
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Aryl Hydrocarbon Receptor
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Neurological Disease
Cancer
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Carbidopa ((S)-(-)-Carbidopa), a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .
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- HY-B0311A
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(S)-(-)-Carbidopa monohydrate
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|
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Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .
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- HY-12028
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PD98059
Maximum Cited Publications
285 Publications Verification
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MEK
ERK
Aryl Hydrocarbon Receptor
Autophagy
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Cancer
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PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .
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- HY-W028393
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- HY-N0170
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- HY-103221
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Aryl Hydrocarbon Receptor
GSK-3
CDK
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Others
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MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β .
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- HY-B0311AS
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(S)-(-)-Carbidopa-d3 (monohydrate)
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Aryl Hydrocarbon Receptor
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Neurological Disease
Cancer
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Carbidopa-d3 (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].
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- HY-B0311S1
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(S)-(-)-Carbidopa-d3
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Aryl Hydrocarbon Receptor
Isotope-Labeled Compounds
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Neurological Disease
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Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .
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- HY-130842
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β-NF-CH2-Br
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Ligands for E3 Ligase
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Cancer
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β-Naphthoflavone-CH2-Br (β-NF-CH2-Br) is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br can be used to synthesize the PROTAC β-NF-JQ1(HY-130256) .
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- HY-131340
-
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Phosphodiesterase (PDE)
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Inflammation/Immunology
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LASSBio-1632 is a new anti-asthmatic lead candidate associated with selective inhibition of PDE4A and PDE4D isoenzymes and blockade of airway hyper-reactivity (AHR) and TNF-α production in the lung tissue. LASSBio-1632 (7j) displays high experimental BBB permeability across BBB through passive diffusion .
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- HY-W718300
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- HY-W007355
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Skatole
3 Publications Verification
3-Methylindole; 3-Methyl-1H-indole
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Aryl Hydrocarbon Receptor
p38 MAPK
Endogenous Metabolite
Apoptosis
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Others
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Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .
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- HY-19826
-
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DNA Methyltransferase
ADC Cytotoxin
Autophagy
Apoptosis
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Cancer
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Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin .
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- HY-156908
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Aryl Hydrocarbon Receptor
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Inflammation/Immunology
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3-OH-Kynurenamine is a lateral metabolite in Tryptophan (HY-N0623) metabolism. 3-OH-Kynurenamine induces a concentration-dependent AhR activation, around 6.5 times higher than L-kynurenine (HY-104026). 3-OH-Kynurenamine confers immunosuppressive properties on dendritic cells (DCs). 3-OH-Kynurenamine can be used for psoriasis research .
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- HY-124421
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NSC-703786
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Aryl Hydrocarbon Receptor
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Others
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5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38 .
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- HY-125019
-
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JAK
STAT
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Inflammation/Immunology
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iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR) .
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- HY-A0083
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Acetyl-β-methylcholine chloride
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mAChR
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Others
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Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .
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- HY-W011338
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Aryl Hydrocarbon Receptor
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Cancer
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Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .
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- HY-A0083B
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Acetyl-β-methylcholine bromide
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mAChR
|
Cardiovascular Disease
|
Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .
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- HY-W014502R
-
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Aryl Hydrocarbon Receptor
Endogenous Metabolite
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Cancer
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D-Kynurenine (Standard) is the analytical standard of D-Kynurenine. This product is intended for research and analytical applications. D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR) .
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- HY-W011338S
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Aryl Hydrocarbon Receptor
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Cancer
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Benzyl butyl phthalate-d4 is the deuterium labeled Benzyl butyl phthalate[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[2][3][4].
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- HY-119019
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Cat. No. |
Product Name |
Type |
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- HY-111157
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AhR11748; AN051; ADD94057
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Cell Assay Reagents
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Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-17357S
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Nepafenac-d5 is the deuterium labeled Nepafenac, which is a selective COX-2 inhibitor.
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- HY-B0678S
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Metaxalone-d3 is the deuterium labeled Metaxalone. Metaxalone (AHR438;NSC170959) is a muscle relaxant used to relax muscles.
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- HY-104026CS
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L-Kynurenine- 13C10 (sulfate hemihydrate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .
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- HY-125926S
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2-Ketodoxapram-d5 is deuterium labeled 2-Ketodoxapram.
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- HY-B0678S1
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Metaxalone-d6 is deuterium labeled Metaxalone.
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- HY-104026BS
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L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .
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- HY-B0311AS
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Carbidopa-d3 (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].
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- HY-B0311S1
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Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .
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- HY-W718300
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Indole-3-pyruvic acid-d5 is deuterated labeled Indole-3-pyruvic acid. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety .
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- HY-W011338S
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Benzyl butyl phthalate-d4 is the deuterium labeled Benzyl butyl phthalate[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[2][3][4].
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Cat. No. |
Product Name |
Application |
Reactivity |
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- HY-P80378
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Ah receptor; Aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; BHLHE76; Class E basic helix loop helix protein 76; HGNC:348; AhR_HUMAN.
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WB, ICC/IF
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Human |
Aryl hydrocarbon Receptor Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 96 kDa, targeting to Aryl hydrocarbon Receptor. It can be used for WB,ICC/IF assays with tag free, in the background of Human.
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- HY-P82417
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Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76; AhR
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WB
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Human |
Cat. No. |
Product Name |
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Classification |
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- HY-155505
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Alkynes
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AHR agonist 4 (compound 24e) is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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