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Signaling Pathway

ITE

HY-19317

ITE

ITE Chemical Structure

ITE is a aryl hydrocarbon receptor (AhR) agonist with Ki of 3 nM, and the estimated IC50 of ITE for OVCAR-3 cell proliferation was 0.2 nM.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $109 In-stock
5 mg $99 In-stock
10 mg $150 In-stock
50 mg $500 In-stock
100 mg $800 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €107 In-stock
5 mg €97 In-stock
10 mg €147 In-stock
50 mg €490 In-stock
100 mg €784 In-stock
200 mg Get quote
500 mg Get quote

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Product name: ITE
Cat. No.: HY-19317

ITE Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of ITE

ITE is a aryl hydrocarbon receptor (AhR) agonist with Ki of 3 nM, and the estimated IC50 of ITE for OVCAR-3 cell proliferation was 0.2 nM.
IC50 value: 0.2?nM (for OVCAR-3 cell), 3 nM (Ki) [1]
Target: AhR
in vitro: ITE is the endogenous high-affinity AhR agonist, possesses potent anticancer activity but the mechanism of action remains unclear. ITE enhances the binding of the AhR to the promoter of Oct4 and suppresses its transcription. ITE is presumably high enough in exerting its biological functions. [1]
in vivo: ITE is a potential compound to induce functional FoxP3+ Treg in vivo and treat autoimmune diseases.[2]

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 286.31 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C14H10N2O3S
CAS No 448906-42-1
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.4927 mL 17.4636 mL 34.9272 mL
5 mM 0.6985 mL 3.4927 mL 6.9854 mL
10 mM 0.3493 mL 1.7464 mL 3.4927 mL

References on ITE

Inhibitor Kit