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ITE 

Cat. No.: HY-19317 Purity: >98.0%
Data Sheet SDS Handling Instructions

ITE is a aryl hydrocarbon receptor (AhR) agonist with Ki of 3 nM, and the estimated IC50 of ITE for OVCAR-3 cell proliferation was 0.2 nM.

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ITE Chemical Structure

ITE Chemical Structure

CAS No. : 448906-42-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO $109 In-stock
5 mg $99 In-stock
10 mg $150 In-stock
50 mg $500 In-stock
100 mg $800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

ITE is a aryl hydrocarbon receptor (AhR) agonist with Ki of 3 nM, and the estimated IC50 of ITE for OVCAR-3 cell proliferation was 0.2 nM. IC50 value: 0.2?nM (for OVCAR-3 cell), 3 nM (Ki) [1] Target: AhR in vitro: ITE is the endogenous high-affinity AhR agonist, possesses potent anticancer activity but the mechanism of action remains unclear. ITE enhances the binding of the AhR to the promoter of Oct4 and suppresses its transcription. ITE is presumably high enough in exerting its biological functions. [1] in vivo: ITE is a potential compound to induce functional FoxP3+ Treg in vivo and treat autoimmune diseases.[2]

References
Molecular Weight

286.31

Formula

C₁₄H₁₀N₂O₃S

CAS No.

448906-42-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 41 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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ITE
Cat. No.:
HY-19317
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