DNA/RNA

Pathways Recommended:	Cell Cycle/DNA Damage

By Targets:	DNA Alkylator/Crosslinker (4) DNA Methyltransferase (1) DNA Stain (6) DNA/RNA Synthesis (87) ADC Cytotoxin (5) Antibiotic (26) Antifolate (4) Apoptosis (13) Autophagy (7) Bacterial (28) Biochemical Assay Reagents (6) c-Myc (2) Dihydrofolate reductase (DHFR) (3) Dihydroorotate Dehydrogenase (2) Drug Metabolite (2) Drug-Linker Conjugates for ADC (3) Endogenous Metabolite (33) Fluorescent Dye (5) Fungal (3) G-quadruplex (1) HBV (9) HCV (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (4) HIV (4) HSV (2) Influenza Virus (3) Isotope-Labeled Compounds (14) Liposome (1) Lipoxygenase (2) MicroRNA (3) Nucleoside Antimetabolite/Analog (28) Parasite (9) Phosphatase (2) Potassium Channel (2) Reverse Transcriptase (3) SARS-CoV (4) Sirtuin (2) Sodium Channel (1) STING (1) Topoisomerase (16)
By Research Areas:	Cancer (82) Cardiovascular Disease (2) Infection (62) Inflammation/Immunology (11) Metabolic Disease (9) Neurological Disease (4)
Click Chemistry:	Azide (1) Alkynes (1)

Targets Recommended: DNA/RNA Synthesis DNA-PK DNA Methyltransferase DNA Stain Small Interfering RNA (siRNA) DNA Alkylator/Crosslinker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112680A

Carboxy pyridostatin trifluoroacetate salt 1 Publications Verification	G-quadruplex	Cancer
Carboxy pyridostatin trifluoroacetate salt has the peculiarity to exhibit high molecular specificity for RNA over DNA G4s .

HY-W570884

5-Me-dC(Ac) amidite

DNA/RNA Synthesis Others

5-Me-dC(Ac) amidite is used for synthesizing DNA or RNA .

5-Me-dC(Ac) amidite	DNA/RNA Synthesis	Others
5-Me-dC(Ac) amidite is used for synthesizing DNA or RNA .

HY-W008990

Xanthosine 5'-monophosphate sodium salt 1 Publications Verification 5'-Xanthylic acid sodium salt	DNA/RNA Synthesis	Metabolic Disease
Xanthosine 5'-monophosphate sodium salt (5'-Xanthylic acid sodium salt) is an intermediate in purine metabolism. Xanthosine 5'-monophosphate sodium salt can be used for genetic code, nucleic acid structure, and DNA, RNA and protein synthesis research .

HY-125930

T-2513	Topoisomerase DNA/RNA Synthesis	Cancer
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .

HY-125930A

T-2513 hydrochloride	Topoisomerase DNA/RNA Synthesis	Cancer
T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .

HY-139912

Biotin-aniline	DNA Stain	Others
Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity .

HY-D1020

7-Aminoactinomycin D 4 Publications Verification 7-AAD	DNA/RNA Synthesis Bacterial DNA Stain Antibiotic	Infection Cancer
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-131160

Nuclease, Serratia marcescens Serratia marcescens nuclease	Biochemical Assay Reagents	Inflammation/Immunology
Serratia marcescens nuclease (EC 3.1.30.2) is a nonspecific nuclease. Serratia marcescens nuclease has broad utility due to its potent digestive activity toward both DNA and RNA .

HY-12484

BMH-21 5 Publications Verification	DNA/RNA Synthesis	Cancer
BMH-21 is a first-in-class *DNA* intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .

HY-144047

HBV-IN-16	HBV DNA/RNA Synthesis	Infection
HBV-IN-16 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-16 is a quinoline derivative. HBV-IN-16 has the potential for the research of HBV infection (extracted from patent WO2019121357A1, compound 1) .

HY-144045

HBV-IN-14	HBV DNA/RNA Synthesis	Infection
HBV-IN-14 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-14 is a pyridinopyrimidinones compound. HBV-IN-14 has the potential for the research of HBV infection (extracted from patent WO2021190502A1, compound 5) .

HY-144046

HBV-IN-15	HBV DNA/RNA Synthesis	Infection
HBV-IN-15 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-15 is a flavone derivative. HBV-IN-16 has the potential for the research of HBV infection (extracted from patent WO2020052774A1, compound 2) .

HY-N12201

Funiculosin	Antibiotic Fungal	Infection
Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts .

HY-Y1055

Guanine 3 Publications Verification	DNA/RNA Synthesis Endogenous Metabolite	Cancer
Guanine is one of the fundamental components of nucleic acids (DNA and *RNA*). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool .

HY-W004056

4-Methoxyphenethyl alcohol p-Methoxyphenylethanol	DNA/RNA Synthesis Bacterial	Infection
4-Methoxyphenethyl alcohol, an aromatic alcohol, is the major component in the anise-like odour produced by Amorphophallus. 4-Methoxyphenethyl alcohol can inhibits the protein, RNA and DNA synthesis in Escherichia coli .

HY-13735

Quinacrine Acriquine	Parasite Sodium Channel DNA Stain Apoptosis	Infection Neurological Disease Cancer
Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC₅₀: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm) .

HY-152980

4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154046

4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-148781

HBV-IN-30	HBV	Infection
HBV-IN-30 (ex44), a flavone derivative, is a potent *covalently closed circular DNA* (cccDNA)** inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-30 has the potential for the research of HBV infection .

HY-148780

HBV-IN-29	HBV	Infection
HBV-IN-29 (ex8), a flavone derivative, is a potent *covalently closed circular DNA* (cccDNA)** inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-29 has the potential for the research of HBV infection .

HY-152990

Methyl 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate	Nucleoside Antimetabolite/Analog	Others
Methyl 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154122

6-Amino-4-methoxy-1-(2-deoxy-a-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
6-Amino-4-methoxy-1-(2-deoxy-a-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-152987

7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Nucleoside Antimetabolite/Analog	Others
7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-152986

4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154047

6-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
6-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154008

6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154002

4-Amino-5-cyano-1-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
4-Amino-5-cyano-1-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154005

4-Amino-6-bromo-5-cyano-1-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
4-Amino-6-bromo-5-cyano-1-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-152977

4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine	Nucleoside Antimetabolite/Analog	Others
4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-126327

UNC4976	Histone Methyltransferase	Cancer
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-137067

IMT1B 4 Publications Verification LDC203974	DNA/RNA Synthesis	Cancer
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of *mitochondrial RNA* polymerase (POLRMT)** and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects .

HY-126327A

UNC4976 TFA	Histone Methyltransferase	Cancer
UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-D0093

Ethidium homodimer EthD-1	DNA Stain	Others
Ethidium homodimer (EthD-1) is a high-affinity fluorescent nucleic acid dye commonly used to stain mammals, bacteria, yeast, and fungi. Ethidium homodimer binds to DNA or RNA, enhancing fluorescence more than 30 times. The Ethidium homodimer has a strong positive charge, so it cannot cross cell membranes and stain living cells; But the Ethidium homodimer can cross the disordered region of the dead cell membrane to reach the nucleus and embed the DNA double strand to produce red fluorescence. Therefore, Ethidium homodimer is a relatively sensitive nucleic acid stain that can accurately detect nucleic acids in solution or in decomposing cells. Ethidium homodimer binds DNA, Ex/Em=528/617 nm .

HY-23789

2′-O-(2-Methoxyethyl)guanosine 2'-O-MOE-rG	Nucleoside Antimetabolite/Analog	Others
2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA .

HY-P1923

L-Asparaginase 5+ Cited Publications L-ASNase	Apoptosis DNA/RNA Synthesis	Cancer
L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis .

HY-W008915

Cytidine 5'-diphosphate trisodium salt CDP	DNA/RNA Synthesis	Metabolic Disease
Cytidine 5'-diphosphate trisodium salt (CDP) is produced by the transfer of phosphoryl group from ATP to cytidine monophosphate (CMP) catalyzed by uridine monophosphate kinase (UMPK). Cytidine 5′-diphosphate can be used to produce Cytidine triphosphate (CTP) for synthesis of DNA and RNA .

HY-B0420A

Moroxydine hydrochloride ABOB hydrochloride	Influenza Virus HCV	Infection
Moroxydine (ABOB) hydrochloride has multi-antiviral activities against DNA and RNA viruses including influenza symptoms, herpes simplex, varicellazoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride shows high anti-grass carp reovirus (GCRV) activity .

HY-128917

DNA31

DNA/RNA Synthesis Infection

DNA31 is a potent RNA polymerase inhibitor .
HY-112060

Saccharin 1-methylimidazole

DNA/RNA Synthesis Cancer

Saccharin 1-methylimidazole is an activator for DNA/RNA Synthesis.
HY-163015

RNA polymerase-IN-1

Others Infection

RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .
HY-163016

RNA polymerase-IN-2

Others Infection

RNA polymerase-IN-2 (compound 5) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .
HY-13585

Carmustine

5+ Cited Publications

DNA Alkylator/Crosslinker Cancer

Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.

DNA31	DNA/RNA Synthesis	Infection
DNA31 is a potent RNA polymerase inhibitor .

Saccharin 1-methylimidazole	DNA/RNA Synthesis	Cancer
Saccharin 1-methylimidazole is an activator for DNA/RNA Synthesis.

RNA polymerase-IN-1	Others	Infection
RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .

RNA polymerase-IN-2	Others	Infection
RNA polymerase-IN-2 (compound 5) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .

Carmustine 5+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.

HY-155743A

ddUTP (lithium), 100mM in H2O 2',3'-Dideoxyuridine-5'-triphosphate lithium	Nucleoside Antimetabolite/Analog	Others
ddUTP (lithium), 100mM in H₂O is a nucleotide analog that can be incorporated into DNA, RNA, or other nucleic acids. ddUTP (lithium), 100mM in H₂O can be used to prepare DNA/RNA hybridization experiments, such as Southern blots and Northern blots.

HY-138581

DMT-dA(PAc) Phosphoramidite

DNA/RNA Synthesis Infection Cancer

DMT-dA(PAc) Phosphoramidite is a dIPhosphoramidite and can be used for DNA or RNA synthesis.
HY-160199

3'-L-Histidyl-AMP

Others Others

3'-L-Histidyl-AMP is applicable for nucleoside modification (DNA, RNA) .

DMT-dA(PAc) Phosphoramidite	DNA/RNA Synthesis	Infection Cancer
DMT-dA(PAc) Phosphoramidite is a dIPhosphoramidite and can be used for DNA or RNA synthesis.

3'-L-Histidyl-AMP	Others	Others
3'-L-Histidyl-AMP is applicable for nucleoside modification (DNA, RNA) .

HY-E70090

T7 RNA polymerase	DNA/RNA Synthesis	Others
T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg ²⁺, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .

HY-13585S

Carmustine-d8	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Carmustine-d₈ is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA[1][2].

HY-160199A

3'-L-histidyl-AMP disodium

Others Others

3'-L-histidyl-AMP (disodium) is applicable for nucleoside modification (DNA, RNA) .
HY-138599

5'-O-TBDMS-dA

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Infection Cancer

5'-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
HY-138610

5'-O-DMT-Bz-rC

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Infection Cancer

5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.

Cat. No.	Product Name

HY-L155

Mitochondrial Toxicity Compound Library

470 compounds

Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.

MCE contains 470 mitochondrial toxic compounds, which can be used as tool compounds for drug development, organ toxicity and disease mechanism research.

HY-L004

Cell Cycle/DNA Damage Compound Library

2001 compounds

DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair.

MCE owns a unique collection of 2001 cell cycle/DNA damage-related compounds which can be used in the research of the same.

HY-L044

Nucleotide Compound Library

491 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 491 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

HY-L005

Epigenetics Compound Library

1225 compounds

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases.

MCE provide a unique collection of 1225 epigenetics-related compounds that can be used in the research of the related diseases.

HY-L090

Transcription Factor-Targeted Library

1288 compounds

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential.

MCE offers a unique collection of 1288 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Cat. No.	Product Name	Type

HY-D1020

7-Aminoactinomycin D 4 Publications Verification 7-AAD	DNA Stain
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-D0093

Ethidium homodimer

EthD-1

DNA Stain

Ethidium homodimer (EthD-1) is a high-affinity fluorescent nucleic acid dye commonly used to stain mammals, bacteria, yeast, and fungi. Ethidium homodimer binds to DNA or RNA, enhancing fluorescence more than 30 times. The Ethidium homodimer has a strong positive charge, so it cannot cross cell membranes and stain living cells; But the Ethidium homodimer can cross the disordered region of the dead cell membrane to reach the nucleus and embed the DNA double strand to produce red fluorescence. Therefore, Ethidium homodimer is a relatively sensitive nucleic acid stain that can accurately detect nucleic acids in solution or in decomposing cells. Ethidium homodimer binds DNA, Ex/Em=528/617 nm .

HY-108166A

Hydroxystilbamidine bis(fluoroGlod)	DNA Stain
Hydroxystilbamidine bis(methanesulfonate), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases.

HY-D0971

Pyronin Y

3 Publications Verification

Pyronine G; C.I. 45005

Fluorescent Dyes/Probes

Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. Pyronin Y forms fluorescent complexes with double-stranded nucleic acids (especially RNA) enabling semi-quantitative analysis of cellular RNA. Pyronin Y can be used to identify specific RNA subspecies of ribonuclear proteins complexes in live cells .

HY-W073524

DFAME

Fluorescent Dyes/Probes

DFAME is a red fluorophore (Ex=508 nm, Em=641 nm). Beetroot and Corn are dimeric fluorogenic RNA aptamers that can bind to DFAME to form Beetroot-DFAME (K_d=460nM) and Corn-DFAME (K_d= 3600nM). Beetroot-DFAME (Kd=460nM) and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research .

HY-D0952

Acridine Orange base

Fluorescent Dyes/Probes

Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays .

HY-43520

BODIPY-FL	Fluorescent Dyes/Probes
BODIPY-FL is a potent fluorescent dye. BODIPY-FL can be used to label probe or primer for fluorescent quenching-based quantitative detection of specific DNA/RNA.BODIPY-FL-labeled monoterpenoid can be used to examine the features of a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi as well .

HY-D0079

Dihydroethidium

Maximum Cited Publications

49 Publications Verification

Hydroethidine; PD-MY 003

Fluorescent Dyes/Probes

Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .

HY-W250143

Toluidine blue (ZnCl2)

Dyes

Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.

Cat. No.	Product Name	Type

HY-23789

2′-O-(2-Methoxyethyl)guanosine 2'-O-MOE-rG	Biochemical Assay Reagents
2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA .

HY-E70090

T7 RNA polymerase

Biochemical Assay Reagents

T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg ²⁺, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .

HY-W088070A

Agarose,Low melting point

Biochemical Assay Reagents

Agarose,Low melting point is a kind of agarose, a kind of polysaccharide that can be derived from seaweed. It is commonly used in molecular biology and biochemistry to isolate and purify DNA and RNA fragments. Agarose,Low melting point is a low melting point agarose, which is suitable for the recovery of large DNA fragments and enzymatic reactions in gels and other applications. In addition, it has been used in various techniques, such as pulsed field gel electrophoresis and capillary electrophoresis for analyzing genetic material.

HY-155743A

ddUTP (lithium), 100mM in H2O 2',3'-Dideoxyuridine-5'-triphosphate lithium	Gene Sequencing and Synthesis
ddUTP (lithium), 100mM in H₂O is a nucleotide analog that can be incorporated into DNA, RNA, or other nucleic acids. ddUTP (lithium), 100mM in H₂O can be used to prepare DNA/RNA hybridization experiments, such as Southern blots and Northern blots.

HY-144016

16:0 EPC chloride	Drug Delivery
16:0 EPC chloride, a P-O-ethyl derivative, is a saturated cationic lipid. 16:0 EPC chloride can serve as a DNA and RNA transfecting agent. 16:0 EPC chloride can be used as a co-adjuvant for preparing vaccines and promote drug delivery .

HY-W127378

DOTAP methylsulfate 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate	Biochemical Assay Reagents
DOTAP Transfection Reagent is a cationic derivative of trimethylammonium attached to two 18-carbon fatty acid tails, each with a single alkene group. 18:1 TAP is a cationic liposome-forming compound useful for the transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells.

HY-W460471

Tris Buffered Saline

Buffer Reagents

Tris Buffered Saline is a common buffer reagent in molecular biology, consisting of Tris and NaCl. Tris Buffered Saline can adjust pH and ionic strength and is widely used in DNA/RNA extraction, PCR and protein electrophoresis. Tris Buffered Saline can purify and protect nucleic acid materials and improve reaction efficiency and concentration. In protein electrophoresis, Tris Buffered Saline stabilizes gels and maintains pH. Overall, Tris Buffered Saline offers versatility, good solubility, and low toxicity in molecular biology applications.

Cat. No.	Product Name	Target	Research Area

HY-126327A

UNC4976 TFA	Histone Methyltransferase	Cancer
UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-126327

UNC4976	Histone Methyltransferase	Cancer
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

Cat. No.	Product Name

HY-KE7058

RNase H

RNase H is an endoribonuclease expressed and purified from Escherichia coli and can specifically hydrolyze RNA in DNA-RNA hybrid strands.

HY-K1049

T4 DNA Ligase (Fast)
MCE T4 DNA Ligase (Fast) is produced by Escherichia coli carrying a T4 phage, catalyzes the formation of a phosphodiester bond between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex DNA or RNA.

HY-KE7066

FnCas12a

FnCas12a(Cpf1), is an RNA-guided, DNA-editable recombinant endonuclease that can be used for gene editing and detection.

HY-K1014

PolyFast Transfection Reagent Maximum Cited Publications 16 Publications Verification
MCE PolyFast Transfection Reagent consists of cationic polymers and can introduce nucleic acids (DNA or RNA) into eukaryotic cells efficiently, including some hard-to-transfect cells.

HY-K1082

*Viral DNA/RNA* Mini Purification Kit**
MCE Viral DNA/RNA Mini Purification Kit allows rapid and efficient purification of viral DNA/RNA based on the selective binding of DNA/RNA to the silica-based membrane. Viral DNA/RNA purified with this kit can be used for PCR, RT-PCR, qPCR, and qRT-PCR.

HY-K1031

Agarose

MCE Agarose can be made into 0.5-2.5% agarose gel according to different needs and can resolve DNA and RNA fragments from 50-15,000 bp.

HY-K0511A

RT Master Mix for qPCR II (gDNA digester plus) 10+ Cited Publications
MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. With updated reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically.

HY-K0511

RT Master Mix for qPCR (gDNA digester plus) 5 Publications Verification
MCE RT Master Mix for qPCR (gDNA digester plus) is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. The cDNA product can be directly applied as a template in a standard PCR and real time quantitative PCR (qPCR).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y1055

Guanine 3 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	DNA/RNA Synthesis Endogenous Metabolite
Guanine is one of the fundamental components of nucleic acids (DNA and *RNA*). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool .

HY-W004056

4-Methoxyphenethyl alcohol p-Methoxyphenylethanol	Infection Natural Products Classification of Application Fields Araceae Source classification Plants Amorphophallus Disease Research Fields	DNA/RNA Synthesis Bacterial
4-Methoxyphenethyl alcohol, an aromatic alcohol, is the major component in the anise-like odour produced by Amorphophallus. 4-Methoxyphenethyl alcohol can inhibits the protein, RNA and DNA synthesis in Escherichia coli .

HY-W008915

Cytidine 5'-diphosphate trisodium salt CDP	Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis
Cytidine 5'-diphosphate trisodium salt (CDP) is produced by the transfer of phosphoryl group from ATP to cytidine monophosphate (CMP) catalyzed by uridine monophosphate kinase (UMPK). Cytidine 5′-diphosphate can be used to produce Cytidine triphosphate (CTP) for synthesis of DNA and RNA .

HY-N8533

Sodium Camptothecin	Infection Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields	DNA/RNA Synthesis
Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA .

HY-N12201

Funiculosin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Fungal
Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts .

HY-113226

Orotidine	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Orotidine, a nucleotide, is an intermediate in pyrimidine nucleotide biosynthesis in RNA and DNA. Orotidine is mainly found in bacteria, fungi and plants .

HY-13744

Rubitecan RFS 2000; 9-Nitrocamptothecin	Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer	Topoisomerase
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-100126

Tubercidin 4 Publications Verification 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating *DNA* or *RNA, thereby inhibiting DNA* replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-I0626

Cytosine 1 Publications Verification	Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging .

HY-12695B

Guanosine 5'-triphosphate trisodium salt hydrate 5'-GTP trisodium salt hydrate	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
5'-GTP trisodium salt hydrate is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

HY-B0152

Adenine 5+ Cited Publications 6-Aminopurine; Vitamin B4	Structural Classification Natural Products Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Cancer	DNA/RNA Synthesis Endogenous Metabolite
Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis .

HY-B0152A

Adenine hydrochloride 5+ Cited Publications 6-Aminopurine hydrochloride; Vitamin B4 hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	DNA/RNA Synthesis Endogenous Metabolite
Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis .

HY-W004924

5-Hydroxymethyluracil	Natural Products Classification of Application Fields Other disease Source classification Other Diseases Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-B0152B

Adenine hemisulfate 5+ Cited Publications 6-Aminopurine hemisulfate; Vitamin B4 hemisulfate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	DNA/RNA Synthesis Endogenous Metabolite
Adenine hemisulfate (6-Aminopurine hemisulfate), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hemisulfate acts as a chemical component of DNA and RNA. Adenine hemisulfate also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis .

HY-W002272

Isocytosine	Classification of Application Fields Other Diseases Disease Research Fields	Nucleoside Antimetabolite/Analog
Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA .

HY-121360

Cylindrospermopsin	Microorganisms Source classification	DNA/RNA Synthesis
Cylindrospermopsin is a cyanotoxin produced by a variety of freshwater cyanobacteria. It is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA .

HY-135780

3'-Deoxyuridine-5'-triphosphate 3'-dUTP	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-135780A

3'-Deoxyuridine-5'-triphosphate trisodium 3'-dUTP trisodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-W010737

Guanosine-5'-triphosphate disodium salt 5 Publications Verification 5'-GTP disodium salt	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Guanosine-5'-triphosphate disodium salt (5'-GTP trisodium salt) is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA .

HY-B0152R

Adenine (Standard) 6-Aminopurine (Standard); Vitamin B4 (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite	DNA/RNA Synthesis Endogenous Metabolite
Adenine (Standard) is the analytical standard of Adenine. This product is intended for research and analytical applications. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis .

HY-13704

SN-38 Maximum Cited Publications 33 Publications Verification 7-Ethyl-10-hydroxycamptothecin	Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Quinoline Alkaloids Plants Disease Research Fields Cancer	Topoisomerase ADC Cytotoxin Autophagy
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits *DNA* and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively .

HY-W008091

5-Methylcytosine 1 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Endogenous Metabolite
5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine in mRNA is a new epitranscriptome marker inArabidopsis, and that regulation of this modification is an integral part of gene regulatory networks underlying plant development .

HY-N10404

Junceellolide C	Classification of Application Fields Animals Terpenoids Source classification Diterpenoids Inflammation/Immunology Disease Research Fields	HBV
Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC₅₀ values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent .

HY-W010970

5'-Guanylic acid disodium salt 1 Publications Verification 5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes .

HY-N6961

Lapachol 1 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Tabebuia avellanedae Plants Bignoniaceae Naphthalene Quinones Inflammation/Immunology Disease Research Fields	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-13062

Daunorubicin hydrochloride 20+ Cited Publications Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13062A

Daunorubicin Daunomycin; RP 13057; Rubidomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Autophagy Bacterial Antibiotic Apoptosis
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-N2513

β-Boswellic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

HY-N2513R

β-Boswellic acid (Standard)	Structural Classification other families Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

HY-N6792

T-2 Toxin 1 Publications Verification T-2 Mycotoxin	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Disease Research Fields	Apoptosis DNA/RNA Synthesis
T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD₅₀ values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BW ^a,respectively . T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates . T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of *DNA* and *RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides . T-2 Toxin (T-2 Mycotoxin) induces apoptosis* in the immune system, gastrointestinal tissues, and fetal tissues .

Cat. No.	Compare	Product Name	Species	Source

HY-P702630

FUS Protein, Human (His, Myc)

RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein; TLS
Human E. coli

Cat. No.	Product Name	Chemical Structure

HY-13585S

Carmustine-d8

Carmustine-d₈ is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA[1][2].

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-B0152S

Adenine-d1
Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

HY-16637S3

Folic acid-13C5
Folic acid- ¹³C₅ is the ¹³C-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-16637S1

Folic acid-d4
Folic acid-d₄ is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-B0152S1

Adenine-13C
Adenine- ¹³C is the ¹³C labeled Adenine[1]. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[2][3][4].

HY-I0626S2

Cytosine-d2
Cytosine-d₂ is the deuterium labeled Cytosine[1]. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[2][3].

HY-Y1055S

Guanine-13C
Guanine- ¹³C is the ¹³C labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-16637S

Folic acid-d2
Folic acid-d₂ (Vitamin B9-d₂) is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-16637S2

(Rac)-Folic acid-13C5,15N
(Rac)-Folic acid- ¹³C₅, ¹⁵N is the ¹³C-labeled and ¹⁵N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-B0152S3

Adenine-13C5

Adenine- ¹³C₅ (6-Aminopurine- ¹³C₅; Vitamin B4- ¹³C₅) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-B0152S4

Adenine-15N5

Adenine- ¹⁵N₅ (6-Aminopurine- ¹⁵N₅; Vitamin B4- ¹⁵N₅) is ¹⁵N labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-I0626S1

Cytosine-13C,15N2
Cytosine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Cytosine[1]. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[2][3].

HY-Y1055S3

Guanine-15N5
Guanine- ¹⁵N₅ is ¹⁵N labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and *RNA*). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-I0626S

Cytosine-2,4-13C2-1,3-15N2
Cytosine- ¹³C₂, ¹⁵N₂ is the ¹³C-labeled and ¹⁵N-labeled Cytosine. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[1][2].

HY-Y1055S4

Guanine-13C5
Guanine- ¹³C₅ is ¹³C-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and *RNA*). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-W004924S

5-Hydroxymethyluracil-d3
5-Hydroxymethyluracil-d₃ is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].

HY-Y1055S1

Guanine-13C,15N2
Guanine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-Y1055S2

Guanine-13C5,15N5
Guanine- ¹³C₅, ¹⁵N₅ is ¹³C and ¹⁵N-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and *RNA*). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-B1002S

Oxolinic acid-d5
Oxolinic acid-d₅ is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].

HY-B0268S1

Enoxacin-d8 hydrochloride

Enoxacin-d₈ (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing[1][2][3][4].

HY-13704S

SN-38-d3
SN-38-d₃ is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].

HY-B0152S2

Adenine-13C5,15N5

Adenine- ¹³C₅,15C5 (6-Aminopurine- ¹³C₅,15C5; Vitamin B4- ¹³C₅,15C5) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-W008091S

5-Methylcytosine-d4

5-Methylcytosine-d₄ is the deuterium labeled 5-Methylcytosine[1]. 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine in mRNA is a new epitranscriptome marker inArabidopsis, and that regulation of this modification is an integral part of gene regulatory networks underlying plant development[2].

HY-N6792S

T-2 Toxin-13C24

T-2 Toxin- ¹³C₂₄ (T-2 Mycotoxin- ¹³C₂₄) is ¹³C-labeled T-2 Toxin (HY-N6792). T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .

Cat. No.	Product Name	Application	Reactivity

HY-P80883

RNA Polymerase II Subunit B1 Antibody POLR2A; POLR2; DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
RNA Polymerase II Subunit B1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 217 kDa, targeting to RNA Polymerase II Subunit B1. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P81140

*8-OHdG (DNA/RNA* Damage) Antibody** 8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-7,8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-Oxo-7,8-dihydro-2μ-deoxyguanosine,8-Oxo-dG; 2'-Deoxy-8-hydroxyguanosine;	ELISA; IHC-P; IHC-F; IF	Human
8-OHdG (DNA/RNA Damage) Antibody is an unconjugated, approximately 0.283 kDa, rabbit-derived, anti-8-OHdG (DNA/RNA Damage) polyclonal antibody. 8-OHdG (DNA/RNA Damage) Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in human, background without labeling.

Cat. No.	Product Name		Classification

HY-124614

GLP-26 1 Publications Verification		Alkynes
GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC₅₀=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools . GLP-26 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-134320

8-Azido-ATP 8-Azidoadenosine 5'-triphosphate; 8-N3-ATP		Azide
8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase . 8-Azido-ATP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.


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Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

DNA/RNA

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products