Bcl-2 Family Inhibitors

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

Bcl-2 Family Inducers, Degraders, Inhibitors, Agonists, Antagonists, Activators & Modulators

Product Name	Bcl-2	Bcl-xL	Bcl-W	Mcl-1	Bfl-1	Bcl-B	Bax	Bak	Bim	Purity
Venetoclax	Bcl-2, Ki: 0.01 nM	Bcl-xL, Ki: 48 nM	Bcl-W, Ki: 245 nM							99.95%
Navitoclax	Bcl-2, Ki: 1 nM	Bcl-xL, Ki: 1 nM	Bcl-W, Ki: 1 nM							99.97%
Polyinosinic-polycytidylic acid	Bcl-2						Bax			99.40%
Sulforaphane							Bax			99.75%
S63845				MCL1, Kd: 0.19 nM						99.94%
ABT-737	Bcl-2, EC₅₀: 30.3 nM	Bcl-xL, EC₅₀: 78.7 nM	Bcl-W, EC₅₀: 197.8 nM	Mcl-1, EC₅₀: >10 μM	Bfl-1, EC₅₀: >10 μM	Bcl-B, EC₅₀: 1820 nM				99.96%
A-1331852	Bcl-2, Ki: 6 nM	Bcl-xL, Ki: 0.01 nM	Bcl-W, Ki: 4 nM	Mcl-1, Ki: 142 nM						99.65%
Chlorin e6	Bcl-2						Bax
AZD-5991				Mcl-1, IC₅₀: 0.7 nM Mcl-1, Kd: 0.17 nM						99.50%
BT2				Mcl-1, Ki: 59 μM						98.93%
A-1155463	Bcl-2, Ki: 80 nM	Bcl-xL, Ki: 0.01 nM								99.60%
BAI1							Bax			99.73%
Estradiol benzoate							Bax			99.89%
MIK665				Mcl-1, IC₅₀: 1.81 nM						99.72%
Benzbromarone	Bcl-2									99.80%
Obatoclax Mesylate	Bcl-2, Ki: 220 nM	Bcl-xL, Ki: 1-7 μM	Bcl-W, Ki: 1-7 μM	Mcl-1, Ki: 1-7 μM		Bcl-B, Ki: 1-7 μM				99.74%
AZD4320	BCL2, IC₅₀: 17 nM (KPUM-UH1 cells)	BCLxL, IC₅₀: 17 nM (KPUM-UH1 cells)								99.68%
WEHI-539 hydrochloride		Bcl-xL, IC₅₀: 1.1 nM								98.31%
Dehydrocorydaline	Bcl-2						Bax			99.77%
Digitoxin	Bcl-2						Bax			99.36%
Tapotoclax				Mcl-1, Ki: 0.13 nM						99.80%
Bax inhibitor peptide V5							Bax			98.28%
Gambogic Acid	Bcl-2, IC₅₀: 1.21 μM	Bcl-xL, IC₅₀: 1.47 μM	Bcl-W, IC₅₀: 2.02 μM	Mcl-1, IC₅₀: 0.79 μM	Bfl-1, IC₅₀: 1.06 μM	Bcl-B, IC₅₀: 0.66 μM				98.79%
A-1210477	Bcl-2, Ki: 132 nM		Bcl-W, Ki: 2280 nM	Mcl-1, Ki: 0.45 nM	Bfl-1, Ki: 660 nM					99.40%
BTSA1							Bax, IC₅₀: 250 nM Bax, EC₅₀: 144 nM			99.49%
Gossypol	Bcl-2, Ki: 0.2-0.3 mM	Bcl-xL, Ki: 0.5-0.6 μM								99.56%
UMI-77	Bcl-2, Ki: 23.83 μM	Bcl-xL, Ki: 32.99 μM	Bcl-W, Ki: 8.19 μM	Mcl-1, Ki: 0.49 μM	Bfl-1, Ki: 5.33 μM					99.66%
Gossypol (acetic acid)	Bcl-2, Ki: 0.2-0.3 mM	Bcl-xL, Ki: 0.5-0.6 μM								99.17%
Dihydrocapsaicin	Bcl-2	Bcl-xL					Bax			99.86%
PROTAC Mcl1 degrader-1	Bcl-2, IC₅₀: 0.54 μM			Mcl-1, IC₅₀: 0.78 μM						98.13%
TCPOBOP	Bcl-2									98.67%
Paris saponin VII	Bcl-2									99.96%
Hydralazine hydrochloride	Bcl-2	Bcl-xL								99.66%
Amantadine hydrochloride	Bcl-2						Bax			≥98.0%
(R)-(-)-Gossypol acetic acid	Bcl-2, Ki: 260 nM	Bcl-xL, Ki: 480 nM		Mcl-1, Ki: 170 nM						98.93%
(R)-Sulforaphane							Bax			99.37%
PROTAC Bcl2 degrader-1	Bcl-2, DC₅₀: 3 μM Bcl-2, IC₅₀: 4.94 μM			Mcl-1, IC₅₀: 11.81 μM						98.78%
Peiminine	Bcl-2									99.94%
S55746	Bcl-2, Ki: 1.3 nM Bcl-2, Kd: 3.9 nM	Bcl-xL, Ki: 520 nM Bcl-xL, Kd: 186 nM								99.89%
Navitoclax-piperazine		Bcl-xL								99.21%
XZ739		Bcl-xL, DC₅₀: 2.5 nM								99.06%
Jaceosidin							Bax			99.51%
TW-37	Bcl-2, Ki: 290 nM	Bcl-xL, Ki: 1110 nM		Mcl-1, Ki: 260 nM						99.27%
MSN-125							Bax	Bak		99.00%
Triclabendazole	Bcl-2						Bax			98.72%
Sabutoclax	BCL2, IC₅₀: 0.32 μM	Bcl-xL, IC₅₀: 0.31 μM		Mcl-1, IC₅₀: 0.2 μM	Bfl-1, IC₅₀: 0.62 μM					99.80%
TC11				MCL1						98.04%
Bz 423							Bax	Bak		99.83%
CLZ-8				Mcl-1, Ki: 0.3 μM						99.85%
Lisaftoclax	Bcl-2, IC₅₀: 2 nM	Bcl-xL, IC₅₀: 5.9 nM								99.28%
Bim-IN-1									Bim	99.57%
Pyraclostrobin	Bcl-2						Bax			99.91%
Maritoclax				Mcl-1, IC₅₀: 10.1 μM						99.97%
PROTAC Bcl-xL degrader-2		Bcl-xL, IC₅₀: 0.6 nM								98.16%
HA14-1	Bcl-2, IC₅₀: 9 μM									≥98.0%
Humanin							Bax
BAM7							Bax, IC₅₀: 3.3 μM			98.53%
BM-1197	Bcl-2, IC₅₀: 3.5 nM	Bcl-xL, IC₅₀: 5.2 nM								99.43%
Isolinderalactone	Bcl-2									98.79%
MSN-50							Bax	Bak		98.40%
ML311				Mcl-1					Bim	98.26%
Pyridoclax				Mcl-1						99.74%
MCL-1/BCL-2-IN-1	Bcl-2, IC₅₀: 3.18 μM			Mcl-1, IC₅₀: 4.45 μM						99.86%
VU0661013				Mcl-1						98.52%
S55746 hydrochloride	Bcl-2, Ki: 1.3 nM Bcl-2, Kd: 3.9 nM	Bcl-xL, Ki: 520 nM Bcl-xL, Kd: 186 nM								99.66%
BH3I-1	Bcl-2	Bcl-xL						Bak	Bim	≥98.0%
L6H21	Bcl-2						Bax			99.46%
Destruxin B	Bcl-2									99.86%
A-385358	Bcl-2, Ki: 67 nM	Bcl-xL, Ki: 0.8 nM								98.19%
MIM1				Mcl-1						≥98.0%
Murizatoclax				MCL1, Ki: 15 pM						98.85%
GL0388							Bax			98.01%
Mcl-1 inhibitor 6	Bcl-2, Kd: >10 μM Bcl2A1, Kd: >10 μM Bcl-2, Ki: 10 μM	Bcl-xL, Kd: >10 μM	Bcl-W, Kd: >10 μM	Mcl-1, Kd: 0.23 nM Mcl-1, Ki: 0.02 μM	Bfl-1, Ki: 1.57 μM					98.40%
n-Butyl-β-D-fructofuranoside	Bcl-2						Bax
Bax activator-1							Bax			98.45%
Aspidin BB	Bcl-2						Bax			98.08%
PZ703b		Bcl-xL								98.47%
Mcl1-IN-1				Mcl-1, IC₅₀: 2.4 μM						98.40%
(R)-(-)-Gossypol	Bcl-2, Ki: 260 nM	Bcl-xL, Ki: 480 nM		Mcl-1, Ki: 170 nM						98.82%
Obatoclax	BCL2, Ki: 200 nM	Bcl-xL, Ki: 1-7 μM	Bcl-W, Ki: 1-7 μM	Mcl-1, Ki: 1-7 μM		Bcl-B, Ki: 1-7 μM
IMB-XH1				Mcl-1						≥98.0%
(+)-Apogossypol	Bcl-2, EC₅₀: 2.8 μM	Bcl-xL, EC₅₀: 3.69 μM		Mcl-1, EC₅₀: 2.6 μM
BBR-BODIPY							Bax			98.15%
PUMA BH3								Bak, Kd: 26 nM		98.24%
Thevetiaflavone	Bcl-2						Bax			≥98.0%
PZ703b TFA		Bcl-xL								98.62%
(S)-Gossypol (acetic acid)	Bcl-2	Bcl-xL								98.39%
WEHI-539		Bcl-xL, IC₅₀: 1.1 nM
Mcl1-IN-9				Mcl-1, Ki: 0.03 nM
PROTAC Bcl-xL degrader-3		Bcl-xL
PROTAC Bcl-xL degrader-1		Bcl-xL
Bcl-2-IN-2	Bcl-2, IC₅₀: 0.034 nM	Bcl-xL, IC₅₀: 43 nM
AZD-5991 Racemate				Mcl-1, IC₅₀: 3 nM
AZD-5991 (S-enantiomer)				Mcl-1, IC₅₀: 6.3 μM Mcl-1, Kd: 0.98 μM
BPA-B9	Bcl-2			Mcl-1
(E)-Mcl-1 inhibitor 7				Mcl-1, Ki: <10 nM Mcl-1, IC₅₀: <500 nM
Mcl-1 inhibitor 3				Mcl-1, IC₅₀: 19 nM Mcl-1, Ki: 0.061 nM
Amantadine sulfate	Bcl-2						Bax
BM 957	Bcl-2, IC₅₀: 5.4 nM Bcl-2, Ki: 1.2 nM	Bcl-xL, IC₅₀: 6.0 nM Bcl-xL, Ki: <1 nM
Mcl-1 inhibitor 12				Mcl-1, Ki: 0.22 nM
Jaceosidin (Standard)							Bax
Bcl-2-IN-10							Bax
Antitumor agent-77	Bcl-2						Bax
Bcl-2-IN-4	Bcl-2, IC₅₀: 1.5 nM	Bcl-xL, IC₅₀: 411 nM
Lobetyol	Bcl-2						Bax
8α-Tigloyloxyhirsutinolide 13-O-acetate	Bcl-2	Bcl-xL		Mcl-1
A09-003				Mcl-1
TRP-601	Bcl-2
MNK8	Bcl-2									99.76%
Bcl-2/Mcl-1-IN-2	Bcl-2, Ki: 4.70 μM			Mcl-1, Ki: 0.88 μM
BRD4 Inhibitor-15	Bcl-2						Bax
Antitumor agent-78	Bcl-2						Bax
JNJ-4355				Mcl-1, Ki: 18 pM
BM-1074	Bcl-2, IC₅₀: 1.8 nM	Bcl-xL, IC₅₀: 6.9 nM
SMBA1							Bax, Ki: 43.3 nM
Apoptotic agent-2	Bcl-2						Bax
Bcl-2-IN-9	Bcl-2, IC₅₀: 2.9 μM (^[1])
Bcl-2-IN-11	Bcl-2, IC₅₀: 0.9 nM	Bcl-xL, IC₅₀: >1000 nM
KRN5500	Bcl-2
LSD1-IN-26	Bcl-2
Bcl-2/Mcl-1-IN-1	Bcl-2, Ki: 4.53 μM			Mcl-1, Ki: 1.19 μM
Anticancer agent 64	Bcl-2						Bax
Bcl-2-IN-5	Bcl-2, IC₅₀: 0.12 nM
Mcl-1 inhibitor 13				Mcl-1, Ki: 8.2 nM
CYD-4-61							Bax
Bcl-2-IN-6	Bcl-2						Bax
Aviculin	Bcl-2						Bax
Bcl-2/Mcl-1-IN-3	Bcl-2, Ki: 0.23 μM	Bcl-xL, Ki: 15 μM		Mcl-1, Ki: 0.14 μM
Bcl-2-IN-7	Bcl-2						Bax
Anticancer agent 201	Bcl-2	Bcl-xL
Astin B	Bcl-2						Bax
EGFR-IN-109	Bcl-2						Bax
CDK1/2/4-IN-1	Bcl-2						Bax
Dehydrobruceine B	Bcl-2	Bcl-xL					Bax
Apoptotic agent-3	Bcl-2						Bax
Anticancer agent 43							Bax			98.58%
PZ703b hydrochloride		Bcl-xL								99.18%
anti-TNBC agent-3	Bcl-2
Anticancer agent 65	Bcl-2						Bax
Anticancer agent 63	Bcl-2
Furowanin A				Mcl-1
PUMA BH3 TFA								Bak, Kd: 26 nM
Spicamycin	Bcl-2
Bak BH3		Bcl-xL

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