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Results for "

glycoproteins

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glycoprotein VI (4) P-glycoprotein (95) 5-HT Receptor (5) ADC Cytotoxin (4) Adrenergic Receptor (1) AMPK (1) Antibiotic (8) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (17) Arenavirus (3) Autophagy (5) Bacterial (11) BCRP (7) Biochemical Assay Reagents (14) c-Met/HGFR (2) Calcium Channel (10) CaMK (1) Cannabinoid Receptor (1) Carbonic Anhydrase (2) CD28 (2) CETP (1) CFTR (3) Chloride Channel (2) Cholinesterase (ChE) (1) CMV (1) Cytochrome P450 (12) Dopamine Receptor (5) Drug Metabolite (4) Endogenous Metabolite (27) FGFR (1) Filovirus (8) Fluorescent Dye (6) Fungal (2) Glucosidase (1) Glutathione S-transferase (1) HBV (1) HIV (8) HIV Protease (5) HSV (5) iGluR (1) Influenza Virus (4) Integrin (17) Interleukin Related (1) Isotope-Labeled Compounds (8) Liposome (1) LYTACs (1) Mesothelin (1) Microtubule/Tubulin (7) Mitochondrial Metabolism (4) Mucin (1) NF-κB (1) Opioid Receptor (2) P-selectin (2) P2Y Receptor (3) Parasite (4) Potassium Channel (3) PPAR (1) Prostaglandin Receptor (1) Protease Activated Receptor (PAR) (3) Pyroptosis (1) RABV (9) Ras (1) Reactive Oxygen Species (2) RSV (3) SARS-CoV (14) Ser/Thr Protease (2) Serotonin Transporter (1) sFRP-1 (2) Syk (3) TAM Receptor (2) Transferrin Receptor (2) VSV (1) Wnt (2) β-catenin (1)
By Research Areas:	Cancer (117) Cardiovascular Disease (35) Endocrinology (6) Infection (68) Inflammation/Immunology (39) Metabolic Disease (32) Neurological Disease (21)
Click Chemistry:	Labeling and Fluorescence Imaging (1) DBCO (2) Azide (1) Alkynes (1)

277

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Glycoprotein VI P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108560

(+)-Fluprostenol

Prostaglandin Receptor Others

(+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1) .

(+)-Fluprostenol	Prostaglandin Receptor	Others
(+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1) .

HY-W097785

4-Methoxybenzamidine 4-Methoxybenzimidamide	Biochemical Assay Reagents	Metabolic Disease
4-Methoxybenzimidamide is a reagent used for the determination of reducing carbohydrates and glycoproteins.

HY-D2278

GDP-Fucose-Cy5

Fluorescent Dye Others

GDP-Fucose-Cy5 is a fluorescent dye that can be used for labeling free glycans, glycoproteins and glycolipids .

GDP-Fucose-Cy5	Fluorescent Dye	Others
GDP-Fucose-Cy5 is a fluorescent dye that can be used for labeling free glycans, glycoproteins and glycolipids .

HY-161160

Ac4ManNDAz	Others	Others
Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .

HY-149649

SARS-CoV-2-IN-64

SARS-CoV Infection

SARS-CoV-2-IN-64 (compound 9), a chenodeoxycholic acid derivative, is a potent inhibitor of spike glycoprotein of SARS-CoV-2 .
HY-157999

SDI-118

Others Neurological Disease

SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC₅₀ of 13 nM .

SARS-CoV-2-IN-64	SARS-CoV	Infection
SARS-CoV-2-IN-64 (compound 9), a chenodeoxycholic acid derivative, is a potent inhibitor of *spike glycoprotein* of SARS-CoV-2** .

SDI-118	Others	Neurological Disease
SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC₅₀ of 13 nM .

HY-P4086

*Chimeric Rabies Virus Glycoprotein* Fragment (RVG-9R)**	RABV	Infection
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R), a chimeric peptide consisting of 29 amino acids, is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is positively charged and able to bind negatively charged nucleic acids via charge interaction .

HY-P3267

Transferrins	Transferrin Receptor	Others
Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron .

HY-N10627

NA2 Glycan	Others	Others
NA2 Glycan is NA2 N-linked oligosaccharide. NA2 is the asialo-substructure of A2 glycan. NA2 glycan can be isolated from mammalian serum glycoproteins, such as serum IgG .

HY-150756

EBOV-GP-IN-1

Filovirus Infection

EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC₅₀ of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP) .

EBOV-GP-IN-1	Filovirus	Infection
EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC₅₀ of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP) .

HY-P9934

Abciximab C7E3	Integrin	Cardiovascular Disease
Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors .

HY-P99102

Zinlirvimab

10-1074
HIV Infection

Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) .

Zinlirvimab 10-1074	HIV	Infection
Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) .

HY-P0074

GPRP 1 Publications Verification Gly-Pro-Arg-Pro; Pefa 6003	Integrin	Cardiovascular Disease
GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-P99624

Foravirumab

CR4098
RABV Infection

Foravirumab (CR4098) is a monoclonal antibody against rabies virus glycoprotein antigenic site III .

Foravirumab CR4098	RABV	Infection
Foravirumab (CR4098) is a monoclonal antibody against rabies virus glycoprotein antigenic site III .

HY-124871

LASV inhibitor 3.3	Arenavirus	Infection
LASV inhibitor 3.3 is a Lassa fever virus (LASV) inhibitor. LASV inhibitor 3.3 binds with LASV glycoprotein (GP) and promotes virus membrane fusion and infection. LASV inhibitor 3.3 can be used for LASV infection research .

HY-P0074A

GPRP acetate 1 Publications Verification Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate	Integrin	Cardiovascular Disease
GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-115911

GPVI antagonist 2	Glycoprotein VI	Cardiovascular Disease
GPVI antagonist 2 (Compound 1) is a potential antagonist of Glycoprotein VI (GPVI). IC₅₀ values of GPVI antagonist 2 are, respectively, 0.35 μM for collagen, 0.80 μM for CRP, 195.2 μM for convulxin and 81.38 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 2 is a promising antiplatelet agent .

HY-115912

GPVI antagonist 3	Glycoprotein VI	Cardiovascular Disease
GPVI antagonist 3 (Compound 2) is a potential antagonist of Glycoprotein VI (GPVI). IC₅₀ values of GPVI antagonist 3 are, respectively, 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin and 51.74 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 3 is a promising antiplatelet agent .

HY-P99104

Plutavimab

COVI-AMG; STI-2020
SARS-CoV Infection

Plutavimab a human IgG1-κ anti-SARS-CoV-2 antibody, targeting to Spike (S) glycoprotein receptor binding domain (RBD) .

Plutavimab COVI-AMG; STI-2020	SARS-CoV	Infection
Plutavimab a human IgG1-κ anti-SARS-CoV-2 antibody, targeting to Spike (S) glycoprotein receptor binding domain (RBD) .

HY-P99513

Zamerovimab CTB011; SYN023	RABV	Infection
Zamerovimab (CTB011; SYN023) is a mixture of human monoclonal antibodies consisting of CTB011 and CTB012. Zamerovimab binds to non-overlapping epitopes on rabies virus (RABV) glycoprotein, where CTB011 binds to antigenic site III. Zamerovimab can be used in rabies studies .

HY-P99615

Felvizumab

SB 209763; RSHZ19
RSV Infection

Felvizumab (SB 209763) is a humanized IgG1κ monoclonal antibody directed to distinct neutralizing epitopes on the F glycoprotein of RSV .

Felvizumab SB 209763; RSHZ19	RSV	Infection
Felvizumab (SB 209763) is a humanized IgG1κ monoclonal antibody directed to distinct neutralizing epitopes on the F glycoprotein of RSV .

HY-118297

Ac4ManNAz (80% α isomer) 2 Publications Verification	Biochemical Assay Reagents	Metabolic Disease
Ac4ManNAz (80% α isomer) is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins. Ac4ManNAz can be used for cell labeling, tracking and proteomic analysis. Ac4ManNAz (80% α isomer) contains Azide groups and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz (80% α isomer) can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-145644

Ogalvibart C-135-LS; BMS-986414	SARS-CoV	Infection
Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the *spike (S) glycoprotein* receptor-binding domain (RBD) of SARS-CoV-2**. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model .

HY-D1619

Cyanine3 hydrazide dichloride	Fluorescent Dye	Others
Cyanine3 hydrazide dichloride is a carbonyl reactive dye. Cyanine3 hydrazide dichloride allows the labelling of various carbonyl-containing molecules such as antibodies and other glycoproteins after oxidation by periodate, proteins or reducing sugars after oxidative stress or deamination .

HY-P5623B

RVG TFA RVG29 TFA; RDP TFA; Rabies Virus Glycoprotein-29 TFA	Bacterial	Infection
RVG TFA is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-P5623

RVG RVG29; RDP; Rabies Virus Glycoprotein-29	Bacterial	Infection
RVG (RVG29) is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-147063

N-Acetyl-α-D-glucosamine 1-phosphate disodium	Endogenous Metabolite	Others
N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P), an anomeric sugar phosphate, is a key intermediate in the biosynthesis of N-linked glycoproteins. N-acetyl-α-d-glucosamine 1-phosphate disodium is a metabolic precursor of the bacterial cell-wall components teichoic acid and mureine .

HY-145383

Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide	Fluorescent Dye	Others
Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is a clickable, acid-cleavable biotin-picolyl azide. Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is an enrichment handle of cell surface glycoproteins for protein labeling .

HY-P2508

MUC1, mucin core	Mucin	Cancer
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .

HY-P2560

LCMV GP (61-80)	Arenavirus	Infection Inflammation/Immunology
LCMV GP (61-80) is a peptide fragment derived from lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP), and corresponds to amino acids 61-80. LCMV GP (61-80) is a specific epitope which can induce CD4 ⁺ T-cell response .

HY-114351

BODIPY FL hydrazide	Fluorescent Dye	Others
BODIPY FL Hydrazide is a green-fluorescent dye, BODIPY FL Hydrazide is reactive with aldehyde/ketone on polysaccharides and glycoproteins, yielding a reversible Schiff base product that can be transformed to a stable linkage using a reducing agent like sodium borohydride or sodium cyanoborohydride. (λ_ex=495 nm, λ_em=516 nm) .

HY-N10177

Peniterphenyl A	HSV	Infection
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits HSV-1/2 virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-160877

EBOV-IN-2	Filovirus	Infection
EBOV-IN-2 (Compound 2) is an inhibitor of Ebola virus (EBOV) with IC₅₀ values of 0.37 μM and 2.54 against Ebola virus glycoprotein pseudotype virus (pEBOV) and African swine fever virus (ASFV), respectively .

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-126666

PNU-159682 carboxylic acid	ADC Cytotoxin	Inflammation/Immunology Cancer
PNU-159682 carboxylic acid (compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response .

HY-146332

Collagen-IN-1	Others	Cardiovascular Disease
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC₅₀ value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research .

HY-P4743

*FITC-εAhx-HHV-2 Envelope Glycoprotein* G (561-578)**	HSV	Infection
FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a FITC labeled HHV-2 Envelope Glycoprotein G (561-578). HHV-2 Envelope Glycoprotein G (561-578) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera .

HY-P1843

Glycoprotein (276-286)	Arenavirus	Infection
Glycoprotein (276-286) is a Db-restricted peptide derived from lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP), corresponds to amino acids 276-286[1].

HY-P0285

Rabies Virus Glycoprotein	RABV	Infection
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-P4318

*HHV-2 Envelope Glycoprotein* G (552-574)**	HSV	Infection
HHV-2 Envelope Glycoprotein G (552-574) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera .

HY-P0285A

*Rabies Virus Glycoprotein* TFA** 1 Publications Verification	RABV	Infection
Rabies Virus Glycoprotein (TFA) is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells .

HY-U00247

MCI826

P-glycoprotein Cancer

MCI826 is a P-glycoprotein (P-gp) antagonist.

MCI826	P-glycoprotein	Cancer
MCI826 is a *P-glycoprotein* (P-gp) antagonist.

HY-125486

Reversin 121	P-glycoprotein	Cancer
Reversin 121 is a *P-glycoprotein* inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers .

HY-P99764

Odesivimab REGN-3471	Filovirus	Infection
Odesivimab is a human monoclonal antibody, targeting Ebola virus glycoprotein with a K_D value of 7.74 nM for recombinant histidine-tagged Makona strain Ebola virus glycoprotein ectodomain protein. Odesivimab can be used in research of Ebola virus infection .

HY-P2929

PNGase F 1 Publications Verification	Biochemical Assay Reagents Glucosidase	Cancer
PNGase F, a glycosidase, catalyzes the cleavage of an internal glycoside bond in an oligosaccharide. PNGase F removes nearly all N-linked oligosaccharides from glycoproteins. PNGase F can release N-glycans from glycoproteins in glycoanalytical workflows .

HY-19626

NSC23925

P-glycoprotein Cancer

NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor.
HY-107760

Decanoyl-RVKR-CMK

DecRVKRcmk
HIV Infection Inflammation/Immunology

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication .

NSC23925	P-glycoprotein	Cancer
NSC23925 is a novel, selective and effective *P-glycoprotein* (Pgp) inhibitor.

HY-107760A

Decanoyl-RVKR-CMK TFA 1 Publications Verification DecRVKRcmk TFA	HIV	Infection Inflammation/Immunology
Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication .

HY-13646

Encequidar

3 Publications Verification

HM30181; HM30181A
P-glycoprotein Metabolic Disease

Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein.

HY-13646A

Encequidar mesylate 3 Publications Verification HM30181 mesylate; HM30181A mesylate	P-glycoprotein	Cancer
Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent *P-glycoprotein* inhibitor.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P2352

Fetuin, Fetal Bovine Serum 2 Publications Verification	Natural Products Animals Source classification Metabolic Disease Disease Research Fields	Others
Fetuin, Fetal Bovine Serum is a liver-secreted 64 kDa plasma glycoprotein isolated from fetal bovine serum. Fetuin, Fetal Bovine Serum inhibits trypsin activity and promote cellular attachment, growth, and differentiation .

HY-147063

N-Acetyl-α-D-glucosamine 1-phosphate disodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P), an anomeric sugar phosphate, is a key intermediate in the biosynthesis of N-linked glycoproteins. N-acetyl-α-d-glucosamine 1-phosphate disodium is a metabolic precursor of the bacterial cell-wall components teichoic acid and mureine .

HY-N10177

Peniterphenyl A	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	HSV
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits HSV-1/2 virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-N12840

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-P0285

Rabies Virus Glycoprotein	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	RABV
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-I0400

N-Acetylneuraminic acid 2 Publications Verification NANA; Lactaminic acid	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides	Influenza Virus Endogenous Metabolite
N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells.

HY-N10075

Euphohelioscopin A	Structural Classification Terpenoids Source classification Euphorbia helioscopia L. Diterpenoids Euphorbiaceae Plants	P-glycoprotein
Euphohelioscopin A is a diterpenoid can be isolated from the Euphorbia helioscopia L. plant. Euphohelioscopin A weakly inhibits P-glycoprotein-mediated efflux of mitoxantrone .

HY-W009141

1-Monopalmitin Glyceryl palmitate	Source classification Plants	P-glycoprotein
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

HY-101916

Heparan Sulfate 10+ Cited Publications	Structural Classification Polysaccharides Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	FGFR Wnt Endogenous Metabolite
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

HY-121793

Roemerine (-)-Roemerine	Structural Classification Aporphine Alkaloids Classification of Application Fields Source classification Fibraurea recisa Pierre Plants Nymphaeaceae Menispermaceae Alkaloids Nelumbo nucifera Gaertn. Isoquinoline Alkaloids Disease Research Fields Cancer	P-glycoprotein Endogenous Metabolite
Roemerine, an aporphine alkaloid, isolated from the leaves of Fibraurea recisa Pierre, functions by interacting with *P-glycoprotein*. Roemerine reverses the multidrug-resistance phenotype with cultured cells .

HY-N0425

Epoxylathyrol	Structural Classification Classification of Application Fields Euphorbia boetica Terpenoids Source classification Diterpenoids Euphorbiaceae Plants Disease Research Fields Cancer	P-glycoprotein
Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a *P-glycoprotein* (P-gp)** inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser .

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Cyclopeptides Source classification Other Diseases Antibacterial Disease Research Disease Research Fields	Bacterial Antibiotic
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of *P-glycoprotein* and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-N1941

Isosinensetin	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Plants Inflammation/Immunology Disease Research Fields	P-glycoprotein Bacterial
Isosinensetin, a polymethoxylated flavone extracted from pericarpium citri reticulatae viride, exhibits inhibition on *P-glycoprotein* (P-gp)** in MDR1-MDCKII cells .

HY-N2103

Tenacissoside G	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	P-glycoprotein
Tenacissoside G is a C21 steroid from the stems of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells .

HY-N6932

Voacamine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Indole Alkaloids	Cannabinoid Receptor P-glycoprotein
Voacamine, an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity . Voacamine also inhibits *P-glycoprotein* (P-gp) action in multidrug-resistant tumor cells .

HY-N1916

Coniferyl ferulate	Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Dicerothamnus rhinocerotis Phenylpropanoids Umbelliferae Plants Disease Research Fields Cancer	Glutathione S-transferase P-glycoprotein
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.

HY-113044

Uridine diphosphate glucose	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite P2Y Receptor
Uridine diphosphate glucose is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine diphosphate glucose is an agonist of the P2Y₁₄ receptor, a neuroimmune system GPCR ^1.

HY-N6684

Deoxynivalenol 4 Publications Verification Vomitoxin	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Disease Research Fields	Others
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N10491

Spongionellol A	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer .

HY-N0144

Piperine 5+ Cited Publications Bioperine; 1-Piperoylpiperidine	Structural Classification Classification of Application Fields Source classification Piperaceae Plants Endogenous metabolite Piper nigrum Linn. Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	P-glycoprotein Autophagy Endogenous Metabolite
Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of *P-glycoprotein* and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-N4108

Hypophyllanthin	Phyllanthus urinaria Linn. Structural Classification Classification of Application Fields Source classification Lignans Euphorbiaceae Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	P-glycoprotein
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits *P-glycoprotein* (P-gp)** activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .

HY-19332

Kifunensine 3 Publications Verification FR-900494	Alkaloids Piperidine Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Others
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-N11287

UDP-xylose	Structural Classification Alkaloids Microorganisms Source classification	Endogenous Metabolite
UDP-xylose is a natural product that could be isolated from Cryptococcus laurentii (NRRL Y-1401). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi .

HY-N3197

Neostenine (+)-Neostenine	Structural Classification Alkaloids Pyrrole Alkaloids Stemonaceae Other Alkaloids Source classification Plants Stemona sesslifolia	P-glycoprotein
Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of *P-glycoprotein* with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .

HY-N3085

Phellamurin	Flavanonols Phellodendron amurense Rupr. Flavonoids Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	P-glycoprotein Apoptosis
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal *P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis* and has anti-tumor activity .

HY-P3160

Fibronectin 2 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Integrin
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

HY-126854

N-Acetyllactosamine N-Acetyl-D-lactosamine	Structural Classification Natural Products Microorganisms	Endogenous Metabolite
N-Acetyllactosamine (LacNAc), a nitrogen-containing disaccharide, is an important component of various oligosaccharides such as glycoproteins and sialyl Lewis X. N-Acetyllactosamine can be used as the starting material for the synthesis of various oligosaccharides. N-Acetyllactosamine has prebiotic effects .

HY-N10562

Mutabilol	Terpenoids Labiatae Smallanthus uvedalia (Linnaeus) Mackenzie Diterpenoids Plants	P-glycoprotein
Mutabilol (compound 1) is a potent *p-glycoprotein* (P-gp)** regulator. Mutabilol is a nature product could be isolated from Plectranthus mutabilis leaves. Mutabilol increases the P-gp expression in NCI-H460/R cells .

HY-N11287A

UDP-xylose disodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
UDP-xylose disodium is a natural product that could be isolated from Cryptococcus laurentii (N RRL Y-1401). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi ..

HY-N2947

Boeravinone B	Natural Products other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	P-glycoprotein
Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress .

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Endogenous Metabolite
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .

HY-N7032

Uridine 5′-diphosphoglucose disodium salt 3 Publications Verification UDP-D-Glucose disodium salt	Natural Products Source classification Endogenous metabolite	Endogenous Metabolite P2Y Receptor
Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y₁₄ receptor, a neuroimmune system GPCR .

HY-126940

Furanodiene	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Disease Research Fields Cancer Zingiberaceae	Reactive Oxygen Species P-glycoprotein Apoptosis
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level .

HY-N0692

Schisandrol B 1 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	Reactive Oxygen Species Cytochrome P450 Autophagy
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of *P-glycoprotein* and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N10492

Spongionellol A analog 1	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer .

HY-N3028

Taccalonolide B	Structural Classification Classification of Application Fields Source classification Schizocapsa plantaginea Hance Plants Disease Research Fields Taccaceae Steroids Cancer	Microtubule/Tubulin
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Plants Solanaceae Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and *P-glycoprotein* inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-N0639

Punicalin	Structural Classification Punica granatum L. Classification of Application Fields Source classification Phenols Polyphenols Punicaceae Plants Inflammation/Immunology Disease Research Fields	HBV Pyroptosis Carbonic Anhydrase
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of *S-glycoprotein* and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-W415798

Ac4GalNAlk	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .

HY-17367

Atazanavir 10+ Cited Publications BMS-232632	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of *P-glycoprotein* (P-gp) . Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀** of 3.49 μM .

HY-17367A

Atazanavir sulfate 10+ Cited Publications BMS-232632 sulfate	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of *P-glycoprotein* (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀** of 3.49 μM .

HY-147089

PRRSV/CD163-IN-1	Infection Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Bacterial Endogenous Metabolite
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) .

HY-N2416

Taccalonolide A	Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities . Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-N2453

Convallatoxin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Adonis amurensis Regel et Radde Plants Inflammation/Immunology Disease Research Fields	PPAR NF-κB P-glycoprotein
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-A0098

Tunicamycin Maximum Cited Publications 81 Publications Verification	Structural Classification Antifungal Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Antiviral Anticancer Inflammation/Immunology Disease Research Fields	Bacterial Fungal Influenza Virus Antibiotic
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity .Tunicamycin increases exosome release in cervical cancer cells .

HY-N10564

8α,9α-Epoxycoleon-U-quinone	Structural Classification Ketones, Aldehydes, Acids Labiatae Smallanthus uvedalia (Linnaeus) Mackenzie Plants	P-glycoprotein
8α,9α-Epoxycoleon-U-quinone (compound 3) is a *p-glycoprotein* (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp** activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX .

Cat. No.	Product Name	Chemical Structure

HY-135328AS

Norverapamil-d7 hydrochloride
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-110232

Risperidone-d4
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-A0064S

Verapamil-d3 hydrochloride

Verapamil-d₃ (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-135336S

(R)-Verapamil-d7 hydrochloride
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2].

HY-14275S1

Verapamil-d7
Verapamil-d₇ is the deuterium labeled Verapamil (HY-14275). Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation *P-glycoprotein* (P-gp) inhibitor. Verapamil also inhibits CYP3A4**. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-A0064S1

Verapamil-d6 hydrochloride

Verapamil-d₆ (CP-16533-1-d₆) hydrochloride is the deuterium labled Verapamil (hydrochloride) (HY-A0064). Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

HY-11018S2

Risperidone-d6
Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively .

HY-N7032S1

Uridine 5′-diphosphoglucose-13C6 disodium

Uridine 5′-diphosphoglucose- ¹³C₆ (disodium) is the ¹³C labeled Uridine 5′-diphosphoglucose disodium salt[1]. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[2].

HY-17367S3

Atazanavir-d5
Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S2

Atazanavir-d9
Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S4

Atazanavir-d6
Atazanavir-d₆ is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

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