2. Gene
  3. Mtor - mechanistic target of rapamycin kinase Gene

Mtor - mechanistic target of rapamycin kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Frap1; RAFT1

Gene ID: 56718 | Gene type: protein coding

About Mtor

Primary_assembly 5: 158,884,804-158,994,311 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 102 phenotypes. Biased expression in Kidney (RPKM 158.6), Heart (RPKM 127.5) and 9 other tissues.

Summary

Enables several functions, including protein kinase binding activity; protein serine/threonine kinase activity; and translation regulator activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of cellular protein metabolic process; and regulation of muscle adaptation. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in cytosol and nucleus. Part of TORC1 complex. Is active in glutamatergic synapse and postsynaptic cytosol. Colocalizes with dendrite and neuronal cell body. Used to study several diseases, including artery disease (multiple); brain disease (multiple); crescentic glomerulonephritis; kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including middle cerebral artery infarction; obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human mTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mtor Products(1)

mRNA Protein Name
NM_019906.2 NP_063971.1 serine/threonine-protein kinase mTOR

Mtor Protein Structure

TEL1

TEL1: COG5032 (362 - 2548)

HEAT

HEAT: sd00044 (654 - 680)

HEAT

HEAT: sd00044 (690 - 720)

HEAT

HEAT: sd00044 (728 - 758)

HEAT

HEAT: sd00044 (771 - 804)

HEAT

HEAT: sd00044 (816 - 846)

HEAT

HEAT: sd00044 (954 - 980)

HEAT

HEAT: sd00044 (992 - 1020)

HEAT

HEAT: sd00044 (1032 - 1061)

HEAT

HEAT: sd00044 (1072 - 1098)

HEAT

HEAT: sd00044 (1110 - 1141)

HEAT

HEAT: sd00044 (1153 - 1179)

  • 0
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  • 2000
  • 2400
  • 2549 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase mTOR

FK506 binding protein 12-rapamycin associated protein 1

FK506-binding protein 12-rapamycin complex-associated protein 1

FKBP12-rapamycin complex-associated protein

RAPT1

mammalian target of rapamycin

mechanistic target of rapamycin (serine/threonine kinase)

rapamycin and FKBP12 target-1 protein

rapamycin target protein 1

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10219 Rapamycin Inhibitor 99.94% Yes
HY-10218 Everolimus Inhibitor 99.85% Yes
HY-50910 Temsirolimus Inhibitor 99.56% Yes
HY-N0486 L-Leucine Activator 99.79% Unkown
HY-N0281 Daphnetin Inhibitor 99.86% Unkown
HY-B1232A Metyrapone Tartrate Modulator / Unkown
HY-10218R Everolimus (Standard) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (28)
Cat. No. Product Name Effect
Purity Phase
HY-50673 Dactolisib Inhibitor 99.94% Phase 3
HY-50908 Ridaforolimus Inhibitor 99.20% Phase 3
HY-15174 Dactolisib Tosylate Inhibitor 99.87% Phase 3
HY-13328 Sapanisertib Inhibitor 99.66% Phase 2
HY-139609 Camonsertib Inhibitor 99.75% Phase 2
HY-N0112 Dihydromyricetin Inhibitor 98.10% Phase 2
HY-114384 NV-5138 Activator ≥98.0% Phase 2
HY-15247 Vistusertib Inhibitor 98.21% Phase 2
HY-15177 PF-04691502 Inhibitor 99.91% Phase 2
HY-12513 Samotolisib Inhibitor 99.42% Phase 2
HY-114384B NV-5138 hydrochloride Activator ≥98.0% Phase 2
HY-15900 Voxtalisib Inhibitor 98.81% Phase 2
HY-13246 Apitolisib Inhibitor 99.65% Phase 2
HY-12868 Bimiralisib Inhibitor 99.80% Phase 2
HY-13334 BGT226 maleate Inhibitor 99.87% Phase 2
HY-16956 Onatasertib Inhibitor ≥97.0% Phase 2
HY-13334A BGT226 Inhibitor 99.51% Phase 2
HY-13691 MKC-1 Inhibitor 99.23% Phase 2
HY-10422 AZD-8055 Inhibitor 99.60% Phase 1
HY-10297 Omipalisib Inhibitor 99.93% Phase 1
HY-132168 RMC-5552 Inhibitor 98.10% Phase 1
HY-16962 CC-115 Inhibitor 95.76% Phase 1
HY-12036 GSK1059615 Inhibitor ≥99.0% Phase 1
HY-10423 OSI-027 Inhibitor 99.40% Phase 1
HY-16585 VS-5584 Inhibitor 99.14% Phase 1
HY-16962A CC-115 hydrochloride Inhibitor 98.03% Phase 1
HY-15248 GDC-0349 Inhibitor 96.46% Phase 1
HY-14581 Palomid 529 Inhibitor 99.47% Phase 1
Pre-clinical Phase
Bioactive Molecules (174)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0795 MHY1485 Activator 99.86% Unkown
HY-13003 Torin 1 Inhibitor 99.08% Unkown
HY-N0109 Salidroside Activator 99.79% Unkown
HY-13002 Torin 2 Inhibitor 99.98% Unkown
HY-122022 JR-AB2-011 Inhibitor 99.16% Unkown
HY-U00434 3BDO Activator 99.91% Unkown
HY-111373 RapaLink-1 Inhibitor 99.27% Unkown
HY-10474 Torkinib Inhibitor 98.37% Unkown
HY-10115 PI-103 Inhibitor 98.93% Unkown
HY-100542 D-α-Hydroxyglutaric acid disodium Inhibitor ≥98.0% Unkown
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.81% Unkown
HY-124798 Rheb inhibitor NR1 Inhibitor 99.46% Unkown
HY-N0047 Polyphyllin I Inhibitor 99.61% Unkown
HY-10681 Gedatolisib Inhibitor 99.68% Unkown
HY-N0189 Aloe emodin Inhibitor 98.32% Unkown
HY-50710 KU-0063794 Inhibitor 99.55% Unkown
HY-N0787 Cryptochlorogenic acid Inhibitor 99.88% Unkown
HY-124760 hSMG-1 inhibitor 11e Inhibitor 99.81% Unkown
HY-10044 WYE-132 Inhibitor 99.40% Unkown
HY-134904 RMC-6272 Inhibitor 95.54% Unkown
HY-13431 KU-0060648 Inhibitor 99.62% Unkown
HY-10372 PP121 Inhibitor 98.67% Unkown
HY-115449 Chromeceptin p53 Inhibitor 99.91% Unkown
HY-10683 PKI-402 Inhibitor 98.43% Unkown
HY-100222 CZ415 Inhibitor 98.74% Unkown
HY-W016412 Coenzyme Q0 Inhibitor 99.88% Unkown
HY-18353 mTOR inhibitor-3 Inhibitor 99.09% Unkown
HY-146751 PI3K/Akt/mTOR-IN-2 Inhibitor 99.86% Unkown
HY-N0486S9 L-Leucine-d3 Activator ≥98.0% Unkown
HY-N0486S1 L-Leucine-13C Activator ≥98.00% Unkown
HY-N6626 Pyraclostrobin 99.91% Unkown
HY-12034 WYE-354 Inhibitor 98.04% Unkown
HY-N0656A (+)-Usnic acid Inhibitor 99.63% Unkown
HY-12763 GNE-317 Inhibitor 99.14% Unkown
HY-10219S Rapamycin-d3 Inhibitor 95.48% Unkown
HY-107365 PQR530 Inhibitor 99.98% Unkown
HY-N6996 Methyl Eugenol Inhibitor 98.64% Unkown
HY-10115A PI-103 Hydrochloride Inhibitor 98.00% Unkown
HY-100026 PQR620 Inhibitor 98.01% Unkown
HY-15272 WAY-600 Inhibitor 99.75% Unkown
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 98.21% Unkown
HY-109046 Tulrampator 98.92% Unkown
HY-137175 TMBIM6 antagonist-1 Antagonist 99.60% Unkown
HY-110109 ETP-45658 Inhibitor 98.05% Unkown
HY-W058849 MT 63-78 Inhibitor 98.50% Unkown
HY-N0486S3 L-Leucine-15N Activator ≥98.0% Unkown
HY-N0107 Cyclovirobuxine D Inhibitor ≥98.0% Unkown
HY-15521 ETP-46464 Inhibitor 99.55% Unkown
HY-W592871 10-Hydroxy-2-decenoic acid 99.99% Unkown
HY-100470 NSC781406 Inhibitor 99.97% Unkown
HY-112914 mTOR inhibitor-1 Inhibitor 99.50% Unkown
HY-N0486S L-Leucine-d10 Activator ≥98.0% Unkown
HY-15271 WYE-687 Inhibitor 98.05% Unkown
HY-111508 PI3K/mTOR Inhibitor-2 Inhibitor 98.25% Unkown
HY-11080 PKI-179 Inhibitor ≥98.0% Unkown
HY-128333 PI3K/mTOR Inhibitor-4 Inhibitor 97.00% Unkown
HY-11042 GNE-477 Inhibitor 98.70% Unkown
HY-13806 XL388 Inhibitor 99.74% Unkown
HY-10811 GNE-493 Inhibitor 98.33% Unkown
HY-137315 TML-6 Inhibitor 99.01% Unkown
HY-136660 PQR626 Inhibitor 98.05% Unkown
HY-100398 PF-04979064 Inhibitor 99.83% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-141805 MHY-1685 Inhibitor 99.97% Unkown
HY-N6950 Hederacolchiside A1 Modulator 99.69% Unkown
HY-N0486S12 L-Leucine-d2 Activator ≥99.0% Unkown
HY-N6843 Arnicolide D Inhibitor 99.20% Unkown
HY-N0486S8 L-Leucine-13C6,15N Activator 99.90% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-118717 mTOR inhibitor WYE-28 Inhibitor 99.75% Unkown
HY-134903 (32-Carbonyl)-RMC-5552 Inhibitor 95.04% Unkown
HY-11080A PKI-179 hydrochloride Inhibitor 98.11% Unkown
HY-N0486S2 L-Leucine-13C6 Activator ≥98.0% Unkown
HY-153120A PI3K/mTOR Inhibitor-13 sodium Inhibitor 98.13% Unkown
HY-145931 CC214-2 Inhibitor 98.41% Unkown
HY-114267 Cbz-B3A Inhibitor ≥98.0% Unkown
HY-126077 MTI-31 Inhibitor 99.94% Unkown
HY-10812 GNE-490 Inhibitor 96.29% Unkown
HY-111065 OXA-01 Inhibitor / Unkown
HY-151622 PI3K/mTOR Inhibitor-11 Inhibitor 98.74% Unkown
HY-143510 RMC-4627 / Unkown
HY-131344 mTOR inhibitor-8 Inhibitor 98.04% Unkown
HY-124036 DS-7423 Inhibitor 99.75% Unkown
HY-N4315 Pomiferin Inhibitor 97.36% Unkown
HY-N2590 Lupenone ≥98.0% Unkown
HY-124582 NEO214 Activator ≥98.0% Unkown
HY-15271A WYE-687 dihydrochloride Inhibitor ≥98.0% Unkown
HY-12652 AZD3147 Inhibitor 99.93% Unkown
HY-163199 ASCT2-IN-2 Inhibitor / Unkown
HY-157169 IBL-302 Inhibitor / Unkown
HY-125927 8-Aminoadenosine Inhibitor 99.94% Unkown
HY-101776A Desmethyl-VS-5584 hydrochloride Inhibitor 98.63% Unkown
HY-10219GL Rapamycin (GMP Like) Inhibitor / Unkown
HY-151137 HSP90/mTOR-IN-1 Inhibitor / Unkown
HY-112602 PI3K/mTOR Inhibitor-1 Inhibitor / Unkown
HY-107363 FT-1518 Inhibitor 98.14% Unkown
HY-111370 mTOR inhibitor-2 Inhibitor / Unkown
HY-10218S Everolimus-d4 Inhibitor / Unkown
HY-N0486S11 L-Leucine-d1 Activator / Unkown
HY-147284 PI3K-IN-37 Inhibitor / Unkown
HY-147285 PI3K/mTOR Inhibitor-9 Inhibitor / Unkown
HY-10620 PI3K-IN-22 Inhibitor / Unkown
HY-127067 Yuanhuadin Inhibitor / Unkown
HY-154958 mTOR inhibitor-12 Inhibitor / Unkown
HY-146016 PI3K/mTOR Inhibitor-5 Inhibitor / Unkown
HY-123849 SN32976 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-144686 ATM Inhibitor-3 Inhibitor / Unkown
HY-115869 RMC-4529 Inhibitor / Unkown
HY-N0486S6 L-Leucine-2-13C,15N Activator / Unkown
HY-137996 Dehydrovomifoliol Inhibitor / Unkown
HY-15281 QL-IX-55 Inhibitor / Unkown
HY-144687 ATM Inhibitor-4 Inhibitor / Unkown
HY-13847 GNE-555 Inhibitor / Unkown
HY-N6626R Pyraclostrobin (Standard) / Unkown
HY-N0109R Salidroside (Standard) Activator / Unkown
HY-128027 eCF309 Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-141476 PI3K/mTOR Inhibitor-3 Inhibitor / Unkown
HY-144295 PI3Kα-IN-5 Inhibitor / Unkown
HY-154957 mTOR inhibitor-11 Inhibitor / Unkown
HY-N10754 Aschantin Inhibitor / Unkown
HY-155376 mTOR inhibitor-14 Inhibitor / Unkown
HY-162382 KTC1101 Inhibitor / Unkown
HY-137315S TML-6-d3 / Unkown
HY-15269 PP30 Inhibitor / Unkown
HY-N0486S4 L-Leucine-d7 Activator / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-N3628 Coronarin A Inhibitor / Unkown
HY-109633 PI3K-IN-18 Inhibitor / Unkown
HY-163511 PI3K/Akt/mTOR-IN-4 Inhibitor / Unkown
HY-113038 D-α-Hydroxyglutaric acid Inhibitor / Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.84% Unkown
HY-152238 PI3K/mTOR Inhibitor-12 Inhibitor / Unkown
HY-150061 NVP-BBD130 Inhibitor / Unkown
HY-155066 FD274 Inhibitor / Unkown
HY-15268 PP487 Inhibitor / Unkown
HY-163198 ASCT2-IN-1 Inhibitor / Unkown
HY-P5984A Thioether-cyclized helix B peptide, CHBP TFA Inhibitor / Unkown
HY-146200 PI3K/mTOR Inhibitor-8 Inhibitor / Unkown
HY-119665 Asteltoxin Inhibitor / Unkown
HY-N0486S10 L-Leucine-18O2 Activator / Unkown
HY-151915 ATR-IN-20 Inhibitor / Unkown
HY-147913 PI3K/Akt/mTOR-IN-3 Inhibitor / Unkown
HY-154910 CC214-1 Inhibitor / Unkown
HY-121726 3HOI-BA-01 Inhibitor / Unkown
HY-15901A LGB321 monohydrochloride Inhibitor / Unkown
HY-N0486S13 L-Leucine-15N,d10 / Unkown
HY-139832 MCX 28 Inhibitor / Unkown
HY-N1244 Sarmentosin Inhibitor / Unkown
HY-101776 Desmethyl-VS-5584 Inhibitor / Unkown
HY-N0486S5 L-Leucine-2-13C Activator / Unkown
HY-156445 PI3K/mTOR Inhibitor-14 Inhibitor / Unkown
HY-144449 mTOR/HDAC6-IN-1 Inhibitor / Unkown
HY-N2517 Dihydroevocarpine Inhibitor 99.62% Unkown
HY-147614 PI3K/mTOR Inhibitor-7 Inhibitor / Unkown
HY-103438 BIBU1361 / Unkown
HY-N1338 Royleanone Inhibitor / Unkown
HY-P5984 Thioether-cyclized helix B peptide, CHBP Inhibitor / Unkown
HY-118712 mTOR inhibitor WYE-23 Inhibitor / Unkown
HY-162147 Nur77 modulator 3 Inhibitor / Unkown
HY-160548 mTOR inhibitor-18 Inhibitor / Unkown
HY-162143 SKI-349 Inhibitor 99.58% Unkown
HY-156432 ALK-IN-26 Inhibitor 99.87% Unkown
HY-147613 PI3K/mTOR Inhibitor-6 Inhibitor / Unkown
HY-118704 P-2281 Inhibitor / Unkown
HY-10116 PI-540 Inhibitor / Unkown
HY-N0486S7 L-Leucine-1-13C,15N Activator ≥98.0% Unkown
HY-153120 PI3K/mTOR Inhibitor-13 Inhibitor / Unkown
HY-155211 mTOR inhibitor-13 Inhibitor / Unkown
HY-155475 mTORC1-IN-2 Inhibitor / Unkown
HY-157167 mTORC1-IN-1 / Unkown
HY-U00326 PI3Kα/mTOR-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtor NCBI NCBI:2475