Search Result
Results for "
Compound-2
" in MedChemExpress (MCE) Product Catalog:
5
Biochemical Assay Reagents
9
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N2138
-
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Others
|
Inflammation/Immunology
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Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 % .
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-
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- HY-U00358
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-
-
- HY-101730
-
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Bacterial
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Infection
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Antibacterial compound 2 is a useful antibacterial agent extracted from patent US5652238, compound example 9.
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-
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- HY-N1722
-
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Others
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Others
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(–)-Erythro-saccharinic acid lactone (compound2) can be isolated from the leaves of Talauma arcabucoana .
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-
-
- HY-161006
-
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Others
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Inflammation/Immunology
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(S)-TETS-C4-acid (Compound 2d) is a hapten coupled directly to a carrier protein through a carboxylic acid functionality. (S)-TETS-C4-acid (Compound 2d) can be used to detect tetramethylenedisulfotetramine (TETS) .
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-
-
- HY-149216
-
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Others
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Cancer
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Anticancer agent 103 (Compound 2k) is a potent anticancer agent .
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-
-
- HY-133232
-
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Others
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Others
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Sonnerphenolic B (compound 2) is a phenolic that can be found in Sonneratia ovata .
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-
-
- HY-N2888
-
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Others
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Others
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Araneosol (Compound 2) is a flavonoid that can be isolated from Herissantia tiubae .
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-
-
- HY-114147
-
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Bacterial
|
Infection
Inflammation/Immunology
|
Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against agent-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability .
|
-
-
- HY-147257
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HSK7653
|
Dipeptidyl Peptidase
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Metabolic Disease
|
Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 diabetes mellitus (T2DM) .
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-
-
- HY-34487S
-
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Isotope-Labeled Compounds
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Others
|
1,3-Dimethoxybenzene-d10 is the deuterium labeled 1,3-Dimethoxybenzene[1]. 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds[2].
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-
-
- HY-34487S1
-
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Isotope-Labeled Compounds
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Others
|
1,3-Dimethoxybenzene-d4 is the deuterium labeled 1,3-Dimethoxybenzene[1]. 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds[2].
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-
-
- HY-34487S2
-
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Isotope-Labeled Compounds
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Others
|
1,3-Dimethoxybenzene-d6 is the deuterium labeled 1,3-Dimethoxybenzene[1]. 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds[2].
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-
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- HY-N3987
-
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Others
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Others
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Hancinone C (compound 2) is a natural product that can be found in Piper hancei .
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-
-
- HY-N3969
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(+)-Goniotriol
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Others
|
Others
|
Goniotriol(compound 2) is a styrylpyronethat can be found in Goniothalamus amuyon. Goniotriolshows cytotoxicity .
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-
-
- HY-N12304
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Others
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Others
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Xanthalin (compound 2) is a characteristic component isolated from Peucedanum ledebourielloides root .
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-
-
- HY-N12167
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Others
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Others
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3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide .
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-
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- HY-127029A
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Others
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Others
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Umbelliprenin (compound 2) can be isolated from the chloroform extract of the roots of Heptaptera cilicica .
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-
-
- HY-132273
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-
-
- HY-N1277
-
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Others
|
Others
|
Dimethyl secologanoside (compound 2) is an e iridoid isolated from the leaves of Khaya senegalensis .
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-
-
- HY-N9277
-
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Others
|
Others
|
β-Furoyleupatolide (Compound 2) is a compound that can be isolated from Helogyne apaloidea .
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-
-
- HY-162296
-
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Fungal
|
Infection
|
Antibacterial agent 188 (compound 2d) is an antibacterial agent that inhibits dermatophyte activity .
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-
-
- HY-N9408
-
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Others
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Others
|
Furostan, β-D-glucopyranoside deriv (compound 2) is a oligofurostanoside that can be found in Asparagus cochinchinensis.
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-
-
- HY-146658
-
|
Glutaminase
|
Cancer
|
Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor with an IC50 of 2.3 μM .
|
-
-
- HY-N2857
-
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Others
|
Others
|
Alpinumisoflavone (compound 2) is a flavonoid derivative isolated from the stem bark of Erythrina lysistemon Hutch .
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-
-
- HY-W068420
-
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Others
|
Cancer
|
Antioxidant agent-4 (Compound 2) is an effective antioxidant molecule with antilipid peroxidative activity .
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-
-
- HY-137037
-
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Others
|
Cancer
|
Ingenol 20-palmitate (compound 2) is a diterpene that can be found in Euphorbia lath yris .
|
-
-
- HY-157170
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-
-
- HY-N8892
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-
-
- HY-N12585
-
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Others
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Others
|
Picfeltarraegenin I (Compound 2) is a cucurbitacin that can be isolated from Picria fel-terrae Lour .
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-
-
- HY-121834
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-
-
- HY-N10892
-
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Others
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Others
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Officinaruminane B (compound 2), a diarylheptanoid, is a nature product that could be isolated from the rhizome of Alpinia officinarum .
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-
-
- HY-103074
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Others
|
Neurological Disease
|
GSK2226649A (compound 2) is a novel activator of satellite cell proliferation and enhanced repair of damaged muscle .
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-
-
- HY-N12251
-
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Others
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Others
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Gymnoside IX (compound 2) can be isolated from the methanolic extract from the tubers of Gymnadenia conopsea .
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-
-
- HY-N1350
-
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Others
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Others
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Riligustilide (compound 2) is a kind of phthalide dimer. Riligustilide can be isolated from the radix of Angelica sinensis .
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-
-
- HY-157117
-
|
ICMT
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Cancer
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ICMT-IN-49 (compound 2) is an inhibitor of ICMT (IC50=0.12 μM) .
|
-
-
- HY-N12427
-
|
Tyrosinase
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Cancer
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Litchinol B (compound 2) is a non-competitive tyrosinase inhibitor with an inhibition constant of 5.70 μM .
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-
-
- HY-N12923
-
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Others
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Others
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IB-96212 aglycone (Compound 2) is the hydrolyzate of IB-96212 (HY-161239A) .
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-
-
- HY-18928
-
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FAK
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Cancer
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FAK inhibitor 5 (compound 2) is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range .
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-
-
- HY-N1592
-
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Others
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Others
|
15-Methoxypatagonic acidz (compound 2) is a clerodane diterpenoid compound isolated from the leaves of Casearia sylvestris .
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-
-
- HY-W010562
-
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Others
|
Others
|
2-Methoxypyrazine is an active compound. 2-Methoxypyrazine can be used for the research of various biochemical studies .
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-
-
- HY-151927
-
-
-
- HY-156668
-
-
-
- HY-N8319
-
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Others
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Others
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Leojaponin (compound 2 ) is a labdane diterpene. Leojaponin can be isolated from the EtOH extract of the herb Leonurus japonicus .
|
-
-
- HY-P5699
-
|
Bacterial
|
Infection
|
Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL .
|
-
-
- HY-156826
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-
-
- HY-W710914A
-
-
-
- HY-158303
-
-
-
- HY-132130
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-
-
- HY-136485
-
|
FLAP
|
Cancer
|
FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor .
|
-
- HY-144980
-
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Ligands for E3 Ligase
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Cancer
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E3 ligase Ligand 21 (compound 2) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .
|
-
- HY-153448
-
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MAP4K
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Cancer
|
HPK1-IN-36 (compound 2) is a potent HPK1 inhibitor with an IC50 value of 0.5 nM .
|
-
- HY-156752
-
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Others
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Others
|
Cyclosiversioside F 16,25-diacetate (Compound 6), a glycoside, is an alkaline hydrolysis product of Acetyl Derivative (Compound 2) .
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-
- HY-N4064
-
|
Others
|
Others
|
Hederagenic acid (compound 2) is a kind of triterpenoid saponin. Hederagenic acid can be isolated from the roots of Kalopanax septemlobus (Thunb.) Koidz .
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-
- HY-N8675
-
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Others
|
Others
|
Olivil-4'-O-β-glucopyranoside (Compound 2) is a lignin derived from Jasminum tortuosum stems .
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-
- HY-N12192
-
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Others
|
Others
|
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .
|
-
- HY-156133
-
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Others
|
Others
|
Dihydrospinosyn A aglycone (compound 2) is a derivative of spinosyn A aglycone with a hydrolyzed C9- and C17-glycosidic bond.
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-
- HY-131451
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-
- HY-N2210
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8-Methyl-naringenine
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Others
|
Inflammation/Immunology
|
5,7,4'-Trihydroxy-8-Methylflavanone (Compound 2) is a flavanone isolated from Qualea grandiflora .
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-
- HY-147050
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-
- HY-N1263
-
|
Others
|
Inflammation/Immunology
|
Scutebarbatine X (Compound 2) is a neo-clerodane diterpenoids isolated from Scutellaria barbatae (Labiatae) and has anti-inflammatory properties .
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-
- HY-W063197
-
|
Adenosine Receptor
|
Cancer
|
Adenosine receptor antagonist 4 (compound 2) is an adenosine A1 receptor antagonist with a Ki of 101 nM for human A1 receptor .
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-
- HY-122946
-
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Keap1-Nrf2
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Others
|
Pterisolic acid B (Compound 2) is an ent-Kaurane diterpenoid. Pterisolic acid B can be isolated from fern Pteris semipinnata (Pteridaceae) .
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-
- HY-N12376
-
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Others
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Others
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Renchangianin B (compound 2) is dibenzo cyclooctene-type lignan. Renchangianin B can be isolated from the stems of Kadsura renchangiana .
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-
- HY-147050A
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-
- HY-N10433
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Icarisids E
|
Xanthine Oxidase
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Metabolic Disease
|
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 31.81 μM .
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-
- HY-N8608
-
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Others
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Others
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2''-O-Acetyl-platyconic acid A is an active compound. 2''-O-Acetyl-platyconic acid A can be used for the research of various biochemical .
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-
- HY-N10935
-
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Others
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Others
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2-Desoxyflorilenalin-L-α-arabinopyranoside is an active compound. 2-Desoxyflorilenalin-L-α-arabinopyranoside can be isolated from Helenium amarum .
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-
- HY-N3303
-
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Others
|
Others
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Meliasenin B (compound 2) is an apotirucallane-type triterpenoid. Meliasenin B is a nature product that could be isolated from the fruits of Melia azedarach .
|
-
- HY-103079
-
|
Phosphatase
|
Cancer
|
PRL-3 Inhibitor 2 (compound 2) is a potent PRL-3 inhibitor with an IC50 value of 28.1 µM .
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-
- HY-153673
-
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IRAK
|
Cancer
|
PROTAC IRAK4 degrader-8 (compound 2) is a PROTAC targeting to IRAK4 (IC50=15.5 nM) .
|
-
- HY-W718146
-
|
HIV
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Others
|
Tremuloidin (Compound 2) is a salicylic acid derivative derived from Homalium cochinchinensis. Tremuloidin has a weak activity against HIV-1 .
|
-
- HY-161005
-
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Others
|
Metabolic Disease
|
TETS-Methyl benzoate(compound 2j) is a haptendirectly conjugated to the carrier protein via carboxylic acid function using the standard activated ester method .
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-
- HY-N12638
-
|
Vasopressin Receptor
|
Endocrinology
|
Endolide F (Compound 2) is a proline-containing lactone. Endolide F is a moderate antagonist of the arginine antidiuretic hormone V1A receptor .
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-
- HY-163361
-
|
PI3K
|
Cancer
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PI3Kα-IN-20 (compound 2) is a selective PI3Kα inhibitor .
|
-
- HY-N12107
-
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Others
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Others
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N-[(Z)-Hexadec-9-enoyl]homoserine lactone (Compound 2) is a compound that can be isolated from Roseovarius tolerans .
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-
- HY-W070306
-
-
- HY-70028
-
|
MDM-2/p53
E1/E2/E3 Enzyme
|
Cancer
|
p53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins.
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-
- HY-151566
-
|
Ras
Farnesyl Transferase
Fungal
|
Infection
|
Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase .
|
-
- HY-N8600
-
-
- HY-N12250
-
|
Others
|
Cancer
|
7-Deoxynarciclasine (compound 2b) can be isolated from Hymenocallis littoralis. 7-Deoxynarciclasine inhibits the cancer cell growth .
|
-
- HY-134929
-
|
Hexokinase
|
Infection
|
Hexokinase 2 inhibitor 1 (Compound 2a) is a hexokinase 2 (HK2) inhibitor with anti-tumor activity and can be used in cancer research .
|
-
- HY-111798A
-
-
- HY-N9192
-
|
Others
|
Others
|
2,2-Dimethyl-8-prenylchromene 6-carboxylic acid (compound 2) is a natural product that can be found in Piper aduncum .
|
-
- HY-N3871
-
|
Others
|
Others
|
Ethyl β-D-ribo-hexopyranosid-3-ulose (Compound 2) is a natural product that can be isolated from Coleus forskohlii .
|
-
- HY-156601A
-
-
- HY-155318A
-
|
Others
|
Endocrinology
|
GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC50of 260 nM .
|
-
- HY-157215
-
|
HDAC
|
Cancer
|
HDAC-IN-66 (compound 2F) is a selective HDAC inhibitor and Pomalidomide (HY-10984) derivative that potently inhibits hematological tumor cells .
|
-
- HY-163095
-
|
Autophagy
|
Neurological Disease
|
RH1115 (compound 2c) is a modulator of the autophagy-lysosome. RH1115 induces changes to LAMP1 vesicle properties and alters lysosome positioning .
|
-
- HY-162138
-
-
- HY-163520
-
-
- HY-111758
-
|
PROTACs
Raf
|
Cancer
|
PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity .
|
-
- HY-34544
-
|
Others
|
Others
|
2-Hexylthiophene is an extremely weak basic heteroaromatic compound. 2-Hexylthiophene can be used to modify and improve the molar absorption coefficient of ruthenium sensitizer
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-
- HY-128407
-
Phenylglyoxal hydrate
|
Others
|
Metabolic Disease
|
2,2-Dihydroxy-1-phenylethan-1-one (compound 2d) is an intermediate of pharmaceutical synthesis with antioxidant property .
|
-
- HY-136073
-
|
Wnt
|
Cancer
|
Wnt pathway activator 2 is a potent Wnt activator extracted from patent WO2012024404A1, compound 2, has an EC50s of 13 nM .
|
-
- HY-153214
-
|
Wnt
β-catenin
|
Cancer
|
YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. YW2036 can be used in research of cancer .
|
-
- HY-128427
-
|
SARS-CoV
|
Infection
|
PLpro-IN-1 (Compound 2) is a SARS-CoV PLpro inhibitor (IC50: 8.7 μM). PLpro-IN-1 can be used for antiviral research .
|
-
- HY-149468
-
|
HBV
|
Infection
|
Antiviral agent 38 (compound 2.1-1) is a potent antiviral agent. Antiviral agent 38 can be used for hepatitis B virus (HBV) research .
|
-
- HY-155236
-
-
- HY-155836
-
|
Others
|
Metabolic Disease
|
hPL-IN-1 (compound 2t) is a reversible inhibitor of pancreatic lipase (PL) (IC50=1.86 μM) for anti-obesity research .
|
-
- HY-N12660
-
|
Bacterial
|
Infection
|
Quorum Sensing-IN-4 (compound 2) is a quorum sensing inhibitor, and can be isolated from Thailand mangrove-derived Streptomyces strain, OUCMDZ-5511 .
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-
- HY-113753
-
|
Antibiotic
|
Infection
|
PDF-IN-1 (compound 2) is a potential Peptide deformylase (PDF) inhibitor. PDF-IN-1 can be used for the development of new broad-spectrum antibiotics 。
|
-
- HY-144030
-
|
RET
|
Others
|
RET-IN-12 (compound 2) is a RET inhibitor, with IC50 values of 0.3 nM and 1 nM for RET(WT) and RET(V804M), respectively .
|
-
- HY-144744
-
|
NF-κB
|
Cancer
|
NF-κB-IN-3 (Compound 2) is a NF-κB inhibitor with an IC50 of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent .
|
-
- HY-N10438
-
|
Integrin
|
Inflammation/Immunology
|
Ganodermaones B (Compound 2) is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .
|
-
- HY-N10817
-
|
Others
|
Others
|
(2S)-5-Methoxyflavan-7-ol (compound 2) is a nature product that could be isolated form Dragon's blood resin .
|
-
- HY-N10937
-
|
Others
|
Others
|
2-Desoxypleniradin-L-α-arabinopyranoside, 2-acetate is an active compound. 2-Desoxypleniradin-L-α-arabinopyranoside, 2-acetate can be isolated from Helenium amarum .
|
-
- HY-153763
-
|
Others
|
Neurological Disease
|
PROT-IN-1 (Compound 2) is a proline transporter (PROT) inhibitor (IC50: 1.48 μM). PROT-IN-1 can be used for research of cognitive disorders .
|
-
- HY-W560689
-
|
DNA/RNA Synthesis
|
Cancer
|
DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells .
|
-
- HY-155462
-
|
Bacterial
|
Infection
|
hERG-IN-1 (compound 2a) is an antibacterial agent and inhibitor of hERG. hERG-IN-1 inhibits pulmonary infection caused by Pseudomonas aeruginosa strain ATCC 27853 .
|
-
- HY-N12584
-
|
Others
|
Others
|
Pulchinenoside E4 (compound 2) is an oleanane-type triterpenoidal saponin that can be found in the roots ofPulsatilla chinensis . Pulchinenoside E4 shows cytotoxic activity .
|
-
- HY-163353
-
|
Bacterial
Fungal
|
Infection
|
Antibacterial agent 193 (Compound 2n) is A monobenzene derivative of spiromarone A, which has antibacterial activity against Rhizoctonia solani. with IC50 value of 5.25 μg/mL .
|
-
- HY-162304
-
|
MAGL
|
Neurological Disease
|
MAGL-IN-14 (compound 2) is a potent inhibitor of MAGL, with IC50 of 0.00289 μM and 0.002 μM in HEK293 and PC3 cells, respectively .
|
-
- HY-N1375
-
|
Others
|
Cancer
|
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .
|
-
- HY-138944
-
|
SGLT
|
Metabolic Disease
|
SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor extract from WO2015032272A1, compound 2 .
|
-
- HY-143474
-
-
- HY-N3842
-
|
Others
|
Others
|
Ergosta-4,6,8(14),22-tetraen-3-one (compound 2) is a ergosteroid is isolated from the fruiting bodies of ganoderma applanatum .
|
-
- HY-W012258
-
2-Methoxy-10H-phenothiazine
|
Others
|
Others
|
2-Methoxyphenothiazine (2-Methoxy-10H-phenothiazine) is an active compound. 2-Methoxyphenothiazine can be used for the research of various biochemical studies .
|
-
- HY-148231
-
-
- HY-155837
-
|
Others
|
Metabolic Disease
|
hPL-IN-2 (compound 2u) is a potent, reversible, and non-competitive inhibitor of pancreatic lipase (IC50: 1.63 μM) and can be used in anti-obesity research .
|
-
- HY-N3687
-
|
Others
|
Cancer
|
Dasycarpol (compound 2) is a product of microbial transformation of fraxinellone by Aspergillus niger (AS 3.421). Dasycarpol shows moderate cytotoxicity against A549 cells ,with the IC50 of 20 ug/mL .
|
-
- HY-160647
-
|
CCR
|
Inflammation/Immunology
|
CCR8 antagonist 3 (compound 2) is a CCR8 antagonist with an IC50 value of 0.062 µM. CCR8 antagonist 3 shows human microsomal stability .
|
-
- HY-132820
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VX-147
|
Others
|
Others
|
Inaxaplin (VX-147) is an orally active apolipoprotein L1 (APOL1) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease .
|
-
- HY-150584
-
|
Fungal
|
Infection
|
Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC50 value of 0.16 mM, and MIC of 1 µg/mL against candida albicans. Antifungal activity .
|
-
- HY-149167
-
|
Liposome
Biochemical Assay Reagents
|
Others
|
mRNA-Encapsulating Lipid Excipient 1 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. mRNA-Encapsulating Lipid Excipient 1 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .
|
-
- HY-155645
-
|
Topoisomerase
Apoptosis
|
Cancer
|
Topoisomerase II inhibitor 15 (compound 2g) is a Topoisomerase II inhibitor. Topoisomerase II inhibitor 15 potently is an apoptotic inducer with greater selectivity against head and neck tumors .
|
-
- HY-W681071
-
-
- HY-129144
-
|
Others
|
Cancer
|
Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .
|
-
- HY-N12022
-
|
Others
|
Neurological Disease
|
7(18)-Dehydroschisandro A (Compound 2) is a lignan can be isolated from Schizandra chinensis Baill. 7(18)-Dehydroschisandro A has inhibitory effects on stress gastric ulcer .
|
-
- HY-155498
-
|
GABA Receptor
|
Neurological Disease
|
TETS-4-Methylaniline (compound 2k) is a hapten. TETS-4-Methylaniline conjugates to the carrier protein via using either diazotization or glutaraldehyde methods .
|
-
- HY-N12601
-
|
Apoptosis
|
Cancer
|
Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells .
|
-
- HY-N12703
-
|
Others
|
Inflammation/Immunology
|
N-Acetyldopamine dimmers A (Compound (+)-2) can be isolated from the cast-off shell of the cicada of Cryptotympana sp. N-Acetyldopamine dimmers A increases collagen and α-SMA expression .
|
-
- HY-162446
-
|
Ras
|
Cancer
|
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC50s of 2.75 nM and 2.89 nM for G12D and G12V, respectively
|
-
- HY-136645
-
|
Prostaglandin Receptor
|
Cancer
|
EP4 receptor antagonist 2 (compound 2-13) is a potent EP4 receptor antagonist with an IC50 of 7.8 nM. EP4 receptor antagonist 2 shows antitumor activity .
|
-
- HY-135376
-
|
Others
|
Metabolic Disease
|
Atorvastatin methyl ester (Compound 2a) is a methyl esterified derivative of Atorvastatin. Atorvastatin methyl ester inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin .
|
-
- HY-144697
-
-
- HY-143480
-
-
- HY-W048488
-
|
DNA/RNA Synthesis
|
Others
|
2'-O-MOE-5-Me-rU is an active compound. 2'-O-MOE-5-Me-rU can be used for oligonucleotide synthesis .
|
-
- HY-W048497
-
|
DNA/RNA Synthesis
|
Others
|
2'-O-MOE-5-Me-rC is an active compound. 2'-O-MOE-5-Me-rC can be used for oligonucleotide synthesis .
|
-
- HY-155037
-
|
Others
|
Cancer
|
VE-PTP-IN-1 (compound 2) is a weakly acidic and selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP).VE-PTP-IN-1 is assocaited with vascular homeostasis and angiogenesis.
|
-
- HY-155411
-
-
- HY-120979
-
|
Others
|
Cardiovascular Disease
|
NO-Losartan A (compound 2a) displays vasorelaxing effects, due to the release of NO, and antagonized the vasocontractile effects of Angiotensin II (HY-13948), with potency values similar to that of Losartan (HY-17512) .
|
-
- HY-161336
-
|
Others
|
Cancer
|
Alendronate prodrug-1(compound 2) is an inhibitor of farnesyl diphosphate synthase (FPPS). Alendronate prodrug-1 has an antiproliferative effect with an IC50 value of 34.0 μM .
|
-
- HY-120538
-
-
- HY-100004
-
|
Mitochondrial Metabolism
|
Cancer
|
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM .
|
-
- HY-117089
-
|
Fungal
|
Infection
|
Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields . Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds .
|
-
- HY-144209
-
|
CD73
|
Cancer
|
CD73-IN-6 is a CD73 inhibitor extracted from patent WO2022007677A1 compound 2. CD73-IN-6 can be used for the research of cancer .
|
-
- HY-146586
-
|
Haspin Kinase
CDK
DYRK
|
Cancer
|
Haspin-IN-1 (compound 2a) is a haspin inhibitor with an IC50 of 119 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 221 nM and 916.3 nM, respectively .
|
-
- HY-N4153
-
|
Others
|
Others
|
1-Methyl-2, 8-dihydroxy3-carboxy-9, 10-anthraquinone (compound 2) is compound isolated from the roots of Rheum palmatum .
|
-
- HY-147887
-
|
Microtubule/Tubulin
|
Cancer
|
Tubulin inhibitor 28 (compound 2g) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 28 shows anti-proliferative activity for MCF-7 cells .
|
-
- HY-147979
-
|
CXCR
|
Infection
Cancer
|
CXCR4 antagonist 9 (Compound 2) is a CXCR4 antagonist with an IC50 of 15 nM. CXCR4 antagonist 9 inhibits CXCL12 induced cytosolic calcium increase with an IC50 of 1.3 nM .
|
-
- HY-156522
-
|
CFTR
|
Endocrinology
|
CRF1 receptor antagonist-1 (Compound 2) is a CRF1 receptor antagonist. CRF1 receptor antagonist-1 can be used for research of congenital adrenal hyperplasia (CAH) .
|
-
- HY-155831
-
|
HCV
|
Infection
|
HCV-IN-43 (compound 2) is an HCV NS5B protein inhibitor that can effectively inhibit the replication of HCV virus. HCV-IN-43 can be used for the study of HCV infection .
|
-
- HY-N1716
-
|
Parasite
|
Infection
|
2’’-Acetylastragalin (Compound 2) is a compound isolated from the aerial parts of Delphinium staphisagria, with an IC50 value of 6.5 μM for Vero cells. 2’’-Acetylastragalin has trypanoidal activity .
|
-
- HY-160519
-
|
Bacterial
Antibiotic
|
Infection
|
Targocil-II (Compound 2) is an ABC transporter inhibitor with a IC50 value of 137 nM. Targocil-II prevents ATP hydrolysis by binding to allosteric sites of the TM domain. Targocil-II has (antibacterial) activity .
|
-
- HY-144971
-
|
Molecular Glues
CDK
|
Cancer
|
dCeMM2 (Compound 2) is a glue degrader. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex .
|
-
- HY-145418
-
|
IRE1
|
Others
|
IRE1α kinase-IN-3 (compound 2) is a potent IRE1α inhibitor with an Ki of 480 nM. IRE1α kinase-IN-3 is the ATP-competitive ligands of IRE1α .
|
-
- HY-146331
-
|
Bacterial
Antibiotic
|
Infection
|
PC190723 (Compound 2) is an inhibitor of the bacterial cell division protein FtsZ with an IC50 of 55 ng/ml. FtsZ-IN-3 exhibits anti-staphylococcal activity with MIC values of 1 µg/ml for MSSA and MRSA .
|
-
- HY-147553
-
|
HIV
|
Infection
|
HIV-1 inhibitor-36 (Compound 2) is a potent HIV-1. HIV-1 inhibitor-36 has the potential for further development as novel latency reversing agents .
|
-
- HY-144722
-
|
Bacterial
|
Infection
|
Antitubercular agent-12 (Compound 2c) is an antitubercular agent (MIC = 1.439 μg/mL). Antitubercular agent-12 shows greatly lower cytotoxicity (CC50: 57.34 μg/mL) .
|
-
- HY-18849
-
|
ERK
|
Cancer
|
ERK2-IN-3 (compound 2) is a inhibitor of ERK2, and inhibits Erk2 WT and Erk2 DS1 activation loop phosphorylation, with IC50 of 5 μM and 42 nM, respectively .
|
-
- HY-N1947
-
|
Others
|
Others
|
Ligurobustoside N (compound 2) is an antioxidative glycoside that can be isolated from the Leaves of Ligustrum robustum. Ligurobustoside N shows antioxidant effects and shows inhibition for AAPH (HY-Y0525) induced hemolysis .
|
-
- HY-163395
-
|
Parasite
|
Infection
|
3-Tosylimidazolidine-2,4-dione (compound 2C) is a hydantoins derivative, and exhibits inhibitory activity against the Pf3D7 strain, with an IC50 value of 3.97 nM .
|
-
- HY-163491
-
|
Wee1
|
Cancer
|
PKMYT1-IN-2 (compound 2) is a potent PKMYT1 inhibitor with an IC50 of 5.7 nM. PKMYT1-IN-2 inhibits the growth of HCC1569 cells with an IC50 of 22 nM .
|
-
- HY-160250
-
|
UGT
|
Metabolic Disease
|
UGT1A1-IN-1 (compound 2) is a non-competitive inhibitor of UGT1A1, which can inhibit the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. UGT1A1-IN-1 (compound 2) can bind on UGT1A1 at the same ligand-binding site as bilirubin (HY-N0323). UGT1A1-IN-1 can serve as a ‘turn-on’ fluorescent probe substrate for UGT1A1 .
|
-
- HY-W009708
-
|
Others
|
Others
|
Bis(2-methyl-3-furyl)disulfide, compound (2), is intended to provide a flavoring compound to enhance a natural feeling, a fresh feeling and a milk-rich feeling of a milk-related product .
|
-
- HY-W011955
-
|
Adenosine Receptor
|
Cardiovascular Disease
|
8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) is a selective adenosine A1 receptor antagonist with Kis of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively .
|
-
- HY-143303
-
|
Apoptosis
|
Cancer
|
Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer .
|
-
- HY-153940
-
|
Ras
|
Cancer
|
SOS1/KRAS-IN-1(Compound 2) is a SOS1/KRAS inhibitor, which can be used in the research of SOS1/KRAS-mediated diseases .
|
-
- HY-157143
-
|
Bacterial
|
Infection
|
Antibacterial agent 164 (compound 2a) is an antibacterial and antibiofilm agent. Antibacterial agent 164 inhibits S. aureus and B. subtilis (MIC of 0.09 mM), and also exhibits strong anti-B. Subtilis biofilm formation .
|
-
- HY-B0503
-
Thiouracil
|
NO Synthase
|
Endocrinology
Cancer
|
2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM [2].
|
-
- HY-115948
-
|
Others
|
Cancer
|
Antitumor agent-46 (Compound 2h) is an anti-tumor agent. Antitumor agent-46 demonstrates markedly higher antiproliferative activity on MCF-7 cells with an IC50 value of 2.08 µM .
|
-
- HY-142940
-
|
ROR
|
Inflammation/Immunology
|
RORγt modulator 5 is a RORγt modulator with a Ki value of <100 nM. RORγt modulator 5 has the potential for inflammatory, metabolic, autoimmune and other diseases mediated by RORy study (WO2017132432A1; compound 2) .
|
-
- HY-147528
-
|
mGluR
|
Neurological Disease
|
mGluR2 modulator 2 (compound 2) is a potent, selective and orally bioavailable mGluR2 positive allosteric modulator with an EC50 value of 0.13 μM. mGluR2 modulator 2 can be used for researching antipsychotic .
|
-
- HY-146106
-
|
Bacterial
Fungal
|
Infection
|
Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
|
-
- HY-143496
-
|
RSV
Influenza Virus
|
Infection
|
RSV-IN-4 (Compound 2) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-4 shows anti-RSV activity (EC50 = 11.76 μM) .
|
-
- HY-150027
-
|
VEGFR
PDGFR
|
Cancer
|
Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively .
|
-
- HY-151145
-
|
Glucosidase
|
Metabolic Disease
|
α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity .
|
-
- HY-151371
-
|
CDK
|
Cancer
|
CDK8-IN-10 (compound 2) is a potent, selective cyclin-dependent kinase (CDK8) inhibitor with an IC50 value of 8.25 nM. CDK8-IN-10 can be used for research of cancer .
|
-
- HY-W010562S
-
|
Isotope-Labeled Compounds
|
Others
|
2-Methoxypyrazine-d3 is the deuterium labeled 2-Methoxypyrazine[1]. 2-Methoxypyrazine is an active compound. 2-Methoxypyrazine can be used for the research of various biochemical studies[2].
|
-
- HY-153565
-
|
Others
|
Inflammation/Immunology
|
Immune cell migration-IN-1 (compound 2) is a potent agent to inhibit immune cell migration. Immune cell migration-IN-1 can be used for research in alleviating dry eye diseases, eczema dermatitis and psoriasis .
|
-
- HY-N11880
-
|
COX
|
Cancer
|
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .
|
-
- HY-161236
-
|
Ras
|
Cancer
|
KRAS ligand 4 (Compound 2) is a bifunctional depressant based on SOS1. KRAS ligand 4 reduces the downstream signaling markers pERK and pS6 and shows anti-proliferative activity in multiple KRAS mutated cells .
|
-
- HY-162331
-
|
STING
|
Inflammation/Immunology
Cancer
|
STING Degrader-1 (compound 2) is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 induces STING degradation through a ubiquitin-proteasome system-dependent pathway .
|
-
- HY-N12664
-
|
Glucosidase
|
Metabolic Disease
|
α-Glucosidase-IN-54 (compound 2) is a α-glucosidase inhibitor with the IC50 of 0.011 mM, and can be isolated form Syzygium jambos (L.). α-Glucosidase-IN-54 can be used for study of diabetes .
|
-
- HY-114173
-
-
- HY-117602
-
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
TLR7 agonist 3 (Compound 2) is a potent agonist of toll-like receptor 7 (TLR7). TLR7 has an important role in immune activation processes and represents an emerging agent discovery target for the development of immunomodulators .
|
-
- HY-W019829
-
|
Tyrosinase
Parasite
|
Infection
|
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities [2].
|
-
- HY-134377
-
ASP0367; MA-0211
|
PPAR
|
Metabolic Disease
|
Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta (PPAR-δ). Bocidelpar improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy (DMD) muscle cells (extracted from patent WO2017062468A1, compound 2b) .
|
-
- HY-142481
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 30 is a KRAS G12C inhibitor extracted from patent WO2021252339A1, compound 2. KRAS G12C inhibitor 30 can be used for the research of cancer .
|
-
- HY-N9253
-
|
Others
|
Others
|
2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one (Compound 2) is a pyranone isolated from the hexane extract of the aerial parts of Hypericum choisianum .
|
-
- HY-146030
-
|
Others
|
Cancer
|
Anticancer agent 46 (compound 2) is a potent anticancer agent. Anticancer agent 46 shows antiproliferative activity with an IC50 of 0.986 µM for MGC803 cells. Anticancer agent 46 has the potential for the research of gastric cancer .
|
-
- HY-112555
-
-
- HY-149061
-
|
Apoptosis
|
Cancer
|
Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect .
|
-
- HY-N12130
-
|
Others
|
Others
|
Celangulatin D (Compound 2) is an insecticidal sesquiterpene polyol ester isolated from the root bark of the natural Celastrus angulatus. Celangulatin D has insecticidal activity against armyworms. Celangulatin D can be used for insecticidal and anti-tumor research .
|
-
- HY-N12071
-
|
Others
|
Others
|
Lucidin-ω-Me ether (Compound 2) can be isolated from the roots of Knoxia valerianoides. Lucidin-ω-Me ether inhibits the advanced glycation end products (AGEs) formation in vitro(IC50: 62.79 μM) .
|
-
- HY-125603
-
|
Others
|
Neurological Disease
|
Termitomycamide B (compound 2) is a neuroprotective agent that can be obtained from Termitomyces titanicus. Termitomycamide B effectively inhibits endoplasmic reticulum stress-dependent cell death. Termitomycamide B can be used in the study of neurodegenerative diseases [2].
|
-
- HY-160877
-
|
Filovirus
|
Infection
|
EBOV-IN-2 (Compound 2) is an inhibitor of Ebola virus (EBOV) with IC50 values of 0.37 μM and 2.54 against Ebola virus glycoprotein pseudotype virus (pEBOV) and African swine fever virus (ASFV), respectively .
|
-
- HY-100734
-
|
Histone Acetyltransferase
|
Cancer
|
Histone Acetyltransferase Inhibitor II (compound 2c) is a potent, selective and cell permeable p300 histone acetyltransferase inhibitor, with an IC50 of 5 µM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells .
|
-
- HY-136535
-
hTrkA-IN-1
|
Trk Receptor
|
Inflammation/Immunology
|
Anizatrectinib (hTrkA-IN-1) is a potent and orally active inhibitor of TrkA kinase with an IC50 of 1.3 nM, compound 2 extracted from patent WO2015175788. Anizatrectinib can be used for the study of inflammatory disease, such as prostatitis, pelvic, et al .
|
-
- HY-111798
-
|
Reactive Oxygen Species
|
Cancer
|
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research .
|
-
- HY-129701
-
|
Bcl-2 Family
|
Cancer
|
MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively .
|
-
- HY-N10402
-
|
Fungal
Bacterial
Parasite
|
Infection
Cancer
|
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC50 of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .
|
-
- HY-143269
-
|
Amylases
Glucosidase
|
Metabolic Disease
|
HPA-IN-2 (Compound 2a-1) is a potent and selective human pancreatic α-amylase (HPA) inhibitor with IC50 values of 8.2 μM and 450.7 μM against HPA and α-glucosidase, respectively .
|
-
- HY-151205
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
Antituberculosis agent-3 (Compound 2) is an antituberculosis agent. Antituberculosis agent-3 shows anti-mycobacterial activity, and can inhibit M. tuberculosis H37Rv strain growth (MIC=12.5 μg/mL) .
|
-
- HY-151339
-
|
Bacterial
|
Infection
|
Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM .
|
-
- HY-148134
-
|
Lipoxygenase
|
Inflammation/Immunology
|
5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation .
|
-
- HY-148167
-
|
DNA/RNA Synthesis
Virus Protease
|
Infection
|
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral RNA polymerase inhibitor, thereby inhibiting RNA virus replication .
|
-
- HY-151628
-
|
Others
|
Cancer
|
MRV03-068 (Compound 2) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-068 can be used in colorectal cancer research .
|
-
- HY-155230
-
|
Bacterial
|
Infection
|
T3SS-IN-2 (Compound 2h) is a type three secretion system (T3SS) inhibitor. T3SS-IN-2 can be used for bacterial infection research .
|
-
- HY-156617A
-
|
ADC Cytotoxin
Topoisomerase
|
Cancer
|
(αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent. (αR)-Cyclopropaneacetamide-Exatecan inhibits U87MG and SK-BR-3 cells proliferation, with IC50s of 8.11 and 2.31 μM .
|
-
- HY-162040
-
|
P-glycoprotein
|
Cancer
|
P-gp inhibitor 17 (compound 2g) is a P-gp inhibitor directly interacted with the transmembrane domain of P-gp. P-gp inhibitor 17 can be used for P-gp-mediated multidrug-resistant in tumor cells study .
|
-
- HY-161330
-
|
Bacterial
|
Infection
|
Anti-MRSA agent 10 (Compound 2d) is a Cephalosporin (HY-144229) derivative and exhibits antibacterial activity. Anti-MRSA agent 10 is slightly drug resistane and exhibits low cytotoxicity in cells HUVEC and HBZY-1 .
|
-
- HY-143452
-
|
Tyrosinase
Bacterial
|
Inflammation/Immunology
|
MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent [2].
|
-
- HY-146020
-
|
Topoisomerase
|
Cancer
|
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines .
|
-
- HY-144673
-
-
- HY-154965
-
SIM0417; SARS-CoV-2-IN-41
|
SARS-CoV
|
Infection
|
SARS-CoV-2-IN-41 (compound 2) is a potent SARS-CoV-2 3CL pro inhibitor with an IC50 value of 0.022 µM. SARS-CoV-2-IN-41 shows antiviral effect .
|
-
- HY-156617
-
|
ADC Cytotoxin
Topoisomerase
|
Cancer
|
Cyclopropaneacetamide-Exatecan (Compound 2-A) is an ADC Cytotoxin and an Exatecan analogue. Cyclopropaneacetamide-Exatecan can be used in the synthesis of ADC such as anti-B7H3 antibody-Exatecan analogue conjugate (compound ADC-2) .
|
-
- HY-137978
-
GNS561
|
Others
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Ezurpimtrostat (compound 2-2) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases (extracted from patent WO2020048694 A1) .
|
-
- HY-146286
-
|
Apoptosis
|
Cancer
|
Anticancer agent 44 (compound 2a) is a potent anticancer agent. Anticancer agent 44 shows cytotoxicity activity in cancer cells. Anticancer agent 44 induces apoptosis. Anticancer agent 44 shows low toxicity towards activated lymphocytes of human blood .
|
-
- HY-147570
-
|
ATM/ATR
|
Cancer
|
ATR-IN-18 (compound 2) is an orally active and potent ATR kinase inhibitor, with an IC50 of 0.69 nM. ATR-IN-18 shows antiproliferative activity in LoVo cells, with an IC50 of 37.34 nM. ATR-IN-18 has anti-tumor activity .
|
-
- HY-34887
-
|
Others
|
Others
|
Acridone-4-carboxylic acid (ACA) (Compound 2c) is a heme-interacting acridone derivatives that prevents free heme-mediated protein oxidation and degradation. Acridone-4-carboxylic acid inhibits protein carbonyl formation with an IC50 of 43 μM .
|
-
- HY-Y1093S2
-
Ethyl acetylacetate-d5
|
Bacterial
|
Others
|
Ethyl acetoacetate-d5 is the deuterium labeled Ethyl acetoacetate[1]. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[2][3][4]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[5].
|
-
- HY-Y1093S3
-
|
Bacterial
|
Others
|
Ethyl acetoacetate- 13C is the 13C labeled Ethyl acetoacetate[1]. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[2][3][4]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[5].
|
-
- HY-157934
-
|
Monoamine Oxidase
|
Neurological Disease
|
MAO-IN-4 (Compound 2l) is a monoamine oxidase (MAO) inhibitor, with IC50 values of 0.07 and 0.75 μM for MAO-A and MAO-B Enzymes, respectively. MAO-IN-4 can be used for the research of depression and Parkinson’s disease (PD) .
|
-
- HY-158020
-
|
DNA/RNA Synthesis
|
Cancer
|
Anticancer agent 197 (compound 2b) shows cell cytotoxicity with IC50 values of 10.03 µM and 73.54 µM for HL-60 cells and A549 cells, respectively. Anticancer agent 197 can induce DNA damage .
|
-
- HY-130794
-
-
- HY-144311
-
-
- HY-126536
-
|
Chemerin Receptor
|
Inflammation/Immunology
|
ChemR23-IN-1 (compound 2) is a ChemR23 inhibitor with IC50s of 38 nM and 100 nM for human and mouse ChemR23, respectively. ChemR23-IN-1 inhibits chemotaxis of CAL-1 triggered by Chemerin in vitro .
|
-
- HY-146195
-
-
- HY-N10431
-
|
Keap1-Nrf2
|
Neurological Disease
|
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .
|
-
- HY-146327
-
|
Bacterial
Antibiotic
|
Infection
|
PqsR/LasR-IN-1 (compound 2a) is a potent PqsR and LasR systems inhibitor. PqsR/LasR-IN-1 has anti-virulence activity against Pseudomonas aeruginosa. PqsR/LasR-IN-1 can reduce production of biofilm, pyocyanin, and rhamnolipids in PA .
|
-
- HY-150583
-
|
Fungal
Antibiotic
|
Inflammation/Immunology
|
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .
|
-
- HY-147226
-
|
Prostaglandin Receptor
|
Neurological Disease
Endocrinology
|
EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research .
|
-
- HY-130076
-
|
MMP
|
Cancer
|
MMP-2 Inhibitor II (compound 2) is a selective MMP-2 inhibitor. The Kinetic parameters for MMP inhibition are 2.4 μM (MMP-2), 45 μM (MMP-1), and 379 μM (MMP-7), respectively .
|
-
- HY-121835
-
|
GCGR
|
Metabolic Disease
|
GLP-1R agonist 2 (compound 2) is a potent GLP-1R agonist. GLP-1R agonist 2 has the potential for the research of metabolic diseases like Type2 Diabetes and Obesity .
|
-
- HY-N10947
-
|
Others
|
Others
|
Lanosta-7,9(11),24-trien-3β,15α-dihydrcxy-26-oic acid (compound 2) is a nature product that could be isolated from the Chinese medicinal fungus Ganoderma lucidurn .
|
-
- HY-Y1093S1
-
|
Bacterial
|
Others
|
Ethyl acetoacetate- 13C4 is the 13C labeled Ethyl acetoacetate[1]. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[2][3][4]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[5].
|
-
- HY-149512
-
|
FGFR
VEGFR
|
Cancer
|
FGFR1/VEGFR2-IN-1 (compound 2b) is an FGFR1/VEGFR2 inhibitor. FGFR1/VEGFR2-IN-1 can be used for cancer research .
|
-
- HY-116198
-
|
15-PGDH
|
Metabolic Disease
|
15-PGDH-IN-2 (Compound 2) is a 15-PGDH inhibitor with an IC50 value of 0.274 nM. 15-PGDH-IN-2 can be used in research on hair loss, bone formation, gastric ulcer healing, and dermal wound healing .
|
-
- HY-Y0410
-
2-Iminobenzimidazoline; 1H-Benzimidazol-2-ylamine; 2-Benzimidazolamine
|
Biochemical Assay Reagents
|
Others
|
2-Aminobenzimidazole (2-Iminobenzimidazoline; 1H-Benzimidazol-2-ylamine; 2-Benzimidazolamine) is a heterocyclic aromatic compound. 2-Aminobenzimidazole is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-142830
-
|
Raf
|
Cancer
|
B-Raf IN 6 (compound 2c) is a potent inhibitor of protein kinase B-Raf with an IC50 of 1.7 nM. B-Raf IN 6 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease .
|
-
- HY-146290
-
|
Apoptosis
|
Cancer
|
Anticancer agent 46 (compound 2b) is a potent and selective anticancer agent. Anticancer agent 46 shows cytotoxicity activity in cancer cells. Anticancer agent 46 induces apoptosis. Anticancer agent 46 shows low toxicity towards activated lymphocytes of human blood .
|
-
- HY-153788
-
|
Casein Kinase
|
Cancer
|
CK2-IN-7 (compound 2) is an inhibitor of casein kinase 2 (CK2). CK2-IN-7 shows synergistic effect with structurally distinct CK2 chemical probe: SGC-CK2-1, against cancer .
|
-
- HY-155536
-
|
Parasite
|
Infection
|
Antimalarial agent 28 (Compound 2i) is an antiplasmodial agent. Antimalarial agent 28 inhibits P. berghei, with IC50s of 0.561 μM, 0.14 μM, 4.34 μM for Liver stage, early gametocytes and ring stages of P. falciparum .
|
-
- HY-153701
-
|
JAK
|
Cancer
|
JAK-IN-26 (compound 2) is an orally active JAK inhibitor with good pharmacokinetic characteristics. JAK-IN-26 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=17.2 nM) .
|
-
- HY-N12137
-
|
Others
|
Cancer
|
Glycoside St-J (Compound 2) is a triterpenoid saponin. Glycoside St-J has antitumor activity and inhibits HeLa cell proliferation. Glycoside St-J Isolates from natural Anemone flaccida. Glycoside St-J can be used in the development of new anticancer agents .
|
-
- HY-N1797
-
|
Others
|
Metabolic Disease
|
3, 7-di-o-methylducheside A (Compound 2) is a ethyl acetate extract of Psittacanthus cucullaris. 3, 7-di-o-methylducheside A stimulates the formation of glycosaminoglycan chains. 3, 7-di-o-methylducheside A can be used to study the rate of glycosaminoglycan synthesis .
|
-
- HY-135785
-
|
Acyltransferase
|
Metabolic Disease
|
OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells .
|
-
- HY-116463D
-
|
Sigma Receptor
|
Neurological Disease
|
(Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) used for the research of cognition/memory disorders .
|
-
- HY-139323
-
-
- HY-143899
-
|
Fungal
|
Infection
|
FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL .
|
-
- HY-145869
-
|
Others
|
Inflammation/Immunology
|
Anti-inflammatory agent 12 (Compound 2) is a pentacyclic triterpene compound. Anti-inflammatory agent 12 shows a significant bias in the LPS-induced inflammatory response with an IIC50 value of 2.22 μM. Anti-inflammatory agent 12 has the potential for the research of inflammation disease .
|
-
- HY-146319
-
-
- HY-147719
-
|
COX
|
Inflammation/Immunology
|
COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity .
|
-
- HY-150055
-
|
NO Synthase
|
Inflammation/Immunology
|
iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research .
|
-
- HY-151555
-
|
Fungal
|
Infection
|
Antifungal agent 44 (compound 2A-5) is an antifungal agent, and shows excellent fungicidal activity superior to Kresoxim-methyl (HY-125776). Antifungal agent 44 shows fungicidal activity against Phytophthora capsici most remarkably, with an EC50 value of about 5 μM .
|
-
- HY-W278582
-
|
Topoisomerase
Apoptosis
|
Cancer
|
Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO .
|
-
- HY-156188
-
|
Others
|
Others
|
AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of cholinesterase. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo .
|
-
- HY-123544
-
|
MDM-2/p53
|
Cancer
|
RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively .
|
-
- HY-160168
-
-
- HY-145571
-
D-1553
|
Ras
|
Cancer
|
Garsorasib is a potent inhibitor of KRAS G12C with an IC50 of 10 nM. Garsorasib has the potential for the research of various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (non-small cell lung cancer) (extracted from patent WO2020233592A1, compound 2) .
|
-
- HY-142675
-
|
Epigenetic Reader Domain
|
Cancer
|
BRD4-BD1/2-IN-2 is a potent BRD4 BD2 inhibitor with IC50s of <0.5 nM and <300 nM for BRD4 BD2 and BRD4 BD1, respectively (WO2021233371A1, compound 2) .
|
-
- HY-139331
-
|
Proteasome
|
Neurological Disease
Inflammation/Immunology
Cancer
|
20S Proteasome-IN-1 is a 26S proteasome inhibitor extracted from patent WO2006128196A2 compound 2. 20S Proteasome-IN-1 has the potential for cancer, immune-related disorders, inflammation, ischemic conditions, neurodegenerative disorders and other diseases research .
|
-
- HY-137978A
-
GNS561 hydrochloride
|
Others
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .
|
-
- HY-N11137
-
|
Bacterial
|
Infection
|
3′-Omethyl-5′-hydroxydiplacone (compound 2), an C-6-geranylflavonoid, can be isolated from the ethanol extract of Paulownia tomentosa fruits. 3′-Omethyl-5′-hydroxydiplacone has antibacterial activity against Gram-positive bacteria .
|
-
- HY-W027126
-
|
Apoptosis
|
Metabolic Disease
|
Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, displays a remarkable hepatoprotective effect. Hepatoprotective agent-2 has antiapoptotic activity. Hepatoprotective agent-2 notably prevents the chemically induced elevation of hepatic indicators associated with liver injury .
|
-
- HY-144824
-
|
Cytochrome P450
Monoamine Oxidase
|
Neurological Disease
Cancer
|
Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a highly potent monoamine oxidase (MAO) and aromatase dual inhibitor with IC50s of 39 nM and 31 nM for MAO-B and aromatase, respectively. Monoamine oxidase/Aromatase-IN-1 can be used for researching neurological disorder and breast cancer .
|
-
- HY-151204
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC50=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL) .
|
-
- HY-155597
-
|
NTPDase
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
h-NTPDase8-IN-1 (compound 2d) is a sulfamoyl-benzamides based and selective inhibitor for h-NTPDases8 (IC50=0.28 μM). h-NTPDases8 is involved in a variety of physiological and pathological functions,such as thrombosis,diabetes,inflammation,and cancer .
|
-
- HY-156736
-
|
17β-HSD
|
Cancer
|
HSD17B13-IN-3 (compound 2) is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor. HSD17B13-IN-3 does not have cell experimental activity .
|
-
- HY-149637
-
|
Sirtuin
HSP
|
Cancer
|
HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity .
|
-
- HY-156330
-
|
HIV
Cytochrome P450
|
Infection
|
HIV-IN-9 (Compound 2b) is a HIV inhibitor (IC50: 6.65 μg/mL), and has high binding affinity with HIV-RT. HIV-IN-9 also inhibits CYP3A4, CYP1A2, CYP2C1, and CYP2D6 .
|
-
- HY-N3879
-
|
Others
|
Others
|
Eudesm-4(14)-ene-3α,11-diol (compound 2) is a sesquiterpenoid. Eudesm-4(14)-ene-3α,11-diol can be isolated from Neocallitropsis Pancheri Florin .
|
-
- HY-157766
-
|
FAAH
TRP Channel
|
Inflammation/Immunology
|
FAAH/TRPV1 blocker-1 (compound 2R) is a dual FAAH/TRPV1 blocker, with IC50 of 0.12 and 94.9 μM, respectively. FAAH/TRPV1 blocker-1 plays an important role in analgesic and anti-inflammatory research .
|
-
- HY-119265
-
|
Acyltransferase
|
Metabolic Disease
|
LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC50 of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity .
|
-
- HY-W009245
-
|
HIV
|
Infection
|
Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation .
|
-
- HY-143322
-
|
Parasite
|
Infection
|
CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis .
|
-
- HY-153910
-
|
Others
|
Cancer
|
AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesenchymal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells .
|
-
- HY-155648
-
|
Bacterial
|
Infection
|
Tuberculosis inhibitor 6 (compound 2c) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC90 of ≤1.66 μM) and Mycobacterium marinum (MIC90 of 2.65 μM) .
|
-
- HY-155649
-
|
Bacterial
|
Infection
|
Tuberculosis inhibitor 7 (compound 2d) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC90 of 0.63 μM) and Mycobacterium marinum (MIC90 of 0.63 μM) .
|
-
- HY-139343
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .
|
-
- HY-139341
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .
|
-
- HY-122723
-
|
Others
|
Cancer
|
GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC) .
|
-
- HY-18773
-
|
Oct3/4
|
Inflammation/Immunology
|
Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer. Oct3/4-inducer-1 promotes expression and stabilization of Oct3/4, and enhances its transcriptional activity in diverse human somatic cells .
|
-
- HY-144212
-
|
Ras
|
Cancer
|
SOS1-IN-8 is a potent SOS1 inhibitor with IC50s of 11.6 and 40.7 nM for SOS1-G12D and SOS1-G12V, respectively (WO2022017339A1, compound 2) .
|
-
- HY-147746
-
|
MMP
|
Cancer
|
MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC50 values of 26.6, and 32 μM, respectively .
|
-
- HY-D0113
-
|
Reactive Oxygen Species
|
Others
|
7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .
|
-
- HY-147836
-
|
Akt
NF-κB
JNK
TNF Receptor
COX
|
Inflammation/Immunology
|
Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC50 of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities .
|
-
- HY-N10638
-
|
Reactive Oxygen Species
NF-κB
|
Inflammation/Immunology
|
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .
|
-
- HY-112505
-
|
BCRP
|
Cancer
|
Efflux inhibitor-1 (compound 2) is a pyrazolo[1,5-a]pyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets toward ABCG2/BCRP over ABCB1 with IC50s of 0.45 μM and 2.17 μM, respectively .
|
-
- HY-W088037S
-
|
Isotope-Labeled Compounds
|
Others
|
Tridecane-d28 is the deuterium labeled Tridecane[1]. Tridecane is a short chain aliphatic hydrocarbon containing 13 carbon atoms. Tridecane is an volatile oil component isolated from essential oil of Piper aduncum L. Tridecane is a stress compound released by the brown marmorated stink bugs stress compound[2][3].
|
-
- HY-155557
-
|
Apoptosis
|
Cancer
|
Anti-inflammatory agent 45 (compound 2v) is an anticancer agent with direct inhibitory effects on the growth of different blood cancers including leukemia, lymphoma and myeloma cell lines. Anti-inflammatory agent 45 induces apoptosis and inhibits NO production in HL60 leukemia cells (IC50=14.7 μM) .
|
-
- HY-149496
-
-
- HY-155768
-
|
COX
|
Cancer
|
COX-1/2-IN-5 (compound 2a) is a dual inhibitor of COX1/2 (IC50=2.650 μM, 0.958 μM), with anticancer activity. COX-1/2-IN-5 inhibits liver cancer HepG2 with an IC50 of 60.75 μM .
|
-
- HY-149420
-
|
Epigenetic Reader Domain
|
Others
|
BRD7-IN-2 (compound 2-77) is a potent inhibitor of bromodomain-containing protein 7 (BRD7), targeting to prostate cancer cells. BRD7-IN-2 is selective for BRD7 rather than BRD9, with IC50s of 5.4 μM, and >300 μM, respectively.
|
-
- HY-155389
-
|
Caspase
|
Cancer
|
Caspase-3 activator 2 (Compound 2f) is a caspase 3 activator that induces apoptosis and can be used in cancer research. Caspase-3 activator 2 is cytotoxic to HL-60 cells and K562 cells, with IC50 values of 33.52 μM and 76.90 μM respectively .
|
-
- HY-163041
-
-
- HY-157186
-
|
Others
|
Inflammation/Immunology
|
(22R)-33,34,35-Trinorbacteriohopan-32-oic acid (compound 2c) is a hapten that can be covalently coupled to a carrier protein. (22R)-33,34,35-Trinorbacteriohopan-32-oic acid can be used in antibody generation and immunoassay .
|
-
- HY-161272
-
|
Sodium Channel
|
Neurological Disease
|
Nav1.8-IN-6 (Compound 2j) is a novel pyridinone amide Nav1.8 channel inhibitor. The IC50 values in the resting state and semi-activated state are 513.33 and 471.81 nM, respectively. Nav1.8-IN-6 has analgesic activity .
|
-
- HY-163323
-
|
Aldose Reductase
|
Cancer
|
AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer .
|
-
- HY-161332
-
|
Ferroptosis
Pyroptosis
Apoptosis
Reactive Oxygen Species
|
Cancer
|
Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation of A549 cells during the S phase and induces an early apoptosis. Antitumor agent-143 induces cell death via ferroptosis, apoptosis by a ROS-mediated mitochondrial dysfunction pathway and GSDMD-mediated pyroptosis .
|
-
- HY-125524
-
|
Bacterial
|
Infection
|
Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a Kd of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively .
|
-
- HY-146496
-
|
Bacterial
|
Infection
|
Antitubercular agent-20 (Compound 2d) is an orally active antitubercular agent. Antitubercular agent-20 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: <0.016 µg/ml). Antitubercular agent-20 has low cytotoxicity and good tolerance in BALB/c mice .
|
-
- HY-147725
-
|
Microtubule/Tubulin
|
Cancer
|
Microtubule inhibitor 4 (compound 2) is a potent microtubule inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC50s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization .
|
-
- HY-147922
-
|
Carbonic Anhydrase
|
Inflammation/Immunology
|
hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with Ki values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity .
|
-
- HY-147957
-
|
Bacterial
|
Infection
|
Antibacterial agent 112 (compound 2) is a potent antibacterial agent. Antibacterial agent 112 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values of 625, 625, 1250, 1250, 1250, 1250 and 1250 μM, respectively .
|
-
- HY-B0503S
-
Thiouracil-13C,15N2
|
Isotope-Labeled Compounds
NO Synthase
|
Endocrinology
Cancer
|
2-Thiouracil- 13C, 15N2 is the 13C, 15N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.
|
-
- HY-144046
-
|
HBV
DNA/RNA Synthesis
|
Infection
|
HBV-IN-15 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-15 is a flavone derivative. HBV-IN-16 has the potential for the research of HBV infection (extracted from patent WO2020052774A1, compound 2) .
|
-
- HY-143306
-
|
Isocitrate Dehydrogenase (IDH)
|
Cancer
|
IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively .
|
-
- HY-152945
-
|
NF-κB
|
Cancer
|
Antiproliferative agent-22 (compound 2) is an anticancer agent. Antiproliferative agent-22 shoes anti-proliferative activities against MCF-7, MDA-MB-231 and MDA-MB-468 cells with IC50 values of 6.2 μM, 3.3 μM and 3.3 μM, respectively .
|
-
- HY-155611
-
|
Cathepsin
|
Inflammation/Immunology
|
Cathepsin C-IN-6 (compound 2) is a E-64c-hydrazideas based inhibitor of cathepsin C with anti-inflammatory activity. Cathepsin C-IN-6 inhibts activation of neutrophil elastase,exhibits potential efficacy in inflammatory diseases with high neutrophil load (e.g.,chronic obstructive pulmonary disease) .
|
-
- HY-155119
-
|
SARS-CoV
|
Infection
|
SARS-CoV-2-IN-54 (Compound 2) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-54 has antiviral activity. SARS-CoV-2-IN-54 inhibits SARS-CoV-2 in Vero E6 cells, with an IC50 of 21.4 μM .
|
-
- HY-N12353
-
|
Phosphatase
|
Metabolic Disease
|
Stevisalioside A (Compound 2) can be isolated from Stevia serrata roots. Stevisalioside A is an orally active antidiabetic agent. Stevisaliosides A inhibits PTP1B (IC50: 526.8 μM). Stevisalioside A reduces blood glucose levels and the postprandial peak in oral glucose and insulin tolerance tests in Streptozotocin (HY-13753) induced hyperglycemic mice .
|
-
- HY-Y0045
-
1-(1,3-Thiazol-2-yl)ethanone; 1-(Thiazol-2-yl)ethanone; Methyl 2-thiazolyl ketone
|
Biochemical Assay Reagents
|
Others
|
2-Acetylthiazole (1-(1,3-Thiazol-2-yl)ethanone; 1-(Thiazol-2-yl)ethanone; Methyl 2-thiazolyl ketone) is a flavor compound. 2-Acetylthiazole is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-W007980
-
|
Fungal
|
Infection
|
Antifungal agent 98 (compound 2) is an antifungal agent. Antifungal agent 98 (100 μg/mL) shows insecticidal activity against Bipolaris sorokinianum, Fusarium oxysporium f. sp.vasinfectum, Pyricularia oryzae, Alternaria
Brassicae and Alternaria alternata with a death rate of 41.5%, 40.0%, 23.4, 36.8%, and 35.0% .
|
-
- HY-142723
-
|
Potassium Channel
|
Neurological Disease
|
KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 1 potentiates human KCa2.3 channels with an EC50 value of 0.19 μM and 0.99 μM on the rat KCa2.2 channel subtype .
|
-
- HY-143457
-
|
Others
|
Inflammation/Immunology
|
Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .
|
-
- HY-146354
-
|
Apoptosis
Reactive Oxygen Species
|
Cancer
|
Antiproliferative agent-4 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative agent-4 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative agent-4 inhibits tumour growth in nude mice, with low toxicity .
|
-
- HY-148318
-
|
Casein Kinase
|
Cancer
|
CK2α-IN-1 (compound 2) is a selective CK2α inhibitor (IC50=7.0 µM; Ki=1.6 µM) that exhibits a non-ATP-competitive mode of action. CK2α-IN-1 exhibits good potential for anticancer studies .
|
-
- HY-153762
-
|
NO Synthase
NF-κB
COX
|
Inflammation/Immunology
|
COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM) .
|
-
- HY-153475
-
|
IRE1
|
Cancer
|
IRE1α kinase-IN-9 (compound 2) is a potent IRE-1α inhibitor,exhibits an average IC50 value of <0.1 μM. IRE1α kinase-IN-9 can be used for research in diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) .
|
-
- HY-155127
-
|
Others
|
Cancer
|
Antiproliferative agent-33 (Compound 2g) is an anti-proliferative, antifungal, and antibacterial agent. Antiproliferative agent-33 inhibits MDA-MB-231 cell proliferation (IC50: 16.38 μM). Antiproliferative agent-33 inhibits gram-negative bacteria growth, and inhibits S. faecalis with an MIC value of 8 μg/mL .
|
-
- HY-155390
-
|
Caspase
Apoptosis
|
Cancer
|
Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC50 values of 42.89 and 33.61 μM, respectively .
|
-
- HY-155466
-
|
Dopamine Receptor
|
Neurological Disease
|
Boc-MIF-1-Am (compound 2) is a human dopamine D2 receptor enhancer (EC50=17.82 nM) and is a bioconjugate of melanostatin (MIF-1) and amantadine. Boc-MIF-1-Am (200 μM) exhibited mild neurotoxicity in SH-SY5Y cells .
|
-
- HY-N12604
-
|
NF-κB
|
Others
|
Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a NF-κB inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .
|
-
- HY-161516
-
|
HDAC
|
Cancer
|
HDAC6-IN-42 (compound 2b) is an HDAC6 inhibitor (IC50=0.009 μM). HDAC6-IN-42 shows significant anti-leukemia activity and synergistic effect with Decitabine (HY-A0004). HDAC6-IN-42 can be used for the AML research .
|
-
- HY-101265
-
S1p receptor agonist 1
|
LPL Receptor
|
Inflammation/Immunology
|
Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.
|
-
- HY-144048
-
|
EGFR
|
Cancer
|
EGFR-IN-31 is a potent inhibitor of EGFR. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-31 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185298A1, compound 2) .
|
-
- HY-144049
-
|
EGFR
|
Cancer
|
EGFR-IN-32 is a potent inhibitor of EGFR. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-32 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185297A1, compound 2) .
|
-
- HY-144428
-
|
Bcl-2 Family
|
Cancer
|
Bcl-2/Mcl-1-IN-2 (compound 2) is a Bcl-2/Mcl-1 inhibitor, with Kis of 0.88 μM and 4.70 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-2 can be used for the research of cancer .
|
-
- HY-147855
-
|
ERK
Apoptosis
|
Cancer
|
ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivation
ACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively .
|
-
- HY-N3616
-
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID50 value of 0.76 μM,and has the antimutagenic
activities against furylfuramide, Trp-P-1, and activated Trp-P-1 .
|
-
- HY-163418
-
|
EGFR
|
Cancer
|
HER2-IN-17 (Compound 2) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-17 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC) .
|
-
- HY-111166
-
|
Deubiquitinase
|
Cancer
|
USP7/USP47 inhibitor 1 (compound 2) is an inhibitor of USP47, with an EC50 of 14 μM. USP7/USP47 inhibitor 1 has an EC50 of >31.6 μM for USP7. USP7/USP47 inhibitor 1 can be used for cancer research .
|
-
- HY-161611
-
|
Others
|
Others
|
Plant 14-3-3-IN-1 (Compound 2) is an inhibitor for 14-3-3 proteins in Arabidopsis thaliana, with an IC50 of 1.21 μM. Plant 14-3-3-IN-1 exhibits different inhibitory activities against different 14-3-3 isomers. Plant 14-3-3-IN-1 promotes the closure of stomata on leaves .
|
-
- HY-116463A
-
|
Sigma Receptor
|
Neurological Disease
|
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .
|
-
- HY-116463B
-
|
Sigma Receptor
|
Neurological Disease
|
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .
|
-
- HY-116463C
-
|
Sigma Receptor
|
Neurological Disease
|
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .
|
-
- HY-142441
-
|
Others
|
Endocrinology
|
THR-β Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THR-β Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2) .
|
-
- HY-142735
-
|
Potassium Channel
|
Neurological Disease
|
KCa2 channel modulator 2 (compound 2q) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 2 exhibits similar potency on the rat KCa2.2a and human KCa2.3 channel subtypes, with EC50s of 0.64 μM and 0.60 μM, respectively
|
-
- HY-144307
-
|
Aurora Kinase
PKC
|
Cancer
|
Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity .
|
-
- HY-147863
-
|
HBV
|
Infection
Neurological Disease
|
HBV-IN-24 (compound (2ʹS, 6S)-1a) is a potent HBV inhibitor. HBV-IN-24 exhibits potent inhibition activity against HBV DNA, HBsAg, and HBeAg, with EC50 values of 0.6, 0.6, and 4.6 nM, respectively. HBV-IN-24 shows excellent antiviral activity, could have improved neurotoxicity .
|
-
- HY-149265
-
|
Reactive Oxygen Species
TrxR
Ferroptosis
Apoptosis
|
Cancer
|
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities .
|
-
- HY-155599
-
|
HIV
PKC
|
Infection
|
HIV-1 protease-IN-10 (Compound 2) has HIV-1 latency reversing activity (IC50: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC50: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis .
|
-
- HY-156672
-
|
FGFR
|
Cancer
|
S6K2-IN-1 (Compound 2) is a S6K2 inhibitor (IC50: 22 nM). S6K2-IN-1 also inhibits FGFR4 (IC50: 216 nM). S6K2-IN-1 has acceptable stability in mouse liver microsomes .
|
-
- HY-157876
-
|
P-glycoprotein
BCRP
|
Cancer
|
Anticancer agent 191 (Compound 2) is a derivative of probenecid (HY-B0545). As a cancer cell efflux inhibitor, Anticancer agent 191 is designed to inhibit P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and/or multiple multidrug resistance proteins (MRPs). Anticancer agent 191 increases the accumulation of vinblastine in cancer cells, which is used for cancer research .
|
-
- HY-N4190
-
1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactone
|
NO Synthase
|
Neurological Disease
Inflammation/Immunology
|
Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property .
|
-
- HY-143872
-
|
Bcl-2 Family
|
Cancer
|
Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2) .
|
-
- HY-115912
-
|
Glycoprotein VI
|
Cardiovascular Disease
|
GPVI antagonist 3 (Compound 2) is a potential antagonist of Glycoprotein VI (GPVI). IC50 values of GPVI antagonist 3 are, respectively, 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin and 51.74 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 3 is a promising antiplatelet agent .
|
-
- HY-143599
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 8 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 8 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021107160A1, compound 2) .
|
-
- HY-147692
-
|
COX
|
Inflammation/Immunology
|
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice .
|
-
- HY-147884
-
|
Bacterial
|
Infection
|
Antitubercular agent-28 (compound 2) is a potent antitubercular agent with an IC50 value of 1.5 µM, an MIC value of 4.5 µM, an IC90 value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity .
|
-
- HY-D1684
-
|
Amyloid-β
|
Neurological Disease
|
DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo .
|
-
- HY-148424
-
|
ADC Cytotoxin
|
Cancer
|
PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer [2].
|
-
- HY-156441
-
|
SARS-CoV
|
Infection
|
SARS-CoV-2-IN-65 (compound 2f (81)) is a potent,orally active and reversible SARS-CoV-2 entry inhibitor. SARS-CoV-2-IN-65 inhibits the pseudovirus entry in a ACE2-dependent pathway, via mainly inhibiting RBD:ACE2 interaction and TMPRSS2 activity in Calu-3 cells .
|
-
- HY-148926
-
|
17β-HSD
|
Metabolic Disease
|
HSD17B13-IN-1 (compound 2) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM? estradiol? as substrates. HSD17B13-IN-1? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) .
|
-
- HY-N8374
-
|
Parasite
|
Infection
|
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC50 is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC50 of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC50 is 11.2 μM) and macrophages (PMM, IC50 is 8 μM) .
|
-
- HY-147590
-
|
CD73
|
Inflammation/Immunology
|
CD73-IN-9 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-9 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022068929A1, compound 2) .
|
-
- HY-143723
-
|
Monoamine Oxidase
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
SSAO inhibitor-3 (Compound 2) is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor with IC50s of <10 nM, and 0.1-10 μM for human SSAO and AOC1, respectively. SSAO inhibitor-3 can be used for the research of atherosclerosis, diabetes and its complications, obesity, stroke, chronic kidney disease, retinopathy, chronic obstructive pulmonary disease (COPD), autoimmune diseases, multiple sclerosis, etc .
|
-
- HY-153789
-
|
Others
|
Cancer
|
PI5P4Kγ-IN-1 (compound 2) is a selective PI5P4Kγ inhibitor. PI5P4Kγ-IN-1 can be used to signal mTORC1 in MCF-7 breast cancer cells and further characterize PI5P4Kγ in the cells .
|
-
- HY-157389
-
|
Bcr-Abl
|
Cancer
|
AK-HW-90 (compound 2B) is a potent panBcr-Abl inhibitor with significant inhibitory activity against Imatinib (HY-15463)-resistant mutants. AK-HW-90 inhibits the resistance mutant Bcr-Abl T315I with an IC50 of 0.65 nM. AK-HW-90 has potential anticancer activity and can be used in the study of chronic myelogenous leukemia (CML) .
|
-
- HY-163435
-
|
Apoptosis
Caspase
PARP
Bcl-2 Family
|
Cancer
|
Anticancer agent 201 (Compound 2f) has IC50 values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research .
|
-
- HY-162488
-
|
Fungal
|
Infection
|
Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS .
|
-
- HY-145037
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-11 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-11 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 2) .
|
-
- HY-155764
-
|
COX
|
Cancer
|
COX-1/2-IN-4 (compound 2b) is anCOX inhibitorwith IC50 values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively. COX-1/2-IN-4showsmoderateanticanceractivity against COLO205 and B16F1 cancer cell lines with IC50 values of 30.79 and 74.15 μM, respectively .
|
-
- HY-155705
-
|
TGF-β Receptor
GSK-3
β-catenin
|
Others
|
BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research .
|
-
- HY-161398
-
|
TGF-β Receptor
TGF-beta/Smad
|
Cancer
|
TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) (IC50 = 4.1 μM). TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research .
|
-
- HY-130538
-
|
HDAC
|
Cancer
|
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity [2].1-Naphthohydroxamic acid can induce tubulin acetylation .
|
-
- HY-144038
-
|
DNA-PK
|
Cancer
|
DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2) .
|
-
- HY-162166
-
|
COX
Lipoxygenase
|
Inflammation/Immunology
|
COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments .
|
-
- HY-161213
-
|
17β-HSD
|
Metabolic Disease
|
HSD17B13-IN-11 (Compound 2) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 1 μM for leukotriene B3 and ≤ 0.1 μM for estradiol. HSD17B13-IN-11 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) .
|
-
- HY-157942
-
|
Cytochrome P450
|
Cancer
|
CYP1B1-IN-7 (compound 2a) is a selective inhibitor of CYP1B1 (IC50: 75 nM). CYP1B1-IN-7 also reverses resistance (IC50: 29 μM) and exhibits cytotoxicity in the CYP1B1-overexpressing MCF-7 cell line that is resistant to Docetaxel (HY-B0011) .
|
-
- HY-144056
-
|
EGFR
|
Cancer
|
EGFR-IN-39 is a potent inhibitor of EGFR. EGFR-IN-39 is an anti-tumor agent with low toxic side effects. EGFR-IN-39 is an acrylamide derivative compound. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-39 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 2) .
|
-
- HY-D1637
-
|
Fluorescent Dye
|
Others
|
5-Nitro BAPTA tetramethyl ester is a calcium chelator. 5-Nitro BAPTA tetramethyl ester involves in the two-photon probe synthesis, and is used for real-time imaging of intracellular calcium ions, calcium waves monitoring at a depth of 100-300 μm in liver tissues for 1100-4000 s. 5-Nitro BAPTA tetramethyl ester, together with fluorescent compound 2-Me-substituted TM, can be used to form a red fluorescent probe (CaTM-2 AM) [2].
|
-
- HY-149537
-
|
Potassium Channel
|
Neurological Disease
|
TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant .
|
-
- HY-N12422
-
|
Adenosine Receptor
|
Inflammation/Immunology
Cancer
|
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A2AAR antagonist (IC50=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .
|
-
- HY-103521
-
|
GABA Receptor
|
Neurological Disease
|
Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo .
|
-
- HY-155730
-
|
PI3K
|
Cancer
|
PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect .
|
-
- HY-162299
-
|
EGFR
|
Cancer
|
EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor .
|
-
- HY-147038
-
|
AMPK
|
Metabolic Disease
|
AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes .
|
-
- HY-N10907
-
|
Bacterial
|
Infection
|
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2) is a quinolone alkaloid that can be isolated from Cnidium. 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- has methicillin-resistant Staphylococcus aureus (MRSA) activity, with MIC values of 32 μg/mL (ATCC 33591) and 16 μM/mL (ATCC 25923), respectively .
|
-
- HY-139996
-
|
PROTACs
Ligands for E3 Ligase
|
Cancer
|
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD + acute myeloid leukemia .
|
-
- HY-146307
-
|
TrxR
|
Cancer
|
TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins .
|
-
- HY-N10621
-
|
Others
|
Cancer
|
3,5-Dimethoxy-2,7-phenanthrenediol (compound 2) is a phenanthrene compound isolated from the roots of Combretum laxum. 3,5-Dimethoxy-2,7-phenanthrenediol is cytotoxic to human cancer cell lines 786-0, MCF-7 and NCI/ADR-RES, with IC50s of 73.26 μM, 118.40 μM and 83.99 μM respectively. 3,5-Dimethoxy-2,7-phenanthrenediol also has free radical scavenging activity with an IC50 of 20.4 μM .
|
-
- HY-133736
-
|
PROTAC-Linker Conjugates for PAC
ADC Cytotoxin
|
Cancer
|
PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker . PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-149536
-
|
Potassium Channel
|
Neurological Disease
|
TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects .
|
-
- HY-147946
-
|
Phosphodiesterase (PDE)
Calcium Channel
|
Inflammation/Immunology
|
PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research .
|
-
- HY-153703
-
|
PI3K
|
Cancer
|
PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity . PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-149538
-
|
Potassium Channel
|
Neurological Disease
|
TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects .
|
-
- HY-155811
-
|
Others
|
Neurological Disease
|
DQP-997-74 (compound 2i) is a selective inhibitor of N-methyl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0.069 μM and 0.035 μM), with blood-brain barrier penetrability. Where DQP refers to dihydroquinoline-pyrazoline. DQP-997-74 acts synergistically with the agonist glutamate to exhibit time-dependent enhanced potency in inhibiting hypersynchronous activity driven by high-frequency excitatory synaptic transmission. DQP-997-74 reduces the number of epileptogenesis in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 can be used for research on NMDAR-related neurological diseases .
|
-
- HY-162083
-
|
Cannabinoid Receptor
5-HT Receptor
|
Neurological Disease
|
CB2R/5-HT1AR agonist 1 (Compound 2o) is an orally active partial agonist of the CB2 receptor (EC50=479.6 nM). CB2R/5-HT1AR agonist 1 is a full agonist of 5-HT1A receptor (EC50=2.7 μM). CB2R/5-HT1AR agonist 1 exhibits anti-anxiety and anti-depressive effects. CB2R/5-HT1AR agonist 1 possesses favorable pharmacokinetic properties .
|
-
- HY-N12135
-
|
Others
|
Cancer
|
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2) is an enantio-kaurene diterpenoid (ent -kaurene diterpenoid), which can be isolated from Rubescens rubescens. 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide has cellular activity against EC-1, U87, A549, MCF-7 and HeLa cell lines Toxicity, IC50s are 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, 462.13 μM, and 180.09 μM respectively .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-162129
-
|
Fluorescent Dyes/Probes
|
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC50 value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .
|
-
- HY-D0113
-
|
Fluorescent Dyes/Probes
|
7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage .
|
-
- HY-D1684
-
|
Fluorescent Dyes/Probes
|
DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo .
|
Cat. No. |
Product Name |
Type |
-
- HY-W070306
-
|
Biochemical Assay Reagents
|
PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor, and can be used for research of myeloproliferative disorders or cancer .
|
-
- HY-149167
-
|
Drug Delivery
|
mRNA-Encapsulating Lipid Excipient 1 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. mRNA-Encapsulating Lipid Excipient 1 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .
|
-
- HY-Y0410
-
2-Iminobenzimidazoline; 1H-Benzimidazol-2-ylamine; 2-Benzimidazolamine
|
Biochemical Assay Reagents
|
2-Aminobenzimidazole (2-Iminobenzimidazoline; 1H-Benzimidazol-2-ylamine; 2-Benzimidazolamine) is a heterocyclic aromatic compound. 2-Aminobenzimidazole is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-Y0045
-
1-(1,3-Thiazol-2-yl)ethanone; 1-(Thiazol-2-yl)ethanone; Methyl 2-thiazolyl ketone
|
Biochemical Assay Reagents
|
2-Acetylthiazole (1-(1,3-Thiazol-2-yl)ethanone; 1-(Thiazol-2-yl)ethanone; Methyl 2-thiazolyl ketone) is a flavor compound. 2-Acetylthiazole is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-157915
-
Tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate, sodium salt, trihydrate
|
Chelators
|
HFPB (Compound 2) is a type of cation exchanger with high lipophilicity and acid resistivity, which can be used in membrane electrode research .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P5699
-
|
Bacterial
|
Infection
|
Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL .
|
-
- HY-125357
-
|
Peptides
|
Metabolic Disease
|
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC50 of 0.027 μM in 3T3-L1 adipocytes .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N3687
-
-
- HY-129144
-
-
- HY-N12022
-
-
- HY-N12601
-
-
- HY-N12703
-
-
- HY-155411
-
-
- HY-N1716
-
-
- HY-N1947
-
-
- HY-W009708
-
-
- HY-N11880
-
-
- HY-N12664
-
-
- HY-W019829
-
-
- HY-N12130
-
-
- HY-N12071
-
-
- HY-125603
-
-
- HY-N10402
-
|
Alkaloids
Microorganisms
Source classification
|
Fungal
Bacterial
Parasite
|
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC50 of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .
|
-
- HY-N10431
-
-
- HY-N10947
-
-
- HY-N12137
-
-
- HY-N1797
-
-
- HY-N11137
-
-
- HY-N3879
-
-
- HY-125524
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Bacterial
|
Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a Kd of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively .
|
-
- HY-N12353
-
-
- HY-N12604
-
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
NF-κB
|
Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a NF-κB inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .
|
-
- HY-N3616
-
-
- HY-N8374
-
-
- HY-N12422
-
-
- HY-N10907
-
-
- HY-N10621
-
|
Structural Classification
Combretaceae
Phenols
Polyphenols
Plants
Quisqualis indica Linn.
|
Others
|
3,5-Dimethoxy-2,7-phenanthrenediol (compound 2) is a phenanthrene compound isolated from the roots of Combretum laxum. 3,5-Dimethoxy-2,7-phenanthrenediol is cytotoxic to human cancer cell lines 786-0, MCF-7 and NCI/ADR-RES, with IC50s of 73.26 μM, 118.40 μM and 83.99 μM respectively. 3,5-Dimethoxy-2,7-phenanthrenediol also has free radical scavenging activity with an IC50 of 20.4 μM .
|
-
- HY-N12135
-
|
Structural Classification
Terpenoids
Labiatae
Source classification
Diterpenoids
Plants
Cyrtocymura cincta var. cincta
|
Others
|
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2) is an enantio-kaurene diterpenoid (ent -kaurene diterpenoid), which can be isolated from Rubescens rubescens. 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide has cellular activity against EC-1, U87, A549, MCF-7 and HeLa cell lines Toxicity, IC50s are 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, 462.13 μM, and 180.09 μM respectively .
|
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-Y1093S2
-
|
Ethyl acetoacetate-d5 is the deuterium labeled Ethyl acetoacetate[1]. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[2][3][4]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[5].
|
-
-
- HY-34487S
-
|
1,3-Dimethoxybenzene-d10 is the deuterium labeled 1,3-Dimethoxybenzene[1]. 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds[2].
|
-
-
- HY-34487S1
-
|
1,3-Dimethoxybenzene-d4 is the deuterium labeled 1,3-Dimethoxybenzene[1]. 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds[2].
|
-
-
- HY-34487S2
-
|
1,3-Dimethoxybenzene-d6 is the deuterium labeled 1,3-Dimethoxybenzene[1]. 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds[2].
|
-
-
- HY-W010562S
-
|
2-Methoxypyrazine-d3 is the deuterium labeled 2-Methoxypyrazine[1]. 2-Methoxypyrazine is an active compound. 2-Methoxypyrazine can be used for the research of various biochemical studies[2].
|
-
-
- HY-Y1093S3
-
|
Ethyl acetoacetate- 13C is the 13C labeled Ethyl acetoacetate[1]. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[2][3][4]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[5].
|
-
-
- HY-Y1093S1
-
|
Ethyl acetoacetate- 13C4 is the 13C labeled Ethyl acetoacetate[1]. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[2][3][4]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[5].
|
-
-
- HY-W088037S
-
|
Tridecane-d28 is the deuterium labeled Tridecane[1]. Tridecane is a short chain aliphatic hydrocarbon containing 13 carbon atoms. Tridecane is an volatile oil component isolated from essential oil of Piper aduncum L. Tridecane is a stress compound released by the brown marmorated stink bugs stress compound[2][3].
|
-
-
- HY-B0503S
-
|
2-Thiouracil- 13C, 15N2 is the 13C, 15N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-157573
-
|
|
Azide
|
N-Acetylmuramic acid-azide (Compound 2) is a derivative of N-acetylaminoacetic acid (NAM) in bacterial peptidoglycan. Incorporated into bacterial peptidoglycan during biosynthesis .
|
-
- HY-145472
-
|
|
Alkynes
|
Sphingosine (d18:1) alkyne (compound 2b) is an alkyne-labeled Sphingosine (d18:1) that can be used in click chemistry reactions .
|
-
- HY-162446
-
|
|
Alkynes
|
pan-KRAS-IN-13 (compound 2) is a potent inhibitor of KRAS, with IC50s of 2.75 nM and 2.89 nM for G12D and G12V, respectively
|
-
- HY-162129
-
|
|
Azide
|
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC50 value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .
|
-
- HY-W457949
-
|
|
Azide
|
Pomalidomide 4'-alkylC4-azide (Compound 2) is an azide compound containing a MIDI group and is one of the compounds used to construct a library of MIDI azide compounds. Pomalidomide 4'-alkylC4-azide can be used to develop research on PROTAC degraders .
|
-
- HY-139343
-
|
|
Azide
|
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .
|
-
- HY-139341
-
|
|
Azide
|
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .
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- HY-133736
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Azide
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PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker . PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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