1. Cell Cycle/DNA Damage
    Autophagy
  2. CRISPR/Cas9
    Autophagy

4-Hydroxytamoxifen (Synonyms: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen)

Cat. No.: HY-16950 Purity: 99.27%
Handling Instructions

4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, is a selective estrogen receptor modulator, which increases CRISPR/Cas9-mediated editing frequency.

For research use only. We do not sell to patients.
4-Hydroxytamoxifen Chemical Structure

4-Hydroxytamoxifen Chemical Structure

CAS No. : 68047-06-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 102 In-stock
2 mg USD 60 In-stock
5 mg USD 120 In-stock
10 mg USD 168 In-stock
25 mg USD 360 In-stock
50 mg USD 660 In-stock
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Description

4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, is a selective estrogen receptor modulator, which increases CRISPR/Cas9-mediated editing frequency. Target: In vitro: Myocytes treated with 4-Hydroxytamoxifen responded similarly to Tam-treated cells with regard to both contractility and calcium handling, suggesting an estrogen-receptor independent mechanism is responsible for the effects. In contrast, Ral increased contraction and Ca2+ transient amplitudes. At 10 μM, all drugs had a time-dependent effect to abolish cellular contraction. In conclusion, Tam, 4-Hydroxytamoxifen, and Ral adversely and differentially alter cardiac myocyte contractility and Ca2+ handling. These findings have important implications for understanding the Tam-induced cardiomyopathy in gene excision studies and may be important for understanding effects on cardiac performance in patients undergoing high-dose Tam therapy.[2] 4-hydroxytamoxifen was dissolved in methanol at 25 mM.[2] In vivo: The boronic prodrug, ZB497, can not only be efficiently converted to 4-Hydroxytamoxifen in mice, but also afforded over 30 fold higher plasma concentrations of 4-Hydroxytamoxifen than in mice given either the same dose of 4-Hydroxytamoxifen or tamoxifen. [1] For intraperitoneal administration of drugs, mice were injected with PBS containing ZB497, tamoxifen, or 4-Hydroxytamoxifen by adding appropriate amounts of individual stock solutions of the drugs dissolved in DMSO. For oral administration, mice were given oral gavage containing PBS and ethanol-dissolved ZB497, 4-Hydroxytamoxifen, or tamoxifen at a single dose of 1 mg/kg/mouse. [1]

Clinical Trial
References
Molecular Weight

387.51

Formula

C₂₆H₂₉NO₂

CAS No.

68047-06-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 28 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
4-Hydroxytamoxifen
Cat. No.:
HY-16950
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