1. Anti-infection
  2. Bacterial

AFN-1252 (Synonyms: API-1252; Debio 1452)

Cat. No.: HY-16911 Purity: 98.07%
Data Sheet SDS Handling Instructions

AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.

For research use only. We do not sell to patients.
AFN-1252 Chemical Structure

AFN-1252 Chemical Structure

CAS No. : 620175-39-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO $165 In-stock
5 mg $150 In-stock
10 mg $250 In-stock
50 mg $650 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml. IC50 value: Target: Antibiotic agent AFN-1252 was inactive (MIC90, >4 μg/ml) against clinical isolates of Streptococcus pneumoniae, beta-hemolytic streptococci, Enterococcus spp., Enterobacteriaceae, nonfermentative gram-negative bacilli, and Moraxella catarrhalis. These data support the continued development of AFN-1252 for the treatment of patients with resistant staphylococcal infections.

Clinical Trial
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References
Molecular Weight

375.42

Formula

C₂₂H₂₁N₃O₃

CAS No.

620175-39-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 5.8 mg/mL(Need ultrasonic)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
AFN-1252
Cat. No.:
HY-16911
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