1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)

Alda-1 

Cat. No.: HY-18936 Purity: 99.70%
Handling Instructions

Alda-1 is a potent ALDH2 agonist, which significantly improves ALDH2 activity.

For research use only. We do not sell to patients.
Alda-1 Chemical Structure

Alda-1 Chemical Structure

CAS No. : 349438-38-6

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10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $65 In-stock
50 mg $130 In-stock
100 mg $210 In-stock
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Alda-1 is a potent ALDH2 agonist, which significantly improves ALDH2 activity.

In Vivo

Alda-1 treatment results in a significant decrease of 4-HNE-protein content in the plasma of apoE−/− mice. Alda-1 administration leads to a slight increase in gene expression related to neurogenesis (Nog), mitochondrial biogenesis (CYTB, ND1), and apoptosis (Bax, Gsk3b) in the Hp of apoE−/− mice. Alda-1 administration leads to 2 and 10 differentially expressed proteins in the FCx and Hp of apoE−/− mice, respectively[1]. Alda-1 (1.5 mg/kg, b.w., i.p.) administration significantly increases the climbing time, tends to reduce the immobility time and increases the swimming time of the prenatally stressed rats in the forced swim test. Moreover, treatment of prenatally stressed rats with Alda-1 significantly increases number of entries into the open arms of the maze and the time spent therein, as assessed by elevated plus-maze test[2]. Alda-1 (8.5 mg/kg, i.p.) with glucose significantly lowers 4-HNE and FJB-positive cells in the cerebral cortex of Alda-1-treated rats than in DMSO-treated rats 24 h after glucose administration[3]. Alda-1 (10 mg/kg per day) treatment prevents aldehydic overload, mitochondrial dysfunction and improves ventricular function in post-MI cardiomyopathy rats[4].

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.0849 mL 15.4245 mL 30.8490 mL
5 mM 0.6170 mL 3.0849 mL 6.1698 mL
10 mM 0.3085 mL 1.5424 mL 3.0849 mL
Cell Assay
[2]

Spleen cells (4×106 cells/mL) are stimulated by optimal concentrations of concanavalin A (Con A; 2.5 μg/mL and 0.6 μg/mL) and lipopolysaccharide (LPS, 5 μg/mL) and are incubated in 96-well plates at final volume of 0.2 mL for 72 h. Cell proliferation is determined by adding 0.5 μCi of [3H]-thymidine per well at 16 h before the end of the incubation. The cultures are harvested with an automatic cell harvester, and [3H] thymidine incorporation is assessed using a liquid scintillation counter.

Animal Administration
[2]

Alda-1 is dissolved in 1 mL/kg b.w. DMSO/water 50/50.

After behavioral verification at three months of age, the animals are divided into the following four groups: control, control + Alda-1, prenatally stressed and prenatally stressed + Alda-1 (6 animals per group). Alda-1 injections are given intraperitoneally (i.p.) once daily at a dose of 1.5 mg/kg b.w. (dissolved in 1 mL/kg b.w. DMSO/water 50/50) for 14 days. At the same time, the control and prenatally stressed rats receive 1 mL/kg b.w. DMSO/water 50/50. The injections of Alda-1 and vehicle are given between 10 a.m and 11 a.m. In the last five days of Alda-1 treatment the behavioral parameters in the elevated plus maze test and then in the forced swim test are measured.

References
M.Wt

324.16

Formula

C₁₅H₁₁Cl₂NO₃

CAS No.

349438-38-6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 51 mg/mL

Purity: 99.70%

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Alda-1
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HY-18936
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