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Alda-1

HY-18936

Alda-1

Alda-1 Chemical Structure

Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $65 In-stock
50 mg $130 In-stock
100 mg $210 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
5 mg €49 In-stock
10 mg €64 In-stock
50 mg €127 In-stock
100 mg €206 In-stock
200 mg Get quote
500 mg Get quote

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Product name: Alda-1
Cat. No.: HY-18936

Alda-1 Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Alda-1

Alda-1 is an ALDH2 agonist, cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
Target: ALDH2
in vitro: ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding. Alda-1 activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.
in vivo: Alda-1 inhibits atherosclerosis and attenuates NAFLD in apoE-/- mice. The treatment with Alda-1 results in a significant decrease of TG level in liver of apoE-/- mice.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 324.16 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C15H11Cl2NO3
CAS No 349438-38-6
Solvent & Solubility

DMSO:51mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.0849 mL 15.4245 mL 30.8490 mL
5 mM 0.6170 mL 3.0849 mL 6.1698 mL
10 mM 0.3085 mL 1.5424 mL 3.0849 mL

References on Alda-1

Inhibitor Kit