1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    Autophagy
  2. EGFR
    Autophagy

Butein (Synonyms: 2’,3,4,4’-tetrahydroxy Chalcone)

Cat. No.: HY-16558 Purity: 99.89%
Data Sheet SDS Handling Instructions

Butein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR.

For research use only. We do not sell to patients.
Butein Chemical Structure

Butein Chemical Structure

CAS No. : 487-52-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO $75 In-stock
2 mg $50 In-stock
5 mg $80 In-stock
10 mg $120 In-stock
50 mg $450 In-stock
100 mg $750 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Butein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR. target: EGFR [1] In vitro: 1) Butein inhibited the activation of AKT, extracellular signal-regulated kinase (ERKs) and p38 kinases in the presence of cisplatin.[2] 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.[2] 3) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.[3] 4) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.[4] 5) Butein inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50= 65 μM) and p60c-src(IC50= 65 μM) In vivo: 1) Butein in combination with cisplatin suppresses tumor growth and increases FoxO3a expression.[1]

References
Molecular Weight

272.25

Formula

C₁₅H₁₂O₅

CAS No.

487-52-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 35 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Butein
Cat. No.:
HY-16558
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