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Products are for research use only. Not for human use. We do not sell to patients.

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KML29

HY-18977

(KML-29)

KML29

KML29 Chemical Structure

KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $60 In-stock
5 mg $50 In-stock
10 mg $80 In-stock
50 mg $320 In-stock
100 mg $580 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €59 In-stock
5 mg €49 In-stock
10 mg €78 In-stock
50 mg €314 In-stock
100 mg €568 In-stock
200 mg Get quote
500 mg Get quote

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Product name: KML29
Cat. No.: HY-18977

KML29 Data Sheet

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    DataSheet

Related Compound Libraries

Biological Activity of KML29

KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively.
IC50 value: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes)
Target: MAGL
in vitro: KML29 potently and selectively inhibits MAGL with minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH.[1]
in vivo: KML29 a potentially very useful tool to explore the consequences of inhibiting MAGL in the whole animal and in multiple species, and provides greater selectivity than JZL184 in inhibiting MAGL. [2]

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 549.42 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C24H21F6NO7
CAS No 1380424-42-9
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.8201 mL 9.1005 mL 18.2010 mL
5 mM 0.3640 mL 1.8201 mL 3.6402 mL
10 mM 0.1820 mL 0.9101 mL 1.8201 mL

References on KML29

Inhibitor Kit

Related MAGL Products

  • JW 642

    JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.

  • JZL 184

    JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 (mu)M for inhibition of MAGL and FAAH in mouse brain membranes respectively.

  • JZL195

    JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.