1. Metabolic Enzyme/Protease
  2. MAGL

KML29 

Cat. No.: HY-18977
Handling Instructions

KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively.

For research use only. We do not sell to patients.
KML29 Chemical Structure

KML29 Chemical Structure

CAS No. : 1380424-42-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $60 In-stock
5 mg $50 In-stock
10 mg $80 In-stock
50 mg $320 In-stock
100 mg $580 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

KML29 is a potent and selective MAGL inhibitor with IC50 = 5.9, 15, and 43 nM in human, mouse, and rat brain proteomes, respectively. IC50 value: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes) Target: MAGL in vitro: KML29 potently and selectively inhibits MAGL with minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH.[1] in vivo: KML29 a potentially very useful tool to explore the consequences of inhibiting MAGL in the whole animal and in multiple species, and provides greater selectivity than JZL184 in inhibiting MAGL. [2]

References
Molecular Weight

549.42

Formula

C₂₄H₂₁F₆NO₇

CAS No.

1380424-42-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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KML29
Cat. No.:
HY-18977
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