1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

Olmutinib 

Cat. No.: HY-19730 Purity: 99.95%
Data Sheet SDS Handling Instructions

Olmutinib (HM61713; BI-1482694) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with IC50 values of 9.2 nM and 10 nM in HCC827 and H1975 cell, respectively.

For research use only. We do not sell to patients.
Olmutinib Chemical Structure

Olmutinib Chemical Structure

CAS No. : 1353550-13-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $80 In-stock
50 mg $180 In-stock
100 mg $280 In-stock
200 mg $450 In-stock
500 mg   Get quote  
1 g   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Olmutinib (HM61713; BI-1482694) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with IC50 values of 9.2 nM and 10 nM in HCC827 and H1975 cell, respectively.

IC50 & Target

IC50: 9.2 nM (HCC827) and 10 nM (H1975) [1]

In Vitro

Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1].

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0551 mL 10.2756 mL 20.5512 mL
5 mM 0.4110 mL 2.0551 mL 4.1102 mL
10 mM 0.2055 mL 1.0276 mL 2.0551 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

486.59

Formula

C₂₆H₂₆N₆O₂S

CAS No.

1353550-13-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 44 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Olmutinib
Cat. No.:
HY-19730
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