1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Peficitinib (Synonyms: ASP015K; JNJ-54781532)

Cat. No.: HY-19568 Purity: 99.86%
Data Sheet SDS Handling Instructions

Peficitinb (ASP015K, JNJ-54781532) is a novel oral Janus kinase (JAK) inhibitor. Peficitinib inhibits JAK1, JAK2, JAK3 and Tyk2 enzyme activities with IC50s of 3.9, 5.0, 0.71 and 4.8 nM, respectively, and has moderate selectivity for JAK3 inhibition.

For research use only. We do not sell to patients.
Peficitinib Chemical Structure

Peficitinib Chemical Structure

CAS No. : 944118-01-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $110 In-stock
5 mg $100 In-stock
10 mg $180 In-stock
25 mg $320 In-stock
50 mg $590 In-stock
100 mg $990 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

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Description

Peficitinb (ASP015K, JNJ-54781532) is a novel oral Janus kinase (JAK) inhibitor. Peficitinib inhibits JAK1, JAK2, JAK3 and Tyk2 enzyme activities with IC50s of 3.9, 5.0, 0.71 and 4.8 nM, respectively, and has moderate selectivity for JAK3 inhibition. IC50 value: 3.9/5.0/0.71 nM (for JAK1/2/3) , 4.8 nM (for Tyk2) Target: JAK Peficitinib (ASP015K) is a novel orally bioavailable JAK inhibitor in development for the treatment of severe rheumatoid arthritis (RA). Milder inhibition of JAK2 by Peficitinib may contribute to the mitigation of effects on red blood cells and platelets reported to be caused by JAK2 inhibition. Moreover, Peficitinib has shown an improvement in symptoms in RA animal models after once-daily oral administration, and has demonstrated dose-dependent improvement in psoriatic disease activities in a 6-week phase IIa study. The terminal mean half-life of Peficitinib was estimated to be 7-13 h in pharmacological studies with healthy subjects, suggesting that Peficitinib can be dosed once-daily in the next development stage.

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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.0638 mL 15.3191 mL 30.6382 mL
5 mM 0.6128 mL 3.0638 mL 6.1276 mL
10 mM 0.3064 mL 1.5319 mL 3.0638 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

326.39

Formula

C₁₈H₂₂N₄O₂

CAS No.

944118-01-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 60 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.86%

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Peficitinib
Cat. No.:
HY-19568
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