1. Protein Tyrosine Kinase/RTK
  2. Syk

R112 

Cat. No.: HY-16420
Handling Instructions

R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM.

For research use only. We do not sell to patients.
R112 Chemical Structure

R112 Chemical Structure

CAS No. : 575474-82-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO $385 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM. IC50 value: 226 nM [1] Target: Syk in vitro: R112 blocks leukotriene C4 production and all proinflammatory cytokines tested. Its onset of action was immediate, and the inhibition was reversible. R112 is able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 potently, completely, and rapidly abrogated all mast cell activation cascades triggered by IgE receptor cross-linking.[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.2020 mL 16.0102 mL 32.0205 mL
5 mM 0.6404 mL 3.2020 mL 6.4041 mL
10 mM 0.3202 mL 1.6010 mL 3.2020 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

312.3

Formula

C₁₆H₁₃FN₄O₂

CAS No.

575474-82-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 41 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
R112
Cat. No.:
HY-16420
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