1. Apoptosis
  2. MDM-2/p53

RO8994 (Synonyms: RO-8994)

Cat. No.: HY-16999
Handling Instructions

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

For research use only. We do not sell to patients.
RO8994 Chemical Structure

RO8994 Chemical Structure

CAS No. : 1309684-94-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $472 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). IC50 value: 5 nM (in HTRF binding assays), 20 nM (in MTT proliferation assays) Target: MDM2 in vitro: RO8994 represents a new generation of p53-MDM2 antagonists with marked improvement in pharmacological properties for potential clinical development. RO8994 induces dose-dependent up-regulation of p53 target genes and apoptosis in wild-type p53 cancer cells, consistent with its non-genotoxic mechanism of p53 activation. in vivo: RO8994 displays remarkable tumor growth inhibition in the wild-type p53, MDM2-amplified SJSA-1 osteosarcoma tumor xenograft model - exhibiting significant (>60%) tumor growth inhibition at the low dose of 1.56 mg/kg, tumor stasis at 3.125 mg/kg and regression at 6.25 mg/kg.

Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.6300 mL 8.1498 mL 16.2997 mL
5 mM 0.3260 mL 1.6300 mL 3.2599 mL
10 mM 0.1630 mL 0.8150 mL 1.6300 mL
M.Wt

613.51

Formula

C₃₁H₃₁Cl₂FN₄O₄

CAS No.

1309684-94-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 45 mg/mL

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Product Name:
RO8994
Cat. No.:
HY-16999
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