1. Metabolic Enzyme/Protease
  2. DGAT

AZD7687 

Cat. No.: HY-15497 Purity: 98.09%
Data Sheet SDS Handling Instructions

AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1).

For research use only. We do not sell to patients.
AZD7687 Chemical Structure

AZD7687 Chemical Structure

CAS No. : 1166827-44-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 404 In-stock
5 mg USD 367 In-stock
10 mg USD 660 In-stock
50 mg USD 1800 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1). IC50 value: 80 nM [1] Target: DGAT1 in vitro: Plasma AZD7687 exposure was measured repeatedly. Postprandial serum TAG excursion was measured during 8 h after a standardized mixed meal with fat energy content of 60% (SMM 60%; five cohorts, 1-20 mg), before (baseline) and after dosing, to assess effects on gut DGAT1 activity. AZD7687 markedly reduced postprandial TAG excursion with a steep concentration-effect relationship [2]. in vivo: Multiple doses of AZD7687 (1, 2.5, 5, 10 and 20 mg/day, n=6 or n=12 for each) or placebo (n=20) were administered for 1 week. Dose-dependent reductions in postprandial serum TAG were demonstrated with AZD7687 doses ≥5mg compared with placebo (p<0.01). Significant (p<0.001) increases in plasma GLP-1 and PYY levels were seen at these doses, but no clear effect on gastric emptying was demonstrated at the end of treatment. With AZD7687 doses >5 mg/day, gastrointestinal (GI) side effects increased; 11/18 of these participants discontinued treatment owing to diarrhoea [3].

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References
Molecular Weight

367.44

Formula

C₂₁H₂₅N₃O₃

CAS No.

1166827-44-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
AZD7687
Cat. No.:
HY-15497
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