1. Cell Cycle/DNA Damage
  2. Haspin Kinase

CHR-6494 

Cat. No.: HY-15217 Purity: 98.12%
Data Sheet SDS Handling Instructions

CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation.

For research use only. We do not sell to patients.
CHR-6494 Chemical Structure

CHR-6494 Chemical Structure

CAS No. : 1333377-65-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $73 In-stock
5 mg $66 In-stock
10 mg $124 In-stock
50 mg $370 In-stock
100 mg $626 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

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Description

CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation. IC50 Value: N/A Target: Haspin Kinase CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.

References
Molecular Weight

292.34

Formula

C₁₆H₁₆N₆

CAS No.

1333377-65-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
CHR-6494
Cat. No.:
HY-15217
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