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CHR-6494

HY-15217

(CHR 6494; CHR6494)

CHR-6494

CHR-6494 Chemical Structure

CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $73 In-stock
5 mg $66 In-stock
10 mg $124 In-stock
50 mg $370 In-stock
100 mg $626 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €72 In-stock
5 mg €65 In-stock
10 mg €122 In-stock
50 mg €363 In-stock
100 mg €613 In-stock
200 mg Get quote
500 mg Get quote

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Product name: CHR-6494
Cat. No.: HY-15217

CHR-6494 Data Sheet

  • View current batch:

    Purity: 98.34%

  • Pdf Version Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of CHR-6494

CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation.
IC50 Value: N/A
Target: Haspin Kinase
CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 292.34 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C16H16N6
CAS No 1333377-65-3
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.4207 mL 17.1034 mL 34.2067 mL
5 mM 0.6841 mL 3.4207 mL 6.8413 mL
10 mM 0.3421 mL 1.7103 mL 3.4207 mL

References on CHR-6494

Inhibitor Kit