1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)

Cilomilast (Synonyms: SB-207499; SB207499; SB 207499)

Cat. No.: HY-10790 Purity: 98.81%
Data Sheet SDS Handling Instructions

Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.

For research use only. We do not sell to patients.
Cilomilast Chemical Structure

Cilomilast Chemical Structure

CAS No. : 153259-65-5

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10 mM * 1 mL in DMSO $88 In-stock
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10 mg $140 In-stock
50 mg $460 In-stock
100 mg $810 In-stock
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Description

Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. IC50 value: 110 nM Target: PDE 4 Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00103922 GlaxoSmithKline Pulmonary Disease, Chronic Obstructive November 2004 Phase 3
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References
M.Wt

343.42

Formula

C₂₀H₂₅NO₄

CAS No.

153259-65-5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Cilomilast
Cat. No.:
HY-10790
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