1. GPCR/G Protein
  2. Angiotensin Receptor

PD 123319 (Synonyms: (S)-(+)-PD 123319)

Cat. No.: HY-10259
Handling Instructions

PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

For research use only. We do not sell to patients.
PD 123319 Chemical Structure

PD 123319 Chemical Structure

CAS No. : 130663-39-7

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5 mg USD 115 Get quote
10 mg USD 144 Get quote
50 mg USD 480 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

IC50 & Target

IC50: 34 nM (AT2 Receptor)[1]

In Vitro

PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)[2]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.9661 mL 9.8307 mL 19.6614 mL
5 mM 0.3932 mL 1.9661 mL 3.9323 mL
10 mM 0.1966 mL 0.9831 mL 1.9661 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[3]

PD 123319 is dissolved in saline.

The lower limit of CBF autoregulation is studied in 16 SHR. Eight animals receive PD 123319, while eight serve as controls. PD 123319 or saline is administered intravenously, and the BP is allowed to stabilise for 10 minutes after the injection and prior to the commencement of the autoregulation study. Haemorrhagic hypotension is subsequently induced by withdrawing blood into a syringe. By this means, BP is reduced stepwise to the lowest obtainable level. Throughout the study, CBF is measured at 10 to 15 mmHg BP intervals. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

508.61

Formula

C₃₁H₃₂N₄O₃

CAS No.

130663-39-7

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
PD 123319
Cat. No.:
HY-10259
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