1. GPCR/G Protein
  2. Orexin Receptor (OX Receptor)

SB-674042 

Cat. No.: HY-10898 Purity: 99.70%
Handling Instructions

SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.

For research use only. We do not sell to patients.
SB-674042 Chemical Structure

SB-674042 Chemical Structure

CAS No. : 483313-22-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 131 In-stock
5 mg USD 119 In-stock
10 mg USD 198 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors. IC50 value: 3.76 nM (Kd) Target: OX1 receptor SB-674042 has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca2+ mobilization in CHO-DG44 cells stably transfected with the OX1 receptor.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.2296 mL 11.1480 mL 22.2960 mL
5 mM 0.4459 mL 2.2296 mL 4.4592 mL
10 mM 0.2230 mL 1.1148 mL 2.2296 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

448.51

Formula

C₂₄H₂₁FN₄O₂S

CAS No.

483313-22-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
SB-674042
Cat. No.:
HY-10898
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