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Torin 1 Chemical Structure
|Product name: Torin 1|
|Cat. No.: HY-13003|
Torin 1 is potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34.
|M.Wt||607.64||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
1 mM in DMSO with gentle warming
|1 mg||5 mg||10 mg|
|1 mM||1.6457 mL||8.2286 mL||16.4571 mL|
|5 mM||0.3291 mL||1.6457 mL||3.2914 mL|
|10 mM||0.1646 mL||0.8229 mL||1.6457 mL|
1 . Timothy R. Peterson, Shomit S. Sengupta, Thurl E. Harris, Anne E. Carmack, Seong A. Kang, Eric Balderas, David A. Guertin, Katherine L. Madden, Anne E. Carpenter, Brian N. Finck, David M. Sabatini.mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway.Cell, Volume 146, Issue 3, 408-420, 5 August 2011.
The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes the function of SREBP, a master regulator of lipo- and sterolgenic gene transcription. Here, we demonstrate that mTORC1 regulates SREBP by controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase. Dephosphorylated, nuclear, catalytically active lipin 1 promotes nuclear remodeling and mediates the effects of mTORC1 on SREBP target gene, SREBP promoter activity, and nuclear SREBP protein abundance. Inhibition of mTORC1 in the liver significantly impairs SREBP function and makes mice resistant, in a lipin 1-dependent fashion, to the hepatic steatosis and hypercholesterolemia induced by a high-fat and -cholesterol diet. These findings establish lipin 1 as a key component of the mTORC1-SREBP pathway.
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