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Signaling Pathway

UPF 1069

HY-14478

(UPF-1069; UPF1069)

UPF 1069

UPF 1069 Chemical Structure

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1.

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Free sample   Apply now  
10 mM * 1 mL in DMSO $99 In-stock
10 mg $90 In-stock
50 mg $290 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €97 In-stock
10 mg €88 In-stock
50 mg €284 In-stock
100 mg Get quote
200 mg Get quote

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Product name: UPF 1069
Cat. No.: HY-14478

UPF 1069 Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of UPF 1069

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1.
IC50 Value:  0.3 μM
Target: PARP2
in vitro: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no effect on OGD injury [1].
in vivo: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
Clinical trial: N/A
 

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 279.29 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C17H13NO3
CAS No 1048371-03-4
Solvent & Solubility

100 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.5805 mL 17.9025 mL 35.8051 mL
5 mM 0.7161 mL 3.5805 mL 7.1610 mL
10 mM 0.3581 mL 1.7903 mL 3.5805 mL

References on UPF 1069

Inhibitor Kit

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