1. Metabolic Enzyme/Protease
  2. HIV Protease

DPC-681 (Synonyms: DPH-153893)

Cat. No.: HY-19400
Handling Instructions

DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.

For research use only. We do not sell to patients.
DPC-681 Chemical Structure

DPC-681 Chemical Structure

CAS No. : 284661-68-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 884 In-stock
1 mg USD 180 In-stock
5 mg USD 600 In-stock
10 mg USD 960 In-stock
25 mg USD 1680 In-stock
50 mg USD 2640 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM. IC50 value: 4 - 40 nM [1] Target: HIV protease in vitro: DPC 681 is extremely potent inhibitor of wild-type HIV-1. When all of the HIV-1 strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681. DPC 681 shows no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions. [1] in vivo: The total body clearance (CL) of DPC 681 in dogs was high (1.8 liter/h/kg) equaling hepatic blood flow for this species (1.8 liter/h/kg). After an oral dosing, the Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively). These data suggest that hepatic extraction (first-pass effect) can be saturated in the dog. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.4929 mL 7.4644 mL 14.9287 mL
5 mM 0.2986 mL 1.4929 mL 2.9857 mL
10 mM 0.1493 mL 0.7464 mL 1.4929 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

669.85

Formula

C₃₅H₄₈FN₅O₅S

CAS No.

284661-68-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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DPC-681
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HY-19400
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