2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease HIV
  4. DPC-681

DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM.

For research use only. We do not sell to patients.

DPC-681 Chemical Structure

DPC-681 Chemical Structure

CAS No. : 284661-68-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 660 In-stock
Solution
10 mM * 1 mL in DMSO USD 660 In-stock
Solid
1 mg USD 180 In-stock
5 mg USD 600 In-stock
10 mg USD 960 In-stock
25 mg USD 1680 In-stock
50 mg USD 2640 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

DPC-681 Related Antibodies

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Description

DPC-681 is a potent and selective inhibitor of HIV protease with IC90s for wild-type HIV-1 of 4 to 40 nM. IC50 value: 4 - 40 nM [1] Target: HIV protease in vitro: DPC 681 is extremely potent inhibitor of wild-type HIV-1. When all of the HIV-1 strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681. DPC 681 shows no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions. [1] in vivo: The total body clearance (CL) of DPC 681 in dogs was high (1.8 liter/h/kg) equaling hepatic blood flow for this species (1.8 liter/h/kg). After an oral dosing, the Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively). These data suggest that hepatic extraction (first-pass effect) can be saturated in the dog. [1]

IC50 & Target

HIV-1

 

Molecular Weight

669.85

Formula

C35H48FN5O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC(N)=CC=C1)(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC([C@H](C(C)(C)C)NC(CNCC3=CC=CC(F)=C3)=O)=O)CC(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (149.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4929 mL 7.4644 mL 14.9287 mL
5 mM 0.2986 mL 1.4929 mL 2.9857 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.89%

COA (250 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4929 mL 7.4644 mL 14.9287 mL 37.3218 mL
5 mM 0.2986 mL 1.4929 mL 2.9857 mL 7.4644 mL
10 mM 0.1493 mL 0.7464 mL 1.4929 mL 3.7322 mL
15 mM 0.0995 mL 0.4976 mL 0.9952 mL 2.4881 mL
20 mM 0.0746 mL 0.3732 mL 0.7464 mL 1.8661 mL
25 mM 0.0597 mL 0.2986 mL 0.5971 mL 1.4929 mL
30 mM 0.0498 mL 0.2488 mL 0.4976 mL 1.2441 mL
40 mM 0.0373 mL 0.1866 mL 0.3732 mL 0.9330 mL
50 mM 0.0299 mL 0.1493 mL 0.2986 mL 0.7464 mL
60 mM 0.0249 mL 0.1244 mL 0.2488 mL 0.6220 mL
80 mM 0.0187 mL 0.0933 mL 0.1866 mL 0.4665 mL
100 mM 0.0149 mL 0.0746 mL 0.1493 mL 0.3732 mL
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DPC-681 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPC-681284661-68-3DPH-153893DPC681DPC 681DPH153893DPH 153893HIV ProteaseHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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