1. GPCR/G Protein
  2. GNRH Receptor

Elagolix (Synonyms: NBI-56418)

Cat. No.: HY-14789 Purity: 99.57%
Data Sheet SDS Handling Instructions

Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).

For research use only. We do not sell to patients.
Elagolix Chemical Structure

Elagolix Chemical Structure

CAS No. : 834153-87-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $139 In-stock
2 mg $50 In-stock
5 mg $100 In-stock
10 mg $150 In-stock
50 mg $450 In-stock
100 mg $650 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM). Target: GnRH in vitro: Elagolix is a short-acting, nonpeptide, GnRH antagonist, administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses. Elagolix is regarded as the frontrunner of a new class of GnRH inhibitors that have been denoted as second-generation, due to their non-peptide nature and oral bioavailability.

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.5833 mL 7.9165 mL 15.8331 mL
5 mM 0.3167 mL 1.5833 mL 3.1666 mL
10 mM 0.1583 mL 0.7917 mL 1.5833 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

631.59

Formula

C₃₂H₃₀F₅N₃O₅

CAS No.

834153-87-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Elagolix
Cat. No.:
HY-14789
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