2. Cell Cycle/DNA Damage
  3. STK33
  4. ML281

ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.

For research use only. We do not sell to patients.

ML281 Chemical Structure

ML281 Chemical Structure

CAS No. : 1404437-62-2

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 119 In-stock
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10 mg USD 144 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

ML281 Related Antibodies

Top Publications Citing Use of Products

    ML281 purchased from MedChemExpress. Usage Cited in: Neoplasma. 2017;64(6):869-879.   [Abstract]

    Representative images and analysis results of western blotting validation after incubation with ML281.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA. target: STK33 IC50: 14 nM [1] ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]

    In Vitro

    ML281 (10 μM; 72 hours) suppresses cell viability of NCI-H446 cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ML281 Related Antibodies

    Cell Viability Assay[3]

    Cell Line: NCI-H446 cells
    Concentration: 10 μM
    Incubation Time: 72 hours
    Result: Suppressed cell viability of NCI-H446 cells.
    Molecular Weight

    389.47

    Formula

    C22H19N3O2S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1NC2=CC=CC=C2N=C1C3=CC(C(C)C)=CC=C3NC(C4=CC=CS4)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (256.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5676 mL 12.8380 mL 25.6759 mL
    5 mM 0.5135 mL 2.5676 mL 5.1352 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.5676 mL 12.8380 mL 25.6759 mL 64.1898 mL
    5 mM 0.5135 mL 2.5676 mL 5.1352 mL 12.8380 mL
    10 mM 0.2568 mL 1.2838 mL 2.5676 mL 6.4190 mL
    15 mM 0.1712 mL 0.8559 mL 1.7117 mL 4.2793 mL
    20 mM 0.1284 mL 0.6419 mL 1.2838 mL 3.2095 mL
    25 mM 0.1027 mL 0.5135 mL 1.0270 mL 2.5676 mL
    30 mM 0.0856 mL 0.4279 mL 0.8559 mL 2.1397 mL
    40 mM 0.0642 mL 0.3209 mL 0.6419 mL 1.6047 mL
    50 mM 0.0514 mL 0.2568 mL 0.5135 mL 1.2838 mL
    60 mM 0.0428 mL 0.2140 mL 0.4279 mL 1.0698 mL
    80 mM 0.0321 mL 0.1605 mL 0.3209 mL 0.8024 mL
    100 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6419 mL
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    ML281 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ML2811404437-62-2ML 281ML-281STK33Serine/threonine kinase 33Inhibitorinhibitorinhibit

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